Amino acid dipepetide frequency for uncultured archaeon A07HN63

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.928AlaAla: 14.928 ± 0.267	0.687AlaCys: 0.687 ± 0.034	11.562AlaAsp: 11.562 ± 0.195	8.819AlaGlu: 8.819 ± 0.137	3.492AlaPhe: 3.492 ± 0.086	9.728AlaGly: 9.728 ± 0.168	1.764AlaHis: 1.764 ± 0.06	5.221AlaIle: 5.221 ± 0.111	1.898AlaLys: 1.898 ± 0.061	9.043AlaLeu: 9.043 ± 0.152	2.051AlaMet: 2.051 ± 0.065	2.417AlaAsn: 2.417 ± 0.063	3.667AlaPro: 3.667 ± 0.077	2.298AlaGln: 2.298 ± 0.063	5.368AlaArg: 5.368 ± 0.102	5.511AlaSer: 5.511 ± 0.111	8.002AlaThr: 8.002 ± 0.13	10.929AlaVal: 10.929 ± 0.171	1.017AlaTrp: 1.017 ± 0.047	2.564AlaTyr: 2.564 ± 0.067	0.018AlaXaa: 0.018 ± 0.005
Cys	0.62CysAla: 0.62 ± 0.032	0.113CysCys: 0.113 ± 0.015	0.609CysAsp: 0.609 ± 0.031	0.632CysGlu: 0.632 ± 0.036	0.235CysPhe: 0.235 ± 0.019	0.922CysGly: 0.922 ± 0.044	0.155CysHis: 0.155 ± 0.017	0.279CysIle: 0.279 ± 0.024	0.113CysLys: 0.113 ± 0.014	0.601CysLeu: 0.601 ± 0.035	0.139CysMet: 0.139 ± 0.014	0.206CysAsn: 0.206 ± 0.018	0.486CysPro: 0.486 ± 0.03	0.206CysGln: 0.206 ± 0.019	0.583CysArg: 0.583 ± 0.03	0.475CysSer: 0.475 ± 0.03	0.372CysThr: 0.372 ± 0.022	0.485CysVal: 0.485 ± 0.026	0.121CysTrp: 0.121 ± 0.012	0.193CysTyr: 0.193 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	10.874AspAla: 10.874 ± 0.186	0.8AspCys: 0.8 ± 0.036	9.451AspAsp: 9.451 ± 0.19	8.504AspGlu: 8.504 ± 0.145	1.815AspPhe: 1.815 ± 0.054	8.044AspGly: 8.044 ± 0.144	2.213AspHis: 2.213 ± 0.07	4.137AspIle: 4.137 ± 0.096	1.16AspLys: 1.16 ± 0.047	6.844AspLeu: 6.844 ± 0.125	1.226AspMet: 1.226 ± 0.045	1.74AspAsn: 1.74 ± 0.06	4.354AspPro: 4.354 ± 0.094	2.042AspGln: 2.042 ± 0.053	6.719AspArg: 6.719 ± 0.131	5.04AspSer: 5.04 ± 0.102	5.625AspThr: 5.625 ± 0.106	5.911AspVal: 5.911 ± 0.125	0.947AspTrp: 0.947 ± 0.045	1.794AspTyr: 1.794 ± 0.061	0.007AspXaa: 0.007 ± 0.003
Glu	8.884GluAla: 8.884 ± 0.145	0.524GluCys: 0.524 ± 0.033	4.7GluAsp: 4.7 ± 0.118	6.012GluGlu: 6.012 ± 0.147	2.938GluPhe: 2.938 ± 0.083	4.721GluGly: 4.721 ± 0.107	1.767GluHis: 1.767 ± 0.061	4.721GluIle: 4.721 ± 0.111	1.616GluLys: 1.616 ± 0.057	7.832GluLeu: 7.832 ± 0.129	1.9GluMet: 1.9 ± 0.054	1.958GluAsn: 1.958 ± 0.064	4.108GluPro: 4.108 ± 0.094	3.321GluGln: 3.321 ± 0.072	5.975GluArg: 5.975 ± 0.112	5.434GluSer: 5.434 ± 0.129	7.137GluThr: 7.137 ± 0.14	5.115GluVal: 5.115 ± 0.098	1.015GluTrp: 1.015 ± 0.046	2.51GluTyr: 2.51 ± 0.081	0.007GluXaa: 0.007 ± 0.003
Phe	3.208PheAla: 3.208 ± 0.074	0.25PheCys: 0.25 ± 0.021	3.319PheAsp: 3.319 ± 0.088	2.954PheGlu: 2.954 ± 0.079	0.932PhePhe: 0.932 ± 0.047	3.101PheGly: 3.101 ± 0.088	0.576PheHis: 0.576 ± 0.033	1.193PheIle: 1.193 ± 0.049	0.524PheLys: 0.524 ± 0.033	2.433PheLeu: 2.433 ± 0.075	0.472PheMet: 0.472 ± 0.027	0.7PheAsn: 0.7 ± 0.038	1.234PhePro: 1.234 ± 0.044	0.778PheGln: 0.778 ± 0.038	1.621PheArg: 1.621 ± 0.045	1.647PheSer: 1.647 ± 0.051	1.838PheThr: 1.838 ± 0.053	2.929PheVal: 2.929 ± 0.084	0.338PheTrp: 0.338 ± 0.026	0.805PheTyr: 0.805 ± 0.035	0.002PheXaa: 0.002 ± 0.002
Gly	7.207GlyAla: 7.207 ± 0.135	0.738GlyCys: 0.738 ± 0.036	7.23GlyAsp: 7.23 ± 0.126	6.694GlyGlu: 6.694 ± 0.107	2.97GlyPhe: 2.97 ± 0.071	7.31GlyGly: 7.31 ± 0.166	1.676GlyHis: 1.676 ± 0.053	4.465GlyIle: 4.465 ± 0.106	1.707GlyLys: 1.707 ± 0.06	7.301GlyLeu: 7.301 ± 0.138	1.668GlyMet: 1.668 ± 0.063	1.831GlyAsn: 1.831 ± 0.057	2.936GlyPro: 2.936 ± 0.067	2.249GlyGln: 2.249 ± 0.061	4.64GlyArg: 4.64 ± 0.091	5.196GlySer: 5.196 ± 0.109	5.275GlyThr: 5.275 ± 0.106	7.347GlyVal: 7.347 ± 0.128	1.044GlyTrp: 1.044 ± 0.045	2.552GlyTyr: 2.552 ± 0.07	0.015GlyXaa: 0.015 ± 0.004
His	1.988HisAla: 1.988 ± 0.062	0.212HisCys: 0.212 ± 0.02	1.877HisAsp: 1.877 ± 0.065	1.604HisGlu: 1.604 ± 0.058	0.441HisPhe: 0.441 ± 0.029	1.926HisGly: 1.926 ± 0.052	0.54HisHis: 0.54 ± 0.033	0.916HisIle: 0.916 ± 0.039	0.299HisLys: 0.299 ± 0.023	1.614HisLeu: 1.614 ± 0.051	0.287HisMet: 0.287 ± 0.022	0.532HisAsn: 0.532 ± 0.025	1.178HisPro: 1.178 ± 0.045	0.486HisGln: 0.486 ± 0.031	1.333HisArg: 1.333 ± 0.057	0.943HisSer: 0.943 ± 0.04	1.154HisThr: 1.154 ± 0.048	1.593HisVal: 1.593 ± 0.051	0.227HisTrp: 0.227 ± 0.02	0.503HisTyr: 0.503 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.343IleAla: 5.343 ± 0.108	0.335IleCys: 0.335 ± 0.022	5.097IleAsp: 5.097 ± 0.107	4.992IleGlu: 4.992 ± 0.1	0.969IlePhe: 0.969 ± 0.042	4.142IleGly: 4.142 ± 0.101	0.912IleHis: 0.912 ± 0.035	1.813IleIle: 1.813 ± 0.06	0.914IleLys: 0.914 ± 0.043	3.102IleLeu: 3.102 ± 0.081	0.561IleMet: 0.561 ± 0.029	1.219IleAsn: 1.219 ± 0.045	2.224IlePro: 2.224 ± 0.066	1.26IleGln: 1.26 ± 0.045	2.743IleArg: 2.743 ± 0.082	2.525IleSer: 2.525 ± 0.073	3.101IleThr: 3.101 ± 0.077	3.86IleVal: 3.86 ± 0.097	0.341IleTrp: 0.341 ± 0.027	0.982IleTyr: 0.982 ± 0.046	0.007IleXaa: 0.007 ± 0.003
Lys	1.735LysAla: 1.735 ± 0.055	0.124LysCys: 0.124 ± 0.013	1.007LysAsp: 1.007 ± 0.043	1.366LysGlu: 1.366 ± 0.052	0.53LysPhe: 0.53 ± 0.027	1.273LysGly: 1.273 ± 0.054	0.467LysHis: 0.467 ± 0.029	0.912LysIle: 0.912 ± 0.038	0.511LysLys: 0.511 ± 0.037	1.767LysLeu: 1.767 ± 0.058	0.313LysMet: 0.313 ± 0.024	0.54LysAsn: 0.54 ± 0.036	1.004LysPro: 1.004 ± 0.037	1.033LysGln: 1.033 ± 0.042	1.523LysArg: 1.523 ± 0.055	1.253LysSer: 1.253 ± 0.053	1.374LysThr: 1.374 ± 0.047	1.031LysVal: 1.031 ± 0.046	0.209LysTrp: 0.209 ± 0.02	0.534LysTyr: 0.534 ± 0.03	0.005LysXaa: 0.005 ± 0.002
Leu	10.441LeuAla: 10.441 ± 0.188	0.588LeuCys: 0.588 ± 0.029	8.183LeuAsp: 8.183 ± 0.165	5.444LeuGlu: 5.444 ± 0.113	2.959LeuPhe: 2.959 ± 0.094	7.084LeuGly: 7.084 ± 0.119	1.428LeuHis: 1.428 ± 0.052	3.585LeuIle: 3.585 ± 0.087	1.593LeuLys: 1.593 ± 0.054	8.547LeuLeu: 8.547 ± 0.185	1.379LeuMet: 1.379 ± 0.056	1.898LeuAsn: 1.898 ± 0.057	4.22LeuPro: 4.22 ± 0.09	2.464LeuGln: 2.464 ± 0.071	5.495LeuArg: 5.495 ± 0.104	5.774LeuSer: 5.774 ± 0.1	5.963LeuThr: 5.963 ± 0.113	7.584LeuVal: 7.584 ± 0.156	0.795LeuTrp: 0.795 ± 0.035	1.97LeuTyr: 1.97 ± 0.057	0.018LeuXaa: 0.018 ± 0.006
Met	1.89MetAla: 1.89 ± 0.048	0.106MetCys: 0.106 ± 0.013	1.273MetAsp: 1.273 ± 0.047	1.1MetGlu: 1.1 ± 0.045	0.47MetPhe: 0.47 ± 0.032	1.39MetGly: 1.39 ± 0.056	0.318MetHis: 0.318 ± 0.023	0.798MetIle: 0.798 ± 0.04	0.428MetLys: 0.428 ± 0.027	1.555MetLeu: 1.555 ± 0.053	0.305MetMet: 0.305 ± 0.023	0.524MetAsn: 0.524 ± 0.03	0.845MetPro: 0.845 ± 0.037	0.573MetGln: 0.573 ± 0.028	0.947MetArg: 0.947 ± 0.047	1.683MetSer: 1.683 ± 0.046	1.511MetThr: 1.511 ± 0.047	1.235MetVal: 1.235 ± 0.038	0.135MetTrp: 0.135 ± 0.017	0.326MetTyr: 0.326 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.57AsnAla: 2.57 ± 0.06	0.225AsnCys: 0.225 ± 0.016	1.8AsnAsp: 1.8 ± 0.054	1.828AsnGlu: 1.828 ± 0.058	0.676AsnPhe: 0.676 ± 0.031	1.877AsnGly: 1.877 ± 0.058	0.509AsnHis: 0.509 ± 0.03	1.075AsnIle: 1.075 ± 0.047	0.463AsnLys: 0.463 ± 0.033	1.909AsnLeu: 1.909 ± 0.061	0.441AsnMet: 0.441 ± 0.028	0.545AsnAsn: 0.545 ± 0.035	1.544AsnPro: 1.544 ± 0.05	0.633AsnGln: 0.633 ± 0.032	1.715AsnArg: 1.715 ± 0.054	1.206AsnSer: 1.206 ± 0.049	1.495AsnThr: 1.495 ± 0.051	1.903AsnVal: 1.903 ± 0.058	0.277AsnTrp: 0.277 ± 0.023	0.646AsnTyr: 0.646 ± 0.032	0.002AsnXaa: 0.002 ± 0.002
Pro	5.077ProAla: 5.077 ± 0.096	0.295ProCys: 0.295 ± 0.023	4.845ProAsp: 4.845 ± 0.109	4.289ProGlu: 4.289 ± 0.077	1.503ProPhe: 1.503 ± 0.05	3.439ProGly: 3.439 ± 0.076	0.8ProHis: 0.8 ± 0.036	2.001ProIle: 2.001 ± 0.066	0.849ProLys: 0.849 ± 0.04	3.589ProLeu: 3.589 ± 0.081	0.801ProMet: 0.801 ± 0.032	1.061ProAsn: 1.061 ± 0.043	2.27ProPro: 2.27 ± 0.061	1.201ProGln: 1.201 ± 0.05	2.295ProArg: 2.295 ± 0.067	2.577ProSer: 2.577 ± 0.062	3.491ProThr: 3.491 ± 0.091	3.985ProVal: 3.985 ± 0.098	0.449ProTrp: 0.449 ± 0.025	1.005ProTyr: 1.005 ± 0.041	0.007ProXaa: 0.007 ± 0.003
Gln	2.957GlnAla: 2.957 ± 0.072	0.207GlnCys: 0.207 ± 0.02	1.47GlnAsp: 1.47 ± 0.046	1.771GlnGlu: 1.771 ± 0.06	1.108GlnPhe: 1.108 ± 0.043	1.645GlnGly: 1.645 ± 0.053	0.681GlnHis: 0.681 ± 0.035	1.304GlnIle: 1.304 ± 0.049	0.578GlnLys: 0.578 ± 0.034	3.016GlnLeu: 3.016 ± 0.074	0.568GlnMet: 0.568 ± 0.027	0.679GlnAsn: 0.679 ± 0.038	1.687GlnPro: 1.687 ± 0.062	1.704GlnGln: 1.704 ± 0.076	2.342GlnArg: 2.342 ± 0.061	1.919GlnSer: 1.919 ± 0.063	2.038GlnThr: 2.038 ± 0.067	1.87GlnVal: 1.87 ± 0.054	0.379GlnTrp: 0.379 ± 0.027	0.898GlnTyr: 0.898 ± 0.045	0.007GlnXaa: 0.007 ± 0.004
Arg	5.769ArgAla: 5.769 ± 0.105	0.547ArgCys: 0.547 ± 0.033	4.555ArgAsp: 4.555 ± 0.092	6.025ArgGlu: 6.025 ± 0.114	2.244ArgPhe: 2.244 ± 0.06	4.083ArgGly: 4.083 ± 0.082	1.265ArgHis: 1.265 ± 0.047	3.016ArgIle: 3.016 ± 0.073	1.359ArgLys: 1.359 ± 0.051	6.12ArgLeu: 6.12 ± 0.105	1.219ArgMet: 1.219 ± 0.048	1.598ArgAsn: 1.598 ± 0.052	2.389ArgPro: 2.389 ± 0.062	2.164ArgGln: 2.164 ± 0.071	4.556ArgArg: 4.556 ± 0.117	3.528ArgSer: 3.528 ± 0.074	3.616ArgThr: 3.616 ± 0.085	4.948ArgVal: 4.948 ± 0.11	0.785ArgTrp: 0.785 ± 0.039	1.718ArgTyr: 1.718 ± 0.051	0.011ArgXaa: 0.011 ± 0.004
Ser	5.784SerAla: 5.784 ± 0.103	0.344SerCys: 0.344 ± 0.026	4.858SerAsp: 4.858 ± 0.102	4.707SerGlu: 4.707 ± 0.088	1.754SerPhe: 1.754 ± 0.059	5.348SerGly: 5.348 ± 0.106	1.12SerHis: 1.12 ± 0.043	2.737SerIle: 2.737 ± 0.083	1.304SerLys: 1.304 ± 0.05	5.128SerLeu: 5.128 ± 0.095	1.139SerMet: 1.139 ± 0.039	1.426SerAsn: 1.426 ± 0.056	2.716SerPro: 2.716 ± 0.078	1.668SerGln: 1.668 ± 0.059	3.195SerArg: 3.195 ± 0.079	3.205SerSer: 3.205 ± 0.085	4.036SerThr: 4.036 ± 0.096	5.328SerVal: 5.328 ± 0.09	0.589SerTrp: 0.589 ± 0.03	1.436SerTyr: 1.436 ± 0.048	0.011SerXaa: 0.011 ± 0.004
Thr	8.509ThrAla: 8.509 ± 0.152	0.366ThrCys: 0.366 ± 0.022	6.472ThrAsp: 6.472 ± 0.12	5.257ThrGlu: 5.257 ± 0.092	1.95ThrPhe: 1.95 ± 0.062	5.949ThrGly: 5.949 ± 0.104	1.284ThrHis: 1.284 ± 0.048	3.106ThrIle: 3.106 ± 0.077	1.186ThrLys: 1.186 ± 0.046	6.236ThrLeu: 6.236 ± 0.098	1.072ThrMet: 1.072 ± 0.037	1.683ThrAsn: 1.683 ± 0.057	3.572ThrPro: 3.572 ± 0.079	1.785ThrGln: 1.785 ± 0.053	3.326ThrArg: 3.326 ± 0.083	2.986ThrSer: 2.986 ± 0.074	5.198ThrThr: 5.198 ± 0.127	7.478ThrVal: 7.478 ± 0.138	0.543ThrTrp: 0.543 ± 0.032	1.516ThrTyr: 1.516 ± 0.046	0.008ThrXaa: 0.008 ± 0.004
Val	9.945ValAla: 9.945 ± 0.188	0.685ValCys: 0.685 ± 0.037	7.845ValAsp: 7.845 ± 0.13	7.058ValGlu: 7.058 ± 0.117	2.703ValPhe: 2.703 ± 0.074	7.283ValGly: 7.283 ± 0.153	1.372ValHis: 1.372 ± 0.051	3.74ValIle: 3.74 ± 0.084	1.34ValLys: 1.34 ± 0.054	7.174ValLeu: 7.174 ± 0.14	1.299ValMet: 1.299 ± 0.046	1.857ValAsn: 1.857 ± 0.056	3.736ValPro: 3.736 ± 0.083	1.789ValGln: 1.789 ± 0.053	4.589ValArg: 4.589 ± 0.104	5.139ValSer: 5.139 ± 0.105	6.051ValThr: 6.051 ± 0.101	8.326ValVal: 8.326 ± 0.152	0.744ValTrp: 0.744 ± 0.033	1.862ValTyr: 1.862 ± 0.059	0.01ValXaa: 0.01 ± 0.003
Trp	0.912TrpAla: 0.912 ± 0.039	0.127TrpCys: 0.127 ± 0.014	0.69TrpAsp: 0.69 ± 0.038	0.749TrpGlu: 0.749 ± 0.041	0.424TrpPhe: 0.424 ± 0.028	0.702TrpGly: 0.702 ± 0.038	0.228TrpHis: 0.228 ± 0.022	0.488TrpIle: 0.488 ± 0.028	0.219TrpLys: 0.219 ± 0.019	1.245TrpLeu: 1.245 ± 0.055	0.175TrpMet: 0.175 ± 0.017	0.297TrpAsn: 0.297 ± 0.022	0.444TrpPro: 0.444 ± 0.029	0.449TrpGln: 0.449 ± 0.028	0.818TrpArg: 0.818 ± 0.041	0.498TrpSer: 0.498 ± 0.031	0.633TrpThr: 0.633 ± 0.034	0.783TrpVal: 0.783 ± 0.039	0.142TrpTrp: 0.142 ± 0.017	0.372TrpTyr: 0.372 ± 0.023	0.008TrpXaa: 0.008 ± 0.003
Tyr	2.327TyrAla: 2.327 ± 0.069	0.264TyrCys: 0.264 ± 0.021	2.388TyrAsp: 2.388 ± 0.06	2.383TyrGlu: 2.383 ± 0.066	0.739TyrPhe: 0.739 ± 0.034	2.064TyrGly: 2.064 ± 0.061	0.574TyrHis: 0.574 ± 0.032	0.927TyrIle: 0.927 ± 0.034	0.452TyrLys: 0.452 ± 0.029	2.344TyrLeu: 2.344 ± 0.073	0.392TyrMet: 0.392 ± 0.027	0.63TyrAsn: 0.63 ± 0.038	1.201TyrPro: 1.201 ± 0.044	0.721TyrGln: 0.721 ± 0.029	1.725TyrArg: 1.725 ± 0.061	1.283TyrSer: 1.283 ± 0.048	1.567TyrThr: 1.567 ± 0.053	1.9TyrVal: 1.9 ± 0.053	0.305TyrTrp: 0.305 ± 0.023	0.716TyrTyr: 0.716 ± 0.041	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.015XaaAla: 0.015 ± 0.005	0.005XaaCys: 0.005 ± 0.002	0.015XaaAsp: 0.015 ± 0.005	0.007XaaGlu: 0.007 ± 0.003	0.0XaaPhe: 0.0 ± 0.0	0.02XaaGly: 0.02 ± 0.005	0.002XaaHis: 0.002 ± 0.002	0.008XaaIle: 0.008 ± 0.004	0.0XaaLys: 0.0 ± 0.0	0.011XaaLeu: 0.011 ± 0.004	0.005XaaMet: 0.005 ± 0.003	0.0XaaAsn: 0.0 ± 0.0	0.011XaaPro: 0.011 ± 0.004	0.003XaaGln: 0.003 ± 0.002	0.011XaaArg: 0.011 ± 0.004	0.011XaaSer: 0.011 ± 0.004	0.007XaaThr: 0.007 ± 0.003	0.008XaaVal: 0.008 ± 0.004	0.002XaaTrp: 0.002 ± 0.002	0.002XaaTyr: 0.002 ± 0.002	0.878XaaXaa: 0.878 ± 0.092

Statistics based on 2505 proteins (612759 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---