Amino acid dipepetide frequency for Bosea sp. OK403

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.061AlaAla: 19.061 ± 0.157
1.168AlaCys: 1.168 ± 0.029
6.166AlaAsp: 6.166 ± 0.058
7.499AlaGlu: 7.499 ± 0.086
4.996AlaPhe: 4.996 ± 0.055
11.967AlaGly: 11.967 ± 0.107
2.223AlaHis: 2.223 ± 0.032
7.207AlaIle: 7.207 ± 0.06
4.365AlaLys: 4.365 ± 0.066
15.426AlaLeu: 15.426 ± 0.129
3.848AlaMet: 3.848 ± 0.047
2.86AlaAsn: 2.86 ± 0.051
6.091AlaPro: 6.091 ± 0.067
4.511AlaGln: 4.511 ± 0.058
9.501AlaArg: 9.501 ± 0.082
7.15AlaSer: 7.15 ± 0.076
6.768AlaThr: 6.768 ± 0.091
9.182AlaVal: 9.182 ± 0.067
1.623AlaTrp: 1.623 ± 0.027
2.697AlaTyr: 2.697 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.978CysAla: 0.978 ± 0.024
0.101CysCys: 0.101 ± 0.008
0.501CysAsp: 0.501 ± 0.016
0.442CysGlu: 0.442 ± 0.016
0.329CysPhe: 0.329 ± 0.014
0.908CysGly: 0.908 ± 0.023
0.213CysHis: 0.213 ± 0.01
0.39CysIle: 0.39 ± 0.013
0.174CysLys: 0.174 ± 0.01
0.844CysLeu: 0.844 ± 0.021
0.136CysMet: 0.136 ± 0.009
0.195CysAsn: 0.195 ± 0.01
0.392CysPro: 0.392 ± 0.014
0.215CysGln: 0.215 ± 0.012
0.571CysArg: 0.571 ± 0.017
0.439CysSer: 0.439 ± 0.017
0.37CysThr: 0.37 ± 0.015
0.621CysVal: 0.621 ± 0.019
0.11CysTrp: 0.11 ± 0.007
0.184CysTyr: 0.184 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.699AspAla: 6.699 ± 0.061
0.431AspCys: 0.431 ± 0.014
2.636AspAsp: 2.636 ± 0.044
3.185AspGlu: 3.185 ± 0.048
2.045AspPhe: 2.045 ± 0.032
4.88AspGly: 4.88 ± 0.057
1.073AspHis: 1.073 ± 0.023
2.933AspIle: 2.933 ± 0.045
1.673AspLys: 1.673 ± 0.038
5.709AspLeu: 5.709 ± 0.058
1.125AspMet: 1.125 ± 0.024
1.033AspAsn: 1.033 ± 0.026
3.384AspPro: 3.384 ± 0.044
1.476AspGln: 1.476 ± 0.025
3.696AspArg: 3.696 ± 0.053
1.958AspSer: 1.958 ± 0.031
2.247AspThr: 2.247 ± 0.03
3.762AspVal: 3.762 ± 0.045
0.896AspTrp: 0.896 ± 0.022
1.305AspTyr: 1.305 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
8.342GluAla: 8.342 ± 0.102
0.314GluCys: 0.314 ± 0.013
2.236GluAsp: 2.236 ± 0.039
2.597GluGlu: 2.597 ± 0.043
1.61GluPhe: 1.61 ± 0.03
3.983GluGly: 3.983 ± 0.055
1.089GluHis: 1.089 ± 0.024
3.547GluIle: 3.547 ± 0.045
1.813GluLys: 1.813 ± 0.033
5.141GluLeu: 5.141 ± 0.057
1.402GluMet: 1.402 ± 0.031
1.274GluAsn: 1.274 ± 0.027
2.965GluPro: 2.965 ± 0.045
1.912GluGln: 1.912 ± 0.034
5.054GluArg: 5.054 ± 0.064
2.211GluSer: 2.211 ± 0.034
3.339GluThr: 3.339 ± 0.041
3.482GluVal: 3.482 ± 0.046
0.592GluTrp: 0.592 ± 0.014
0.762GluTyr: 0.762 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
4.923PheAla: 4.923 ± 0.052
0.374PheCys: 0.374 ± 0.015
2.504PheAsp: 2.504 ± 0.04
2.041PheGlu: 2.041 ± 0.034
1.358PhePhe: 1.358 ± 0.031
3.805PheGly: 3.805 ± 0.047
0.741PheHis: 0.741 ± 0.018
1.713PheIle: 1.713 ± 0.03
1.108PheLys: 1.108 ± 0.026
3.335PheLeu: 3.335 ± 0.051
0.813PheMet: 0.813 ± 0.02
0.968PheAsn: 0.968 ± 0.023
1.701PhePro: 1.701 ± 0.032
1.058PheGln: 1.058 ± 0.022
2.272PheArg: 2.272 ± 0.039
2.218PheSer: 2.218 ± 0.035
1.909PheThr: 1.909 ± 0.034
2.921PheVal: 2.921 ± 0.044
0.55PheTrp: 0.55 ± 0.019
0.804PheTyr: 0.804 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
10.062GlyAla: 10.062 ± 0.113
0.879GlyCys: 0.879 ± 0.024
3.995GlyAsp: 3.995 ± 0.045
4.788GlyGlu: 4.788 ± 0.061
3.827GlyPhe: 3.827 ± 0.051
7.608GlyGly: 7.608 ± 0.121
1.871GlyHis: 1.871 ± 0.029
4.559GlyIle: 4.559 ± 0.048
3.268GlyLys: 3.268 ± 0.043
10.105GlyLeu: 10.105 ± 0.081
2.224GlyMet: 2.224 ± 0.034
1.956GlyAsn: 1.956 ± 0.044
3.824GlyPro: 3.824 ± 0.048
3.003GlyGln: 3.003 ± 0.043
6.483GlyArg: 6.483 ± 0.065
4.838GlySer: 4.838 ± 0.065
4.476GlyThr: 4.476 ± 0.094
6.194GlyVal: 6.194 ± 0.061
1.379GlyTrp: 1.379 ± 0.028
2.301GlyTyr: 2.301 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.311HisAla: 2.311 ± 0.032
0.208HisCys: 0.208 ± 0.01
1.181HisAsp: 1.181 ± 0.029
1.0HisGlu: 1.0 ± 0.022
0.761HisPhe: 0.761 ± 0.02
1.904HisGly: 1.904 ± 0.031
0.508HisHis: 0.508 ± 0.018
0.872HisIle: 0.872 ± 0.025
0.448HisLys: 0.448 ± 0.014
2.073HisLeu: 2.073 ± 0.037
0.427HisMet: 0.427 ± 0.015
0.402HisAsn: 0.402 ± 0.015
1.242HisPro: 1.242 ± 0.027
0.494HisGln: 0.494 ± 0.017
1.343HisArg: 1.343 ± 0.032
0.891HisSer: 0.891 ± 0.021
0.658HisThr: 0.658 ± 0.02
1.507HisVal: 1.507 ± 0.025
0.304HisTrp: 0.304 ± 0.013
0.481HisTyr: 0.481 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
8.215IleAla: 8.215 ± 0.063
0.53IleCys: 0.53 ± 0.019
3.463IleAsp: 3.463 ± 0.045
3.504IleGlu: 3.504 ± 0.044
1.668IlePhe: 1.668 ± 0.033
5.308IleGly: 5.308 ± 0.06
0.884IleHis: 0.884 ± 0.021
2.288IleIle: 2.288 ± 0.038
1.496IleLys: 1.496 ± 0.03
4.659IleLeu: 4.659 ± 0.051
1.001IleMet: 1.001 ± 0.023
1.253IleAsn: 1.253 ± 0.033
2.373IlePro: 2.373 ± 0.039
1.199IleGln: 1.199 ± 0.026
3.217IleArg: 3.217 ± 0.042
2.78IleSer: 2.78 ± 0.046
2.642IleThr: 2.642 ± 0.049
4.671IleVal: 4.671 ± 0.052
0.612IleTrp: 0.612 ± 0.018
1.046IleTyr: 1.046 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
4.688LysAla: 4.688 ± 0.058
0.117LysCys: 0.117 ± 0.008
1.495LysAsp: 1.495 ± 0.03
1.325LysGlu: 1.325 ± 0.027
0.791LysPhe: 0.791 ± 0.021
2.649LysGly: 2.649 ± 0.037
0.513LysHis: 0.513 ± 0.017
1.613LysIle: 1.613 ± 0.033
0.991LysLys: 0.991 ± 0.03
3.552LysLeu: 3.552 ± 0.046
0.597LysMet: 0.597 ± 0.018
0.746LysAsn: 0.746 ± 0.023
2.331LysPro: 2.331 ± 0.041
0.961LysGln: 0.961 ± 0.025
2.383LysArg: 2.383 ± 0.037
1.731LysSer: 1.731 ± 0.03
1.903LysThr: 1.903 ± 0.027
2.372LysVal: 2.372 ± 0.041
0.319LysTrp: 0.319 ± 0.013
0.472LysTyr: 0.472 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
15.765LeuAla: 15.765 ± 0.123
0.9LeuCys: 0.9 ± 0.023
6.172LeuAsp: 6.172 ± 0.062
4.833LeuGlu: 4.833 ± 0.057
3.71LeuPhe: 3.71 ± 0.047
9.283LeuGly: 9.283 ± 0.077
1.772LeuHis: 1.772 ± 0.037
5.451LeuIle: 5.451 ± 0.068
3.694LeuLys: 3.694 ± 0.049
10.218LeuLeu: 10.218 ± 0.115
2.346LeuMet: 2.346 ± 0.039
2.495LeuAsn: 2.495 ± 0.037
6.018LeuPro: 6.018 ± 0.066
2.765LeuGln: 2.765 ± 0.033
7.199LeuArg: 7.199 ± 0.076
6.834LeuSer: 6.834 ± 0.061
5.831LeuThr: 5.831 ± 0.06
8.04LeuVal: 8.04 ± 0.089
1.178LeuTrp: 1.178 ± 0.024
2.003LeuTyr: 2.003 ± 0.031
0.0LeuXaa: 0.0 ± 0.0
Met
3.145MetAla: 3.145 ± 0.043
0.138MetCys: 0.138 ± 0.009
0.958MetAsp: 0.958 ± 0.023
0.926MetGlu: 0.926 ± 0.02
0.627MetPhe: 0.627 ± 0.021
1.657MetGly: 1.657 ± 0.028
0.377MetHis: 0.377 ± 0.017
1.342MetIle: 1.342 ± 0.029
0.883MetLys: 0.883 ± 0.023
2.599MetLeu: 2.599 ± 0.043
0.628MetMet: 0.628 ± 0.021
0.73MetAsn: 0.73 ± 0.02
1.489MetPro: 1.489 ± 0.026
0.799MetGln: 0.799 ± 0.023
1.856MetArg: 1.856 ± 0.034
1.681MetSer: 1.681 ± 0.031
1.895MetThr: 1.895 ± 0.031
1.647MetVal: 1.647 ± 0.032
0.179MetTrp: 0.179 ± 0.011
0.26MetTyr: 0.26 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.15AsnAla: 3.15 ± 0.05
0.208AsnCys: 0.208 ± 0.01
1.124AsnAsp: 1.124 ± 0.03
1.123AsnGlu: 1.123 ± 0.027
0.84AsnPhe: 0.84 ± 0.023
2.254AsnGly: 2.254 ± 0.061
0.436AsnHis: 0.436 ± 0.015
1.156AsnIle: 1.156 ± 0.026
0.621AsnLys: 0.621 ± 0.018
2.59AsnLeu: 2.59 ± 0.041
0.498AsnMet: 0.498 ± 0.016
0.606AsnAsn: 0.606 ± 0.021
1.7AsnPro: 1.7 ± 0.03
0.699AsnGln: 0.699 ± 0.021
1.628AsnArg: 1.628 ± 0.028
1.129AsnSer: 1.129 ± 0.034
1.119AsnThr: 1.119 ± 0.029
1.723AsnVal: 1.723 ± 0.036
0.414AsnTrp: 0.414 ± 0.014
0.583AsnTyr: 0.583 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
7.155ProAla: 7.155 ± 0.074
0.319ProCys: 0.319 ± 0.015
3.366ProAsp: 3.366 ± 0.047
3.503ProGlu: 3.503 ± 0.052
2.1ProPhe: 2.1 ± 0.038
4.875ProGly: 4.875 ± 0.051
1.088ProHis: 1.088 ± 0.024
2.413ProIle: 2.413 ± 0.036
1.683ProLys: 1.683 ± 0.032
5.15ProLeu: 5.15 ± 0.056
1.196ProMet: 1.196 ± 0.025
1.34ProAsn: 1.34 ± 0.027
2.671ProPro: 2.671 ± 0.05
1.762ProGln: 1.762 ± 0.03
3.218ProArg: 3.218 ± 0.051
2.953ProSer: 2.953 ± 0.041
2.526ProThr: 2.526 ± 0.036
4.259ProVal: 4.259 ± 0.055
0.675ProTrp: 0.675 ± 0.019
1.17ProTyr: 1.17 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
4.762GlnAla: 4.762 ± 0.06
0.172GlnCys: 0.172 ± 0.009
1.482GlnAsp: 1.482 ± 0.029
1.369GlnGlu: 1.369 ± 0.025
0.997GlnPhe: 0.997 ± 0.024
2.534GlnGly: 2.534 ± 0.036
0.586GlnHis: 0.586 ± 0.018
1.883GlnIle: 1.883 ± 0.033
0.915GlnLys: 0.915 ± 0.024
2.775GlnLeu: 2.775 ± 0.038
0.774GlnMet: 0.774 ± 0.023
0.8GlnAsn: 0.8 ± 0.023
1.817GlnPro: 1.817 ± 0.034
1.179GlnGln: 1.179 ± 0.03
2.572GlnArg: 2.572 ± 0.048
1.747GlnSer: 1.747 ± 0.031
1.637GlnThr: 1.637 ± 0.032
2.091GlnVal: 2.091 ± 0.033
0.348GlnTrp: 0.348 ± 0.016
0.547GlnTyr: 0.547 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
8.17ArgAla: 8.17 ± 0.09
0.516ArgCys: 0.516 ± 0.016
4.041ArgAsp: 4.041 ± 0.049
4.125ArgGlu: 4.125 ± 0.06
3.104ArgPhe: 3.104 ± 0.04
4.911ArgGly: 4.911 ± 0.054
1.639ArgHis: 1.639 ± 0.031
4.183ArgIle: 4.183 ± 0.05
2.198ArgLys: 2.198 ± 0.038
8.396ArgLeu: 8.396 ± 0.089
1.834ArgMet: 1.834 ± 0.031
1.755ArgAsn: 1.755 ± 0.033
3.647ArgPro: 3.647 ± 0.058
2.544ArgGln: 2.544 ± 0.042
5.639ArgArg: 5.639 ± 0.071
3.863ArgSer: 3.863 ± 0.04
3.162ArgThr: 3.162 ± 0.034
4.613ArgVal: 4.613 ± 0.056
0.967ArgTrp: 0.967 ± 0.024
1.667ArgTyr: 1.667 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.656SerAla: 6.656 ± 0.081
0.452SerCys: 0.452 ± 0.018
2.741SerAsp: 2.741 ± 0.042
2.85SerGlu: 2.85 ± 0.046
2.458SerPhe: 2.458 ± 0.037
5.666SerGly: 5.666 ± 0.093
1.055SerHis: 1.055 ± 0.027
2.663SerIle: 2.663 ± 0.052
1.487SerLys: 1.487 ± 0.029
5.979SerLeu: 5.979 ± 0.063
1.209SerMet: 1.209 ± 0.025
1.298SerAsn: 1.298 ± 0.03
2.913SerPro: 2.913 ± 0.043
1.704SerGln: 1.704 ± 0.031
3.64SerArg: 3.64 ± 0.046
3.012SerSer: 3.012 ± 0.065
2.632SerThr: 2.632 ± 0.048
4.024SerVal: 4.024 ± 0.057
0.844SerTrp: 0.844 ± 0.022
1.324SerTyr: 1.324 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
6.45ThrAla: 6.45 ± 0.094
0.39ThrCys: 0.39 ± 0.015
2.388ThrAsp: 2.388 ± 0.034
2.498ThrGlu: 2.498 ± 0.04
1.805ThrPhe: 1.805 ± 0.032
5.035ThrGly: 5.035 ± 0.068
1.012ThrHis: 1.012 ± 0.025
3.169ThrIle: 3.169 ± 0.052
1.41ThrLys: 1.41 ± 0.028
6.21ThrLeu: 6.21 ± 0.083
1.188ThrMet: 1.188 ± 0.024
1.168ThrAsn: 1.168 ± 0.033
3.232ThrPro: 3.232 ± 0.04
1.561ThrGln: 1.561 ± 0.029
3.329ThrArg: 3.329 ± 0.044
2.855ThrSer: 2.855 ± 0.058
2.982ThrThr: 2.982 ± 0.073
4.158ThrVal: 4.158 ± 0.054
0.579ThrTrp: 0.579 ± 0.018
1.06ThrTyr: 1.06 ± 0.024
0.0ThrXaa: 0.0 ± 0.0
Val
10.018ValAla: 10.018 ± 0.073
0.554ValCys: 0.554 ± 0.015
3.77ValAsp: 3.77 ± 0.045
4.4ValGlu: 4.4 ± 0.052
2.734ValPhe: 2.734 ± 0.04
5.494ValGly: 5.494 ± 0.059
1.234ValHis: 1.234 ± 0.028
4.0ValIle: 4.0 ± 0.051
2.355ValLys: 2.355 ± 0.037
7.777ValLeu: 7.777 ± 0.078
1.91ValMet: 1.91 ± 0.032
1.788ValAsn: 1.788 ± 0.037
3.76ValPro: 3.76 ± 0.047
1.978ValGln: 1.978 ± 0.032
4.499ValArg: 4.499 ± 0.045
4.407ValSer: 4.407 ± 0.057
4.646ValThr: 4.646 ± 0.067
5.996ValVal: 5.996 ± 0.066
0.808ValTrp: 0.808 ± 0.021
1.354ValTyr: 1.354 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.197TrpAla: 1.197 ± 0.024
0.133TrpCys: 0.133 ± 0.008
0.55TrpAsp: 0.55 ± 0.018
0.511TrpGlu: 0.511 ± 0.017
0.548TrpPhe: 0.548 ± 0.017
0.884TrpGly: 0.884 ± 0.022
0.296TrpHis: 0.296 ± 0.012
0.646TrpIle: 0.646 ± 0.02
0.394TrpLys: 0.394 ± 0.015
1.758TrpLeu: 1.758 ± 0.033
0.29TrpMet: 0.29 ± 0.013
0.416TrpAsn: 0.416 ± 0.014
0.747TrpPro: 0.747 ± 0.023
0.518TrpGln: 0.518 ± 0.015
1.221TrpArg: 1.221 ± 0.028
0.849TrpSer: 0.849 ± 0.021
0.78TrpThr: 0.78 ± 0.024
0.704TrpVal: 0.704 ± 0.018
0.255TrpTrp: 0.255 ± 0.011
0.272TrpTyr: 0.272 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.564TyrAla: 2.564 ± 0.043
0.209TyrCys: 0.209 ± 0.011
1.375TyrAsp: 1.375 ± 0.028
1.144TyrGlu: 1.144 ± 0.025
0.81TyrPhe: 0.81 ± 0.02
2.038TyrGly: 2.038 ± 0.032
0.407TyrHis: 0.407 ± 0.017
0.782TyrIle: 0.782 ± 0.021
0.575TyrLys: 0.575 ± 0.02
2.21TyrLeu: 2.21 ± 0.031
0.369TyrMet: 0.369 ± 0.014
0.518TyrAsn: 0.518 ± 0.019
1.125TyrPro: 1.125 ± 0.025
0.648TyrGln: 0.648 ± 0.018
1.651TyrArg: 1.651 ± 0.033
1.057TyrSer: 1.057 ± 0.025
0.96TyrThr: 0.96 ± 0.025
1.512TyrVal: 1.512 ± 0.032
0.337TyrTrp: 0.337 ± 0.015
0.493TyrTyr: 0.493 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6030 proteins (1935374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski