Amino acid dipepetide frequency for Methylophilaceae bacterium 11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.827AlaAla: 9.827 ± 0.156
0.966AlaCys: 0.966 ± 0.039
5.278AlaAsp: 5.278 ± 0.083
5.982AlaGlu: 5.982 ± 0.107
3.613AlaPhe: 3.613 ± 0.074
6.884AlaGly: 6.884 ± 0.126
2.376AlaHis: 2.376 ± 0.064
6.492AlaIle: 6.492 ± 0.09
5.741AlaLys: 5.741 ± 0.098
11.005AlaLeu: 11.005 ± 0.145
2.87AlaMet: 2.87 ± 0.068
4.463AlaAsn: 4.463 ± 0.1
3.561AlaPro: 3.561 ± 0.068
4.713AlaGln: 4.713 ± 0.09
4.256AlaArg: 4.256 ± 0.076
5.929AlaSer: 5.929 ± 0.099
5.474AlaThr: 5.474 ± 0.131
6.634AlaVal: 6.634 ± 0.11
1.247AlaTrp: 1.247 ± 0.038
2.94AlaTyr: 2.94 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.832CysAla: 0.832 ± 0.033
0.101CysCys: 0.101 ± 0.012
0.448CysAsp: 0.448 ± 0.026
0.455CysGlu: 0.455 ± 0.024
0.315CysPhe: 0.315 ± 0.021
0.738CysGly: 0.738 ± 0.033
0.237CysHis: 0.237 ± 0.017
0.516CysIle: 0.516 ± 0.029
0.399CysLys: 0.399 ± 0.023
0.825CysLeu: 0.825 ± 0.033
0.211CysMet: 0.211 ± 0.014
0.333CysAsn: 0.333 ± 0.024
0.389CysPro: 0.389 ± 0.024
0.31CysGln: 0.31 ± 0.02
0.359CysArg: 0.359 ± 0.02
0.474CysSer: 0.474 ± 0.028
0.464CysThr: 0.464 ± 0.026
0.648CysVal: 0.648 ± 0.028
0.079CysTrp: 0.079 ± 0.01
0.244CysTyr: 0.244 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.801AspAla: 5.801 ± 0.098
0.42AspCys: 0.42 ± 0.026
2.69AspAsp: 2.69 ± 0.061
3.055AspGlu: 3.055 ± 0.065
2.243AspPhe: 2.243 ± 0.061
3.808AspGly: 3.808 ± 0.089
1.016AspHis: 1.016 ± 0.038
3.742AspIle: 3.742 ± 0.071
2.765AspLys: 2.765 ± 0.062
4.964AspLeu: 4.964 ± 0.09
1.306AspMet: 1.306 ± 0.038
1.963AspAsn: 1.963 ± 0.057
2.092AspPro: 2.092 ± 0.06
1.824AspGln: 1.824 ± 0.041
2.197AspArg: 2.197 ± 0.061
2.657AspSer: 2.657 ± 0.064
3.004AspThr: 3.004 ± 0.064
3.863AspVal: 3.863 ± 0.072
0.832AspTrp: 0.832 ± 0.029
1.934AspTyr: 1.934 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.72GluAla: 5.72 ± 0.094
0.36GluCys: 0.36 ± 0.023
2.589GluAsp: 2.589 ± 0.057
2.748GluGlu: 2.748 ± 0.071
2.081GluPhe: 2.081 ± 0.04
3.127GluGly: 3.127 ± 0.071
1.427GluHis: 1.427 ± 0.044
3.801GluIle: 3.801 ± 0.071
3.337GluLys: 3.337 ± 0.078
5.455GluLeu: 5.455 ± 0.094
1.482GluMet: 1.482 ± 0.044
2.198GluAsn: 2.198 ± 0.051
1.745GluPro: 1.745 ± 0.055
2.826GluGln: 2.826 ± 0.067
2.903GluArg: 2.903 ± 0.071
3.112GluSer: 3.112 ± 0.065
3.149GluThr: 3.149 ± 0.066
4.112GluVal: 4.112 ± 0.075
0.627GluTrp: 0.627 ± 0.026
1.593GluTyr: 1.593 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.622PheAla: 3.622 ± 0.077
0.385PheCys: 0.385 ± 0.023
2.437PheAsp: 2.437 ± 0.063
2.173PheGlu: 2.173 ± 0.051
1.606PhePhe: 1.606 ± 0.055
3.155PheGly: 3.155 ± 0.07
0.717PheHis: 0.717 ± 0.03
2.31PheIle: 2.31 ± 0.064
2.094PheLys: 2.094 ± 0.053
3.274PheLeu: 3.274 ± 0.077
0.916PheMet: 0.916 ± 0.044
2.052PheAsn: 2.052 ± 0.061
1.401PhePro: 1.401 ± 0.045
1.282PheGln: 1.282 ± 0.04
1.366PheArg: 1.366 ± 0.043
2.846PheSer: 2.846 ± 0.061
2.254PheThr: 2.254 ± 0.054
2.743PheVal: 2.743 ± 0.062
0.484PheTrp: 0.484 ± 0.024
1.286PheTyr: 1.286 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
6.127GlyAla: 6.127 ± 0.099
0.751GlyCys: 0.751 ± 0.028
3.493GlyAsp: 3.493 ± 0.078
3.783GlyGlu: 3.783 ± 0.072
3.147GlyPhe: 3.147 ± 0.076
5.005GlyGly: 5.005 ± 0.13
1.558GlyHis: 1.558 ± 0.05
4.472GlyIle: 4.472 ± 0.082
4.114GlyLys: 4.114 ± 0.082
7.263GlyLeu: 7.263 ± 0.095
2.034GlyMet: 2.034 ± 0.056
2.988GlyAsn: 2.988 ± 0.112
1.581GlyPro: 1.581 ± 0.044
2.81GlyGln: 2.81 ± 0.061
3.08GlyArg: 3.08 ± 0.062
3.731GlySer: 3.731 ± 0.092
3.799GlyThr: 3.799 ± 0.109
5.39GlyVal: 5.39 ± 0.09
0.986GlyTrp: 0.986 ± 0.035
2.393GlyTyr: 2.393 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
2.65HisAla: 2.65 ± 0.076
0.256HisCys: 0.256 ± 0.019
1.215HisAsp: 1.215 ± 0.04
1.168HisGlu: 1.168 ± 0.037
1.009HisPhe: 1.009 ± 0.035
1.603HisGly: 1.603 ± 0.05
0.866HisHis: 0.866 ± 0.039
1.544HisIle: 1.544 ± 0.041
0.98HisLys: 0.98 ± 0.036
2.479HisLeu: 2.479 ± 0.062
0.636HisMet: 0.636 ± 0.026
0.771HisAsn: 0.771 ± 0.031
1.265HisPro: 1.265 ± 0.04
1.312HisGln: 1.312 ± 0.045
1.054HisArg: 1.054 ± 0.036
1.252HisSer: 1.252 ± 0.04
1.313HisThr: 1.313 ± 0.042
1.518HisVal: 1.518 ± 0.05
0.364HisTrp: 0.364 ± 0.022
0.89HisTyr: 0.89 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
7.22IleAla: 7.22 ± 0.101
0.539IleCys: 0.539 ± 0.028
3.788IleAsp: 3.788 ± 0.067
4.13IleGlu: 4.13 ± 0.073
2.085IlePhe: 2.085 ± 0.061
4.767IleGly: 4.767 ± 0.078
1.366IleHis: 1.366 ± 0.043
3.222IleIle: 3.222 ± 0.071
3.386IleLys: 3.386 ± 0.062
5.206IleLeu: 5.206 ± 0.099
1.268IleMet: 1.268 ± 0.042
2.782IleAsn: 2.782 ± 0.07
2.805IlePro: 2.805 ± 0.067
2.892IleGln: 2.892 ± 0.061
2.723IleArg: 2.723 ± 0.055
4.155IleSer: 4.155 ± 0.063
3.953IleThr: 3.953 ± 0.088
4.278IleVal: 4.278 ± 0.091
0.588IleTrp: 0.588 ± 0.03
1.696IleTyr: 1.696 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
5.185LysAla: 5.185 ± 0.101
0.254LysCys: 0.254 ± 0.018
2.566LysAsp: 2.566 ± 0.068
2.783LysGlu: 2.783 ± 0.065
1.583LysPhe: 1.583 ± 0.048
2.987LysGly: 2.987 ± 0.068
1.356LysHis: 1.356 ± 0.042
3.145LysIle: 3.145 ± 0.074
2.946LysLys: 2.946 ± 0.068
5.714LysLeu: 5.714 ± 0.091
1.363LysMet: 1.363 ± 0.04
2.204LysAsn: 2.204 ± 0.06
2.667LysPro: 2.667 ± 0.057
3.045LysGln: 3.045 ± 0.062
2.747LysArg: 2.747 ± 0.056
3.228LysSer: 3.228 ± 0.065
3.26LysThr: 3.26 ± 0.062
3.771LysVal: 3.771 ± 0.072
0.473LysTrp: 0.473 ± 0.025
1.337LysTyr: 1.337 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
10.601LeuAla: 10.601 ± 0.144
0.876LeuCys: 0.876 ± 0.037
5.378LeuAsp: 5.378 ± 0.093
5.307LeuGlu: 5.307 ± 0.093
3.708LeuPhe: 3.708 ± 0.084
7.209LeuGly: 7.209 ± 0.092
2.38LeuHis: 2.38 ± 0.057
6.24LeuIle: 6.24 ± 0.101
5.635LeuLys: 5.635 ± 0.096
10.543LeuLeu: 10.543 ± 0.169
2.697LeuMet: 2.697 ± 0.065
4.879LeuAsn: 4.879 ± 0.084
4.909LeuPro: 4.909 ± 0.078
4.433LeuGln: 4.433 ± 0.075
4.622LeuArg: 4.622 ± 0.083
7.236LeuSer: 7.236 ± 0.113
6.19LeuThr: 6.19 ± 0.113
6.734LeuVal: 6.734 ± 0.121
1.011LeuTrp: 1.011 ± 0.035
2.51LeuTyr: 2.51 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.491MetAla: 2.491 ± 0.059
0.174MetCys: 0.174 ± 0.015
1.202MetAsp: 1.202 ± 0.039
1.106MetGlu: 1.106 ± 0.042
0.859MetPhe: 0.859 ± 0.035
1.65MetGly: 1.65 ± 0.049
0.779MetHis: 0.779 ± 0.028
1.43MetIle: 1.43 ± 0.044
1.329MetLys: 1.329 ± 0.036
3.011MetLeu: 3.011 ± 0.062
0.83MetMet: 0.83 ± 0.029
1.069MetAsn: 1.069 ± 0.037
1.323MetPro: 1.323 ± 0.044
1.759MetGln: 1.759 ± 0.048
1.47MetArg: 1.47 ± 0.039
1.599MetSer: 1.599 ± 0.038
1.525MetThr: 1.525 ± 0.044
1.759MetVal: 1.759 ± 0.043
0.219MetTrp: 0.219 ± 0.015
0.545MetTyr: 0.545 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
4.477AsnAla: 4.477 ± 0.089
0.305AsnCys: 0.305 ± 0.021
2.074AsnAsp: 2.074 ± 0.057
1.986AsnGlu: 1.986 ± 0.049
1.538AsnPhe: 1.538 ± 0.051
3.093AsnGly: 3.093 ± 0.086
1.006AsnHis: 1.006 ± 0.036
2.97AsnIle: 2.97 ± 0.067
2.092AsnLys: 2.092 ± 0.059
4.08AsnLeu: 4.08 ± 0.079
1.034AsnMet: 1.034 ± 0.034
1.968AsnAsn: 1.968 ± 0.072
2.23AsnPro: 2.23 ± 0.059
2.227AsnGln: 2.227 ± 0.066
2.02AsnArg: 2.02 ± 0.072
2.264AsnSer: 2.264 ± 0.079
2.855AsnThr: 2.855 ± 0.077
2.93AsnVal: 2.93 ± 0.07
0.566AsnTrp: 0.566 ± 0.028
1.207AsnTyr: 1.207 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.042ProAla: 4.042 ± 0.082
0.292ProCys: 0.292 ± 0.018
2.345ProAsp: 2.345 ± 0.051
2.775ProGlu: 2.775 ± 0.063
1.64ProPhe: 1.64 ± 0.047
2.264ProGly: 2.264 ± 0.06
0.994ProHis: 0.994 ± 0.036
2.6ProIle: 2.6 ± 0.064
2.133ProLys: 2.133 ± 0.05
3.925ProLeu: 3.925 ± 0.075
1.109ProMet: 1.109 ± 0.034
2.086ProAsn: 2.086 ± 0.051
1.539ProPro: 1.539 ± 0.056
1.864ProGln: 1.864 ± 0.05
1.441ProArg: 1.441 ± 0.045
2.619ProSer: 2.619 ± 0.056
2.522ProThr: 2.522 ± 0.059
3.173ProVal: 3.173 ± 0.063
0.47ProTrp: 0.47 ± 0.024
1.29ProTyr: 1.29 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
5.255GlnAla: 5.255 ± 0.1
0.33GlnCys: 0.33 ± 0.021
2.08GlnAsp: 2.08 ± 0.052
2.179GlnGlu: 2.179 ± 0.057
1.857GlnPhe: 1.857 ± 0.044
2.792GlnGly: 2.792 ± 0.066
1.63GlnHis: 1.63 ± 0.047
2.668GlnIle: 2.668 ± 0.059
2.231GlnLys: 2.231 ± 0.057
5.282GlnLeu: 5.282 ± 0.094
1.18GlnMet: 1.18 ± 0.037
1.58GlnAsn: 1.58 ± 0.047
1.927GlnPro: 1.927 ± 0.053
2.944GlnGln: 2.944 ± 0.067
2.409GlnArg: 2.409 ± 0.059
2.906GlnSer: 2.906 ± 0.071
2.679GlnThr: 2.679 ± 0.069
3.406GlnVal: 3.406 ± 0.065
0.602GlnTrp: 0.602 ± 0.027
1.482GlnTyr: 1.482 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
4.003ArgAla: 4.003 ± 0.07
0.357ArgCys: 0.357 ± 0.019
2.544ArgAsp: 2.544 ± 0.059
2.775ArgGlu: 2.775 ± 0.061
2.024ArgPhe: 2.024 ± 0.05
2.724ArgGly: 2.724 ± 0.065
1.096ArgHis: 1.096 ± 0.036
3.161ArgIle: 3.161 ± 0.07
2.255ArgLys: 2.255 ± 0.06
4.908ArgLeu: 4.908 ± 0.086
1.329ArgMet: 1.329 ± 0.043
1.904ArgAsn: 1.904 ± 0.048
1.659ArgPro: 1.659 ± 0.047
2.09ArgGln: 2.09 ± 0.049
2.174ArgArg: 2.174 ± 0.055
2.208ArgSer: 2.208 ± 0.054
2.351ArgThr: 2.351 ± 0.059
3.389ArgVal: 3.389 ± 0.061
0.675ArgTrp: 0.675 ± 0.028
1.713ArgTyr: 1.713 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.023SerAla: 6.023 ± 0.103
0.493SerCys: 0.493 ± 0.024
2.94SerAsp: 2.94 ± 0.07
3.003SerGlu: 3.003 ± 0.067
2.353SerPhe: 2.353 ± 0.057
4.722SerGly: 4.722 ± 0.09
1.398SerHis: 1.398 ± 0.039
3.956SerIle: 3.956 ± 0.073
3.003SerLys: 3.003 ± 0.065
6.187SerLeu: 6.187 ± 0.109
1.585SerMet: 1.585 ± 0.045
2.673SerAsn: 2.673 ± 0.079
2.555SerPro: 2.555 ± 0.061
2.775SerGln: 2.775 ± 0.061
2.673SerArg: 2.673 ± 0.053
3.706SerSer: 3.706 ± 0.091
3.636SerThr: 3.636 ± 0.107
4.291SerVal: 4.291 ± 0.074
0.65SerTrp: 0.65 ± 0.027
1.788SerTyr: 1.788 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.513ThrAla: 5.513 ± 0.114
0.457ThrCys: 0.457 ± 0.025
2.899ThrAsp: 2.899 ± 0.08
3.014ThrGlu: 3.014 ± 0.065
2.235ThrPhe: 2.235 ± 0.052
4.375ThrGly: 4.375 ± 0.095
1.471ThrHis: 1.471 ± 0.047
3.612ThrIle: 3.612 ± 0.096
2.643ThrLys: 2.643 ± 0.062
6.686ThrLeu: 6.686 ± 0.108
1.245ThrMet: 1.245 ± 0.039
2.235ThrAsn: 2.235 ± 0.087
3.187ThrPro: 3.187 ± 0.061
3.08ThrGln: 3.08 ± 0.075
2.427ThrArg: 2.427 ± 0.059
3.365ThrSer: 3.365 ± 0.091
3.687ThrThr: 3.687 ± 0.192
4.159ThrVal: 4.159 ± 0.11
0.626ThrTrp: 0.626 ± 0.028
1.775ThrTyr: 1.775 ± 0.125
0.0ThrXaa: 0.0 ± 0.0
Val
6.957ValAla: 6.957 ± 0.089
0.647ValCys: 0.647 ± 0.032
3.93ValAsp: 3.93 ± 0.073
3.994ValGlu: 3.994 ± 0.067
2.664ValPhe: 2.664 ± 0.065
4.803ValGly: 4.803 ± 0.096
1.397ValHis: 1.397 ± 0.043
4.736ValIle: 4.736 ± 0.086
3.69ValLys: 3.69 ± 0.078
7.409ValLeu: 7.409 ± 0.11
2.071ValMet: 2.071 ± 0.046
3.242ValAsn: 3.242 ± 0.075
2.661ValPro: 2.661 ± 0.062
2.605ValGln: 2.605 ± 0.052
3.147ValArg: 3.147 ± 0.063
4.768ValSer: 4.768 ± 0.071
4.307ValThr: 4.307 ± 0.11
5.587ValVal: 5.587 ± 0.099
0.846ValTrp: 0.846 ± 0.035
1.913ValTyr: 1.913 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.923TrpAla: 0.923 ± 0.036
0.123TrpCys: 0.123 ± 0.013
0.561TrpAsp: 0.561 ± 0.025
0.515TrpGlu: 0.515 ± 0.024
0.48TrpPhe: 0.48 ± 0.028
0.655TrpGly: 0.655 ± 0.029
0.36TrpHis: 0.36 ± 0.02
0.681TrpIle: 0.681 ± 0.029
0.548TrpLys: 0.548 ± 0.025
1.757TrpLeu: 1.757 ± 0.055
0.333TrpMet: 0.333 ± 0.021
0.433TrpAsn: 0.433 ± 0.024
0.381TrpPro: 0.381 ± 0.024
0.925TrpGln: 0.925 ± 0.035
0.682TrpArg: 0.682 ± 0.027
0.623TrpSer: 0.623 ± 0.029
0.539TrpThr: 0.539 ± 0.024
0.941TrpVal: 0.941 ± 0.034
0.177TrpTrp: 0.177 ± 0.014
0.323TrpTyr: 0.323 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.983TyrAla: 2.983 ± 0.057
0.293TyrCys: 0.293 ± 0.018
1.72TyrAsp: 1.72 ± 0.129
1.463TyrGlu: 1.463 ± 0.042
1.363TyrPhe: 1.363 ± 0.045
2.144TyrGly: 2.144 ± 0.057
0.715TyrHis: 0.715 ± 0.031
1.554TyrIle: 1.554 ± 0.044
1.291TyrLys: 1.291 ± 0.044
3.128TyrLeu: 3.128 ± 0.064
0.628TyrMet: 0.628 ± 0.028
1.096TyrAsn: 1.096 ± 0.06
1.245TyrPro: 1.245 ± 0.044
1.703TyrGln: 1.703 ± 0.043
1.586TyrArg: 1.586 ± 0.046
1.729TyrSer: 1.729 ± 0.052
1.729TyrThr: 1.729 ± 0.079
2.047TyrVal: 2.047 ± 0.057
0.441TyrTrp: 0.441 ± 0.024
0.966TyrTyr: 0.966 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2589 proteins (851956 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski