Amino acid dipepetide frequency for Salibacterium qingdaonense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.525AlaAla: 9.525 ± 0.136
0.69AlaCys: 0.69 ± 0.031
4.513AlaAsp: 4.513 ± 0.072
6.164AlaGlu: 6.164 ± 0.1
3.53AlaPhe: 3.53 ± 0.066
7.536AlaGly: 7.536 ± 0.114
1.347AlaHis: 1.347 ± 0.039
3.645AlaIle: 3.645 ± 0.065
3.282AlaLys: 3.282 ± 0.058
7.647AlaLeu: 7.647 ± 0.089
2.164AlaMet: 2.164 ± 0.041
1.904AlaAsn: 1.904 ± 0.045
2.578AlaPro: 2.578 ± 0.06
2.255AlaGln: 2.255 ± 0.052
3.269AlaArg: 3.269 ± 0.047
4.841AlaSer: 4.841 ± 0.085
2.542AlaThr: 2.542 ± 0.062
7.867AlaVal: 7.867 ± 0.126
0.767AlaTrp: 0.767 ± 0.026
2.3AlaTyr: 2.3 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.469CysAla: 0.469 ± 0.023
0.097CysCys: 0.097 ± 0.01
0.311CysAsp: 0.311 ± 0.02
0.339CysGlu: 0.339 ± 0.019
0.3CysPhe: 0.3 ± 0.017
0.69CysGly: 0.69 ± 0.029
0.188CysHis: 0.188 ± 0.014
0.419CysIle: 0.419 ± 0.023
0.19CysLys: 0.19 ± 0.013
0.653CysLeu: 0.653 ± 0.027
0.191CysMet: 0.191 ± 0.014
0.199CysAsn: 0.199 ± 0.015
0.371CysPro: 0.371 ± 0.023
0.176CysGln: 0.176 ± 0.014
0.503CysArg: 0.503 ± 0.024
0.548CysSer: 0.548 ± 0.022
0.377CysThr: 0.377 ± 0.019
0.387CysVal: 0.387 ± 0.022
0.073CysTrp: 0.073 ± 0.009
0.217CysTyr: 0.217 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.94AspAla: 3.94 ± 0.074
0.303AspCys: 0.303 ± 0.021
2.828AspAsp: 2.828 ± 0.059
4.625AspGlu: 4.625 ± 0.081
2.175AspPhe: 2.175 ± 0.048
3.755AspGly: 3.755 ± 0.066
1.369AspHis: 1.369 ± 0.041
4.413AspIle: 4.413 ± 0.066
2.628AspLys: 2.628 ± 0.057
4.721AspLeu: 4.721 ± 0.069
1.876AspMet: 1.876 ± 0.041
2.143AspAsn: 2.143 ± 0.055
2.283AspPro: 2.283 ± 0.049
2.001AspGln: 2.001 ± 0.052
2.591AspArg: 2.591 ± 0.057
2.803AspSer: 2.803 ± 0.065
3.22AspThr: 3.22 ± 0.053
4.441AspVal: 4.441 ± 0.074
0.695AspTrp: 0.695 ± 0.028
2.134AspTyr: 2.134 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
6.797GluAla: 6.797 ± 0.087
0.371GluCys: 0.371 ± 0.02
4.982GluAsp: 4.982 ± 0.086
9.384GluGlu: 9.384 ± 0.146
2.064GluPhe: 2.064 ± 0.051
5.129GluGly: 5.129 ± 0.08
1.815GluHis: 1.815 ± 0.049
4.273GluIle: 4.273 ± 0.069
6.077GluLys: 6.077 ± 0.089
6.648GluLeu: 6.648 ± 0.103
2.588GluMet: 2.588 ± 0.053
4.156GluAsn: 4.156 ± 0.079
2.485GluPro: 2.485 ± 0.057
4.297GluGln: 4.297 ± 0.081
4.125GluArg: 4.125 ± 0.069
4.143GluSer: 4.143 ± 0.07
5.176GluThr: 5.176 ± 0.083
4.828GluVal: 4.828 ± 0.076
1.102GluTrp: 1.102 ± 0.035
2.187GluTyr: 2.187 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
2.933PheAla: 2.933 ± 0.053
0.347PheCys: 0.347 ± 0.016
2.331PheAsp: 2.331 ± 0.052
2.788PheGlu: 2.788 ± 0.058
2.284PhePhe: 2.284 ± 0.05
3.085PheGly: 3.085 ± 0.06
1.13PheHis: 1.13 ± 0.032
3.117PheIle: 3.117 ± 0.067
1.495PheLys: 1.495 ± 0.041
4.476PheLeu: 4.476 ± 0.096
1.256PheMet: 1.256 ± 0.04
1.448PheAsn: 1.448 ± 0.035
1.713PhePro: 1.713 ± 0.044
1.893PheGln: 1.893 ± 0.048
1.756PheArg: 1.756 ± 0.046
3.239PheSer: 3.239 ± 0.064
2.522PheThr: 2.522 ± 0.051
2.765PheVal: 2.765 ± 0.053
0.508PheTrp: 0.508 ± 0.032
1.507PheTyr: 1.507 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.708GlyAla: 5.708 ± 0.099
0.608GlyCys: 0.608 ± 0.027
3.551GlyAsp: 3.551 ± 0.069
5.292GlyGlu: 5.292 ± 0.09
3.379GlyPhe: 3.379 ± 0.058
5.559GlyGly: 5.559 ± 0.103
1.489GlyHis: 1.489 ± 0.046
5.436GlyIle: 5.436 ± 0.081
3.752GlyLys: 3.752 ± 0.063
6.593GlyLeu: 6.593 ± 0.094
2.628GlyMet: 2.628 ± 0.05
2.53GlyAsn: 2.53 ± 0.052
1.957GlyPro: 1.957 ± 0.055
2.235GlyGln: 2.235 ± 0.045
3.748GlyArg: 3.748 ± 0.063
5.025GlySer: 5.025 ± 0.07
4.793GlyThr: 4.793 ± 0.079
5.205GlyVal: 5.205 ± 0.078
0.976GlyTrp: 0.976 ± 0.033
2.635GlyTyr: 2.635 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.646HisAla: 1.646 ± 0.044
0.213HisCys: 0.213 ± 0.015
1.206HisAsp: 1.206 ± 0.037
1.575HisGlu: 1.575 ± 0.039
1.076HisPhe: 1.076 ± 0.035
1.602HisGly: 1.602 ± 0.045
0.823HisHis: 0.823 ± 0.029
1.493HisIle: 1.493 ± 0.04
0.918HisLys: 0.918 ± 0.03
2.296HisLeu: 2.296 ± 0.053
0.629HisMet: 0.629 ± 0.029
0.734HisAsn: 0.734 ± 0.028
1.321HisPro: 1.321 ± 0.034
0.96HisGln: 0.96 ± 0.034
1.16HisArg: 1.16 ± 0.037
1.332HisSer: 1.332 ± 0.04
1.271HisThr: 1.271 ± 0.038
1.664HisVal: 1.664 ± 0.046
0.269HisTrp: 0.269 ± 0.016
0.938HisTyr: 0.938 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
4.867IleAla: 4.867 ± 0.085
0.448IleCys: 0.448 ± 0.022
3.609IleAsp: 3.609 ± 0.061
4.581IleGlu: 4.581 ± 0.077
2.634IlePhe: 2.634 ± 0.06
5.317IleGly: 5.317 ± 0.078
1.661IleHis: 1.661 ± 0.037
4.352IleIle: 4.352 ± 0.074
2.82IleLys: 2.82 ± 0.049
5.614IleLeu: 5.614 ± 0.084
1.614IleMet: 1.614 ± 0.042
2.48IleAsn: 2.48 ± 0.056
3.057IlePro: 3.057 ± 0.063
2.618IleGln: 2.618 ± 0.054
2.985IleArg: 2.985 ± 0.059
4.311IleSer: 4.311 ± 0.068
3.971IleThr: 3.971 ± 0.071
4.437IleVal: 4.437 ± 0.069
0.611IleTrp: 0.611 ± 0.025
1.873IleTyr: 1.873 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.122LysAla: 4.122 ± 0.065
0.189LysCys: 0.189 ± 0.014
2.916LysAsp: 2.916 ± 0.052
6.029LysGlu: 6.029 ± 0.098
1.078LysPhe: 1.078 ± 0.036
3.536LysGly: 3.536 ± 0.059
1.172LysHis: 1.172 ± 0.035
2.847LysIle: 2.847 ± 0.053
4.243LysLys: 4.243 ± 0.079
3.845LysLeu: 3.845 ± 0.068
1.722LysMet: 1.722 ± 0.041
2.509LysAsn: 2.509 ± 0.054
1.872LysPro: 1.872 ± 0.046
2.924LysGln: 2.924 ± 0.055
2.95LysArg: 2.95 ± 0.056
2.599LysSer: 2.599 ± 0.05
3.181LysThr: 3.181 ± 0.057
3.245LysVal: 3.245 ± 0.061
0.657LysTrp: 0.657 ± 0.025
1.453LysTyr: 1.453 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
6.892LeuAla: 6.892 ± 0.096
0.6LeuCys: 0.6 ± 0.023
4.913LeuAsp: 4.913 ± 0.079
7.099LeuGlu: 7.099 ± 0.107
4.662LeuPhe: 4.662 ± 0.104
6.058LeuGly: 6.058 ± 0.095
2.39LeuHis: 2.39 ± 0.055
5.76LeuIle: 5.76 ± 0.082
4.862LeuLys: 4.862 ± 0.087
9.545LeuLeu: 9.545 ± 0.139
2.562LeuMet: 2.562 ± 0.045
3.407LeuAsn: 3.407 ± 0.059
4.246LeuPro: 4.246 ± 0.076
4.294LeuGln: 4.294 ± 0.07
4.002LeuArg: 4.002 ± 0.073
6.416LeuSer: 6.416 ± 0.077
5.399LeuThr: 5.399 ± 0.083
5.455LeuVal: 5.455 ± 0.087
0.831LeuTrp: 0.831 ± 0.031
3.073LeuTyr: 3.073 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.409MetAla: 2.409 ± 0.051
0.139MetCys: 0.139 ± 0.012
1.789MetAsp: 1.789 ± 0.045
2.822MetGlu: 2.822 ± 0.049
1.174MetPhe: 1.174 ± 0.033
1.784MetGly: 1.784 ± 0.047
0.523MetHis: 0.523 ± 0.019
1.991MetIle: 1.991 ± 0.042
2.388MetLys: 2.388 ± 0.05
2.842MetLeu: 2.842 ± 0.053
1.066MetMet: 1.066 ± 0.032
1.712MetAsn: 1.712 ± 0.045
1.175MetPro: 1.175 ± 0.034
1.242MetGln: 1.242 ± 0.038
1.142MetArg: 1.142 ± 0.035
1.728MetSer: 1.728 ± 0.043
1.946MetThr: 1.946 ± 0.047
1.855MetVal: 1.855 ± 0.049
0.206MetTrp: 0.206 ± 0.013
0.808MetTyr: 0.808 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.652AsnAla: 2.652 ± 0.061
0.198AsnCys: 0.198 ± 0.014
2.222AsnAsp: 2.222 ± 0.057
3.244AsnGlu: 3.244 ± 0.067
1.184AsnPhe: 1.184 ± 0.031
3.169AsnGly: 3.169 ± 0.06
0.962AsnHis: 0.962 ± 0.032
2.742AsnIle: 2.742 ± 0.061
2.092AsnLys: 2.092 ± 0.051
3.099AsnLeu: 3.099 ± 0.053
1.199AsnMet: 1.199 ± 0.041
1.681AsnAsn: 1.681 ± 0.055
1.863AsnPro: 1.863 ± 0.04
1.768AsnGln: 1.768 ± 0.047
2.029AsnArg: 2.029 ± 0.045
1.869AsnSer: 1.869 ± 0.049
2.119AsnThr: 2.119 ± 0.05
2.924AsnVal: 2.924 ± 0.053
0.498AsnTrp: 0.498 ± 0.022
1.174AsnTyr: 1.174 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
3.286ProAla: 3.286 ± 0.065
0.248ProCys: 0.248 ± 0.016
2.751ProAsp: 2.751 ± 0.055
3.934ProGlu: 3.934 ± 0.077
1.911ProPhe: 1.911 ± 0.048
3.082ProGly: 3.082 ± 0.066
0.863ProHis: 0.863 ± 0.032
1.953ProIle: 1.953 ± 0.041
1.606ProLys: 1.606 ± 0.039
3.684ProLeu: 3.684 ± 0.063
0.984ProMet: 0.984 ± 0.032
1.2ProAsn: 1.2 ± 0.034
1.305ProPro: 1.305 ± 0.039
1.149ProGln: 1.149 ± 0.039
1.342ProArg: 1.342 ± 0.043
2.512ProSer: 2.512 ± 0.052
1.514ProThr: 1.514 ± 0.046
3.657ProVal: 3.657 ± 0.067
0.434ProTrp: 0.434 ± 0.021
1.406ProTyr: 1.406 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.358GlnAla: 3.358 ± 0.065
0.198GlnCys: 0.198 ± 0.014
2.092GlnAsp: 2.092 ± 0.05
3.798GlnGlu: 3.798 ± 0.071
1.467GlnPhe: 1.467 ± 0.042
2.521GlnGly: 2.521 ± 0.046
0.978GlnHis: 0.978 ± 0.03
2.1GlnIle: 2.1 ± 0.046
2.505GlnLys: 2.505 ± 0.053
3.572GlnLeu: 3.572 ± 0.069
1.293GlnMet: 1.293 ± 0.034
1.761GlnAsn: 1.761 ± 0.049
1.469GlnPro: 1.469 ± 0.044
2.372GlnGln: 2.372 ± 0.067
1.962GlnArg: 1.962 ± 0.043
2.279GlnSer: 2.279 ± 0.055
2.474GlnThr: 2.474 ± 0.058
2.445GlnVal: 2.445 ± 0.043
0.519GlnTrp: 0.519 ± 0.025
1.269GlnTyr: 1.269 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.892ArgAla: 2.892 ± 0.057
0.305ArgCys: 0.305 ± 0.017
2.514ArgAsp: 2.514 ± 0.054
3.966ArgGlu: 3.966 ± 0.071
2.17ArgPhe: 2.17 ± 0.052
2.804ArgGly: 2.804 ± 0.049
1.154ArgHis: 1.154 ± 0.038
3.143ArgIle: 3.143 ± 0.062
2.992ArgLys: 2.992 ± 0.057
4.483ArgLeu: 4.483 ± 0.079
1.663ArgMet: 1.663 ± 0.04
1.814ArgAsn: 1.814 ± 0.041
1.592ArgPro: 1.592 ± 0.047
2.044ArgGln: 2.044 ± 0.048
2.883ArgArg: 2.883 ± 0.063
2.879ArgSer: 2.879 ± 0.055
2.635ArgThr: 2.635 ± 0.05
2.758ArgVal: 2.758 ± 0.058
0.536ArgTrp: 0.536 ± 0.025
1.789ArgTyr: 1.789 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.525SerAla: 4.525 ± 0.075
0.427SerCys: 0.427 ± 0.022
3.177SerAsp: 3.177 ± 0.071
4.151SerGlu: 4.151 ± 0.086
3.274SerPhe: 3.274 ± 0.06
5.43SerGly: 5.43 ± 0.079
1.312SerHis: 1.312 ± 0.036
4.388SerIle: 4.388 ± 0.071
2.484SerLys: 2.484 ± 0.051
5.897SerLeu: 5.897 ± 0.087
2.111SerMet: 2.111 ± 0.05
2.177SerAsn: 2.177 ± 0.053
2.381SerPro: 2.381 ± 0.055
1.899SerGln: 1.899 ± 0.048
3.198SerArg: 3.198 ± 0.058
4.727SerSer: 4.727 ± 0.095
3.252SerThr: 3.252 ± 0.06
4.345SerVal: 4.345 ± 0.064
0.755SerTrp: 0.755 ± 0.029
2.252SerTyr: 2.252 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.486ThrAla: 5.486 ± 0.095
0.336ThrCys: 0.336 ± 0.019
2.899ThrAsp: 2.899 ± 0.053
4.024ThrGlu: 4.024 ± 0.069
2.77ThrPhe: 2.77 ± 0.048
5.061ThrGly: 5.061 ± 0.073
1.026ThrHis: 1.026 ± 0.032
3.858ThrIle: 3.858 ± 0.057
2.66ThrLys: 2.66 ± 0.051
5.216ThrLeu: 5.216 ± 0.072
1.747ThrMet: 1.747 ± 0.04
2.006ThrAsn: 2.006 ± 0.05
2.497ThrPro: 2.497 ± 0.049
1.419ThrGln: 1.419 ± 0.039
2.154ThrArg: 2.154 ± 0.049
3.553ThrSer: 3.553 ± 0.061
2.985ThrThr: 2.985 ± 0.06
4.283ThrVal: 4.283 ± 0.067
0.621ThrTrp: 0.621 ± 0.025
1.928ThrTyr: 1.928 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
3.988ValAla: 3.988 ± 0.072
0.615ValCys: 0.615 ± 0.029
3.821ValAsp: 3.821 ± 0.059
5.443ValGlu: 5.443 ± 0.08
3.281ValPhe: 3.281 ± 0.064
3.91ValGly: 3.91 ± 0.081
1.698ValHis: 1.698 ± 0.048
5.036ValIle: 5.036 ± 0.082
3.798ValLys: 3.798 ± 0.066
7.381ValLeu: 7.381 ± 0.103
2.111ValMet: 2.111 ± 0.054
2.88ValAsn: 2.88 ± 0.055
2.954ValPro: 2.954 ± 0.058
2.948ValGln: 2.948 ± 0.057
2.985ValArg: 2.985 ± 0.063
4.808ValSer: 4.808 ± 0.086
4.623ValThr: 4.623 ± 0.068
4.963ValVal: 4.963 ± 0.084
0.713ValTrp: 0.713 ± 0.027
2.4ValTyr: 2.4 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.696TrpAla: 0.696 ± 0.029
0.094TrpCys: 0.094 ± 0.01
0.528TrpAsp: 0.528 ± 0.023
0.795TrpGlu: 0.795 ± 0.033
0.565TrpPhe: 0.565 ± 0.025
0.686TrpGly: 0.686 ± 0.03
0.241TrpHis: 0.241 ± 0.014
0.813TrpIle: 0.813 ± 0.026
0.829TrpLys: 0.829 ± 0.031
1.224TrpLeu: 1.224 ± 0.039
0.467TrpMet: 0.467 ± 0.022
0.615TrpAsn: 0.615 ± 0.025
0.296TrpPro: 0.296 ± 0.017
0.449TrpGln: 0.449 ± 0.02
0.488TrpArg: 0.488 ± 0.02
0.642TrpSer: 0.642 ± 0.027
0.683TrpThr: 0.683 ± 0.027
0.678TrpVal: 0.678 ± 0.028
0.177TrpTrp: 0.177 ± 0.012
0.373TrpTyr: 0.373 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.175TyrAla: 2.175 ± 0.046
0.268TyrCys: 0.268 ± 0.014
1.991TyrAsp: 1.991 ± 0.046
2.575TyrGlu: 2.575 ± 0.057
1.612TyrPhe: 1.612 ± 0.04
2.387TyrGly: 2.387 ± 0.051
0.986TyrHis: 0.986 ± 0.032
2.082TyrIle: 2.082 ± 0.043
1.469TyrLys: 1.469 ± 0.038
3.032TyrLeu: 3.032 ± 0.057
0.87TyrMet: 0.87 ± 0.028
1.331TyrAsn: 1.331 ± 0.039
1.404TyrPro: 1.404 ± 0.034
1.486TyrGln: 1.486 ± 0.038
1.743TyrArg: 1.743 ± 0.045
1.909TyrSer: 1.909 ± 0.051
1.848TyrThr: 1.848 ± 0.041
2.157TyrVal: 2.157 ± 0.047
0.391TyrTrp: 0.391 ± 0.021
1.337TyrTyr: 1.337 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3532 proteins (1002558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski