Amino acid dipepetide frequency for Buchnera aphidicola subsp. Cinara cedri (strain Cc)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.908AlaAla: 1.908 ± 0.162
0.569AlaCys: 0.569 ± 0.079
1.222AlaAsp: 1.222 ± 0.122
1.448AlaGlu: 1.448 ± 0.124
1.356AlaPhe: 1.356 ± 0.121
1.916AlaGly: 1.916 ± 0.151
0.778AlaHis: 0.778 ± 0.084
4.259AlaIle: 4.259 ± 0.199
3.38AlaLys: 3.38 ± 0.171
3.523AlaLeu: 3.523 ± 0.192
0.82AlaMet: 0.82 ± 0.103
1.816AlaAsn: 1.816 ± 0.136
0.745AlaPro: 0.745 ± 0.09
1.155AlaGln: 1.155 ± 0.111
1.523AlaArg: 1.523 ± 0.112
2.033AlaSer: 2.033 ± 0.142
1.682AlaThr: 1.682 ± 0.132
1.598AlaVal: 1.598 ± 0.15
0.251AlaTrp: 0.251 ± 0.056
1.414AlaTyr: 1.414 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.536CysAla: 0.536 ± 0.078
0.226CysCys: 0.226 ± 0.048
0.502CysAsp: 0.502 ± 0.072
0.435CysGlu: 0.435 ± 0.066
0.686CysPhe: 0.686 ± 0.071
0.862CysGly: 0.862 ± 0.09
0.31CysHis: 0.31 ± 0.056
1.799CysIle: 1.799 ± 0.132
1.012CysLys: 1.012 ± 0.082
1.146CysLeu: 1.146 ± 0.104
0.226CysMet: 0.226 ± 0.041
0.862CysAsn: 0.862 ± 0.077
0.46CysPro: 0.46 ± 0.061
0.268CysGln: 0.268 ± 0.05
0.385CysArg: 0.385 ± 0.059
1.205CysSer: 1.205 ± 0.098
0.611CysThr: 0.611 ± 0.067
0.628CysVal: 0.628 ± 0.072
0.117CysTrp: 0.117 ± 0.036
0.51CysTyr: 0.51 ± 0.064
0.0CysXaa: 0.0 ± 0.0
Asp
1.414AspAla: 1.414 ± 0.129
0.469AspCys: 0.469 ± 0.06
1.088AspAsp: 1.088 ± 0.113
1.448AspGlu: 1.448 ± 0.104
2.343AspPhe: 2.343 ± 0.167
1.615AspGly: 1.615 ± 0.154
0.653AspHis: 0.653 ± 0.059
6.024AspIle: 6.024 ± 0.241
3.238AspLys: 3.238 ± 0.132
3.916AspLeu: 3.916 ± 0.179
0.703AspMet: 0.703 ± 0.081
2.1AspAsn: 2.1 ± 0.116
0.912AspPro: 0.912 ± 0.077
0.862AspGln: 0.862 ± 0.071
1.054AspArg: 1.054 ± 0.093
2.293AspSer: 2.293 ± 0.138
1.732AspThr: 1.732 ± 0.119
1.782AspVal: 1.782 ± 0.135
0.301AspTrp: 0.301 ± 0.063
1.732AspTyr: 1.732 ± 0.13
0.0AspXaa: 0.0 ± 0.0
Glu
1.682GluAla: 1.682 ± 0.138
0.326GluCys: 0.326 ± 0.04
1.607GluAsp: 1.607 ± 0.126
2.092GluGlu: 2.092 ± 0.161
1.908GluPhe: 1.908 ± 0.111
1.732GluGly: 1.732 ± 0.137
0.703GluHis: 0.703 ± 0.077
5.874GluIle: 5.874 ± 0.232
7.121GluLys: 7.121 ± 0.318
4.142GluLeu: 4.142 ± 0.174
0.879GluMet: 0.879 ± 0.08
3.313GluAsn: 3.313 ± 0.18
0.904GluPro: 0.904 ± 0.09
1.021GluGln: 1.021 ± 0.088
1.523GluArg: 1.523 ± 0.124
2.083GluSer: 2.083 ± 0.124
1.69GluThr: 1.69 ± 0.127
1.899GluVal: 1.899 ± 0.149
0.351GluTrp: 0.351 ± 0.052
1.807GluTyr: 1.807 ± 0.11
0.0GluXaa: 0.0 ± 0.0
Phe
1.088PheAla: 1.088 ± 0.1
1.029PheCys: 1.029 ± 0.091
2.134PheAsp: 2.134 ± 0.133
1.657PheGlu: 1.657 ± 0.132
6.125PhePhe: 6.125 ± 0.42
2.753PheGly: 2.753 ± 0.175
1.255PheHis: 1.255 ± 0.087
6.125PheIle: 6.125 ± 0.283
5.481PheLys: 5.481 ± 0.266
7.941PheLeu: 7.941 ± 0.331
0.904PheMet: 0.904 ± 0.09
4.05PheAsn: 4.05 ± 0.199
1.623PhePro: 1.623 ± 0.148
1.699PheGln: 1.699 ± 0.124
1.322PheArg: 1.322 ± 0.101
5.723PheSer: 5.723 ± 0.315
2.017PheThr: 2.017 ± 0.136
1.874PheVal: 1.874 ± 0.134
0.552PheTrp: 0.552 ± 0.064
2.761PheTyr: 2.761 ± 0.228
0.0PheXaa: 0.0 ± 0.0
Gly
2.033GlyAla: 2.033 ± 0.155
0.92GlyCys: 0.92 ± 0.095
1.916GlyAsp: 1.916 ± 0.136
2.167GlyGlu: 2.167 ± 0.158
2.569GlyPhe: 2.569 ± 0.155
3.104GlyGly: 3.104 ± 0.196
1.004GlyHis: 1.004 ± 0.105
6.326GlyIle: 6.326 ± 0.248
5.163GlyLys: 5.163 ± 0.196
4.083GlyLeu: 4.083 ± 0.179
1.205GlyMet: 1.205 ± 0.108
2.41GlyAsn: 2.41 ± 0.145
1.255GlyPro: 1.255 ± 0.108
1.272GlyGln: 1.272 ± 0.11
2.017GlyArg: 2.017 ± 0.142
3.171GlySer: 3.171 ± 0.196
2.376GlyThr: 2.376 ± 0.167
2.443GlyVal: 2.443 ± 0.164
0.443GlyTrp: 0.443 ± 0.066
2.067GlyTyr: 2.067 ± 0.14
0.0GlyXaa: 0.0 ± 0.0
His
0.912HisAla: 0.912 ± 0.096
0.276HisCys: 0.276 ± 0.042
0.644HisAsp: 0.644 ± 0.075
0.653HisGlu: 0.653 ± 0.067
0.82HisPhe: 0.82 ± 0.084
1.113HisGly: 1.113 ± 0.105
0.41HisHis: 0.41 ± 0.06
2.385HisIle: 2.385 ± 0.158
1.665HisLys: 1.665 ± 0.115
1.791HisLeu: 1.791 ± 0.13
0.427HisMet: 0.427 ± 0.059
1.121HisAsn: 1.121 ± 0.096
0.929HisPro: 0.929 ± 0.089
0.527HisGln: 0.527 ± 0.061
0.72HisArg: 0.72 ± 0.079
1.263HisSer: 1.263 ± 0.105
0.895HisThr: 0.895 ± 0.083
0.887HisVal: 0.887 ± 0.103
0.067HisTrp: 0.067 ± 0.023
0.694HisTyr: 0.694 ± 0.07
0.0HisXaa: 0.0 ± 0.0
Ile
4.853IleAla: 4.853 ± 0.204
1.849IleCys: 1.849 ± 0.128
5.531IleAsp: 5.531 ± 0.19
5.757IleGlu: 5.757 ± 0.22
8.275IlePhe: 8.275 ± 0.35
6.091IleGly: 6.091 ± 0.228
2.694IleHis: 2.694 ± 0.139
15.772IleIle: 15.772 ± 0.46
17.036IleLys: 17.036 ± 0.55
13.455IleLeu: 13.455 ± 0.493
1.958IleMet: 1.958 ± 0.139
10.819IleAsn: 10.819 ± 0.334
4.301IlePro: 4.301 ± 0.218
4.334IleGln: 4.334 ± 0.201
4.217IleArg: 4.217 ± 0.213
10.526IleSer: 10.526 ± 0.324
5.548IleThr: 5.548 ± 0.192
4.384IleVal: 4.384 ± 0.192
0.954IleTrp: 0.954 ± 0.111
5.581IleTyr: 5.581 ± 0.252
0.0IleXaa: 0.0 ± 0.0
Lys
2.309LysAla: 2.309 ± 0.14
0.887LysCys: 0.887 ± 0.076
3.64LysAsp: 3.64 ± 0.207
6.016LysGlu: 6.016 ± 0.248
5.723LysPhe: 5.723 ± 0.213
3.431LysGly: 3.431 ± 0.163
1.565LysHis: 1.565 ± 0.112
21.044LysIle: 21.044 ± 0.587
33.202LysLys: 33.202 ± 1.098
9.514LysLeu: 9.514 ± 0.333
2.301LysMet: 2.301 ± 0.145
16.408LysAsn: 16.408 ± 0.488
2.159LysPro: 2.159 ± 0.133
2.284LysGln: 2.284 ± 0.141
3.598LysArg: 3.598 ± 0.185
6.568LysSer: 6.568 ± 0.216
4.627LysThr: 4.627 ± 0.198
3.154LysVal: 3.154 ± 0.145
0.946LysTrp: 0.946 ± 0.093
6.527LysTyr: 6.527 ± 0.257
0.0LysXaa: 0.0 ± 0.0
Leu
3.138LeuAla: 3.138 ± 0.183
1.255LeuCys: 1.255 ± 0.093
3.933LeuAsp: 3.933 ± 0.226
4.636LeuGlu: 4.636 ± 0.216
5.497LeuPhe: 5.497 ± 0.296
5.02LeuGly: 5.02 ± 0.203
1.841LeuHis: 1.841 ± 0.12
10.501LeuIle: 10.501 ± 0.427
12.643LeuLys: 12.643 ± 0.333
9.681LeuLeu: 9.681 ± 0.359
1.757LeuMet: 1.757 ± 0.117
7.991LeuAsn: 7.991 ± 0.284
2.887LeuPro: 2.887 ± 0.154
2.92LeuGln: 2.92 ± 0.159
3.088LeuArg: 3.088 ± 0.158
7.656LeuSer: 7.656 ± 0.247
3.422LeuThr: 3.422 ± 0.15
3.506LeuVal: 3.506 ± 0.176
0.745LeuTrp: 0.745 ± 0.081
4.242LeuTyr: 4.242 ± 0.225
0.0LeuXaa: 0.0 ± 0.0
Met
0.761MetAla: 0.761 ± 0.077
0.184MetCys: 0.184 ± 0.043
0.536MetAsp: 0.536 ± 0.076
0.703MetGlu: 0.703 ± 0.075
0.971MetPhe: 0.971 ± 0.095
1.012MetGly: 1.012 ± 0.1
0.452MetHis: 0.452 ± 0.056
2.251MetIle: 2.251 ± 0.145
2.343MetLys: 2.343 ± 0.128
2.083MetLeu: 2.083 ± 0.145
0.36MetMet: 0.36 ± 0.053
1.615MetAsn: 1.615 ± 0.11
0.577MetPro: 0.577 ± 0.078
0.536MetGln: 0.536 ± 0.066
0.686MetArg: 0.686 ± 0.075
1.238MetSer: 1.238 ± 0.104
0.778MetThr: 0.778 ± 0.075
0.636MetVal: 0.636 ± 0.073
0.075MetTrp: 0.075 ± 0.022
0.795MetTyr: 0.795 ± 0.087
0.0MetXaa: 0.0 ± 0.0
Asn
1.924AsnAla: 1.924 ± 0.127
0.87AsnCys: 0.87 ± 0.092
2.51AsnAsp: 2.51 ± 0.149
2.485AsnGlu: 2.485 ± 0.153
5.966AsnPhe: 5.966 ± 0.26
2.619AsnGly: 2.619 ± 0.148
1.263AsnHis: 1.263 ± 0.1
14.049AsnIle: 14.049 ± 0.413
10.861AsnLys: 10.861 ± 0.383
6.694AsnLeu: 6.694 ± 0.219
1.581AsnMet: 1.581 ± 0.122
7.982AsnAsn: 7.982 ± 0.332
2.075AsnPro: 2.075 ± 0.133
2.527AsnGln: 2.527 ± 0.124
2.234AsnArg: 2.234 ± 0.134
5.221AsnSer: 5.221 ± 0.206
3.28AsnThr: 3.28 ± 0.151
2.636AsnVal: 2.636 ± 0.136
0.694AsnTrp: 0.694 ± 0.084
3.698AsnTyr: 3.698 ± 0.184
0.0AsnXaa: 0.0 ± 0.0
Pro
0.929ProAla: 0.929 ± 0.095
0.318ProCys: 0.318 ± 0.049
0.812ProAsp: 0.812 ± 0.09
1.573ProGlu: 1.573 ± 0.1
1.297ProPhe: 1.297 ± 0.104
1.766ProGly: 1.766 ± 0.144
0.485ProHis: 0.485 ± 0.061
3.941ProIle: 3.941 ± 0.209
3.247ProLys: 3.247 ± 0.178
2.376ProLeu: 2.376 ± 0.153
0.586ProMet: 0.586 ± 0.07
1.866ProAsn: 1.866 ± 0.127
0.636ProPro: 0.636 ± 0.071
0.611ProGln: 0.611 ± 0.072
0.761ProArg: 0.761 ± 0.081
1.54ProSer: 1.54 ± 0.108
1.314ProThr: 1.314 ± 0.101
1.272ProVal: 1.272 ± 0.109
0.259ProTrp: 0.259 ± 0.048
1.222ProTyr: 1.222 ± 0.106
0.0ProXaa: 0.0 ± 0.0
Gln
1.171GlnAla: 1.171 ± 0.111
0.251GlnCys: 0.251 ± 0.05
0.887GlnAsp: 0.887 ± 0.1
1.548GlnGlu: 1.548 ± 0.116
1.247GlnPhe: 1.247 ± 0.104
1.163GlnGly: 1.163 ± 0.107
0.435GlnHis: 0.435 ± 0.067
3.372GlnIle: 3.372 ± 0.179
3.774GlnLys: 3.774 ± 0.17
3.037GlnLeu: 3.037 ± 0.163
0.494GlnMet: 0.494 ± 0.069
1.858GlnAsn: 1.858 ± 0.099
0.761GlnPro: 0.761 ± 0.084
0.653GlnGln: 0.653 ± 0.074
0.72GlnArg: 0.72 ± 0.073
1.832GlnSer: 1.832 ± 0.131
1.146GlnThr: 1.146 ± 0.103
1.054GlnVal: 1.054 ± 0.1
0.31GlnTrp: 0.31 ± 0.06
1.289GlnTyr: 1.289 ± 0.103
0.0GlnXaa: 0.0 ± 0.0
Arg
1.289ArgAla: 1.289 ± 0.096
0.368ArgCys: 0.368 ± 0.056
1.012ArgAsp: 1.012 ± 0.098
1.581ArgGlu: 1.581 ± 0.147
1.74ArgPhe: 1.74 ± 0.124
1.682ArgGly: 1.682 ± 0.144
0.561ArgHis: 0.561 ± 0.065
4.075ArgIle: 4.075 ± 0.196
3.908ArgLys: 3.908 ± 0.168
2.962ArgLeu: 2.962 ± 0.192
0.753ArgMet: 0.753 ± 0.074
2.41ArgAsn: 2.41 ± 0.126
0.879ArgPro: 0.879 ± 0.085
0.787ArgGln: 0.787 ± 0.095
1.422ArgArg: 1.422 ± 0.128
2.351ArgSer: 2.351 ± 0.162
1.314ArgThr: 1.314 ± 0.106
1.431ArgVal: 1.431 ± 0.129
0.284ArgTrp: 0.284 ± 0.052
1.18ArgTyr: 1.18 ± 0.102
0.0ArgXaa: 0.0 ± 0.0
Ser
2.477SerAla: 2.477 ± 0.173
0.987SerCys: 0.987 ± 0.106
2.77SerAsp: 2.77 ± 0.14
2.945SerGlu: 2.945 ± 0.168
4.234SerPhe: 4.234 ± 0.231
4.552SerGly: 4.552 ± 0.224
1.071SerHis: 1.071 ± 0.098
9.43SerIle: 9.43 ± 0.243
7.572SerLys: 7.572 ± 0.275
6.895SerLeu: 6.895 ± 0.264
1.222SerMet: 1.222 ± 0.099
4.979SerAsn: 4.979 ± 0.182
1.556SerPro: 1.556 ± 0.124
1.699SerGln: 1.699 ± 0.108
2.301SerArg: 2.301 ± 0.148
5.112SerSer: 5.112 ± 0.231
2.778SerThr: 2.778 ± 0.152
3.33SerVal: 3.33 ± 0.188
0.761SerTrp: 0.761 ± 0.088
2.761SerTyr: 2.761 ± 0.161
0.0SerXaa: 0.0 ± 0.0
Thr
1.858ThrAla: 1.858 ± 0.153
0.536ThrCys: 0.536 ± 0.06
1.673ThrAsp: 1.673 ± 0.128
1.807ThrGlu: 1.807 ± 0.122
1.782ThrPhe: 1.782 ± 0.125
2.895ThrGly: 2.895 ± 0.178
0.904ThrHis: 0.904 ± 0.089
5.104ThrIle: 5.104 ± 0.216
4.259ThrLys: 4.259 ± 0.185
3.832ThrLeu: 3.832 ± 0.148
0.736ThrMet: 0.736 ± 0.087
3.004ThrAsn: 3.004 ± 0.158
1.489ThrPro: 1.489 ± 0.107
1.18ThrGln: 1.18 ± 0.093
1.448ThrArg: 1.448 ± 0.102
2.845ThrSer: 2.845 ± 0.174
1.983ThrThr: 1.983 ± 0.162
1.891ThrVal: 1.891 ± 0.125
0.326ThrTrp: 0.326 ± 0.056
1.372ThrTyr: 1.372 ± 0.111
0.0ThrXaa: 0.0 ± 0.0
Val
1.498ValAla: 1.498 ± 0.141
0.628ValCys: 0.628 ± 0.074
1.498ValAsp: 1.498 ± 0.132
1.774ValGlu: 1.774 ± 0.164
2.251ValPhe: 2.251 ± 0.161
2.109ValGly: 2.109 ± 0.154
0.812ValHis: 0.812 ± 0.085
4.769ValIle: 4.769 ± 0.224
3.615ValLys: 3.615 ± 0.178
4.016ValLeu: 4.016 ± 0.182
0.644ValMet: 0.644 ± 0.079
2.502ValAsn: 2.502 ± 0.131
1.364ValPro: 1.364 ± 0.11
1.163ValGln: 1.163 ± 0.107
1.364ValArg: 1.364 ± 0.108
2.895ValSer: 2.895 ± 0.158
1.59ValThr: 1.59 ± 0.119
1.899ValVal: 1.899 ± 0.161
0.226ValTrp: 0.226 ± 0.044
1.289ValTyr: 1.289 ± 0.099
0.0ValXaa: 0.0 ± 0.0
Trp
0.176TrpAla: 0.176 ± 0.038
0.159TrpCys: 0.159 ± 0.044
0.251TrpAsp: 0.251 ± 0.048
0.318TrpGlu: 0.318 ± 0.049
0.452TrpPhe: 0.452 ± 0.069
0.36TrpGly: 0.36 ± 0.058
0.134TrpHis: 0.134 ± 0.034
1.247TrpIle: 1.247 ± 0.105
1.138TrpLys: 1.138 ± 0.105
0.87TrpLeu: 0.87 ± 0.088
0.226TrpMet: 0.226 ± 0.042
0.845TrpAsn: 0.845 ± 0.083
0.209TrpPro: 0.209 ± 0.044
0.159TrpGln: 0.159 ± 0.033
0.284TrpArg: 0.284 ± 0.048
0.418TrpSer: 0.418 ± 0.063
0.209TrpThr: 0.209 ± 0.042
0.243TrpVal: 0.243 ± 0.042
0.05TrpTrp: 0.05 ± 0.019
0.418TrpTyr: 0.418 ± 0.063
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.439TyrAla: 1.439 ± 0.116
0.678TyrCys: 0.678 ± 0.077
1.514TyrAsp: 1.514 ± 0.112
1.615TyrGlu: 1.615 ± 0.108
2.87TyrPhe: 2.87 ± 0.175
2.15TyrGly: 2.15 ± 0.112
0.87TyrHis: 0.87 ± 0.08
5.589TyrIle: 5.589 ± 0.247
5.246TyrLys: 5.246 ± 0.231
4.401TyrLeu: 4.401 ± 0.18
0.803TyrMet: 0.803 ± 0.098
3.23TyrAsn: 3.23 ± 0.194
1.088TyrPro: 1.088 ± 0.111
1.347TyrGln: 1.347 ± 0.105
1.322TyrArg: 1.322 ± 0.117
3.456TyrSer: 3.456 ± 0.193
1.933TyrThr: 1.933 ± 0.119
1.356TyrVal: 1.356 ± 0.108
0.452TyrTrp: 0.452 ± 0.063
1.682TyrTyr: 1.682 ± 0.144
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 362 proteins (119513 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski