Amino acid dipepetide frequency for Streptomyces virus TG1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.83AlaAla: 15.83 ± 1.758
0.816AlaCys: 0.816 ± 0.259
11.75AlaAsp: 11.75 ± 1.144
8.976AlaGlu: 8.976 ± 1.309
3.509AlaPhe: 3.509 ± 0.512
9.874AlaGly: 9.874 ± 0.965
2.04AlaHis: 2.04 ± 0.411
4.243AlaIle: 4.243 ± 0.587
5.875AlaLys: 5.875 ± 1.121
11.506AlaLeu: 11.506 ± 0.814
3.427AlaMet: 3.427 ± 0.684
3.264AlaAsn: 3.264 ± 0.586
5.712AlaPro: 5.712 ± 0.762
4.162AlaGln: 4.162 ± 0.652
7.426AlaArg: 7.426 ± 0.809
6.365AlaSer: 6.365 ± 0.825
6.446AlaThr: 6.446 ± 0.573
11.016AlaVal: 11.016 ± 0.928
2.203AlaTrp: 2.203 ± 0.442
3.101AlaTyr: 3.101 ± 0.532
0.0AlaXaa: 0.0 ± 0.0
Cys
1.469CysAla: 1.469 ± 0.405
0.082CysCys: 0.082 ± 0.087
0.49CysAsp: 0.49 ± 0.176
0.653CysGlu: 0.653 ± 0.187
0.082CysPhe: 0.082 ± 0.068
0.734CysGly: 0.734 ± 0.277
0.163CysHis: 0.163 ± 0.112
0.163CysIle: 0.163 ± 0.106
0.408CysLys: 0.408 ± 0.167
0.49CysLeu: 0.49 ± 0.224
0.245CysMet: 0.245 ± 0.118
0.408CysAsn: 0.408 ± 0.207
0.979CysPro: 0.979 ± 0.284
0.245CysGln: 0.245 ± 0.139
0.653CysArg: 0.653 ± 0.229
0.408CysSer: 0.408 ± 0.176
0.49CysThr: 0.49 ± 0.199
0.734CysVal: 0.734 ± 0.25
0.163CysTrp: 0.163 ± 0.106
0.245CysTyr: 0.245 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
11.424AspAla: 11.424 ± 1.327
0.245AspCys: 0.245 ± 0.125
5.059AspAsp: 5.059 ± 0.986
2.448AspGlu: 2.448 ± 0.48
1.632AspPhe: 1.632 ± 0.378
6.854AspGly: 6.854 ± 0.765
1.061AspHis: 1.061 ± 0.312
0.898AspIle: 0.898 ± 0.281
2.04AspLys: 2.04 ± 0.388
5.794AspLeu: 5.794 ± 0.672
1.55AspMet: 1.55 ± 0.365
1.469AspAsn: 1.469 ± 0.417
4.651AspPro: 4.651 ± 0.587
1.55AspGln: 1.55 ± 0.371
3.672AspArg: 3.672 ± 0.609
2.448AspSer: 2.448 ± 0.447
3.754AspThr: 3.754 ± 0.556
6.691AspVal: 6.691 ± 0.796
1.714AspTrp: 1.714 ± 0.374
1.714AspTyr: 1.714 ± 0.452
0.0AspXaa: 0.0 ± 0.0
Glu
8.242GluAla: 8.242 ± 0.92
0.653GluCys: 0.653 ± 0.257
2.938GluAsp: 2.938 ± 0.588
4.162GluGlu: 4.162 ± 0.703
3.019GluPhe: 3.019 ± 0.496
5.712GluGly: 5.712 ± 0.94
1.387GluHis: 1.387 ± 0.347
2.122GluIle: 2.122 ± 0.462
0.408GluLys: 0.408 ± 0.207
5.059GluLeu: 5.059 ± 0.666
1.061GluMet: 1.061 ± 0.352
1.061GluAsn: 1.061 ± 0.33
4.243GluPro: 4.243 ± 0.966
0.898GluGln: 0.898 ± 0.212
4.978GluArg: 4.978 ± 0.645
3.346GluSer: 3.346 ± 0.607
3.754GluThr: 3.754 ± 0.477
4.733GluVal: 4.733 ± 0.674
1.55GluTrp: 1.55 ± 0.385
1.795GluTyr: 1.795 ± 0.336
0.0GluXaa: 0.0 ± 0.0
Phe
3.998PheAla: 3.998 ± 0.687
0.163PheCys: 0.163 ± 0.098
2.448PheAsp: 2.448 ± 0.474
1.958PheGlu: 1.958 ± 0.45
0.571PhePhe: 0.571 ± 0.224
3.264PheGly: 3.264 ± 0.451
0.326PheHis: 0.326 ± 0.158
0.653PheIle: 0.653 ± 0.239
0.979PheLys: 0.979 ± 0.239
3.346PheLeu: 3.346 ± 0.463
0.653PheMet: 0.653 ± 0.241
1.469PheAsn: 1.469 ± 0.326
1.469PhePro: 1.469 ± 0.317
0.408PheGln: 0.408 ± 0.153
2.366PheArg: 2.366 ± 0.475
1.958PheSer: 1.958 ± 0.512
2.693PheThr: 2.693 ± 0.409
2.693PheVal: 2.693 ± 0.37
0.245PheTrp: 0.245 ± 0.138
0.571PheTyr: 0.571 ± 0.186
0.0PheXaa: 0.0 ± 0.0
Gly
9.874GlyAla: 9.874 ± 0.78
1.142GlyCys: 1.142 ± 0.332
4.814GlyAsp: 4.814 ± 0.686
4.733GlyGlu: 4.733 ± 0.864
4.08GlyPhe: 4.08 ± 0.588
6.61GlyGly: 6.61 ± 1.014
1.387GlyHis: 1.387 ± 0.321
3.509GlyIle: 3.509 ± 0.671
4.896GlyLys: 4.896 ± 0.612
7.018GlyLeu: 7.018 ± 1.188
1.55GlyMet: 1.55 ± 0.327
2.448GlyAsn: 2.448 ± 0.394
4.57GlyPro: 4.57 ± 1.243
2.611GlyGln: 2.611 ± 0.476
6.12GlyArg: 6.12 ± 0.601
5.549GlySer: 5.549 ± 0.822
5.712GlyThr: 5.712 ± 0.876
6.283GlyVal: 6.283 ± 0.595
2.285GlyTrp: 2.285 ± 0.485
3.59GlyTyr: 3.59 ± 0.625
0.0GlyXaa: 0.0 ± 0.0
His
2.611HisAla: 2.611 ± 0.561
0.082HisCys: 0.082 ± 0.086
1.306HisAsp: 1.306 ± 0.257
1.306HisGlu: 1.306 ± 0.325
0.571HisPhe: 0.571 ± 0.29
0.734HisGly: 0.734 ± 0.23
0.408HisHis: 0.408 ± 0.179
0.653HisIle: 0.653 ± 0.25
0.734HisLys: 0.734 ± 0.219
1.714HisLeu: 1.714 ± 0.311
0.408HisMet: 0.408 ± 0.23
0.49HisAsn: 0.49 ± 0.18
1.061HisPro: 1.061 ± 0.309
0.082HisGln: 0.082 ± 0.07
0.734HisArg: 0.734 ± 0.189
1.306HisSer: 1.306 ± 0.337
0.816HisThr: 0.816 ± 0.25
1.224HisVal: 1.224 ± 0.293
0.49HisTrp: 0.49 ± 0.182
0.571HisTyr: 0.571 ± 0.234
0.0HisXaa: 0.0 ± 0.0
Ile
3.998IleAla: 3.998 ± 0.608
0.082IleCys: 0.082 ± 0.087
2.53IleAsp: 2.53 ± 0.415
2.285IleGlu: 2.285 ± 0.496
0.571IlePhe: 0.571 ± 0.209
2.693IleGly: 2.693 ± 0.381
1.142IleHis: 1.142 ± 0.397
1.142IleIle: 1.142 ± 0.316
2.122IleLys: 2.122 ± 0.465
2.122IleLeu: 2.122 ± 0.381
0.571IleMet: 0.571 ± 0.185
0.408IleAsn: 0.408 ± 0.193
2.366IlePro: 2.366 ± 0.361
0.979IleGln: 0.979 ± 0.31
2.53IleArg: 2.53 ± 0.459
1.387IleSer: 1.387 ± 0.311
2.938IleThr: 2.938 ± 0.397
2.122IleVal: 2.122 ± 0.437
0.163IleTrp: 0.163 ± 0.111
0.408IleTyr: 0.408 ± 0.177
0.0IleXaa: 0.0 ± 0.0
Lys
5.63LysAla: 5.63 ± 0.82
0.326LysCys: 0.326 ± 0.151
1.714LysAsp: 1.714 ± 0.397
2.448LysGlu: 2.448 ± 0.52
0.979LysPhe: 0.979 ± 0.367
3.264LysGly: 3.264 ± 0.574
0.979LysHis: 0.979 ± 0.316
1.306LysIle: 1.306 ± 0.391
0.653LysLys: 0.653 ± 0.208
2.774LysLeu: 2.774 ± 0.511
0.408LysMet: 0.408 ± 0.171
1.061LysAsn: 1.061 ± 0.343
3.835LysPro: 3.835 ± 0.796
0.408LysGln: 0.408 ± 0.177
3.917LysArg: 3.917 ± 0.696
2.611LysSer: 2.611 ± 0.454
2.04LysThr: 2.04 ± 0.489
3.672LysVal: 3.672 ± 0.51
0.734LysTrp: 0.734 ± 0.182
0.734LysTyr: 0.734 ± 0.277
0.0LysXaa: 0.0 ± 0.0
Leu
9.058LeuAla: 9.058 ± 1.09
0.653LeuCys: 0.653 ± 0.23
7.507LeuAsp: 7.507 ± 0.69
3.019LeuGlu: 3.019 ± 0.631
2.285LeuPhe: 2.285 ± 0.426
6.038LeuGly: 6.038 ± 0.732
1.387LeuHis: 1.387 ± 0.353
3.346LeuIle: 3.346 ± 0.502
3.754LeuLys: 3.754 ± 0.463
4.406LeuLeu: 4.406 ± 0.775
1.224LeuMet: 1.224 ± 0.259
2.856LeuAsn: 2.856 ± 0.413
5.386LeuPro: 5.386 ± 0.438
1.958LeuGln: 1.958 ± 0.409
6.038LeuArg: 6.038 ± 0.923
5.141LeuSer: 5.141 ± 0.645
6.202LeuThr: 6.202 ± 0.718
5.549LeuVal: 5.549 ± 0.785
0.653LeuTrp: 0.653 ± 0.183
1.958LeuTyr: 1.958 ± 0.437
0.0LeuXaa: 0.0 ± 0.0
Met
2.53MetAla: 2.53 ± 0.463
0.163MetCys: 0.163 ± 0.115
1.142MetAsp: 1.142 ± 0.337
0.326MetGlu: 0.326 ± 0.166
0.326MetPhe: 0.326 ± 0.166
2.611MetGly: 2.611 ± 0.555
0.49MetHis: 0.49 ± 0.197
0.898MetIle: 0.898 ± 0.295
0.653MetLys: 0.653 ± 0.216
1.387MetLeu: 1.387 ± 0.345
0.245MetMet: 0.245 ± 0.137
0.653MetAsn: 0.653 ± 0.186
1.224MetPro: 1.224 ± 0.334
0.49MetGln: 0.49 ± 0.192
2.04MetArg: 2.04 ± 0.322
2.04MetSer: 2.04 ± 0.351
1.142MetThr: 1.142 ± 0.276
1.55MetVal: 1.55 ± 0.372
0.245MetTrp: 0.245 ± 0.121
0.245MetTyr: 0.245 ± 0.186
0.0MetXaa: 0.0 ± 0.0
Asn
4.651AsnAla: 4.651 ± 0.545
0.082AsnCys: 0.082 ± 0.085
1.714AsnAsp: 1.714 ± 0.523
0.979AsnGlu: 0.979 ± 0.284
0.571AsnPhe: 0.571 ± 0.177
4.162AsnGly: 4.162 ± 0.512
0.408AsnHis: 0.408 ± 0.196
0.571AsnIle: 0.571 ± 0.267
1.224AsnLys: 1.224 ± 0.341
1.958AsnLeu: 1.958 ± 0.351
0.734AsnMet: 0.734 ± 0.263
0.326AsnAsn: 0.326 ± 0.174
2.611AsnPro: 2.611 ± 0.362
0.571AsnGln: 0.571 ± 0.247
0.816AsnArg: 0.816 ± 0.305
1.306AsnSer: 1.306 ± 0.365
1.061AsnThr: 1.061 ± 0.273
2.122AsnVal: 2.122 ± 0.381
0.653AsnTrp: 0.653 ± 0.261
0.245AsnTyr: 0.245 ± 0.142
0.0AsnXaa: 0.0 ± 0.0
Pro
7.018ProAla: 7.018 ± 0.801
0.816ProCys: 0.816 ± 0.344
3.59ProAsp: 3.59 ± 0.466
5.386ProGlu: 5.386 ± 0.734
1.55ProPhe: 1.55 ± 0.311
5.63ProGly: 5.63 ± 0.746
0.734ProHis: 0.734 ± 0.261
0.979ProIle: 0.979 ± 0.327
3.346ProLys: 3.346 ± 0.819
3.101ProLeu: 3.101 ± 0.517
1.061ProMet: 1.061 ± 0.281
1.958ProAsn: 1.958 ± 0.405
1.224ProPro: 1.224 ± 0.478
1.306ProGln: 1.306 ± 0.385
2.53ProArg: 2.53 ± 0.476
3.182ProSer: 3.182 ± 0.455
3.998ProThr: 3.998 ± 0.544
5.386ProVal: 5.386 ± 0.707
0.898ProTrp: 0.898 ± 0.244
2.04ProTyr: 2.04 ± 0.415
0.0ProXaa: 0.0 ± 0.0
Gln
3.019GlnAla: 3.019 ± 0.517
0.326GlnCys: 0.326 ± 0.146
1.061GlnAsp: 1.061 ± 0.339
0.816GlnGlu: 0.816 ± 0.269
1.061GlnPhe: 1.061 ± 0.263
2.53GlnGly: 2.53 ± 0.572
0.571GlnHis: 0.571 ± 0.203
0.816GlnIle: 0.816 ± 0.272
0.245GlnLys: 0.245 ± 0.129
1.714GlnLeu: 1.714 ± 0.419
0.571GlnMet: 0.571 ± 0.223
0.734GlnAsn: 0.734 ± 0.322
1.306GlnPro: 1.306 ± 0.318
0.408GlnGln: 0.408 ± 0.173
3.59GlnArg: 3.59 ± 0.63
1.061GlnSer: 1.061 ± 0.304
1.877GlnThr: 1.877 ± 0.375
2.366GlnVal: 2.366 ± 0.436
0.326GlnTrp: 0.326 ± 0.166
0.898GlnTyr: 0.898 ± 0.32
0.0GlnXaa: 0.0 ± 0.0
Arg
8.813ArgAla: 8.813 ± 0.712
0.979ArgCys: 0.979 ± 0.363
3.835ArgAsp: 3.835 ± 0.494
3.998ArgGlu: 3.998 ± 0.65
2.774ArgPhe: 2.774 ± 0.531
4.733ArgGly: 4.733 ± 0.6
1.469ArgHis: 1.469 ± 0.405
3.754ArgIle: 3.754 ± 0.51
3.264ArgLys: 3.264 ± 0.506
5.304ArgLeu: 5.304 ± 0.78
1.795ArgMet: 1.795 ± 0.394
2.203ArgAsn: 2.203 ± 0.432
2.611ArgPro: 2.611 ± 0.452
2.04ArgGln: 2.04 ± 0.341
5.141ArgArg: 5.141 ± 0.768
4.08ArgSer: 4.08 ± 0.648
4.406ArgThr: 4.406 ± 0.652
5.875ArgVal: 5.875 ± 0.785
1.877ArgTrp: 1.877 ± 0.342
1.55ArgTyr: 1.55 ± 0.421
0.0ArgXaa: 0.0 ± 0.0
Ser
6.854SerAla: 6.854 ± 0.678
0.408SerCys: 0.408 ± 0.221
2.774SerAsp: 2.774 ± 0.431
3.509SerGlu: 3.509 ± 0.509
1.795SerPhe: 1.795 ± 0.347
5.63SerGly: 5.63 ± 0.869
0.898SerHis: 0.898 ± 0.256
1.714SerIle: 1.714 ± 0.308
3.101SerLys: 3.101 ± 0.472
4.733SerLeu: 4.733 ± 0.633
0.816SerMet: 0.816 ± 0.226
1.061SerAsn: 1.061 ± 0.358
2.448SerPro: 2.448 ± 0.435
1.224SerGln: 1.224 ± 0.372
3.509SerArg: 3.509 ± 0.555
2.856SerSer: 2.856 ± 0.444
5.059SerThr: 5.059 ± 0.52
4.488SerVal: 4.488 ± 0.614
1.061SerTrp: 1.061 ± 0.257
1.142SerTyr: 1.142 ± 0.278
0.0SerXaa: 0.0 ± 0.0
Thr
7.099ThrAla: 7.099 ± 0.734
0.408ThrCys: 0.408 ± 0.169
4.162ThrAsp: 4.162 ± 0.657
3.509ThrGlu: 3.509 ± 0.519
2.938ThrPhe: 2.938 ± 0.408
7.181ThrGly: 7.181 ± 0.876
0.734ThrHis: 0.734 ± 0.282
1.958ThrIle: 1.958 ± 0.483
2.122ThrLys: 2.122 ± 0.407
5.957ThrLeu: 5.957 ± 0.813
1.469ThrMet: 1.469 ± 0.31
1.55ThrAsn: 1.55 ± 0.369
3.346ThrPro: 3.346 ± 0.563
2.611ThrGln: 2.611 ± 0.491
3.427ThrArg: 3.427 ± 0.575
2.938ThrSer: 2.938 ± 0.551
4.406ThrThr: 4.406 ± 1.058
6.12ThrVal: 6.12 ± 0.82
0.979ThrTrp: 0.979 ± 0.277
2.611ThrTyr: 2.611 ± 0.499
0.0ThrXaa: 0.0 ± 0.0
Val
9.466ValAla: 9.466 ± 1.023
0.653ValCys: 0.653 ± 0.232
4.651ValAsp: 4.651 ± 0.628
7.67ValGlu: 7.67 ± 1.444
2.53ValPhe: 2.53 ± 0.479
5.875ValGly: 5.875 ± 0.727
1.224ValHis: 1.224 ± 0.285
2.938ValIle: 2.938 ± 0.483
2.611ValLys: 2.611 ± 0.373
7.181ValLeu: 7.181 ± 0.808
1.877ValMet: 1.877 ± 0.446
2.53ValAsn: 2.53 ± 0.47
5.222ValPro: 5.222 ± 0.413
1.795ValGln: 1.795 ± 0.371
6.283ValArg: 6.283 ± 0.833
4.243ValSer: 4.243 ± 0.502
6.446ValThr: 6.446 ± 0.912
5.712ValVal: 5.712 ± 0.774
1.55ValTrp: 1.55 ± 0.374
2.285ValTyr: 2.285 ± 0.434
0.0ValXaa: 0.0 ± 0.0
Trp
2.285TrpAla: 2.285 ± 0.354
0.734TrpCys: 0.734 ± 0.239
1.142TrpAsp: 1.142 ± 0.27
1.142TrpGlu: 1.142 ± 0.301
0.898TrpPhe: 0.898 ± 0.338
1.306TrpGly: 1.306 ± 0.316
0.326TrpHis: 0.326 ± 0.157
0.653TrpIle: 0.653 ± 0.228
0.49TrpLys: 0.49 ± 0.214
1.469TrpLeu: 1.469 ± 0.311
0.0TrpMet: 0.0 ± 0.0
0.163TrpAsn: 0.163 ± 0.098
0.49TrpPro: 0.49 ± 0.231
1.061TrpGln: 1.061 ± 0.232
1.632TrpArg: 1.632 ± 0.358
1.061TrpSer: 1.061 ± 0.32
0.898TrpThr: 0.898 ± 0.297
1.877TrpVal: 1.877 ± 0.499
0.245TrpTrp: 0.245 ± 0.176
0.326TrpTyr: 0.326 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.672TyrAla: 3.672 ± 0.526
0.49TyrCys: 0.49 ± 0.186
2.04TyrAsp: 2.04 ± 0.311
1.795TyrGlu: 1.795 ± 0.464
0.49TyrPhe: 0.49 ± 0.221
3.346TyrGly: 3.346 ± 0.434
0.163TyrHis: 0.163 ± 0.102
0.245TyrIle: 0.245 ± 0.229
0.571TyrLys: 0.571 ± 0.287
1.387TyrLeu: 1.387 ± 0.338
0.653TyrMet: 0.653 ± 0.233
0.653TyrAsn: 0.653 ± 0.22
0.979TyrPro: 0.979 ± 0.42
0.571TyrGln: 0.571 ± 0.184
3.101TyrArg: 3.101 ± 0.55
1.795TyrSer: 1.795 ± 0.4
1.387TyrThr: 1.387 ± 0.405
2.53TyrVal: 2.53 ± 0.575
0.163TyrTrp: 0.163 ± 0.127
0.326TyrTyr: 0.326 ± 0.164
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (12256 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski