Amino acid dipepetide frequency for Edaphobacter aggregans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.864AlaAla: 12.864 ± 0.116	0.902AlaCys: 0.902 ± 0.027	4.997AlaAsp: 4.997 ± 0.065	5.727AlaGlu: 5.727 ± 0.078	3.814AlaPhe: 3.814 ± 0.049	8.505AlaGly: 8.505 ± 0.082	2.108AlaHis: 2.108 ± 0.044	5.762AlaIle: 5.762 ± 0.068	4.106AlaLys: 4.106 ± 0.067	10.398AlaLeu: 10.398 ± 0.106	2.686AlaMet: 2.686 ± 0.049	3.742AlaAsn: 3.742 ± 0.076	5.055AlaPro: 5.055 ± 0.068	4.269AlaGln: 4.269 ± 0.066	5.58AlaArg: 5.58 ± 0.075	6.663AlaSer: 6.663 ± 0.085	6.896AlaThr: 6.896 ± 0.108	7.657AlaVal: 7.657 ± 0.103	1.344AlaTrp: 1.344 ± 0.035	2.616AlaTyr: 2.616 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.849CysAla: 0.849 ± 0.022	0.139CysCys: 0.139 ± 0.01	0.437CysAsp: 0.437 ± 0.016	0.385CysGlu: 0.385 ± 0.015	0.37CysPhe: 0.37 ± 0.014	0.908CysGly: 0.908 ± 0.024	0.24CysHis: 0.24 ± 0.013	0.402CysIle: 0.402 ± 0.016	0.244CysLys: 0.244 ± 0.014	0.828CysLeu: 0.828 ± 0.024	0.186CysMet: 0.186 ± 0.01	0.264CysAsn: 0.264 ± 0.012	0.461CysPro: 0.461 ± 0.018	0.231CysGln: 0.231 ± 0.012	0.473CysArg: 0.473 ± 0.015	0.608CysSer: 0.608 ± 0.022	0.546CysThr: 0.546 ± 0.023	0.65CysVal: 0.65 ± 0.019	0.138CysTrp: 0.138 ± 0.009	0.252CysTyr: 0.252 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.248AspAla: 5.248 ± 0.065	0.421AspCys: 0.421 ± 0.015	2.483AspAsp: 2.483 ± 0.048	2.799AspGlu: 2.799 ± 0.049	2.164AspPhe: 2.164 ± 0.042	4.372AspGly: 4.372 ± 0.071	1.185AspHis: 1.185 ± 0.025	2.479AspIle: 2.479 ± 0.04	1.785AspLys: 1.785 ± 0.036	5.093AspLeu: 5.093 ± 0.057	0.922AspMet: 0.922 ± 0.025	1.563AspAsn: 1.563 ± 0.033	3.339AspPro: 3.339 ± 0.057	1.858AspGln: 1.858 ± 0.04	3.023AspArg: 3.023 ± 0.051	2.945AspSer: 2.945 ± 0.051	2.673AspThr: 2.673 ± 0.042	3.603AspVal: 3.603 ± 0.049	0.844AspTrp: 0.844 ± 0.025	1.581AspTyr: 1.581 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	5.543GluAla: 5.543 ± 0.073	0.364GluCys: 0.364 ± 0.015	2.415GluAsp: 2.415 ± 0.037	2.875GluGlu: 2.875 ± 0.055	1.914GluPhe: 1.914 ± 0.036	3.503GluGly: 3.503 ± 0.049	1.275GluHis: 1.275 ± 0.029	3.023GluIle: 3.023 ± 0.045	2.409GluLys: 2.409 ± 0.048	5.161GluLeu: 5.161 ± 0.075	1.374GluMet: 1.374 ± 0.034	1.652GluAsn: 1.652 ± 0.038	2.262GluPro: 2.262 ± 0.039	2.409GluGln: 2.409 ± 0.049	3.712GluArg: 3.712 ± 0.056	2.96GluSer: 2.96 ± 0.048	2.988GluThr: 2.988 ± 0.041	3.519GluVal: 3.519 ± 0.058	0.687GluTrp: 0.687 ± 0.022	1.339GluTyr: 1.339 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.219PheAla: 4.219 ± 0.056	0.407PheCys: 0.407 ± 0.018	2.433PheAsp: 2.433 ± 0.04	1.934PheGlu: 1.934 ± 0.037	1.793PhePhe: 1.793 ± 0.042	3.597PheGly: 3.597 ± 0.054	1.005PheHis: 1.005 ± 0.022	1.664PheIle: 1.664 ± 0.035	1.107PheLys: 1.107 ± 0.028	3.807PheLeu: 3.807 ± 0.057	0.686PheMet: 0.686 ± 0.018	1.561PheAsn: 1.561 ± 0.036	1.824PhePro: 1.824 ± 0.034	1.315PheGln: 1.315 ± 0.028	2.25PheArg: 2.25 ± 0.037	2.831PheSer: 2.831 ± 0.048	2.665PheThr: 2.665 ± 0.06	2.8PheVal: 2.8 ± 0.044	0.594PheTrp: 0.594 ± 0.019	1.219PheTyr: 1.219 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.496GlyAla: 7.496 ± 0.124	0.824GlyCys: 0.824 ± 0.022	3.871GlyAsp: 3.871 ± 0.058	3.732GlyGlu: 3.732 ± 0.049	3.36GlyPhe: 3.36 ± 0.054	6.675GlyGly: 6.675 ± 0.105	1.754GlyHis: 1.754 ± 0.035	4.421GlyIle: 4.421 ± 0.052	3.518GlyLys: 3.518 ± 0.05	7.446GlyLeu: 7.446 ± 0.074	1.9GlyMet: 1.9 ± 0.041	3.075GlyAsn: 3.075 ± 0.076	3.354GlyPro: 3.354 ± 0.052	2.997GlyGln: 2.997 ± 0.056	4.359GlyArg: 4.359 ± 0.058	5.458GlySer: 5.458 ± 0.068	5.787GlyThr: 5.787 ± 0.126	6.045GlyVal: 6.045 ± 0.071	1.27GlyTrp: 1.27 ± 0.03	2.469GlyTyr: 2.469 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.05HisAla: 2.05 ± 0.036	0.226HisCys: 0.226 ± 0.012	1.106HisAsp: 1.106 ± 0.027	1.067HisGlu: 1.067 ± 0.023	0.981HisPhe: 0.981 ± 0.024	1.841HisGly: 1.841 ± 0.031	0.637HisHis: 0.637 ± 0.023	1.158HisIle: 1.158 ± 0.027	0.64HisLys: 0.64 ± 0.02	2.329HisLeu: 2.329 ± 0.035	0.499HisMet: 0.499 ± 0.016	0.737HisAsn: 0.737 ± 0.024	1.509HisPro: 1.509 ± 0.036	0.79HisGln: 0.79 ± 0.023	1.356HisArg: 1.356 ± 0.032	1.35HisSer: 1.35 ± 0.03	1.316HisThr: 1.316 ± 0.028	1.481HisVal: 1.481 ± 0.031	0.361HisTrp: 0.361 ± 0.014	0.676HisTyr: 0.676 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.288IleAla: 6.288 ± 0.066	0.469IleCys: 0.469 ± 0.015	3.108IleAsp: 3.108 ± 0.046	3.055IleGlu: 3.055 ± 0.045	2.017IlePhe: 2.017 ± 0.039	4.266IleGly: 4.266 ± 0.056	1.16IleHis: 1.16 ± 0.024	2.077IleIle: 2.077 ± 0.044	1.519IleLys: 1.519 ± 0.031	4.686IleLeu: 4.686 ± 0.068	0.776IleMet: 0.776 ± 0.022	1.813IleAsn: 1.813 ± 0.033	3.01IlePro: 3.01 ± 0.045	1.799IleGln: 1.799 ± 0.032	3.017IleArg: 3.017 ± 0.044	3.37IleSer: 3.37 ± 0.046	3.51IleThr: 3.51 ± 0.057	3.913IleVal: 3.913 ± 0.052	0.581IleTrp: 0.581 ± 0.02	1.473IleTyr: 1.473 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.892LysAla: 3.892 ± 0.054	0.209LysCys: 0.209 ± 0.012	1.965LysAsp: 1.965 ± 0.04	1.892LysGlu: 1.892 ± 0.034	1.219LysPhe: 1.219 ± 0.028	2.532LysGly: 2.532 ± 0.044	0.783LysHis: 0.783 ± 0.021	1.986LysIle: 1.986 ± 0.036	1.795LysLys: 1.795 ± 0.042	3.721LysLeu: 3.721 ± 0.053	1.0LysMet: 1.0 ± 0.024	1.351LysAsn: 1.351 ± 0.03	2.262LysPro: 2.262 ± 0.047	1.568LysGln: 1.568 ± 0.032	2.179LysArg: 2.179 ± 0.041	2.236LysSer: 2.236 ± 0.044	2.495LysThr: 2.495 ± 0.042	2.601LysVal: 2.601 ± 0.046	0.425LysTrp: 0.425 ± 0.016	0.958LysTyr: 0.958 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.849LeuAla: 10.849 ± 0.102	0.925LeuCys: 0.925 ± 0.025	4.931LeuAsp: 4.931 ± 0.057	4.887LeuGlu: 4.887 ± 0.061	3.602LeuPhe: 3.602 ± 0.059	7.258LeuGly: 7.258 ± 0.084	2.305LeuHis: 2.305 ± 0.04	4.8LeuIle: 4.8 ± 0.064	3.734LeuLys: 3.734 ± 0.059	10.16LeuLeu: 10.16 ± 0.121	2.019LeuMet: 2.019 ± 0.035	3.535LeuAsn: 3.535 ± 0.044	5.641LeuPro: 5.641 ± 0.057	3.566LeuGln: 3.566 ± 0.058	6.554LeuArg: 6.554 ± 0.08	6.481LeuSer: 6.481 ± 0.073	6.584LeuThr: 6.584 ± 0.109	6.518LeuVal: 6.518 ± 0.075	1.313LeuTrp: 1.313 ± 0.033	2.488LeuTyr: 2.488 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.344MetAla: 2.344 ± 0.039	0.153MetCys: 0.153 ± 0.008	1.048MetAsp: 1.048 ± 0.025	1.104MetGlu: 1.104 ± 0.028	0.705MetPhe: 0.705 ± 0.018	1.625MetGly: 1.625 ± 0.028	0.47MetHis: 0.47 ± 0.015	1.042MetIle: 1.042 ± 0.023	1.099MetLys: 1.099 ± 0.026	2.156MetLeu: 2.156 ± 0.04	0.563MetMet: 0.563 ± 0.016	0.865MetAsn: 0.865 ± 0.02	1.32MetPro: 1.32 ± 0.031	0.995MetGln: 0.995 ± 0.021	1.558MetArg: 1.558 ± 0.03	1.441MetSer: 1.441 ± 0.032	1.444MetThr: 1.444 ± 0.029	1.557MetVal: 1.557 ± 0.031	0.221MetTrp: 0.221 ± 0.012	0.43MetTyr: 0.43 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.637AsnAla: 3.637 ± 0.054	0.333AsnCys: 0.333 ± 0.016	1.728AsnAsp: 1.728 ± 0.037	1.603AsnGlu: 1.603 ± 0.031	1.564AsnPhe: 1.564 ± 0.035	3.304AsnGly: 3.304 ± 0.07	0.777AsnHis: 0.777 ± 0.022	1.84AsnIle: 1.84 ± 0.036	1.074AsnLys: 1.074 ± 0.029	3.501AsnLeu: 3.501 ± 0.059	0.674AsnMet: 0.674 ± 0.019	1.436AsnAsn: 1.436 ± 0.042	2.652AsnPro: 2.652 ± 0.058	1.451AsnGln: 1.451 ± 0.034	1.986AsnArg: 1.986 ± 0.042	2.242AsnSer: 2.242 ± 0.05	2.171AsnThr: 2.171 ± 0.044	2.586AsnVal: 2.586 ± 0.051	0.538AsnTrp: 0.538 ± 0.018	1.29AsnTyr: 1.29 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	5.989ProAla: 5.989 ± 0.078	0.36ProCys: 0.36 ± 0.013	3.184ProAsp: 3.184 ± 0.05	3.434ProGlu: 3.434 ± 0.05	2.027ProPhe: 2.027 ± 0.039	4.5ProGly: 4.5 ± 0.061	1.153ProHis: 1.153 ± 0.027	2.763ProIle: 2.763 ± 0.044	1.927ProLys: 1.927 ± 0.034	4.758ProLeu: 4.758 ± 0.063	1.082ProMet: 1.082 ± 0.027	2.178ProAsn: 2.178 ± 0.049	2.868ProPro: 2.868 ± 0.057	2.186ProGln: 2.186 ± 0.041	2.503ProArg: 2.503 ± 0.041	3.667ProSer: 3.667 ± 0.061	3.724ProThr: 3.724 ± 0.062	4.19ProVal: 4.19 ± 0.056	0.681ProTrp: 0.681 ± 0.021	1.436ProTyr: 1.436 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.919GlnAla: 3.919 ± 0.065	0.247GlnCys: 0.247 ± 0.012	1.636GlnAsp: 1.636 ± 0.031	1.712GlnGlu: 1.712 ± 0.036	1.537GlnPhe: 1.537 ± 0.031	2.563GlnGly: 2.563 ± 0.047	0.874GlnHis: 0.874 ± 0.023	2.237GlnIle: 2.237 ± 0.037	1.484GlnLys: 1.484 ± 0.031	3.83GlnLeu: 3.83 ± 0.055	1.055GlnMet: 1.055 ± 0.026	1.505GlnAsn: 1.505 ± 0.034	2.312GlnPro: 2.312 ± 0.043	2.179GlnGln: 2.179 ± 0.048	2.5GlnArg: 2.5 ± 0.042	2.501GlnSer: 2.501 ± 0.04	2.56GlnThr: 2.56 ± 0.043	2.686GlnVal: 2.686 ± 0.047	0.521GlnTrp: 0.521 ± 0.017	1.027GlnTyr: 1.027 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.516ArgAla: 5.516 ± 0.073	0.482ArgCys: 0.482 ± 0.019	2.997ArgAsp: 2.997 ± 0.04	3.518ArgGlu: 3.518 ± 0.061	2.581ArgPhe: 2.581 ± 0.038	3.82ArgGly: 3.82 ± 0.057	1.321ArgHis: 1.321 ± 0.029	3.452ArgIle: 3.452 ± 0.042	2.325ArgLys: 2.325 ± 0.046	5.847ArgLeu: 5.847 ± 0.081	1.628ArgMet: 1.628 ± 0.034	2.095ArgAsn: 2.095 ± 0.039	2.75ArgPro: 2.75 ± 0.046	2.357ArgGln: 2.357 ± 0.04	4.079ArgArg: 4.079 ± 0.066	3.621ArgSer: 3.621 ± 0.051	3.417ArgThr: 3.417 ± 0.049	4.208ArgVal: 4.208 ± 0.063	0.991ArgTrp: 0.991 ± 0.024	1.843ArgTyr: 1.843 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.526SerAla: 6.526 ± 0.075	0.559SerCys: 0.559 ± 0.02	3.041SerAsp: 3.041 ± 0.04	3.02SerGlu: 3.02 ± 0.05	2.764SerPhe: 2.764 ± 0.044	6.079SerGly: 6.079 ± 0.091	1.341SerHis: 1.341 ± 0.031	3.547SerIle: 3.547 ± 0.055	2.258SerLys: 2.258 ± 0.038	6.32SerLeu: 6.32 ± 0.068	1.325SerMet: 1.325 ± 0.031	2.38SerAsn: 2.38 ± 0.047	3.722SerPro: 3.722 ± 0.064	2.316SerGln: 2.316 ± 0.045	3.459SerArg: 3.459 ± 0.053	4.814SerSer: 4.814 ± 0.092	4.397SerThr: 4.397 ± 0.074	4.596SerVal: 4.596 ± 0.055	0.854SerTrp: 0.854 ± 0.025	1.763SerTyr: 1.763 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.956ThrAla: 6.956 ± 0.138	0.52ThrCys: 0.52 ± 0.017	3.039ThrAsp: 3.039 ± 0.051	2.824ThrGlu: 2.824 ± 0.044	2.683ThrPhe: 2.683 ± 0.051	5.713ThrGly: 5.713 ± 0.089	1.357ThrHis: 1.357 ± 0.029	3.65ThrIle: 3.65 ± 0.052	2.028ThrLys: 2.028 ± 0.039	6.684ThrLeu: 6.684 ± 0.099	1.28ThrMet: 1.28 ± 0.024	2.314ThrAsn: 2.314 ± 0.055	4.393ThrPro: 4.393 ± 0.076	2.296ThrGln: 2.296 ± 0.041	3.107ThrArg: 3.107 ± 0.041	4.183ThrSer: 4.183 ± 0.07	4.487ThrThr: 4.487 ± 0.097	5.166ThrVal: 5.166 ± 0.118	0.816ThrTrp: 0.816 ± 0.025	1.775ThrTyr: 1.775 ± 0.076	0.0ThrXaa: 0.0 ± 0.0
Val	7.748ValAla: 7.748 ± 0.078	0.689ValCys: 0.689 ± 0.022	3.761ValAsp: 3.761 ± 0.049	3.89ValGlu: 3.89 ± 0.056	2.754ValPhe: 2.754 ± 0.043	5.363ValGly: 5.363 ± 0.069	1.418ValHis: 1.418 ± 0.03	3.632ValIle: 3.632 ± 0.046	2.482ValLys: 2.482 ± 0.04	7.296ValLeu: 7.296 ± 0.083	1.571ValMet: 1.571 ± 0.031	2.628ValAsn: 2.628 ± 0.05	3.895ValPro: 3.895 ± 0.08	2.579ValGln: 2.579 ± 0.044	4.319ValArg: 4.319 ± 0.062	4.896ValSer: 4.896 ± 0.066	4.928ValThr: 4.928 ± 0.109	5.77ValVal: 5.77 ± 0.07	0.954ValTrp: 0.954 ± 0.027	1.849ValTyr: 1.849 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.103TrpAla: 1.103 ± 0.029	0.131TrpCys: 0.131 ± 0.008	0.619TrpAsp: 0.619 ± 0.019	0.565TrpGlu: 0.565 ± 0.019	0.591TrpPhe: 0.591 ± 0.021	0.934TrpGly: 0.934 ± 0.023	0.339TrpHis: 0.339 ± 0.015	0.802TrpIle: 0.802 ± 0.025	0.646TrpLys: 0.646 ± 0.021	1.488TrpLeu: 1.488 ± 0.037	0.4TrpMet: 0.4 ± 0.014	0.622TrpAsn: 0.622 ± 0.019	0.587TrpPro: 0.587 ± 0.019	0.668TrpGln: 0.668 ± 0.02	0.952TrpArg: 0.952 ± 0.023	0.936TrpSer: 0.936 ± 0.026	0.892TrpThr: 0.892 ± 0.023	0.937TrpVal: 0.937 ± 0.023	0.258TrpTrp: 0.258 ± 0.012	0.375TrpTyr: 0.375 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.654TyrAla: 2.654 ± 0.04	0.251TyrCys: 0.251 ± 0.012	1.582TyrAsp: 1.582 ± 0.032	1.361TyrGlu: 1.361 ± 0.028	1.272TyrPhe: 1.272 ± 0.032	2.451TyrGly: 2.451 ± 0.054	0.61TyrHis: 0.61 ± 0.018	1.17TyrIle: 1.17 ± 0.031	0.89TyrLys: 0.89 ± 0.021	2.642TyrLeu: 2.642 ± 0.042	0.513TyrMet: 0.513 ± 0.017	1.071TyrAsn: 1.071 ± 0.043	1.395TyrPro: 1.395 ± 0.029	1.055TyrGln: 1.055 ± 0.026	1.883TyrArg: 1.883 ± 0.035	1.879TyrSer: 1.879 ± 0.045	1.79TyrThr: 1.79 ± 0.05	1.938TyrVal: 1.938 ± 0.052	0.451TyrTrp: 0.451 ± 0.016	0.826TyrTyr: 0.826 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4941 proteins (1776201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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