Amino acid dipepetide frequency for Vibrio ishigakensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.713AlaAla: 6.713 ± 0.092	0.877AlaCys: 0.877 ± 0.026	4.39AlaAsp: 4.39 ± 0.056	5.681AlaGlu: 5.681 ± 0.078	3.43AlaPhe: 3.43 ± 0.052	5.841AlaGly: 5.841 ± 0.076	1.577AlaHis: 1.577 ± 0.036	5.982AlaIle: 5.982 ± 0.075	4.892AlaLys: 4.892 ± 0.074	9.409AlaLeu: 9.409 ± 0.098	2.764AlaMet: 2.764 ± 0.05	3.481AlaAsn: 3.481 ± 0.047	2.923AlaPro: 2.923 ± 0.057	3.473AlaGln: 3.473 ± 0.058	3.558AlaArg: 3.558 ± 0.05	5.507AlaSer: 5.507 ± 0.077	4.564AlaThr: 4.564 ± 0.06	5.922AlaVal: 5.922 ± 0.073	0.97AlaTrp: 0.97 ± 0.028	2.325AlaTyr: 2.325 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.81CysAla: 0.81 ± 0.026	0.164CysCys: 0.164 ± 0.011	0.596CysAsp: 0.596 ± 0.023	0.636CysGlu: 0.636 ± 0.022	0.43CysPhe: 0.43 ± 0.015	0.889CysGly: 0.889 ± 0.027	0.316CysHis: 0.316 ± 0.017	0.626CysIle: 0.626 ± 0.021	0.408CysLys: 0.408 ± 0.019	0.969CysLeu: 0.969 ± 0.029	0.288CysMet: 0.288 ± 0.016	0.364CysAsn: 0.364 ± 0.016	0.423CysPro: 0.423 ± 0.018	0.398CysGln: 0.398 ± 0.018	0.438CysArg: 0.438 ± 0.02	0.73CysSer: 0.73 ± 0.022	0.49CysThr: 0.49 ± 0.02	0.668CysVal: 0.668 ± 0.022	0.145CysTrp: 0.145 ± 0.01	0.319CysTyr: 0.319 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.546AspAla: 4.546 ± 0.066	0.521AspCys: 0.521 ± 0.02	2.959AspAsp: 2.959 ± 0.058	3.923AspGlu: 3.923 ± 0.059	2.569AspPhe: 2.569 ± 0.046	3.92AspGly: 3.92 ± 0.062	1.006AspHis: 1.006 ± 0.032	3.922AspIle: 3.922 ± 0.058	3.43AspLys: 3.43 ± 0.054	5.344AspLeu: 5.344 ± 0.059	1.451AspMet: 1.451 ± 0.031	2.446AspAsn: 2.446 ± 0.049	1.999AspPro: 1.999 ± 0.039	1.858AspGln: 1.858 ± 0.034	2.191AspArg: 2.191 ± 0.045	3.593AspSer: 3.593 ± 0.049	2.801AspThr: 2.801 ± 0.044	3.859AspVal: 3.859 ± 0.056	0.849AspTrp: 0.849 ± 0.023	2.184AspTyr: 2.184 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.493GluAla: 5.493 ± 0.068	0.563GluCys: 0.563 ± 0.022	3.038GluAsp: 3.038 ± 0.051	4.286GluGlu: 4.286 ± 0.064	2.792GluPhe: 2.792 ± 0.044	3.917GluGly: 3.917 ± 0.064	1.668GluHis: 1.668 ± 0.036	3.868GluIle: 3.868 ± 0.061	3.81GluLys: 3.81 ± 0.066	7.546GluLeu: 7.546 ± 0.082	1.78GluMet: 1.78 ± 0.037	2.769GluAsn: 2.769 ± 0.046	2.164GluPro: 2.164 ± 0.043	4.013GluGln: 4.013 ± 0.063	3.317GluArg: 3.317 ± 0.056	4.116GluSer: 4.116 ± 0.058	3.321GluThr: 3.321 ± 0.051	4.792GluVal: 4.792 ± 0.07	0.832GluTrp: 0.832 ± 0.027	2.002GluTyr: 2.002 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.735PheAla: 3.735 ± 0.059	0.514PheCys: 0.514 ± 0.02	2.944PheAsp: 2.944 ± 0.041	2.91PheGlu: 2.91 ± 0.051	1.673PhePhe: 1.673 ± 0.042	3.451PheGly: 3.451 ± 0.061	0.848PheHis: 0.848 ± 0.026	2.819PheIle: 2.819 ± 0.059	2.045PheLys: 2.045 ± 0.037	3.442PheLeu: 3.442 ± 0.056	1.128PheMet: 1.128 ± 0.032	2.076PheAsn: 2.076 ± 0.038	1.421PhePro: 1.421 ± 0.038	1.265PheGln: 1.265 ± 0.033	1.451PheArg: 1.451 ± 0.036	3.274PheSer: 3.274 ± 0.052	2.474PheThr: 2.474 ± 0.046	3.05PheVal: 3.05 ± 0.05	0.555PheTrp: 0.555 ± 0.021	1.325PheTyr: 1.325 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.5GlyAla: 5.5 ± 0.078	0.876GlyCys: 0.876 ± 0.026	3.867GlyAsp: 3.867 ± 0.069	4.628GlyGlu: 4.628 ± 0.065	3.526GlyPhe: 3.526 ± 0.061	4.957GlyGly: 4.957 ± 0.085	1.48GlyHis: 1.48 ± 0.035	4.844GlyIle: 4.844 ± 0.065	4.009GlyLys: 4.009 ± 0.057	7.104GlyLeu: 7.104 ± 0.082	2.21GlyMet: 2.21 ± 0.043	2.672GlyAsn: 2.672 ± 0.052	1.617GlyPro: 1.617 ± 0.04	2.616GlyGln: 2.616 ± 0.049	2.987GlyArg: 2.987 ± 0.05	4.154GlySer: 4.154 ± 0.062	3.546GlyThr: 3.546 ± 0.056	5.433GlyVal: 5.433 ± 0.078	0.994GlyTrp: 0.994 ± 0.027	2.655GlyTyr: 2.655 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.522HisAla: 1.522 ± 0.034	0.3HisCys: 0.3 ± 0.015	1.096HisAsp: 1.096 ± 0.032	1.086HisGlu: 1.086 ± 0.029	1.06HisPhe: 1.06 ± 0.028	1.553HisGly: 1.553 ± 0.045	0.634HisHis: 0.634 ± 0.027	1.323HisIle: 1.323 ± 0.032	1.084HisLys: 1.084 ± 0.031	2.174HisLeu: 2.174 ± 0.042	0.54HisMet: 0.54 ± 0.021	0.879HisAsn: 0.879 ± 0.027	1.072HisPro: 1.072 ± 0.028	1.101HisGln: 1.101 ± 0.03	1.008HisArg: 1.008 ± 0.027	1.441HisSer: 1.441 ± 0.037	1.086HisThr: 1.086 ± 0.032	1.256HisVal: 1.256 ± 0.029	0.358HisTrp: 0.358 ± 0.017	0.804HisTyr: 0.804 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.232IleAla: 6.232 ± 0.085	0.633IleCys: 0.633 ± 0.025	4.138IleAsp: 4.138 ± 0.054	4.936IleGlu: 4.936 ± 0.066	2.311IlePhe: 2.311 ± 0.051	4.709IleGly: 4.709 ± 0.063	1.213IleHis: 1.213 ± 0.031	3.463IleIle: 3.463 ± 0.063	3.23IleLys: 3.23 ± 0.047	5.305IleLeu: 5.305 ± 0.073	1.366IleMet: 1.366 ± 0.034	2.82IleAsn: 2.82 ± 0.052	2.67IlePro: 2.67 ± 0.052	2.248IleGln: 2.248 ± 0.043	2.625IleArg: 2.625 ± 0.043	4.575IleSer: 4.575 ± 0.062	3.702IleThr: 3.702 ± 0.056	4.1IleVal: 4.1 ± 0.062	0.685IleTrp: 0.685 ± 0.025	1.785IleTyr: 1.785 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.888LysAla: 4.888 ± 0.062	0.32LysCys: 0.32 ± 0.018	2.785LysAsp: 2.785 ± 0.044	3.567LysGlu: 3.567 ± 0.056	1.702LysPhe: 1.702 ± 0.035	3.507LysGly: 3.507 ± 0.053	1.307LysHis: 1.307 ± 0.031	2.858LysIle: 2.858 ± 0.051	2.907LysLys: 2.907 ± 0.056	5.712LysLeu: 5.712 ± 0.063	1.516LysMet: 1.516 ± 0.031	2.061LysAsn: 2.061 ± 0.044	2.453LysPro: 2.453 ± 0.044	3.049LysGln: 3.049 ± 0.053	2.718LysArg: 2.718 ± 0.046	3.299LysSer: 3.299 ± 0.052	2.777LysThr: 2.777 ± 0.05	4.077LysVal: 4.077 ± 0.052	0.605LysTrp: 0.605 ± 0.021	1.49LysTyr: 1.49 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.397LeuAla: 9.397 ± 0.078	1.111LeuCys: 1.111 ± 0.028	5.898LeuAsp: 5.898 ± 0.058	6.654LeuGlu: 6.654 ± 0.068	4.361LeuPhe: 4.361 ± 0.066	7.33LeuGly: 7.33 ± 0.074	1.911LeuHis: 1.911 ± 0.041	6.182LeuIle: 6.182 ± 0.082	5.548LeuLys: 5.548 ± 0.08	9.948LeuLeu: 9.948 ± 0.119	2.829LeuMet: 2.829 ± 0.043	4.446LeuAsn: 4.446 ± 0.055	4.479LeuPro: 4.479 ± 0.058	3.461LeuGln: 3.461 ± 0.055	4.185LeuArg: 4.185 ± 0.056	7.938LeuSer: 7.938 ± 0.089	5.883LeuThr: 5.883 ± 0.076	7.396LeuVal: 7.396 ± 0.087	1.057LeuTrp: 1.057 ± 0.031	2.61LeuTyr: 2.61 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.568MetAla: 2.568 ± 0.049	0.244MetCys: 0.244 ± 0.014	1.331MetAsp: 1.331 ± 0.022	1.344MetGlu: 1.344 ± 0.037	1.091MetPhe: 1.091 ± 0.033	1.929MetGly: 1.929 ± 0.041	0.531MetHis: 0.531 ± 0.019	1.529MetIle: 1.529 ± 0.035	1.665MetLys: 1.665 ± 0.035	3.016MetLeu: 3.016 ± 0.052	0.842MetMet: 0.842 ± 0.025	1.202MetAsn: 1.202 ± 0.031	1.397MetPro: 1.397 ± 0.038	1.258MetGln: 1.258 ± 0.031	1.302MetArg: 1.302 ± 0.031	2.087MetSer: 2.087 ± 0.043	1.692MetThr: 1.692 ± 0.039	2.094MetVal: 2.094 ± 0.034	0.26MetTrp: 0.26 ± 0.015	0.642MetTyr: 0.642 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.161AsnAla: 3.161 ± 0.053	0.388AsnCys: 0.388 ± 0.017	2.165AsnAsp: 2.165 ± 0.044	2.393AsnGlu: 2.393 ± 0.045	1.678AsnPhe: 1.678 ± 0.032	2.934AsnGly: 2.934 ± 0.049	0.979AsnHis: 0.979 ± 0.032	2.682AsnIle: 2.682 ± 0.046	2.316AsnLys: 2.316 ± 0.043	4.25AsnLeu: 4.25 ± 0.056	1.041AsnMet: 1.041 ± 0.025	1.87AsnAsn: 1.87 ± 0.038	2.209AsnPro: 2.209 ± 0.044	2.114AsnGln: 2.114 ± 0.041	1.903AsnArg: 1.903 ± 0.04	2.676AsnSer: 2.676 ± 0.052	2.25AsnThr: 2.25 ± 0.044	2.575AsnVal: 2.575 ± 0.044	0.633AsnTrp: 0.633 ± 0.026	1.445AsnTyr: 1.445 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.91ProAla: 2.91 ± 0.049	0.355ProCys: 0.355 ± 0.018	2.118ProAsp: 2.118 ± 0.046	3.373ProGlu: 3.373 ± 0.05	1.682ProPhe: 1.682 ± 0.038	2.055ProGly: 2.055 ± 0.043	0.884ProHis: 0.884 ± 0.029	2.489ProIle: 2.489 ± 0.043	2.029ProLys: 2.029 ± 0.037	3.945ProLeu: 3.945 ± 0.056	1.193ProMet: 1.193 ± 0.031	1.682ProAsn: 1.682 ± 0.037	1.007ProPro: 1.007 ± 0.033	1.584ProGln: 1.584 ± 0.038	1.382ProArg: 1.382 ± 0.032	2.698ProSer: 2.698 ± 0.047	2.242ProThr: 2.242 ± 0.04	2.981ProVal: 2.981 ± 0.048	0.497ProTrp: 0.497 ± 0.019	1.25ProTyr: 1.25 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.981GlnAla: 3.981 ± 0.059	0.338GlnCys: 0.338 ± 0.016	2.263GlnAsp: 2.263 ± 0.042	2.684GlnGlu: 2.684 ± 0.046	1.7GlnPhe: 1.7 ± 0.039	3.01GlnGly: 3.01 ± 0.049	0.978GlnHis: 0.978 ± 0.032	2.468GlnIle: 2.468 ± 0.041	2.191GlnLys: 2.191 ± 0.04	4.482GlnLeu: 4.482 ± 0.065	1.225GlnMet: 1.225 ± 0.029	1.615GlnAsn: 1.615 ± 0.033	1.485GlnPro: 1.485 ± 0.034	2.433GlnGln: 2.433 ± 0.047	2.052GlnArg: 2.052 ± 0.039	2.759GlnSer: 2.759 ± 0.05	2.259GlnThr: 2.259 ± 0.044	3.173GlnVal: 3.173 ± 0.051	0.579GlnTrp: 0.579 ± 0.021	1.315GlnTyr: 1.315 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.394ArgAla: 3.394 ± 0.05	0.455ArgCys: 0.455 ± 0.018	2.398ArgAsp: 2.398 ± 0.045	2.889ArgGlu: 2.889 ± 0.053	2.229ArgPhe: 2.229 ± 0.042	2.538ArgGly: 2.538 ± 0.047	1.001ArgHis: 1.001 ± 0.026	2.868ArgIle: 2.868 ± 0.043	2.265ArgLys: 2.265 ± 0.04	4.6ArgLeu: 4.6 ± 0.065	1.299ArgMet: 1.299 ± 0.035	1.833ArgAsn: 1.833 ± 0.043	1.533ArgPro: 1.533 ± 0.04	1.867ArgGln: 1.867 ± 0.04	2.194ArgArg: 2.194 ± 0.05	2.686ArgSer: 2.686 ± 0.049	2.16ArgThr: 2.16 ± 0.046	3.223ArgVal: 3.223 ± 0.048	0.556ArgTrp: 0.556 ± 0.024	1.635ArgTyr: 1.635 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.378SerAla: 5.378 ± 0.068	0.604SerCys: 0.604 ± 0.023	3.852SerAsp: 3.852 ± 0.056	4.385SerGlu: 4.385 ± 0.06	3.036SerPhe: 3.036 ± 0.045	5.032SerGly: 5.032 ± 0.075	1.511SerHis: 1.511 ± 0.036	4.434SerIle: 4.434 ± 0.064	3.593SerLys: 3.593 ± 0.053	7.282SerLeu: 7.282 ± 0.079	1.944SerMet: 1.944 ± 0.044	2.79SerAsn: 2.79 ± 0.05	2.301SerPro: 2.301 ± 0.037	2.923SerGln: 2.923 ± 0.05	2.915SerArg: 2.915 ± 0.048	4.495SerSer: 4.495 ± 0.074	3.439SerThr: 3.439 ± 0.056	4.837SerVal: 4.837 ± 0.064	0.905SerTrp: 0.905 ± 0.024	2.13SerTyr: 2.13 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.436ThrAla: 4.436 ± 0.066	0.507ThrCys: 0.507 ± 0.023	2.959ThrAsp: 2.959 ± 0.051	3.342ThrGlu: 3.342 ± 0.053	2.185ThrPhe: 2.185 ± 0.045	4.158ThrGly: 4.158 ± 0.063	1.2ThrHis: 1.2 ± 0.029	3.39ThrIle: 3.39 ± 0.054	2.533ThrLys: 2.533 ± 0.046	6.131ThrLeu: 6.131 ± 0.067	1.339ThrMet: 1.339 ± 0.032	2.013ThrAsn: 2.013 ± 0.038	2.629ThrPro: 2.629 ± 0.043	2.383ThrGln: 2.383 ± 0.047	2.167ThrArg: 2.167 ± 0.038	3.542ThrSer: 3.542 ± 0.054	2.979ThrThr: 2.979 ± 0.053	3.858ThrVal: 3.858 ± 0.065	0.694ThrTrp: 0.694 ± 0.025	1.583ThrTyr: 1.583 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.455ValAla: 6.455 ± 0.076	0.81ValCys: 0.81 ± 0.023	4.217ValAsp: 4.217 ± 0.069	5.113ValGlu: 5.113 ± 0.066	2.874ValPhe: 2.874 ± 0.052	4.998ValGly: 4.998 ± 0.064	1.26ValHis: 1.26 ± 0.035	4.633ValIle: 4.633 ± 0.072	3.523ValLys: 3.523 ± 0.061	6.91ValLeu: 6.91 ± 0.082	2.122ValMet: 2.122 ± 0.045	2.945ValAsn: 2.945 ± 0.049	2.737ValPro: 2.737 ± 0.044	2.276ValGln: 2.276 ± 0.039	2.895ValArg: 2.895 ± 0.044	5.286ValSer: 5.286 ± 0.067	4.229ValThr: 4.229 ± 0.068	5.568ValVal: 5.568 ± 0.074	0.79ValTrp: 0.79 ± 0.026	2.006ValTyr: 2.006 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.852TrpAla: 0.852 ± 0.027	0.159TrpCys: 0.159 ± 0.012	0.662TrpAsp: 0.662 ± 0.026	0.559TrpGlu: 0.559 ± 0.019	0.601TrpPhe: 0.601 ± 0.022	0.814TrpGly: 0.814 ± 0.03	0.342TrpHis: 0.342 ± 0.016	0.686TrpIle: 0.686 ± 0.025	0.611TrpLys: 0.611 ± 0.022	1.646TrpLeu: 1.646 ± 0.035	0.438TrpMet: 0.438 ± 0.018	0.55TrpAsn: 0.55 ± 0.022	0.462TrpPro: 0.462 ± 0.022	0.776TrpGln: 0.776 ± 0.028	0.636TrpArg: 0.636 ± 0.023	0.778TrpSer: 0.778 ± 0.027	0.594TrpThr: 0.594 ± 0.024	0.867TrpVal: 0.867 ± 0.026	0.217TrpTrp: 0.217 ± 0.014	0.403TrpTyr: 0.403 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.307TyrAla: 2.307 ± 0.037	0.369TyrCys: 0.369 ± 0.017	1.693TyrAsp: 1.693 ± 0.038	1.7TyrGlu: 1.7 ± 0.039	1.469TyrPhe: 1.469 ± 0.035	2.135TyrGly: 2.135 ± 0.039	0.732TyrHis: 0.732 ± 0.024	1.68TyrIle: 1.68 ± 0.034	1.509TyrLys: 1.509 ± 0.04	3.408TyrLeu: 3.408 ± 0.057	0.707TyrMet: 0.707 ± 0.023	1.149TyrAsn: 1.149 ± 0.032	1.372TyrPro: 1.372 ± 0.035	1.893TyrGln: 1.893 ± 0.041	1.7TyrArg: 1.7 ± 0.037	2.152TyrSer: 2.152 ± 0.045	1.541TyrThr: 1.541 ± 0.041	1.916TyrVal: 1.916 ± 0.039	0.474TyrTrp: 0.474 ± 0.021	1.062TyrTyr: 1.062 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5867 proteins (1286837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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