Amino acid dipepetide frequency for Rivibacter subsaxonicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.72AlaAla: 21.72 ± 0.22	1.302AlaCys: 1.302 ± 0.039	6.94AlaAsp: 6.94 ± 0.1	7.607AlaGlu: 7.607 ± 0.096	4.249AlaPhe: 4.249 ± 0.059	12.059AlaGly: 12.059 ± 0.119	2.614AlaHis: 2.614 ± 0.053	5.29AlaIle: 5.29 ± 0.077	3.439AlaLys: 3.439 ± 0.073	17.212AlaLeu: 17.212 ± 0.194	3.28AlaMet: 3.28 ± 0.054	2.716AlaAsn: 2.716 ± 0.054	7.36AlaPro: 7.36 ± 0.112	5.526AlaGln: 5.526 ± 0.078	10.585AlaArg: 10.585 ± 0.124	7.278AlaSer: 7.278 ± 0.083	6.684AlaThr: 6.684 ± 0.09	9.483AlaVal: 9.483 ± 0.095	2.189AlaTrp: 2.189 ± 0.053	2.395AlaTyr: 2.395 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.191CysAla: 1.191 ± 0.032	0.119CysCys: 0.119 ± 0.011	0.503CysAsp: 0.503 ± 0.021	0.537CysGlu: 0.537 ± 0.02	0.277CysPhe: 0.277 ± 0.014	0.979CysGly: 0.979 ± 0.03	0.257CysHis: 0.257 ± 0.015	0.365CysIle: 0.365 ± 0.017	0.206CysLys: 0.206 ± 0.014	0.774CysLeu: 0.774 ± 0.028	0.169CysMet: 0.169 ± 0.01	0.228CysAsn: 0.228 ± 0.013	0.458CysPro: 0.458 ± 0.023	0.213CysGln: 0.213 ± 0.014	0.551CysArg: 0.551 ± 0.023	0.473CysSer: 0.473 ± 0.022	0.458CysThr: 0.458 ± 0.022	0.694CysVal: 0.694 ± 0.027	0.12CysTrp: 0.12 ± 0.01	0.189CysTyr: 0.189 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.901AspAla: 7.901 ± 0.103	0.453AspCys: 0.453 ± 0.021	2.712AspAsp: 2.712 ± 0.065	3.418AspGlu: 3.418 ± 0.054	1.931AspPhe: 1.931 ± 0.046	4.892AspGly: 4.892 ± 0.083	1.044AspHis: 1.044 ± 0.034	2.012AspIle: 2.012 ± 0.045	1.474AspLys: 1.474 ± 0.039	5.058AspLeu: 5.058 ± 0.07	0.855AspMet: 0.855 ± 0.027	1.033AspAsn: 1.033 ± 0.034	3.21AspPro: 3.21 ± 0.05	1.423AspGln: 1.423 ± 0.037	3.608AspArg: 3.608 ± 0.052	2.172AspSer: 2.172 ± 0.045	2.232AspThr: 2.232 ± 0.052	3.457AspVal: 3.457 ± 0.065	1.072AspTrp: 1.072 ± 0.031	1.281AspTyr: 1.281 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.701GluAla: 7.701 ± 0.099	0.333GluCys: 0.333 ± 0.018	2.125GluAsp: 2.125 ± 0.05	2.211GluGlu: 2.211 ± 0.052	1.843GluPhe: 1.843 ± 0.042	3.854GluGly: 3.854 ± 0.063	1.472GluHis: 1.472 ± 0.04	2.585GluIle: 2.585 ± 0.046	1.434GluLys: 1.434 ± 0.039	6.976GluLeu: 6.976 ± 0.081	1.141GluMet: 1.141 ± 0.028	0.997GluAsn: 0.997 ± 0.031	3.01GluPro: 3.01 ± 0.055	2.697GluGln: 2.697 ± 0.049	5.475GluArg: 5.475 ± 0.072	2.389GluSer: 2.389 ± 0.044	2.262GluThr: 2.262 ± 0.045	4.089GluVal: 4.089 ± 0.064	0.703GluTrp: 0.703 ± 0.026	0.916GluTyr: 0.916 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.368PheAla: 4.368 ± 0.053	0.363PheCys: 0.363 ± 0.019	2.648PheAsp: 2.648 ± 0.054	2.318PheGlu: 2.318 ± 0.05	1.345PhePhe: 1.345 ± 0.038	3.652PheGly: 3.652 ± 0.062	0.699PheHis: 0.699 ± 0.025	1.43PheIle: 1.43 ± 0.032	1.062PheLys: 1.062 ± 0.029	2.761PheLeu: 2.761 ± 0.053	0.777PheMet: 0.777 ± 0.028	1.036PheAsn: 1.036 ± 0.032	1.364PhePro: 1.364 ± 0.035	0.885PheGln: 0.885 ± 0.03	1.857PheArg: 1.857 ± 0.046	1.951PheSer: 1.951 ± 0.044	1.715PheThr: 1.715 ± 0.045	2.894PheVal: 2.894 ± 0.053	0.557PheTrp: 0.557 ± 0.023	0.858PheTyr: 0.858 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.869GlyAla: 10.869 ± 0.107	0.953GlyCys: 0.953 ± 0.029	4.04GlyAsp: 4.04 ± 0.081	4.651GlyGlu: 4.651 ± 0.07	3.435GlyPhe: 3.435 ± 0.056	7.7GlyGly: 7.7 ± 0.139	1.877GlyHis: 1.877 ± 0.044	3.759GlyIle: 3.759 ± 0.07	2.976GlyLys: 2.976 ± 0.077	9.405GlyLeu: 9.405 ± 0.092	2.013GlyMet: 2.013 ± 0.041	2.006GlyAsn: 2.006 ± 0.064	3.465GlyPro: 3.465 ± 0.059	2.865GlyGln: 2.865 ± 0.057	6.242GlyArg: 6.242 ± 0.08	5.072GlySer: 5.072 ± 0.077	4.512GlyThr: 4.512 ± 0.075	6.674GlyVal: 6.674 ± 0.068	1.617GlyTrp: 1.617 ± 0.042	2.189GlyTyr: 2.189 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.968HisAla: 2.968 ± 0.058	0.258HisCys: 0.258 ± 0.013	1.11HisAsp: 1.11 ± 0.03	1.22HisGlu: 1.22 ± 0.03	0.821HisPhe: 0.821 ± 0.029	2.173HisGly: 2.173 ± 0.043	0.604HisHis: 0.604 ± 0.025	0.725HisIle: 0.725 ± 0.025	0.492HisLys: 0.492 ± 0.022	2.134HisLeu: 2.134 ± 0.05	0.378HisMet: 0.378 ± 0.02	0.446HisAsn: 0.446 ± 0.02	1.443HisPro: 1.443 ± 0.038	0.674HisGln: 0.674 ± 0.024	1.609HisArg: 1.609 ± 0.041	0.934HisSer: 0.934 ± 0.029	0.883HisThr: 0.883 ± 0.027	1.525HisVal: 1.525 ± 0.038	0.425HisTrp: 0.425 ± 0.018	0.613HisTyr: 0.613 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.06IleAla: 6.06 ± 0.082	0.345IleCys: 0.345 ± 0.019	3.251IleAsp: 3.251 ± 0.051	3.405IleGlu: 3.405 ± 0.056	1.133IlePhe: 1.133 ± 0.031	4.422IleGly: 4.422 ± 0.067	0.77IleHis: 0.77 ± 0.029	1.173IleIle: 1.173 ± 0.037	1.264IleLys: 1.264 ± 0.04	2.766IleLeu: 2.766 ± 0.052	0.567IleMet: 0.567 ± 0.024	1.187IleAsn: 1.187 ± 0.031	1.704IlePro: 1.704 ± 0.043	0.981IleGln: 0.981 ± 0.025	2.399IleArg: 2.399 ± 0.037	2.055IleSer: 2.055 ± 0.047	2.132IleThr: 2.132 ± 0.043	3.455IleVal: 3.455 ± 0.063	0.439IleTrp: 0.439 ± 0.02	0.847IleTyr: 0.847 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.712LysAla: 3.712 ± 0.071	0.149LysCys: 0.149 ± 0.012	1.394LysAsp: 1.394 ± 0.041	1.203LysGlu: 1.203 ± 0.034	0.862LysPhe: 0.862 ± 0.024	2.078LysGly: 2.078 ± 0.045	0.579LysHis: 0.579 ± 0.022	1.193LysIle: 1.193 ± 0.043	1.132LysLys: 1.132 ± 0.045	3.452LysLeu: 3.452 ± 0.064	0.646LysMet: 0.646 ± 0.022	0.752LysAsn: 0.752 ± 0.027	1.93LysPro: 1.93 ± 0.043	1.076LysGln: 1.076 ± 0.035	2.149LysArg: 2.149 ± 0.048	1.598LysSer: 1.598 ± 0.042	1.492LysThr: 1.492 ± 0.035	2.202LysVal: 2.202 ± 0.059	0.31LysTrp: 0.31 ± 0.02	0.537LysTyr: 0.537 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	17.095LeuAla: 17.095 ± 0.174	0.947LeuCys: 0.947 ± 0.033	6.108LeuAsp: 6.108 ± 0.075	5.618LeuGlu: 5.618 ± 0.081	3.505LeuPhe: 3.505 ± 0.059	9.329LeuGly: 9.329 ± 0.093	2.384LeuHis: 2.384 ± 0.051	4.19LeuIle: 4.19 ± 0.063	3.449LeuLys: 3.449 ± 0.06	12.634LeuLeu: 12.634 ± 0.166	2.438LeuMet: 2.438 ± 0.051	2.474LeuAsn: 2.474 ± 0.044	6.588LeuPro: 6.588 ± 0.089	4.216LeuGln: 4.216 ± 0.073	8.875LeuArg: 8.875 ± 0.104	5.794LeuSer: 5.794 ± 0.075	4.656LeuThr: 4.656 ± 0.061	8.493LeuVal: 8.493 ± 0.106	1.536LeuTrp: 1.536 ± 0.045	1.988LeuTyr: 1.988 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.731MetAla: 2.731 ± 0.049	0.14MetCys: 0.14 ± 0.011	0.921MetAsp: 0.921 ± 0.027	0.813MetGlu: 0.813 ± 0.031	0.674MetPhe: 0.674 ± 0.025	1.619MetGly: 1.619 ± 0.039	0.476MetHis: 0.476 ± 0.021	0.851MetIle: 0.851 ± 0.03	0.877MetLys: 0.877 ± 0.028	2.589MetLeu: 2.589 ± 0.051	0.481MetMet: 0.481 ± 0.022	0.822MetAsn: 0.822 ± 0.028	1.402MetPro: 1.402 ± 0.031	0.908MetGln: 0.908 ± 0.027	1.649MetArg: 1.649 ± 0.041	1.66MetSer: 1.66 ± 0.024	1.167MetThr: 1.167 ± 0.031	1.525MetVal: 1.525 ± 0.038	0.204MetTrp: 0.204 ± 0.013	0.301MetTyr: 0.301 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.049AsnAla: 3.049 ± 0.058	0.261AsnCys: 0.261 ± 0.016	1.132AsnAsp: 1.132 ± 0.046	1.118AsnGlu: 1.118 ± 0.034	0.9AsnPhe: 0.9 ± 0.029	1.953AsnGly: 1.953 ± 0.045	0.463AsnHis: 0.463 ± 0.022	0.938AsnIle: 0.938 ± 0.027	0.677AsnLys: 0.677 ± 0.026	2.463AsnLeu: 2.463 ± 0.052	0.467AsnMet: 0.467 ± 0.02	0.629AsnAsn: 0.629 ± 0.03	1.709AsnPro: 1.709 ± 0.039	0.674AsnGln: 0.674 ± 0.027	1.531AsnArg: 1.531 ± 0.036	1.09AsnSer: 1.09 ± 0.034	1.227AsnThr: 1.227 ± 0.042	1.713AsnVal: 1.713 ± 0.042	0.39AsnTrp: 0.39 ± 0.018	0.627AsnTyr: 0.627 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.299ProAla: 8.299 ± 0.101	0.347ProCys: 0.347 ± 0.014	2.88ProAsp: 2.88 ± 0.057	3.234ProGlu: 3.234 ± 0.059	1.771ProPhe: 1.771 ± 0.036	5.121ProGly: 5.121 ± 0.061	1.051ProHis: 1.051 ± 0.029	1.928ProIle: 1.928 ± 0.035	1.503ProLys: 1.503 ± 0.043	5.761ProLeu: 5.761 ± 0.085	1.244ProMet: 1.244 ± 0.035	1.248ProAsn: 1.248 ± 0.032	3.087ProPro: 3.087 ± 0.075	2.232ProGln: 2.232 ± 0.051	3.583ProArg: 3.583 ± 0.057	2.784ProSer: 2.784 ± 0.042	2.616ProThr: 2.616 ± 0.045	4.451ProVal: 4.451 ± 0.06	0.814ProTrp: 0.814 ± 0.03	1.036ProTyr: 1.036 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.234GlnAla: 5.234 ± 0.072	0.25GlnCys: 0.25 ± 0.015	1.27GlnAsp: 1.27 ± 0.035	1.25GlnGlu: 1.25 ± 0.033	1.081GlnPhe: 1.081 ± 0.029	2.695GlnGly: 2.695 ± 0.051	0.826GlnHis: 0.826 ± 0.025	1.631GlnIle: 1.631 ± 0.04	0.948GlnLys: 0.948 ± 0.032	4.225GlnLeu: 4.225 ± 0.07	0.892GlnMet: 0.892 ± 0.031	0.679GlnAsn: 0.679 ± 0.027	2.358GlnPro: 2.358 ± 0.052	1.875GlnGln: 1.875 ± 0.051	3.703GlnArg: 3.703 ± 0.065	1.737GlnSer: 1.737 ± 0.039	1.603GlnThr: 1.603 ± 0.037	2.732GlnVal: 2.732 ± 0.05	0.598GlnTrp: 0.598 ± 0.023	0.623GlnTyr: 0.623 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.562ArgAla: 9.562 ± 0.104	0.676ArgCys: 0.676 ± 0.026	3.709ArgAsp: 3.709 ± 0.059	4.745ArgGlu: 4.745 ± 0.076	3.006ArgPhe: 3.006 ± 0.055	5.572ArgGly: 5.572 ± 0.08	1.934ArgHis: 1.934 ± 0.046	3.384ArgIle: 3.384 ± 0.057	1.894ArgLys: 1.894 ± 0.041	8.83ArgLeu: 8.83 ± 0.111	1.815ArgMet: 1.815 ± 0.039	1.678ArgAsn: 1.678 ± 0.043	3.791ArgPro: 3.791 ± 0.065	2.687ArgGln: 2.687 ± 0.047	6.043ArgArg: 6.043 ± 0.087	3.93ArgSer: 3.93 ± 0.063	3.143ArgThr: 3.143 ± 0.05	5.574ArgVal: 5.574 ± 0.08	1.427ArgTrp: 1.427 ± 0.035	1.752ArgTyr: 1.752 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.917SerAla: 6.917 ± 0.084	0.452SerCys: 0.452 ± 0.021	2.418SerAsp: 2.418 ± 0.053	2.514SerGlu: 2.514 ± 0.055	2.222SerPhe: 2.222 ± 0.049	5.094SerGly: 5.094 ± 0.081	1.066SerHis: 1.066 ± 0.028	2.212SerIle: 2.212 ± 0.042	1.412SerLys: 1.412 ± 0.034	5.571SerLeu: 5.571 ± 0.08	1.32SerMet: 1.32 ± 0.034	1.315SerAsn: 1.315 ± 0.036	2.76SerPro: 2.76 ± 0.047	1.634SerGln: 1.634 ± 0.038	3.501SerArg: 3.501 ± 0.057	2.983SerSer: 2.983 ± 0.064	2.788SerThr: 2.788 ± 0.058	3.897SerVal: 3.897 ± 0.055	0.752SerTrp: 0.752 ± 0.028	1.272SerTyr: 1.272 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.828ThrAla: 5.828 ± 0.086	0.34ThrCys: 0.34 ± 0.018	2.221ThrAsp: 2.221 ± 0.051	2.286ThrGlu: 2.286 ± 0.043	1.384ThrPhe: 1.384 ± 0.04	4.373ThrGly: 4.373 ± 0.079	0.973ThrHis: 0.973 ± 0.03	2.051ThrIle: 2.051 ± 0.046	1.049ThrLys: 1.049 ± 0.031	6.362ThrLeu: 6.362 ± 0.083	0.93ThrMet: 0.93 ± 0.027	1.047ThrAsn: 1.047 ± 0.036	3.409ThrPro: 3.409 ± 0.058	1.557ThrGln: 1.557 ± 0.04	3.345ThrArg: 3.345 ± 0.048	2.444ThrSer: 2.444 ± 0.055	2.614ThrThr: 2.614 ± 0.059	3.844ThrVal: 3.844 ± 0.061	0.614ThrTrp: 0.614 ± 0.024	0.898ThrTyr: 0.898 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.521ValAla: 10.521 ± 0.113	0.679ValCys: 0.679 ± 0.021	4.161ValAsp: 4.161 ± 0.064	4.46ValGlu: 4.46 ± 0.069	2.681ValPhe: 2.681 ± 0.052	5.842ValGly: 5.842 ± 0.082	1.55ValHis: 1.55 ± 0.033	3.282ValIle: 3.282 ± 0.05	2.156ValLys: 2.156 ± 0.058	8.686ValLeu: 8.686 ± 0.097	1.667ValMet: 1.667 ± 0.033	1.794ValAsn: 1.794 ± 0.045	4.096ValPro: 4.096 ± 0.066	2.558ValGln: 2.558 ± 0.049	5.289ValArg: 5.289 ± 0.077	3.799ValSer: 3.799 ± 0.059	3.554ValThr: 3.554 ± 0.053	6.263ValVal: 6.263 ± 0.096	1.011ValTrp: 1.011 ± 0.03	1.453ValTyr: 1.453 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.564TrpAla: 1.564 ± 0.042	0.184TrpCys: 0.184 ± 0.013	0.66TrpAsp: 0.66 ± 0.022	0.527TrpGlu: 0.527 ± 0.019	0.596TrpPhe: 0.596 ± 0.022	1.012TrpGly: 1.012 ± 0.028	0.396TrpHis: 0.396 ± 0.019	0.669TrpIle: 0.669 ± 0.026	0.426TrpLys: 0.426 ± 0.021	2.361TrpLeu: 2.361 ± 0.06	0.365TrpMet: 0.365 ± 0.019	0.401TrpAsn: 0.401 ± 0.02	0.834TrpPro: 0.834 ± 0.027	0.823TrpGln: 0.823 ± 0.026	1.437TrpArg: 1.437 ± 0.042	0.875TrpSer: 0.875 ± 0.03	0.731TrpThr: 0.731 ± 0.028	0.998TrpVal: 0.998 ± 0.032	0.364TrpTrp: 0.364 ± 0.018	0.298TrpTyr: 0.298 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.637TyrAla: 2.637 ± 0.05	0.211TyrCys: 0.211 ± 0.013	1.034TyrAsp: 1.034 ± 0.032	1.08TyrGlu: 1.08 ± 0.037	0.826TyrPhe: 0.826 ± 0.027	1.901TyrGly: 1.901 ± 0.05	0.4TyrHis: 0.4 ± 0.019	0.686TyrIle: 0.686 ± 0.026	0.577TyrLys: 0.577 ± 0.023	2.296TyrLeu: 2.296 ± 0.044	0.364TyrMet: 0.364 ± 0.014	0.521TyrAsn: 0.521 ± 0.023	1.014TyrPro: 1.014 ± 0.027	0.703TyrGln: 0.703 ± 0.027	1.721TyrArg: 1.721 ± 0.043	1.082TyrSer: 1.082 ± 0.032	1.104TyrThr: 1.104 ± 0.032	1.538TyrVal: 1.538 ± 0.04	0.379TyrTrp: 0.379 ± 0.016	0.517TyrTyr: 0.517 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3641 proteins (1204091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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