Amino acid dipepetide frequency for Flavobacterium phage vB_FspS_tant8-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.151AlaCys: 0.151 ± 0.108
1.511AlaAsp: 1.511 ± 0.378
2.191AlaGlu: 2.191 ± 0.537
3.399AlaPhe: 3.399 ± 0.451
2.115AlaGly: 2.115 ± 0.425
0.151AlaHis: 0.151 ± 0.112
4.079AlaIle: 4.079 ± 0.506
4.457AlaLys: 4.457 ± 0.673
3.777AlaLeu: 3.777 ± 0.901
0.755AlaMet: 0.755 ± 0.257
3.173AlaAsn: 3.173 ± 0.467
1.511AlaPro: 1.511 ± 0.369
1.964AlaGln: 1.964 ± 0.377
1.813AlaArg: 1.813 ± 0.331
2.191AlaSer: 2.191 ± 0.49
2.946AlaThr: 2.946 ± 0.443
2.719AlaVal: 2.719 ± 0.53
0.302AlaTrp: 0.302 ± 0.139
0.378AlaTyr: 0.378 ± 0.169
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.227CysCys: 0.227 ± 0.13
0.831CysAsp: 0.831 ± 0.265
0.68CysGlu: 0.68 ± 0.28
0.755CysPhe: 0.755 ± 0.258
0.906CysGly: 0.906 ± 0.27
0.076CysHis: 0.076 ± 0.062
0.529CysIle: 0.529 ± 0.193
0.453CysLys: 0.453 ± 0.185
0.755CysLeu: 0.755 ± 0.248
0.0CysMet: 0.0 ± 0.0
0.453CysAsn: 0.453 ± 0.224
0.68CysPro: 0.68 ± 0.225
0.68CysGln: 0.68 ± 0.211
0.604CysArg: 0.604 ± 0.206
0.755CysSer: 0.755 ± 0.238
0.378CysThr: 0.378 ± 0.172
0.453CysVal: 0.453 ± 0.17
0.076CysTrp: 0.076 ± 0.065
0.378CysTyr: 0.378 ± 0.141
0.0CysXaa: 0.0 ± 0.0
Asp
3.173AspAla: 3.173 ± 0.418
0.604AspCys: 0.604 ± 0.252
3.701AspAsp: 3.701 ± 0.648
5.061AspGlu: 5.061 ± 0.699
5.137AspPhe: 5.137 ± 0.53
5.288AspGly: 5.288 ± 0.647
0.302AspHis: 0.302 ± 0.166
4.23AspIle: 4.23 ± 0.661
4.306AspLys: 4.306 ± 0.721
5.968AspLeu: 5.968 ± 0.687
0.982AspMet: 0.982 ± 0.224
3.324AspAsn: 3.324 ± 0.452
2.191AspPro: 2.191 ± 0.352
2.719AspGln: 2.719 ± 0.451
1.737AspArg: 1.737 ± 0.328
3.853AspSer: 3.853 ± 0.449
1.964AspThr: 1.964 ± 0.348
4.004AspVal: 4.004 ± 0.555
1.209AspTrp: 1.209 ± 0.281
1.511AspTyr: 1.511 ± 0.393
0.0AspXaa: 0.0 ± 0.0
Glu
3.626GluAla: 3.626 ± 0.639
0.831GluCys: 0.831 ± 0.235
3.097GluAsp: 3.097 ± 0.435
2.795GluGlu: 2.795 ± 0.548
4.986GluPhe: 4.986 ± 0.874
2.719GluGly: 2.719 ± 0.428
1.284GluHis: 1.284 ± 0.35
8.687GluIle: 8.687 ± 0.831
9.216GluLys: 9.216 ± 1.324
8.46GluLeu: 8.46 ± 0.945
2.342GluMet: 2.342 ± 0.427
6.95GluAsn: 6.95 ± 0.668
1.737GluPro: 1.737 ± 0.358
3.475GluGln: 3.475 ± 0.684
3.475GluArg: 3.475 ± 0.705
3.928GluSer: 3.928 ± 0.729
5.968GluThr: 5.968 ± 0.705
3.173GluVal: 3.173 ± 0.655
1.058GluTrp: 1.058 ± 0.354
3.022GluTyr: 3.022 ± 0.421
0.0GluXaa: 0.0 ± 0.0
Phe
2.644PheAla: 2.644 ± 0.401
0.604PheCys: 0.604 ± 0.275
4.683PheAsp: 4.683 ± 0.623
6.194PheGlu: 6.194 ± 0.72
4.155PhePhe: 4.155 ± 0.616
4.683PheGly: 4.683 ± 0.531
1.511PheHis: 1.511 ± 0.292
4.835PheIle: 4.835 ± 0.67
6.345PheLys: 6.345 ± 0.686
2.946PheLeu: 2.946 ± 0.495
1.284PheMet: 1.284 ± 0.347
4.306PheAsn: 4.306 ± 0.528
2.342PhePro: 2.342 ± 0.443
2.568PheGln: 2.568 ± 0.474
1.964PheArg: 1.964 ± 0.347
4.381PheSer: 4.381 ± 0.506
3.097PheThr: 3.097 ± 0.421
4.759PheVal: 4.759 ± 0.614
0.378PheTrp: 0.378 ± 0.193
1.889PheTyr: 1.889 ± 0.305
0.0PheXaa: 0.0 ± 0.0
Gly
1.889GlyAla: 1.889 ± 0.467
0.529GlyCys: 0.529 ± 0.222
2.644GlyAsp: 2.644 ± 0.584
3.248GlyGlu: 3.248 ± 0.511
4.306GlyPhe: 4.306 ± 0.724
3.022GlyGly: 3.022 ± 0.608
0.529GlyHis: 0.529 ± 0.278
5.59GlyIle: 5.59 ± 0.77
4.683GlyLys: 4.683 ± 0.669
3.928GlyLeu: 3.928 ± 0.68
1.133GlyMet: 1.133 ± 0.303
3.55GlyAsn: 3.55 ± 0.554
0.0GlyPro: 0.0 ± 0.0
1.964GlyGln: 1.964 ± 0.533
1.964GlyArg: 1.964 ± 0.4
4.155GlySer: 4.155 ± 0.721
2.417GlyThr: 2.417 ± 0.458
3.777GlyVal: 3.777 ± 0.544
1.058GlyTrp: 1.058 ± 0.277
1.586GlyTyr: 1.586 ± 0.319
0.0GlyXaa: 0.0 ± 0.0
His
0.227HisAla: 0.227 ± 0.128
0.227HisCys: 0.227 ± 0.146
0.68HisAsp: 0.68 ± 0.205
1.36HisGlu: 1.36 ± 0.391
1.36HisPhe: 1.36 ± 0.367
0.604HisGly: 0.604 ± 0.225
0.378HisHis: 0.378 ± 0.183
1.058HisIle: 1.058 ± 0.255
0.906HisLys: 0.906 ± 0.224
1.133HisLeu: 1.133 ± 0.269
0.076HisMet: 0.076 ± 0.087
0.604HisAsn: 0.604 ± 0.187
0.227HisPro: 0.227 ± 0.117
0.302HisGln: 0.302 ± 0.146
0.906HisArg: 0.906 ± 0.287
1.058HisSer: 1.058 ± 0.327
0.755HisThr: 0.755 ± 0.27
0.68HisVal: 0.68 ± 0.211
0.076HisTrp: 0.076 ± 0.078
0.302HisTyr: 0.302 ± 0.151
0.0HisXaa: 0.0 ± 0.0
Ile
3.853IleAla: 3.853 ± 0.621
0.68IleCys: 0.68 ± 0.232
7.478IleAsp: 7.478 ± 0.785
9.669IleGlu: 9.669 ± 0.855
4.608IlePhe: 4.608 ± 0.587
4.381IleGly: 4.381 ± 0.621
1.662IleHis: 1.662 ± 0.383
5.514IleIle: 5.514 ± 0.689
8.385IleLys: 8.385 ± 0.867
5.666IleLeu: 5.666 ± 0.782
0.831IleMet: 0.831 ± 0.239
6.043IleAsn: 6.043 ± 0.704
3.022IlePro: 3.022 ± 0.61
3.475IleGln: 3.475 ± 0.548
2.795IleArg: 2.795 ± 0.449
4.91IleSer: 4.91 ± 0.648
4.381IleThr: 4.381 ± 0.64
4.835IleVal: 4.835 ± 0.625
0.755IleTrp: 0.755 ± 0.251
2.644IleTyr: 2.644 ± 0.513
0.0IleXaa: 0.0 ± 0.0
Lys
4.155LysAla: 4.155 ± 0.933
1.133LysCys: 1.133 ± 0.32
5.212LysAsp: 5.212 ± 0.756
7.781LysGlu: 7.781 ± 1.32
6.043LysPhe: 6.043 ± 0.682
3.475LysGly: 3.475 ± 0.512
1.435LysHis: 1.435 ± 0.384
7.856LysIle: 7.856 ± 0.778
10.047LysLys: 10.047 ± 1.246
8.536LysLeu: 8.536 ± 0.891
3.248LysMet: 3.248 ± 0.448
7.781LysAsn: 7.781 ± 0.787
2.493LysPro: 2.493 ± 0.465
4.004LysGln: 4.004 ± 0.744
4.079LysArg: 4.079 ± 0.477
6.95LysSer: 6.95 ± 0.935
5.741LysThr: 5.741 ± 0.824
5.439LysVal: 5.439 ± 0.652
0.68LysTrp: 0.68 ± 0.184
3.097LysTyr: 3.097 ± 0.456
0.0LysXaa: 0.0 ± 0.0
Leu
3.928LeuAla: 3.928 ± 0.744
0.755LeuCys: 0.755 ± 0.238
5.59LeuAsp: 5.59 ± 0.662
6.799LeuGlu: 6.799 ± 0.741
4.532LeuPhe: 4.532 ± 0.529
3.248LeuGly: 3.248 ± 0.611
0.378LeuHis: 0.378 ± 0.16
6.799LeuIle: 6.799 ± 0.801
10.5LeuLys: 10.5 ± 0.89
5.59LeuLeu: 5.59 ± 0.608
1.511LeuMet: 1.511 ± 0.377
6.648LeuAsn: 6.648 ± 0.796
1.889LeuPro: 1.889 ± 0.416
2.644LeuGln: 2.644 ± 0.347
2.719LeuArg: 2.719 ± 0.378
4.835LeuSer: 4.835 ± 0.532
5.666LeuThr: 5.666 ± 0.614
4.457LeuVal: 4.457 ± 0.701
0.68LeuTrp: 0.68 ± 0.26
1.511LeuTyr: 1.511 ± 0.325
0.0LeuXaa: 0.0 ± 0.0
Met
0.755MetAla: 0.755 ± 0.201
0.378MetCys: 0.378 ± 0.171
0.529MetAsp: 0.529 ± 0.29
1.889MetGlu: 1.889 ± 0.419
0.831MetPhe: 0.831 ± 0.278
0.68MetGly: 0.68 ± 0.226
0.076MetHis: 0.076 ± 0.07
2.115MetIle: 2.115 ± 0.444
3.475MetLys: 3.475 ± 0.587
1.209MetLeu: 1.209 ± 0.333
0.755MetMet: 0.755 ± 0.285
1.889MetAsn: 1.889 ± 0.326
0.302MetPro: 0.302 ± 0.137
0.604MetGln: 0.604 ± 0.203
0.151MetArg: 0.151 ± 0.1
1.889MetSer: 1.889 ± 0.351
2.342MetThr: 2.342 ± 0.586
1.209MetVal: 1.209 ± 0.306
0.227MetTrp: 0.227 ± 0.123
0.076MetTyr: 0.076 ± 0.079
0.0MetXaa: 0.0 ± 0.0
Asn
2.795AsnAla: 2.795 ± 0.477
1.058AsnCys: 1.058 ± 0.342
5.968AsnAsp: 5.968 ± 0.773
7.478AsnGlu: 7.478 ± 0.673
4.608AsnPhe: 4.608 ± 0.597
4.306AsnGly: 4.306 ± 0.66
1.133AsnHis: 1.133 ± 0.245
4.91AsnIle: 4.91 ± 0.543
5.514AsnLys: 5.514 ± 0.795
5.968AsnLeu: 5.968 ± 0.876
1.209AsnMet: 1.209 ± 0.268
3.928AsnAsn: 3.928 ± 0.618
2.871AsnPro: 2.871 ± 0.423
3.928AsnGln: 3.928 ± 0.618
1.964AsnArg: 1.964 ± 0.434
4.683AsnSer: 4.683 ± 0.598
2.795AsnThr: 2.795 ± 0.539
3.173AsnVal: 3.173 ± 0.458
1.36AsnTrp: 1.36 ± 0.299
2.644AsnTyr: 2.644 ± 0.492
0.0AsnXaa: 0.0 ± 0.0
Pro
0.906ProAla: 0.906 ± 0.322
0.378ProCys: 0.378 ± 0.209
1.813ProAsp: 1.813 ± 0.332
2.871ProGlu: 2.871 ± 0.522
1.813ProPhe: 1.813 ± 0.367
1.586ProGly: 1.586 ± 0.395
0.227ProHis: 0.227 ± 0.141
2.568ProIle: 2.568 ± 0.49
2.493ProLys: 2.493 ± 0.562
1.209ProLeu: 1.209 ± 0.299
0.755ProMet: 0.755 ± 0.223
2.266ProAsn: 2.266 ± 0.399
0.227ProPro: 0.227 ± 0.128
0.906ProGln: 0.906 ± 0.275
0.604ProArg: 0.604 ± 0.198
1.737ProSer: 1.737 ± 0.49
1.737ProThr: 1.737 ± 0.399
1.586ProVal: 1.586 ± 0.285
0.0ProTrp: 0.0 ± 0.0
0.755ProTyr: 0.755 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
2.417GlnAla: 2.417 ± 0.494
0.302GlnCys: 0.302 ± 0.151
1.737GlnAsp: 1.737 ± 0.389
2.719GlnGlu: 2.719 ± 0.611
2.493GlnPhe: 2.493 ± 0.461
1.435GlnGly: 1.435 ± 0.374
0.604GlnHis: 0.604 ± 0.202
4.155GlnIle: 4.155 ± 0.697
4.306GlnLys: 4.306 ± 0.679
4.155GlnLeu: 4.155 ± 0.489
1.209GlnMet: 1.209 ± 0.323
3.173GlnAsn: 3.173 ± 0.543
0.831GlnPro: 0.831 ± 0.248
1.511GlnGln: 1.511 ± 0.324
2.946GlnArg: 2.946 ± 0.584
2.871GlnSer: 2.871 ± 0.494
3.022GlnThr: 3.022 ± 0.513
1.435GlnVal: 1.435 ± 0.377
0.453GlnTrp: 0.453 ± 0.203
0.755GlnTyr: 0.755 ± 0.24
0.0GlnXaa: 0.0 ± 0.0
Arg
1.058ArgAla: 1.058 ± 0.305
0.453ArgCys: 0.453 ± 0.207
1.737ArgAsp: 1.737 ± 0.371
2.795ArgGlu: 2.795 ± 0.765
2.946ArgPhe: 2.946 ± 0.479
0.831ArgGly: 0.831 ± 0.201
0.227ArgHis: 0.227 ± 0.11
3.777ArgIle: 3.777 ± 0.51
4.004ArgLys: 4.004 ± 0.535
3.853ArgLeu: 3.853 ± 0.416
0.831ArgMet: 0.831 ± 0.268
2.191ArgAsn: 2.191 ± 0.388
0.68ArgPro: 0.68 ± 0.287
2.191ArgGln: 2.191 ± 0.474
1.813ArgArg: 1.813 ± 0.303
1.813ArgSer: 1.813 ± 0.304
1.964ArgThr: 1.964 ± 0.469
2.946ArgVal: 2.946 ± 0.546
0.302ArgTrp: 0.302 ± 0.126
0.68ArgTyr: 0.68 ± 0.194
0.0ArgXaa: 0.0 ± 0.0
Ser
2.342SerAla: 2.342 ± 0.4
0.529SerCys: 0.529 ± 0.212
3.475SerAsp: 3.475 ± 0.453
4.608SerGlu: 4.608 ± 0.602
4.004SerPhe: 4.004 ± 0.536
3.626SerGly: 3.626 ± 0.563
0.755SerHis: 0.755 ± 0.21
6.799SerIle: 6.799 ± 0.664
6.345SerLys: 6.345 ± 0.847
4.381SerLeu: 4.381 ± 0.685
1.36SerMet: 1.36 ± 0.264
4.381SerAsn: 4.381 ± 0.607
1.889SerPro: 1.889 ± 0.462
2.871SerGln: 2.871 ± 0.494
2.417SerArg: 2.417 ± 0.428
3.853SerSer: 3.853 ± 0.635
3.248SerThr: 3.248 ± 0.471
4.079SerVal: 4.079 ± 0.616
0.378SerTrp: 0.378 ± 0.18
1.586SerTyr: 1.586 ± 0.35
0.0SerXaa: 0.0 ± 0.0
Thr
2.568ThrAla: 2.568 ± 0.476
0.076ThrCys: 0.076 ± 0.067
4.381ThrAsp: 4.381 ± 0.616
5.439ThrGlu: 5.439 ± 0.776
3.853ThrPhe: 3.853 ± 0.522
3.324ThrGly: 3.324 ± 0.568
1.209ThrHis: 1.209 ± 0.327
5.59ThrIle: 5.59 ± 0.634
5.288ThrLys: 5.288 ± 0.593
4.306ThrLeu: 4.306 ± 0.478
1.435ThrMet: 1.435 ± 0.326
5.137ThrAsn: 5.137 ± 0.67
1.058ThrPro: 1.058 ± 0.261
2.191ThrGln: 2.191 ± 0.407
2.115ThrArg: 2.115 ± 0.39
2.946ThrSer: 2.946 ± 0.405
4.683ThrThr: 4.683 ± 0.671
0.0ThrVal: 0.0 ± 0.0
0.604ThrTrp: 0.604 ± 0.203
1.36ThrTyr: 1.36 ± 0.346
0.0ThrXaa: 0.0 ± 0.0
Val
1.889ValAla: 1.889 ± 0.457
0.378ValCys: 0.378 ± 0.214
3.324ValAsp: 3.324 ± 0.629
5.212ValGlu: 5.212 ± 0.729
3.324ValPhe: 3.324 ± 0.516
3.399ValGly: 3.399 ± 0.557
0.68ValHis: 0.68 ± 0.204
3.173ValIle: 3.173 ± 0.433
5.288ValLys: 5.288 ± 0.589
5.061ValLeu: 5.061 ± 0.478
1.133ValMet: 1.133 ± 0.347
3.324ValAsn: 3.324 ± 0.471
1.889ValPro: 1.889 ± 0.429
2.644ValGln: 2.644 ± 0.553
1.586ValArg: 1.586 ± 0.426
3.475ValSer: 3.475 ± 0.486
2.266ValThr: 2.266 ± 0.451
4.004ValVal: 4.004 ± 0.525
0.68ValTrp: 0.68 ± 0.203
1.964ValTyr: 1.964 ± 0.43
0.0ValXaa: 0.0 ± 0.0
Trp
0.378TrpAla: 0.378 ± 0.153
0.0TrpCys: 0.0 ± 0.0
0.755TrpAsp: 0.755 ± 0.201
0.529TrpGlu: 0.529 ± 0.212
0.755TrpPhe: 0.755 ± 0.288
0.529TrpGly: 0.529 ± 0.194
0.151TrpHis: 0.151 ± 0.118
1.586TrpIle: 1.586 ± 0.343
1.133TrpLys: 1.133 ± 0.296
0.68TrpLeu: 0.68 ± 0.228
0.076TrpMet: 0.076 ± 0.07
0.906TrpAsn: 0.906 ± 0.228
0.0TrpPro: 0.0 ± 0.0
0.68TrpGln: 0.68 ± 0.202
0.529TrpArg: 0.529 ± 0.221
0.453TrpSer: 0.453 ± 0.17
0.831TrpThr: 0.831 ± 0.23
0.604TrpVal: 0.604 ± 0.2
0.0TrpTrp: 0.0 ± 0.0
0.076TrpTyr: 0.076 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.982TyrAla: 0.982 ± 0.232
0.378TyrCys: 0.378 ± 0.148
2.115TyrAsp: 2.115 ± 0.337
1.586TyrGlu: 1.586 ± 0.423
1.662TyrPhe: 1.662 ± 0.346
1.813TyrGly: 1.813 ± 0.391
0.151TyrHis: 0.151 ± 0.106
1.737TyrIle: 1.737 ± 0.382
2.04TyrLys: 2.04 ± 0.37
3.097TyrLeu: 3.097 ± 0.479
0.378TyrMet: 0.378 ± 0.173
2.266TyrAsn: 2.266 ± 0.292
0.604TyrPro: 0.604 ± 0.214
1.209TyrGln: 1.209 ± 0.358
0.906TyrArg: 0.906 ± 0.264
2.191TyrSer: 2.191 ± 0.396
1.36TyrThr: 1.36 ± 0.382
1.36TyrVal: 1.36 ± 0.284
0.378TyrTrp: 0.378 ± 0.168
0.982TyrTyr: 0.982 ± 0.316
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (13239 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski