Amino acid dipepetide frequency for Penicillium antarcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.487AlaAla: 8.487 ± 0.053	1.054AlaCys: 1.054 ± 0.015	4.206AlaAsp: 4.206 ± 0.034	5.113AlaGlu: 5.113 ± 0.042	3.223AlaPhe: 3.223 ± 0.029	5.704AlaGly: 5.704 ± 0.036	1.811AlaHis: 1.811 ± 0.018	4.381AlaIle: 4.381 ± 0.036	3.911AlaLys: 3.911 ± 0.036	7.786AlaLeu: 7.786 ± 0.043	2.068AlaMet: 2.068 ± 0.023	2.992AlaAsn: 2.992 ± 0.027	4.799AlaPro: 4.799 ± 0.05	3.437AlaGln: 3.437 ± 0.027	4.694AlaArg: 4.694 ± 0.038	7.313AlaSer: 7.313 ± 0.048	5.219AlaThr: 5.219 ± 0.031	5.278AlaVal: 5.278 ± 0.039	1.175AlaTrp: 1.175 ± 0.016	2.176AlaTyr: 2.176 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.014	0.228CysCys: 0.228 ± 0.009	0.674CysAsp: 0.674 ± 0.013	0.59CysGlu: 0.59 ± 0.011	0.558CysPhe: 0.558 ± 0.012	0.939CysGly: 0.939 ± 0.016	0.341CysHis: 0.341 ± 0.009	0.719CysIle: 0.719 ± 0.012	0.475CysLys: 0.475 ± 0.009	1.263CysLeu: 1.263 ± 0.018	0.299CysMet: 0.299 ± 0.008	0.426CysAsn: 0.426 ± 0.009	0.648CysPro: 0.648 ± 0.014	0.487CysGln: 0.487 ± 0.011	0.707CysArg: 0.707 ± 0.013	0.91CysSer: 0.91 ± 0.015	0.708CysThr: 0.708 ± 0.013	0.795CysVal: 0.795 ± 0.016	0.199CysTrp: 0.199 ± 0.007	0.354CysTyr: 0.354 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.559AspAla: 4.559 ± 0.031	0.626AspCys: 0.626 ± 0.012	3.897AspAsp: 3.897 ± 0.04	4.27AspGlu: 4.27 ± 0.041	2.219AspPhe: 2.219 ± 0.022	3.842AspGly: 3.842 ± 0.027	1.313AspHis: 1.313 ± 0.016	3.164AspIle: 3.164 ± 0.023	2.296AspLys: 2.296 ± 0.023	5.236AspLeu: 5.236 ± 0.033	1.345AspMet: 1.345 ± 0.015	1.906AspAsn: 1.906 ± 0.022	3.326AspPro: 3.326 ± 0.025	2.098AspGln: 2.098 ± 0.018	3.037AspArg: 3.037 ± 0.026	4.304AspSer: 4.304 ± 0.028	3.087AspThr: 3.087 ± 0.025	3.567AspVal: 3.567 ± 0.031	0.905AspTrp: 0.905 ± 0.015	1.609AspTyr: 1.609 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.25GluAla: 5.25 ± 0.041	0.627GluCys: 0.627 ± 0.011	4.102GluAsp: 4.102 ± 0.038	5.158GluGlu: 5.158 ± 0.057	2.011GluPhe: 2.011 ± 0.021	3.579GluGly: 3.579 ± 0.032	1.44GluHis: 1.44 ± 0.017	3.192GluIle: 3.192 ± 0.028	3.607GluLys: 3.607 ± 0.029	5.075GluLeu: 5.075 ± 0.037	1.538GluMet: 1.538 ± 0.018	2.439GluAsn: 2.439 ± 0.024	2.826GluPro: 2.826 ± 0.04	2.506GluGln: 2.506 ± 0.026	3.743GluArg: 3.743 ± 0.04	4.524GluSer: 4.524 ± 0.038	3.7GluThr: 3.7 ± 0.027	3.393GluVal: 3.393 ± 0.031	0.892GluTrp: 0.892 ± 0.013	1.672GluTyr: 1.672 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.127PheAla: 3.127 ± 0.027	0.574PheCys: 0.574 ± 0.012	2.367PheAsp: 2.367 ± 0.023	2.19PheGlu: 2.19 ± 0.02	1.711PhePhe: 1.711 ± 0.024	2.953PheGly: 2.953 ± 0.029	0.944PheHis: 0.944 ± 0.015	1.929PheIle: 1.929 ± 0.024	1.507PheLys: 1.507 ± 0.02	3.558PheLeu: 3.558 ± 0.036	0.885PheMet: 0.885 ± 0.012	1.503PheAsn: 1.503 ± 0.019	1.998PhePro: 1.998 ± 0.019	1.453PheGln: 1.453 ± 0.019	1.937PheArg: 1.937 ± 0.021	3.096PheSer: 3.096 ± 0.024	2.213PheThr: 2.213 ± 0.022	2.432PheVal: 2.432 ± 0.025	0.657PheTrp: 0.657 ± 0.013	1.14PheTyr: 1.14 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.293GlyAla: 5.293 ± 0.04	0.884GlyCys: 0.884 ± 0.015	3.54GlyAsp: 3.54 ± 0.031	3.468GlyGlu: 3.468 ± 0.026	2.894GlyPhe: 2.894 ± 0.025	5.309GlyGly: 5.309 ± 0.045	1.692GlyHis: 1.692 ± 0.021	3.67GlyIle: 3.67 ± 0.034	3.271GlyLys: 3.271 ± 0.026	6.236GlyLeu: 6.236 ± 0.038	1.616GlyMet: 1.616 ± 0.019	2.595GlyAsn: 2.595 ± 0.024	3.299GlyPro: 3.299 ± 0.029	2.595GlyGln: 2.595 ± 0.029	3.898GlyArg: 3.898 ± 0.034	5.818GlySer: 5.818 ± 0.043	3.941GlyThr: 3.941 ± 0.033	4.324GlyVal: 4.324 ± 0.031	1.153GlyTrp: 1.153 ± 0.017	2.177GlyTyr: 2.177 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.881HisAla: 1.881 ± 0.021	0.328HisCys: 0.328 ± 0.008	1.327HisAsp: 1.327 ± 0.016	1.365HisGlu: 1.365 ± 0.016	0.958HisPhe: 0.958 ± 0.012	1.719HisGly: 1.719 ± 0.021	0.803HisHis: 0.803 ± 0.016	1.265HisIle: 1.265 ± 0.016	0.888HisLys: 0.888 ± 0.012	2.283HisLeu: 2.283 ± 0.022	0.524HisMet: 0.524 ± 0.011	0.87HisAsn: 0.87 ± 0.013	1.664HisPro: 1.664 ± 0.018	0.99HisGln: 0.99 ± 0.015	1.55HisArg: 1.55 ± 0.019	1.932HisSer: 1.932 ± 0.023	1.287HisThr: 1.287 ± 0.016	1.421HisVal: 1.421 ± 0.017	0.379HisTrp: 0.379 ± 0.009	0.699HisTyr: 0.699 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.323IleAla: 4.323 ± 0.033	0.785IleCys: 0.785 ± 0.014	2.928IleAsp: 2.928 ± 0.026	3.009IleGlu: 3.009 ± 0.026	2.164IlePhe: 2.164 ± 0.025	3.335IleGly: 3.335 ± 0.027	1.265IleHis: 1.265 ± 0.014	2.617IleIle: 2.617 ± 0.027	2.178IleLys: 2.178 ± 0.022	4.697IleLeu: 4.697 ± 0.034	1.082IleMet: 1.082 ± 0.015	1.887IleAsn: 1.887 ± 0.019	3.186IlePro: 3.186 ± 0.027	2.064IleGln: 2.064 ± 0.022	2.782IleArg: 2.782 ± 0.024	4.119IleSer: 4.119 ± 0.03	2.919IleThr: 2.919 ± 0.023	3.191IleVal: 3.191 ± 0.027	0.757IleTrp: 0.757 ± 0.014	1.479IleTyr: 1.479 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.05LysAla: 4.05 ± 0.035	0.506LysCys: 0.506 ± 0.011	2.758LysAsp: 2.758 ± 0.028	3.228LysGlu: 3.228 ± 0.032	1.47LysPhe: 1.47 ± 0.019	2.84LysGly: 2.84 ± 0.026	1.108LysHis: 1.108 ± 0.016	2.271LysIle: 2.271 ± 0.021	3.099LysLys: 3.099 ± 0.043	3.952LysLeu: 3.952 ± 0.033	1.021LysMet: 1.021 ± 0.014	1.79LysAsn: 1.79 ± 0.019	2.661LysPro: 2.661 ± 0.031	1.827LysGln: 1.827 ± 0.021	3.216LysArg: 3.216 ± 0.029	3.564LysSer: 3.564 ± 0.029	2.823LysThr: 2.823 ± 0.023	2.689LysVal: 2.689 ± 0.025	0.681LysTrp: 0.681 ± 0.013	1.365LysTyr: 1.365 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.8LeuAla: 7.8 ± 0.04	1.232LeuCys: 1.232 ± 0.014	5.235LeuAsp: 5.235 ± 0.033	5.483LeuGlu: 5.483 ± 0.037	3.453LeuPhe: 3.453 ± 0.034	6.076LeuGly: 6.076 ± 0.043	2.238LeuHis: 2.238 ± 0.021	4.121LeuIle: 4.121 ± 0.033	4.109LeuLys: 4.109 ± 0.033	8.334LeuLeu: 8.334 ± 0.051	1.924LeuMet: 1.924 ± 0.02	3.332LeuAsn: 3.332 ± 0.023	5.394LeuPro: 5.394 ± 0.033	3.893LeuGln: 3.893 ± 0.033	5.589LeuArg: 5.589 ± 0.041	7.551LeuSer: 7.551 ± 0.049	4.843LeuThr: 4.843 ± 0.035	5.5LeuVal: 5.5 ± 0.042	1.213LeuTrp: 1.213 ± 0.016	2.378LeuTyr: 2.378 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.299MetAla: 2.299 ± 0.022	0.272MetCys: 0.272 ± 0.007	1.327MetAsp: 1.327 ± 0.018	1.347MetGlu: 1.347 ± 0.02	0.806MetPhe: 0.806 ± 0.014	1.567MetGly: 1.567 ± 0.018	0.532MetHis: 0.532 ± 0.01	1.114MetIle: 1.114 ± 0.017	1.027MetLys: 1.027 ± 0.013	1.896MetLeu: 1.896 ± 0.02	0.598MetMet: 0.598 ± 0.013	0.891MetAsn: 0.891 ± 0.013	1.347MetPro: 1.347 ± 0.018	0.919MetGln: 0.919 ± 0.013	1.26MetArg: 1.26 ± 0.016	2.022MetSer: 2.022 ± 0.018	1.399MetThr: 1.399 ± 0.018	1.375MetVal: 1.375 ± 0.017	0.274MetTrp: 0.274 ± 0.007	0.522MetTyr: 0.522 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.219AsnAla: 3.219 ± 0.026	0.451AsnCys: 0.451 ± 0.009	2.027AsnAsp: 2.027 ± 0.019	2.132AsnGlu: 2.132 ± 0.02	1.44AsnPhe: 1.44 ± 0.017	2.959AsnGly: 2.959 ± 0.024	0.852AsnHis: 0.852 ± 0.012	2.122AsnIle: 2.122 ± 0.02	1.583AsnLys: 1.583 ± 0.019	3.402AsnLeu: 3.402 ± 0.025	0.893AsnMet: 0.893 ± 0.013	1.479AsnAsn: 1.479 ± 0.018	2.538AsnPro: 2.538 ± 0.024	1.451AsnGln: 1.451 ± 0.018	1.983AsnArg: 1.983 ± 0.022	2.863AsnSer: 2.863 ± 0.027	2.307AsnThr: 2.307 ± 0.023	2.374AsnVal: 2.374 ± 0.024	0.578AsnTrp: 0.578 ± 0.009	1.106AsnTyr: 1.106 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.191ProAla: 5.191 ± 0.051	0.523ProCys: 0.523 ± 0.012	3.173ProAsp: 3.173 ± 0.028	4.002ProGlu: 4.002 ± 0.042	2.078ProPhe: 2.078 ± 0.021	3.816ProGly: 3.816 ± 0.032	1.315ProHis: 1.315 ± 0.017	2.656ProIle: 2.656 ± 0.022	2.639ProLys: 2.639 ± 0.025	4.67ProLeu: 4.67 ± 0.034	1.174ProMet: 1.174 ± 0.016	2.232ProAsn: 2.232 ± 0.025	4.531ProPro: 4.531 ± 0.069	2.467ProGln: 2.467 ± 0.027	3.347ProArg: 3.347 ± 0.036	5.957ProSer: 5.957 ± 0.05	4.02ProThr: 4.02 ± 0.03	3.642ProVal: 3.642 ± 0.035	0.768ProTrp: 0.768 ± 0.012	1.512ProTyr: 1.512 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.437GlnAla: 3.437 ± 0.033	0.458GlnCys: 0.458 ± 0.01	2.108GlnAsp: 2.108 ± 0.02	2.454GlnGlu: 2.454 ± 0.023	1.393GlnPhe: 1.393 ± 0.017	2.437GlnGly: 2.437 ± 0.024	1.037GlnHis: 1.037 ± 0.017	2.054GlnIle: 2.054 ± 0.023	2.031GlnLys: 2.031 ± 0.022	3.478GlnLeu: 3.478 ± 0.032	0.995GlnMet: 0.995 ± 0.017	1.693GlnAsn: 1.693 ± 0.019	2.564GlnPro: 2.564 ± 0.031	2.17GlnGln: 2.17 ± 0.037	2.602GlnArg: 2.602 ± 0.027	3.362GlnSer: 3.362 ± 0.028	2.488GlnThr: 2.488 ± 0.023	2.225GlnVal: 2.225 ± 0.021	0.583GlnTrp: 0.583 ± 0.01	1.194GlnTyr: 1.194 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.565ArgAla: 4.565 ± 0.036	0.666ArgCys: 0.666 ± 0.012	3.306ArgAsp: 3.306 ± 0.028	3.629ArgGlu: 3.629 ± 0.032	2.148ArgPhe: 2.148 ± 0.022	3.605ArgGly: 3.605 ± 0.034	1.528ArgHis: 1.528 ± 0.018	2.849ArgIle: 2.849 ± 0.025	3.23ArgLys: 3.23 ± 0.029	5.365ArgLeu: 5.365 ± 0.036	1.313ArgMet: 1.313 ± 0.017	2.198ArgAsn: 2.198 ± 0.018	3.378ArgPro: 3.378 ± 0.033	2.557ArgGln: 2.557 ± 0.023	4.751ArgArg: 4.751 ± 0.052	4.738ArgSer: 4.738 ± 0.048	3.214ArgThr: 3.214 ± 0.03	3.334ArgVal: 3.334 ± 0.028	0.919ArgTrp: 0.919 ± 0.015	1.617ArgTyr: 1.617 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.784SerAla: 6.784 ± 0.042	0.891SerCys: 0.891 ± 0.016	4.46SerAsp: 4.46 ± 0.032	4.386SerGlu: 4.386 ± 0.031	3.133SerPhe: 3.133 ± 0.024	5.695SerGly: 5.695 ± 0.042	2.077SerHis: 2.077 ± 0.024	4.136SerIle: 4.136 ± 0.028	3.754SerLys: 3.754 ± 0.028	7.487SerLeu: 7.487 ± 0.045	1.863SerMet: 1.863 ± 0.017	3.203SerAsn: 3.203 ± 0.028	5.502SerPro: 5.502 ± 0.055	3.505SerGln: 3.505 ± 0.028	4.926SerArg: 4.926 ± 0.047	8.643SerSer: 8.643 ± 0.075	5.688SerThr: 5.688 ± 0.042	4.826SerVal: 4.826 ± 0.038	1.145SerTrp: 1.145 ± 0.016	2.141SerTyr: 2.141 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.174ThrAla: 5.174 ± 0.035	0.724ThrCys: 0.724 ± 0.012	2.991ThrAsp: 2.991 ± 0.028	3.354ThrGlu: 3.354 ± 0.028	2.243ThrPhe: 2.243 ± 0.021	4.289ThrGly: 4.289 ± 0.033	1.303ThrHis: 1.303 ± 0.017	3.184ThrIle: 3.184 ± 0.027	2.659ThrLys: 2.659 ± 0.024	5.316ThrLeu: 5.316 ± 0.035	1.25ThrMet: 1.25 ± 0.017	2.166ThrAsn: 2.166 ± 0.02	4.344ThrPro: 4.344 ± 0.038	2.184ThrGln: 2.184 ± 0.022	3.096ThrArg: 3.096 ± 0.025	5.386ThrSer: 5.386 ± 0.038	4.101ThrThr: 4.101 ± 0.037	3.85ThrVal: 3.85 ± 0.03	0.875ThrTrp: 0.875 ± 0.012	1.598ThrTyr: 1.598 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.129ValAla: 5.129 ± 0.037	0.825ValCys: 0.825 ± 0.014	3.666ValAsp: 3.666 ± 0.031	3.724ValGlu: 3.724 ± 0.028	2.535ValPhe: 2.535 ± 0.025	3.957ValGly: 3.957 ± 0.033	1.406ValHis: 1.406 ± 0.016	3.102ValIle: 3.102 ± 0.027	2.726ValLys: 2.726 ± 0.025	5.607ValLeu: 5.607 ± 0.039	1.365ValMet: 1.365 ± 0.014	2.338ValAsn: 2.338 ± 0.024	3.609ValPro: 3.609 ± 0.03	2.418ValGln: 2.418 ± 0.025	3.229ValArg: 3.229 ± 0.03	4.91ValSer: 4.91 ± 0.034	3.561ValThr: 3.561 ± 0.026	4.11ValVal: 4.11 ± 0.037	0.834ValTrp: 0.834 ± 0.014	1.758ValTyr: 1.758 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.156TrpAla: 1.156 ± 0.016	0.188TrpCys: 0.188 ± 0.006	0.894TrpAsp: 0.894 ± 0.014	0.826TrpGlu: 0.826 ± 0.014	0.538TrpPhe: 0.538 ± 0.01	0.929TrpGly: 0.929 ± 0.014	0.362TrpHis: 0.362 ± 0.008	0.796TrpIle: 0.796 ± 0.014	0.837TrpLys: 0.837 ± 0.013	1.362TrpLeu: 1.362 ± 0.02	0.39TrpMet: 0.39 ± 0.009	0.671TrpAsn: 0.671 ± 0.013	0.587TrpPro: 0.587 ± 0.011	0.594TrpGln: 0.594 ± 0.012	0.937TrpArg: 0.937 ± 0.015	1.117TrpSer: 1.117 ± 0.016	0.927TrpThr: 0.927 ± 0.015	0.886TrpVal: 0.886 ± 0.013	0.282TrpTrp: 0.282 ± 0.008	0.432TrpTyr: 0.432 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.17TyrAla: 2.17 ± 0.02	0.412TyrCys: 0.412 ± 0.009	1.621TyrAsp: 1.621 ± 0.017	1.545TyrGlu: 1.545 ± 0.019	1.199TyrPhe: 1.199 ± 0.017	2.123TyrGly: 2.123 ± 0.025	0.767TyrHis: 0.767 ± 0.013	1.425TyrIle: 1.425 ± 0.019	1.089TyrLys: 1.089 ± 0.015	2.697TyrLeu: 2.697 ± 0.026	0.65TyrMet: 0.65 ± 0.01	1.151TyrAsn: 1.151 ± 0.015	1.51TyrPro: 1.51 ± 0.018	1.15TyrGln: 1.15 ± 0.016	1.626TyrArg: 1.626 ± 0.019	2.116TyrSer: 2.116 ± 0.021	1.638TyrThr: 1.638 ± 0.017	1.596TyrVal: 1.596 ± 0.02	0.445TyrTrp: 0.445 ± 0.01	0.945TyrTyr: 0.945 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11372 proteins (5328184 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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