Amino acid dipepetide frequency for Buchnera aphidicola (Anoecia oenotherae)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.068AlaAla: 2.068 ± 0.136
0.556AlaCys: 0.556 ± 0.066
1.329AlaAsp: 1.329 ± 0.104
1.941AlaGlu: 1.941 ± 0.137
1.815AlaPhe: 1.815 ± 0.137
2.216AlaGly: 2.216 ± 0.146
0.661AlaHis: 0.661 ± 0.07
4.685AlaIle: 4.685 ± 0.208
3.812AlaLys: 3.812 ± 0.196
3.672AlaLeu: 3.672 ± 0.162
0.907AlaMet: 0.907 ± 0.08
2.089AlaAsn: 2.089 ± 0.138
0.851AlaPro: 0.851 ± 0.071
1.168AlaGln: 1.168 ± 0.089
1.576AlaArg: 1.576 ± 0.094
2.37AlaSer: 2.37 ± 0.128
1.892AlaThr: 1.892 ± 0.122
2.195AlaVal: 2.195 ± 0.134
0.408AlaTrp: 0.408 ± 0.056
1.414AlaTyr: 1.414 ± 0.102
0.0AlaXaa: 0.0 ± 0.0
Cys
0.521CysAla: 0.521 ± 0.058
0.155CysCys: 0.155 ± 0.034
0.521CysAsp: 0.521 ± 0.056
0.415CysGlu: 0.415 ± 0.05
0.76CysPhe: 0.76 ± 0.075
0.851CysGly: 0.851 ± 0.076
0.338CysHis: 0.338 ± 0.051
1.66CysIle: 1.66 ± 0.11
1.147CysLys: 1.147 ± 0.087
1.252CysLeu: 1.252 ± 0.083
0.302CysMet: 0.302 ± 0.038
0.865CysAsn: 0.865 ± 0.074
0.373CysPro: 0.373 ± 0.048
0.324CysGln: 0.324 ± 0.04
0.338CysArg: 0.338 ± 0.045
1.217CysSer: 1.217 ± 0.119
0.633CysThr: 0.633 ± 0.08
0.577CysVal: 0.577 ± 0.069
0.12CysTrp: 0.12 ± 0.03
0.619CysTyr: 0.619 ± 0.077
0.0CysXaa: 0.0 ± 0.0
Asp
1.576AspAla: 1.576 ± 0.117
0.394AspCys: 0.394 ± 0.052
1.238AspAsp: 1.238 ± 0.115
2.005AspGlu: 2.005 ± 0.117
2.378AspPhe: 2.378 ± 0.129
1.737AspGly: 1.737 ± 0.119
0.725AspHis: 0.725 ± 0.075
4.91AspIle: 4.91 ± 0.176
3.679AspLys: 3.679 ± 0.168
4.417AspLeu: 4.417 ± 0.19
0.809AspMet: 0.809 ± 0.07
2.117AspAsn: 2.117 ± 0.136
1.266AspPro: 1.266 ± 0.089
1.048AspGln: 1.048 ± 0.075
1.336AspArg: 1.336 ± 0.106
2.708AspSer: 2.708 ± 0.172
1.766AspThr: 1.766 ± 0.103
2.195AspVal: 2.195 ± 0.109
0.38AspTrp: 0.38 ± 0.053
1.646AspTyr: 1.646 ± 0.102
0.0AspXaa: 0.0 ± 0.0
Glu
1.963GluAla: 1.963 ± 0.129
0.478GluCys: 0.478 ± 0.067
1.723GluAsp: 1.723 ± 0.125
2.947GluGlu: 2.947 ± 0.173
1.773GluPhe: 1.773 ± 0.117
1.977GluGly: 1.977 ± 0.111
0.893GluHis: 0.893 ± 0.075
5.895GluIle: 5.895 ± 0.24
7.386GluLys: 7.386 ± 0.244
4.657GluLeu: 4.657 ± 0.177
1.048GluMet: 1.048 ± 0.09
3.911GluAsn: 3.911 ± 0.183
0.921GluPro: 0.921 ± 0.08
1.344GluGln: 1.344 ± 0.099
1.899GluArg: 1.899 ± 0.133
3.046GluSer: 3.046 ± 0.139
2.138GluThr: 2.138 ± 0.127
2.596GluVal: 2.596 ± 0.162
0.352GluTrp: 0.352 ± 0.054
1.892GluTyr: 1.892 ± 0.101
0.0GluXaa: 0.0 ± 0.0
Phe
1.125PheAla: 1.125 ± 0.082
0.957PheCys: 0.957 ± 0.092
1.667PheAsp: 1.667 ± 0.117
1.829PheGlu: 1.829 ± 0.126
4.621PhePhe: 4.621 ± 0.294
2.56PheGly: 2.56 ± 0.129
1.083PheHis: 1.083 ± 0.083
5.923PheIle: 5.923 ± 0.26
4.811PheLys: 4.811 ± 0.198
6.415PheLeu: 6.415 ± 0.312
0.943PheMet: 0.943 ± 0.08
4.171PheAsn: 4.171 ± 0.187
1.864PhePro: 1.864 ± 0.106
1.344PheGln: 1.344 ± 0.093
1.456PheArg: 1.456 ± 0.099
5.17PheSer: 5.17 ± 0.252
2.054PheThr: 2.054 ± 0.134
1.934PheVal: 1.934 ± 0.106
0.492PheTrp: 0.492 ± 0.072
2.518PheTyr: 2.518 ± 0.157
0.0PheXaa: 0.0 ± 0.0
Gly
2.124GlyAla: 2.124 ± 0.148
0.837GlyCys: 0.837 ± 0.082
2.061GlyAsp: 2.061 ± 0.138
2.328GlyGlu: 2.328 ± 0.152
2.574GlyPhe: 2.574 ± 0.129
2.982GlyGly: 2.982 ± 0.171
1.027GlyHis: 1.027 ± 0.091
6.31GlyIle: 6.31 ± 0.272
4.903GlyLys: 4.903 ± 0.188
4.009GlyLeu: 4.009 ± 0.198
1.351GlyMet: 1.351 ± 0.097
2.954GlyAsn: 2.954 ± 0.165
1.21GlyPro: 1.21 ± 0.092
1.386GlyGln: 1.386 ± 0.111
2.11GlyArg: 2.11 ± 0.131
3.552GlySer: 3.552 ± 0.167
2.708GlyThr: 2.708 ± 0.133
2.926GlyVal: 2.926 ± 0.167
0.478GlyTrp: 0.478 ± 0.061
1.822GlyTyr: 1.822 ± 0.127
0.0GlyXaa: 0.0 ± 0.0
His
0.872HisAla: 0.872 ± 0.069
0.309HisCys: 0.309 ± 0.04
0.647HisAsp: 0.647 ± 0.064
0.788HisGlu: 0.788 ± 0.081
1.083HisPhe: 1.083 ± 0.083
1.308HisGly: 1.308 ± 0.102
0.45HisHis: 0.45 ± 0.054
2.378HisIle: 2.378 ± 0.146
1.484HisLys: 1.484 ± 0.105
1.885HisLeu: 1.885 ± 0.1
0.422HisMet: 0.422 ± 0.047
1.379HisAsn: 1.379 ± 0.104
0.865HisPro: 0.865 ± 0.091
0.45HisGln: 0.45 ± 0.061
0.76HisArg: 0.76 ± 0.064
1.477HisSer: 1.477 ± 0.09
0.914HisThr: 0.914 ± 0.065
0.985HisVal: 0.985 ± 0.085
0.148HisTrp: 0.148 ± 0.037
0.823HisTyr: 0.823 ± 0.07
0.0HisXaa: 0.0 ± 0.0
Ile
5.212IleAla: 5.212 ± 0.215
1.611IleCys: 1.611 ± 0.124
5.564IleAsp: 5.564 ± 0.24
6.084IleGlu: 6.084 ± 0.235
6.394IlePhe: 6.394 ± 0.307
6.31IleGly: 6.31 ± 0.262
2.441IleHis: 2.441 ± 0.121
12.704IleIle: 12.704 ± 0.39
12.577IleLys: 12.577 ± 0.388
11.529IleLeu: 11.529 ± 0.346
2.152IleMet: 2.152 ± 0.136
9.637IleAsn: 9.637 ± 0.266
4.192IlePro: 4.192 ± 0.187
3.82IleGln: 3.82 ± 0.18
3.742IleArg: 3.742 ± 0.157
9.728IleSer: 9.728 ± 0.267
5.353IleThr: 5.353 ± 0.175
5.972IleVal: 5.972 ± 0.198
0.71IleTrp: 0.71 ± 0.073
4.446IleTyr: 4.446 ± 0.225
0.0IleXaa: 0.0 ± 0.0
Lys
2.596LysAla: 2.596 ± 0.136
1.048LysCys: 1.048 ± 0.086
3.953LysAsp: 3.953 ± 0.175
6.338LysGlu: 6.338 ± 0.281
4.235LysPhe: 4.235 ± 0.177
3.524LysGly: 3.524 ± 0.141
1.723LysHis: 1.723 ± 0.095
14.919LysIle: 14.919 ± 0.409
20.793LysLys: 20.793 ± 0.543
8.975LysLeu: 8.975 ± 0.275
2.209LysMet: 2.209 ± 0.105
14.575LysAsn: 14.575 ± 0.413
2.181LysPro: 2.181 ± 0.129
2.821LysGln: 2.821 ± 0.153
3.25LysArg: 3.25 ± 0.175
6.155LysSer: 6.155 ± 0.239
5.332LysThr: 5.332 ± 0.194
4.143LysVal: 4.143 ± 0.145
0.802LysTrp: 0.802 ± 0.08
4.453LysTyr: 4.453 ± 0.186
0.0LysXaa: 0.0 ± 0.0
Leu
3.897LeuAla: 3.897 ± 0.185
1.329LeuCys: 1.329 ± 0.108
4.333LeuAsp: 4.333 ± 0.179
5.058LeuGlu: 5.058 ± 0.212
5.015LeuPhe: 5.015 ± 0.231
4.903LeuGly: 4.903 ± 0.165
2.096LeuHis: 2.096 ± 0.139
9.967LeuIle: 9.967 ± 0.327
11.437LeuLys: 11.437 ± 0.33
10.087LeuLeu: 10.087 ± 0.323
1.801LeuMet: 1.801 ± 0.106
7.66LeuAsn: 7.66 ± 0.237
2.905LeuPro: 2.905 ± 0.143
2.849LeuGln: 2.849 ± 0.128
3.243LeuArg: 3.243 ± 0.157
7.801LeuSer: 7.801 ± 0.259
4.213LeuThr: 4.213 ± 0.18
4.424LeuVal: 4.424 ± 0.191
0.76LeuTrp: 0.76 ± 0.075
3.623LeuTyr: 3.623 ± 0.153
0.0LeuXaa: 0.0 ± 0.0
Met
0.837MetAla: 0.837 ± 0.076
0.204MetCys: 0.204 ± 0.037
0.739MetAsp: 0.739 ± 0.07
0.816MetGlu: 0.816 ± 0.069
1.175MetPhe: 1.175 ± 0.103
0.978MetGly: 0.978 ± 0.092
0.521MetHis: 0.521 ± 0.065
1.991MetIle: 1.991 ± 0.127
2.152MetLys: 2.152 ± 0.135
2.476MetLeu: 2.476 ± 0.13
0.436MetMet: 0.436 ± 0.057
1.744MetAsn: 1.744 ± 0.11
0.703MetPro: 0.703 ± 0.081
0.717MetGln: 0.717 ± 0.071
0.682MetArg: 0.682 ± 0.069
1.54MetSer: 1.54 ± 0.113
1.02MetThr: 1.02 ± 0.092
1.055MetVal: 1.055 ± 0.09
0.113MetTrp: 0.113 ± 0.028
0.837MetTyr: 0.837 ± 0.068
0.0MetXaa: 0.0 ± 0.0
Asn
2.216AsnAla: 2.216 ± 0.119
0.809AsnCys: 0.809 ± 0.071
2.434AsnAsp: 2.434 ± 0.139
3.109AsnGlu: 3.109 ± 0.172
4.424AsnPhe: 4.424 ± 0.186
3.046AsnGly: 3.046 ± 0.153
1.477AsnHis: 1.477 ± 0.093
11.423AsnIle: 11.423 ± 0.364
9.348AsnLys: 9.348 ± 0.271
7.4AsnLeu: 7.4 ± 0.255
1.702AsnMet: 1.702 ± 0.128
7.365AsnAsn: 7.365 ± 0.3
2.159AsnPro: 2.159 ± 0.139
2.237AsnGln: 2.237 ± 0.12
2.349AsnArg: 2.349 ± 0.143
5.733AsnSer: 5.733 ± 0.214
4.164AsnThr: 4.164 ± 0.192
3.883AsnVal: 3.883 ± 0.176
0.732AsnTrp: 0.732 ± 0.075
3.608AsnTyr: 3.608 ± 0.16
0.0AsnXaa: 0.0 ± 0.0
Pro
0.964ProAla: 0.964 ± 0.089
0.387ProCys: 0.387 ± 0.062
1.041ProAsp: 1.041 ± 0.084
1.681ProGlu: 1.681 ± 0.112
1.372ProPhe: 1.372 ± 0.107
1.808ProGly: 1.808 ± 0.114
0.584ProHis: 0.584 ± 0.068
3.855ProIle: 3.855 ± 0.148
2.645ProLys: 2.645 ± 0.14
2.342ProLeu: 2.342 ± 0.13
0.598ProMet: 0.598 ± 0.063
1.963ProAsn: 1.963 ± 0.125
0.703ProPro: 0.703 ± 0.064
0.633ProGln: 0.633 ± 0.07
0.802ProArg: 0.802 ± 0.077
1.843ProSer: 1.843 ± 0.109
1.491ProThr: 1.491 ± 0.101
1.836ProVal: 1.836 ± 0.126
0.302ProTrp: 0.302 ± 0.041
1.259ProTyr: 1.259 ± 0.104
0.0ProXaa: 0.0 ± 0.0
Gln
1.259GlnAla: 1.259 ± 0.099
0.366GlnCys: 0.366 ± 0.052
1.02GlnAsp: 1.02 ± 0.079
1.744GlnGlu: 1.744 ± 0.114
1.484GlnPhe: 1.484 ± 0.108
1.266GlnGly: 1.266 ± 0.104
0.633GlnHis: 0.633 ± 0.066
2.764GlnIle: 2.764 ± 0.131
3.517GlnLys: 3.517 ± 0.164
2.877GlnLeu: 2.877 ± 0.138
0.577GlnMet: 0.577 ± 0.057
1.85GlnAsn: 1.85 ± 0.123
0.549GlnPro: 0.549 ± 0.061
0.858GlnGln: 0.858 ± 0.079
0.907GlnArg: 0.907 ± 0.087
1.822GlnSer: 1.822 ± 0.116
1.238GlnThr: 1.238 ± 0.091
1.442GlnVal: 1.442 ± 0.093
0.288GlnTrp: 0.288 ± 0.046
1.266GlnTyr: 1.266 ± 0.089
0.0GlnXaa: 0.0 ± 0.0
Arg
1.576ArgAla: 1.576 ± 0.106
0.436ArgCys: 0.436 ± 0.055
1.182ArgAsp: 1.182 ± 0.097
1.773ArgGlu: 1.773 ± 0.124
1.653ArgPhe: 1.653 ± 0.111
1.766ArgGly: 1.766 ± 0.102
0.57ArgHis: 0.57 ± 0.065
4.009ArgIle: 4.009 ± 0.19
3.58ArgLys: 3.58 ± 0.172
3.165ArgLeu: 3.165 ± 0.167
0.879ArgMet: 0.879 ± 0.08
2.307ArgAsn: 2.307 ± 0.155
1.02ArgPro: 1.02 ± 0.092
0.928ArgGln: 0.928 ± 0.086
1.583ArgArg: 1.583 ± 0.126
2.363ArgSer: 2.363 ± 0.132
1.639ArgThr: 1.639 ± 0.11
1.766ArgVal: 1.766 ± 0.143
0.317ArgTrp: 0.317 ± 0.047
1.287ArgTyr: 1.287 ± 0.092
0.0ArgXaa: 0.0 ± 0.0
Ser
2.968SerAla: 2.968 ± 0.184
1.041SerCys: 1.041 ± 0.083
2.757SerAsp: 2.757 ± 0.155
3.025SerGlu: 3.025 ± 0.149
4.185SerPhe: 4.185 ± 0.172
4.431SerGly: 4.431 ± 0.176
1.4SerHis: 1.4 ± 0.094
9.728SerIle: 9.728 ± 0.297
6.964SerLys: 6.964 ± 0.233
7.414SerLeu: 7.414 ± 0.242
1.695SerMet: 1.695 ± 0.106
5.17SerAsn: 5.17 ± 0.189
1.751SerPro: 1.751 ± 0.107
1.794SerGln: 1.794 ± 0.096
2.589SerArg: 2.589 ± 0.146
6.331SerSer: 6.331 ± 0.209
3.559SerThr: 3.559 ± 0.163
3.763SerVal: 3.763 ± 0.174
0.654SerTrp: 0.654 ± 0.06
2.835SerTyr: 2.835 ± 0.144
0.0SerXaa: 0.0 ± 0.0
Thr
2.166ThrAla: 2.166 ± 0.132
0.619ThrCys: 0.619 ± 0.071
1.646ThrAsp: 1.646 ± 0.106
2.23ThrGlu: 2.23 ± 0.139
2.37ThrPhe: 2.37 ± 0.132
3.095ThrGly: 3.095 ± 0.154
0.886ThrHis: 0.886 ± 0.082
5.859ThrIle: 5.859 ± 0.229
4.052ThrLys: 4.052 ± 0.187
4.614ThrLeu: 4.614 ± 0.175
0.907ThrMet: 0.907 ± 0.083
3.053ThrAsn: 3.053 ± 0.127
1.632ThrPro: 1.632 ± 0.103
1.273ThrGln: 1.273 ± 0.086
1.625ThrArg: 1.625 ± 0.093
3.51ThrSer: 3.51 ± 0.146
2.778ThrThr: 2.778 ± 0.153
2.912ThrVal: 2.912 ± 0.146
0.408ThrTrp: 0.408 ± 0.051
1.681ThrTyr: 1.681 ± 0.118
0.0ThrXaa: 0.0 ± 0.0
Val
1.977ValAla: 1.977 ± 0.137
0.64ValCys: 0.64 ± 0.074
2.504ValAsp: 2.504 ± 0.157
2.61ValGlu: 2.61 ± 0.138
2.589ValPhe: 2.589 ± 0.159
2.645ValGly: 2.645 ± 0.165
1.062ValHis: 1.062 ± 0.099
5.494ValIle: 5.494 ± 0.191
4.755ValLys: 4.755 ± 0.199
5.423ValLeu: 5.423 ± 0.215
0.95ValMet: 0.95 ± 0.093
3.32ValAsn: 3.32 ± 0.163
1.604ValPro: 1.604 ± 0.1
1.484ValGln: 1.484 ± 0.105
1.97ValArg: 1.97 ± 0.115
3.616ValSer: 3.616 ± 0.165
2.223ValThr: 2.223 ± 0.124
2.764ValVal: 2.764 ± 0.148
0.345ValTrp: 0.345 ± 0.053
1.512ValTyr: 1.512 ± 0.099
0.0ValXaa: 0.0 ± 0.0
Trp
0.19TrpAla: 0.19 ± 0.038
0.106TrpCys: 0.106 ± 0.027
0.317TrpAsp: 0.317 ± 0.046
0.338TrpGlu: 0.338 ± 0.05
0.513TrpPhe: 0.513 ± 0.066
0.366TrpGly: 0.366 ± 0.058
0.162TrpHis: 0.162 ± 0.031
1.386TrpIle: 1.386 ± 0.102
1.027TrpLys: 1.027 ± 0.085
0.739TrpLeu: 0.739 ± 0.088
0.302TrpMet: 0.302 ± 0.04
0.732TrpAsn: 0.732 ± 0.088
0.225TrpPro: 0.225 ± 0.038
0.141TrpGln: 0.141 ± 0.029
0.359TrpArg: 0.359 ± 0.048
0.492TrpSer: 0.492 ± 0.056
0.317TrpThr: 0.317 ± 0.049
0.225TrpVal: 0.225 ± 0.038
0.063TrpTrp: 0.063 ± 0.018
0.288TrpTyr: 0.288 ± 0.044
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.519TyrAla: 1.519 ± 0.114
0.703TyrCys: 0.703 ± 0.078
1.653TyrAsp: 1.653 ± 0.115
1.78TyrGlu: 1.78 ± 0.12
2.532TyrPhe: 2.532 ± 0.143
1.885TyrGly: 1.885 ± 0.116
0.696TyrHis: 0.696 ± 0.062
4.319TyrIle: 4.319 ± 0.176
3.953TyrLys: 3.953 ± 0.213
4.052TyrLeu: 4.052 ± 0.185
0.739TyrMet: 0.739 ± 0.068
2.757TyrAsn: 2.757 ± 0.127
1.132TyrPro: 1.132 ± 0.089
1.111TyrGln: 1.111 ± 0.084
1.224TyrArg: 1.224 ± 0.102
3.58TyrSer: 3.58 ± 0.167
1.885TyrThr: 1.885 ± 0.131
1.892TyrVal: 1.892 ± 0.127
0.415TyrTrp: 0.415 ± 0.062
1.639TyrTyr: 1.639 ± 0.107
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 444 proteins (142166 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski