Amino acid dipepetide frequency for Insolitispirillum peregrinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.429AlaAla: 16.429 ± 0.189	1.369AlaCys: 1.369 ± 0.038	6.91AlaAsp: 6.91 ± 0.081	7.335AlaGlu: 7.335 ± 0.104	3.942AlaPhe: 3.942 ± 0.055	9.629AlaGly: 9.629 ± 0.105	2.385AlaHis: 2.385 ± 0.049	5.534AlaIle: 5.534 ± 0.072	3.139AlaLys: 3.139 ± 0.063	14.595AlaLeu: 14.595 ± 0.154	3.339AlaMet: 3.339 ± 0.053	2.626AlaAsn: 2.626 ± 0.048	5.691AlaPro: 5.691 ± 0.141	4.199AlaGln: 4.199 ± 0.062	7.906AlaArg: 7.906 ± 0.094	6.807AlaSer: 6.807 ± 0.086	5.918AlaThr: 5.918 ± 0.085	9.323AlaVal: 9.323 ± 0.104	1.4AlaTrp: 1.4 ± 0.033	2.432AlaTyr: 2.432 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.077CysAla: 1.077 ± 0.032	0.142CysCys: 0.142 ± 0.011	0.64CysAsp: 0.64 ± 0.023	0.449CysGlu: 0.449 ± 0.021	0.313CysPhe: 0.313 ± 0.017	1.045CysGly: 1.045 ± 0.03	0.326CysHis: 0.326 ± 0.019	0.403CysIle: 0.403 ± 0.019	0.224CysLys: 0.224 ± 0.014	1.09CysLeu: 1.09 ± 0.029	0.174CysMet: 0.174 ± 0.012	0.203CysAsn: 0.203 ± 0.013	0.576CysPro: 0.576 ± 0.026	0.41CysGln: 0.41 ± 0.018	0.701CysArg: 0.701 ± 0.024	0.565CysSer: 0.565 ± 0.019	0.503CysThr: 0.503 ± 0.02	0.661CysVal: 0.661 ± 0.028	0.143CysTrp: 0.143 ± 0.01	0.232CysTyr: 0.232 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.333AspAla: 6.333 ± 0.076	0.595AspCys: 0.595 ± 0.025	3.535AspAsp: 3.535 ± 0.073	3.179AspGlu: 3.179 ± 0.047	1.954AspPhe: 1.954 ± 0.032	5.629AspGly: 5.629 ± 0.11	1.561AspHis: 1.561 ± 0.04	2.896AspIle: 2.896 ± 0.052	1.535AspLys: 1.535 ± 0.039	6.359AspLeu: 6.359 ± 0.079	1.343AspMet: 1.343 ± 0.033	1.23AspAsn: 1.23 ± 0.035	3.281AspPro: 3.281 ± 0.05	2.245AspGln: 2.245 ± 0.045	3.886AspArg: 3.886 ± 0.073	3.117AspSer: 3.117 ± 0.061	2.737AspThr: 2.737 ± 0.075	4.076AspVal: 4.076 ± 0.06	0.991AspTrp: 0.991 ± 0.029	1.385AspTyr: 1.385 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.737GluAla: 6.737 ± 0.137	0.368GluCys: 0.368 ± 0.017	2.871GluAsp: 2.871 ± 0.053	2.839GluGlu: 2.839 ± 0.067	1.388GluPhe: 1.388 ± 0.037	3.539GluGly: 3.539 ± 0.053	1.185GluHis: 1.185 ± 0.032	2.861GluIle: 2.861 ± 0.052	2.111GluLys: 2.111 ± 0.07	4.898GluLeu: 4.898 ± 0.071	1.541GluMet: 1.541 ± 0.039	1.335GluAsn: 1.335 ± 0.033	2.259GluPro: 2.259 ± 0.05	3.178GluGln: 3.178 ± 0.057	4.357GluArg: 4.357 ± 0.063	2.312GluSer: 2.312 ± 0.046	3.123GluThr: 3.123 ± 0.052	3.899GluVal: 3.899 ± 0.06	0.61GluTrp: 0.61 ± 0.023	0.911GluTyr: 0.911 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.837PheAla: 3.837 ± 0.056	0.419PheCys: 0.419 ± 0.019	2.238PheAsp: 2.238 ± 0.042	1.579PheGlu: 1.579 ± 0.036	1.221PhePhe: 1.221 ± 0.037	3.062PheGly: 3.062 ± 0.059	0.758PheHis: 0.758 ± 0.02	1.421PheIle: 1.421 ± 0.038	0.851PheLys: 0.851 ± 0.027	3.39PheLeu: 3.39 ± 0.053	0.716PheMet: 0.716 ± 0.024	0.924PheAsn: 0.924 ± 0.03	1.56PhePro: 1.56 ± 0.029	1.067PheGln: 1.067 ± 0.028	2.053PheArg: 2.053 ± 0.047	2.139PheSer: 2.139 ± 0.047	1.963PheThr: 1.963 ± 0.039	2.352PheVal: 2.352 ± 0.042	0.449PheTrp: 0.449 ± 0.019	0.844PheTyr: 0.844 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.955GlyAla: 7.955 ± 0.097	0.962GlyCys: 0.962 ± 0.03	4.411GlyAsp: 4.411 ± 0.074	4.273GlyGlu: 4.273 ± 0.057	2.936GlyPhe: 2.936 ± 0.055	6.732GlyGly: 6.732 ± 0.097	1.839GlyHis: 1.839 ± 0.042	4.191GlyIle: 4.191 ± 0.065	3.194GlyLys: 3.194 ± 0.051	9.18GlyLeu: 9.18 ± 0.107	2.45GlyMet: 2.45 ± 0.048	2.086GlyAsn: 2.086 ± 0.063	3.277GlyPro: 3.277 ± 0.052	3.52GlyGln: 3.52 ± 0.055	5.365GlyArg: 5.365 ± 0.075	4.84GlySer: 4.84 ± 0.093	4.607GlyThr: 4.607 ± 0.093	6.277GlyVal: 6.277 ± 0.084	1.403GlyTrp: 1.403 ± 0.039	2.205GlyTyr: 2.205 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.3HisAla: 2.3 ± 0.051	0.259HisCys: 0.259 ± 0.016	1.37HisAsp: 1.37 ± 0.038	1.008HisGlu: 1.008 ± 0.032	0.802HisPhe: 0.802 ± 0.027	2.148HisGly: 2.148 ± 0.042	0.79HisHis: 0.79 ± 0.034	0.972HisIle: 0.972 ± 0.028	0.53HisLys: 0.53 ± 0.021	2.483HisLeu: 2.483 ± 0.047	0.519HisMet: 0.519 ± 0.022	0.543HisAsn: 0.543 ± 0.017	1.57HisPro: 1.57 ± 0.041	0.965HisGln: 0.965 ± 0.031	1.583HisArg: 1.583 ± 0.034	1.172HisSer: 1.172 ± 0.028	1.007HisThr: 1.007 ± 0.025	1.431HisVal: 1.431 ± 0.034	0.367HisTrp: 0.367 ± 0.016	0.524HisTyr: 0.524 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.146IleAla: 6.146 ± 0.07	0.467IleCys: 0.467 ± 0.021	3.136IleAsp: 3.136 ± 0.049	2.939IleGlu: 2.939 ± 0.051	1.338IlePhe: 1.338 ± 0.037	4.36IleGly: 4.36 ± 0.074	1.019IleHis: 1.019 ± 0.03	2.133IleIle: 2.133 ± 0.049	1.349IleLys: 1.349 ± 0.032	4.594IleLeu: 4.594 ± 0.063	0.9IleMet: 0.9 ± 0.025	1.453IleAsn: 1.453 ± 0.035	2.416IlePro: 2.416 ± 0.042	1.324IleGln: 1.324 ± 0.035	2.938IleArg: 2.938 ± 0.048	3.108IleSer: 3.108 ± 0.066	3.035IleThr: 3.035 ± 0.065	3.077IleVal: 3.077 ± 0.051	0.394IleTrp: 0.394 ± 0.019	0.956IleTyr: 0.956 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.072LysAla: 4.072 ± 0.074	0.139LysCys: 0.139 ± 0.01	1.743LysAsp: 1.743 ± 0.04	1.477LysGlu: 1.477 ± 0.041	0.682LysPhe: 0.682 ± 0.026	2.621LysGly: 2.621 ± 0.05	0.491LysHis: 0.491 ± 0.021	1.562LysIle: 1.562 ± 0.035	1.262LysLys: 1.262 ± 0.037	2.565LysLeu: 2.565 ± 0.049	0.802LysMet: 0.802 ± 0.03	0.786LysAsn: 0.786 ± 0.025	1.744LysPro: 1.744 ± 0.038	0.999LysGln: 0.999 ± 0.033	1.792LysArg: 1.792 ± 0.043	1.611LysSer: 1.611 ± 0.04	1.929LysThr: 1.929 ± 0.039	2.444LysVal: 2.444 ± 0.045	0.289LysTrp: 0.289 ± 0.015	0.577LysTyr: 0.577 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.125LeuAla: 14.125 ± 0.144	1.234LeuCys: 1.234 ± 0.03	6.151LeuAsp: 6.151 ± 0.079	5.314LeuGlu: 5.314 ± 0.08	3.742LeuPhe: 3.742 ± 0.061	8.237LeuGly: 8.237 ± 0.084	2.346LeuHis: 2.346 ± 0.051	4.892LeuIle: 4.892 ± 0.067	3.359LeuLys: 3.359 ± 0.05	11.402LeuLeu: 11.402 ± 0.13	2.593LeuMet: 2.593 ± 0.046	2.773LeuAsn: 2.773 ± 0.053	6.551LeuPro: 6.551 ± 0.081	3.553LeuGln: 3.553 ± 0.053	7.57LeuArg: 7.57 ± 0.078	7.691LeuSer: 7.691 ± 0.118	6.585LeuThr: 6.585 ± 0.14	7.671LeuVal: 7.671 ± 0.087	1.471LeuTrp: 1.471 ± 0.037	2.297LeuTyr: 2.297 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.525MetAla: 3.525 ± 0.048	0.147MetCys: 0.147 ± 0.011	1.28MetAsp: 1.28 ± 0.03	1.169MetGlu: 1.169 ± 0.031	0.654MetPhe: 0.654 ± 0.027	1.9MetGly: 1.9 ± 0.042	0.42MetHis: 0.42 ± 0.019	1.344MetIle: 1.344 ± 0.036	0.807MetLys: 0.807 ± 0.028	2.508MetLeu: 2.508 ± 0.046	0.781MetMet: 0.781 ± 0.024	0.715MetAsn: 0.715 ± 0.025	1.484MetPro: 1.484 ± 0.033	0.876MetGln: 0.876 ± 0.028	1.542MetArg: 1.542 ± 0.041	1.712MetSer: 1.712 ± 0.033	1.814MetThr: 1.814 ± 0.041	2.213MetVal: 2.213 ± 0.048	0.204MetTrp: 0.204 ± 0.012	0.292MetTyr: 0.292 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.803AsnAla: 2.803 ± 0.048	0.24AsnCys: 0.24 ± 0.014	1.475AsnAsp: 1.475 ± 0.043	1.168AsnGlu: 1.168 ± 0.034	0.734AsnPhe: 0.734 ± 0.022	2.533AsnGly: 2.533 ± 0.056	0.547AsnHis: 0.547 ± 0.02	1.161AsnIle: 1.161 ± 0.032	0.709AsnLys: 0.709 ± 0.023	2.394AsnLeu: 2.394 ± 0.05	0.539AsnMet: 0.539 ± 0.019	0.707AsnAsn: 0.707 ± 0.03	1.698AsnPro: 1.698 ± 0.035	0.846AsnGln: 0.846 ± 0.028	1.773AsnArg: 1.773 ± 0.039	1.368AsnSer: 1.368 ± 0.04	1.37AsnThr: 1.37 ± 0.04	1.633AsnVal: 1.633 ± 0.04	0.305AsnTrp: 0.305 ± 0.016	0.554AsnTyr: 0.554 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.703ProAla: 6.703 ± 0.092	0.438ProCys: 0.438 ± 0.019	3.752ProAsp: 3.752 ± 0.063	3.342ProGlu: 3.342 ± 0.056	1.878ProPhe: 1.878 ± 0.038	3.907ProGly: 3.907 ± 0.06	1.204ProHis: 1.204 ± 0.031	1.809ProIle: 1.809 ± 0.037	1.366ProLys: 1.366 ± 0.038	6.072ProLeu: 6.072 ± 0.079	1.251ProMet: 1.251 ± 0.033	1.18ProAsn: 1.18 ± 0.03	3.255ProPro: 3.255 ± 0.088	2.144ProGln: 2.144 ± 0.049	2.88ProArg: 2.88 ± 0.05	3.036ProSer: 3.036 ± 0.047	2.869ProThr: 2.869 ± 0.109	4.689ProVal: 4.689 ± 0.075	0.802ProTrp: 0.802 ± 0.028	1.175ProTyr: 1.175 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.852GlnAla: 5.852 ± 0.092	0.251GlnCys: 0.251 ± 0.015	2.103GlnAsp: 2.103 ± 0.038	1.811GlnGlu: 1.811 ± 0.041	1.017GlnPhe: 1.017 ± 0.026	3.09GlnGly: 3.09 ± 0.051	0.889GlnHis: 0.889 ± 0.03	1.915GlnIle: 1.915 ± 0.06	1.267GlnLys: 1.267 ± 0.035	2.951GlnLeu: 2.951 ± 0.09	1.146GlnMet: 1.146 ± 0.034	0.904GlnAsn: 0.904 ± 0.03	2.08GlnPro: 2.08 ± 0.041	2.278GlnGln: 2.278 ± 0.069	3.007GlnArg: 3.007 ± 0.049	2.089GlnSer: 2.089 ± 0.042	2.309GlnThr: 2.309 ± 0.045	3.133GlnVal: 3.133 ± 0.067	0.505GlnTrp: 0.505 ± 0.018	0.632GlnTyr: 0.632 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.007ArgAla: 7.007 ± 0.084	0.598ArgCys: 0.598 ± 0.025	3.947ArgAsp: 3.947 ± 0.064	3.405ArgGlu: 3.405 ± 0.056	2.431ArgPhe: 2.431 ± 0.049	4.227ArgGly: 4.227 ± 0.06	1.811ArgHis: 1.811 ± 0.037	3.15ArgIle: 3.15 ± 0.052	2.089ArgLys: 2.089 ± 0.043	8.641ArgLeu: 8.641 ± 0.108	1.749ArgMet: 1.749 ± 0.037	1.613ArgAsn: 1.613 ± 0.037	3.578ArgPro: 3.578 ± 0.065	3.391ArgGln: 3.391 ± 0.061	5.146ArgArg: 5.146 ± 0.074	3.682ArgSer: 3.682 ± 0.053	3.282ArgThr: 3.282 ± 0.053	4.488ArgVal: 4.488 ± 0.071	1.065ArgTrp: 1.065 ± 0.029	1.651ArgTyr: 1.651 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.77SerAla: 6.77 ± 0.081	0.549SerCys: 0.549 ± 0.021	3.213SerAsp: 3.213 ± 0.061	2.815SerGlu: 2.815 ± 0.052	2.117SerPhe: 2.117 ± 0.038	5.745SerGly: 5.745 ± 0.094	1.395SerHis: 1.395 ± 0.033	2.446SerIle: 2.446 ± 0.045	1.521SerLys: 1.521 ± 0.032	7.084SerLeu: 7.084 ± 0.086	1.351SerMet: 1.351 ± 0.032	1.361SerAsn: 1.361 ± 0.035	3.379SerPro: 3.379 ± 0.058	2.05SerGln: 2.05 ± 0.052	3.594SerArg: 3.594 ± 0.063	3.823SerSer: 3.823 ± 0.09	3.284SerThr: 3.284 ± 0.129	4.514SerVal: 4.514 ± 0.071	0.82SerTrp: 0.82 ± 0.026	1.469SerTyr: 1.469 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.697ThrAla: 6.697 ± 0.106	0.493ThrCys: 0.493 ± 0.021	2.86ThrAsp: 2.86 ± 0.068	2.561ThrGlu: 2.561 ± 0.125	1.881ThrPhe: 1.881 ± 0.043	4.678ThrGly: 4.678 ± 0.077	1.045ThrHis: 1.045 ± 0.027	2.983ThrIle: 2.983 ± 0.066	1.183ThrLys: 1.183 ± 0.033	6.913ThrLeu: 6.913 ± 0.095	1.234ThrMet: 1.234 ± 0.031	1.206ThrAsn: 1.206 ± 0.034	3.725ThrPro: 3.725 ± 0.055	1.69ThrGln: 1.69 ± 0.13	3.118ThrArg: 3.118 ± 0.047	3.37ThrSer: 3.37 ± 0.12	3.322ThrThr: 3.322 ± 0.167	4.942ThrVal: 4.942 ± 0.092	0.575ThrTrp: 0.575 ± 0.022	1.218ThrTyr: 1.218 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	9.044ValAla: 9.044 ± 0.101	0.815ValCys: 0.815 ± 0.025	4.138ValAsp: 4.138 ± 0.062	4.037ValGlu: 4.037 ± 0.066	2.576ValPhe: 2.576 ± 0.053	5.505ValGly: 5.505 ± 0.079	1.399ValHis: 1.399 ± 0.032	4.072ValIle: 4.072 ± 0.059	2.097ValLys: 2.097 ± 0.042	8.342ValLeu: 8.342 ± 0.092	2.123ValMet: 2.123 ± 0.046	1.959ValAsn: 1.959 ± 0.048	3.868ValPro: 3.868 ± 0.063	2.683ValGln: 2.683 ± 0.05	4.957ValArg: 4.957 ± 0.071	4.787ValSer: 4.787 ± 0.06	4.274ValThr: 4.274 ± 0.078	6.789ValVal: 6.789 ± 0.091	0.964ValTrp: 0.964 ± 0.033	1.544ValTyr: 1.544 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.194TrpAla: 1.194 ± 0.035	0.158TrpCys: 0.158 ± 0.012	0.717TrpAsp: 0.717 ± 0.026	0.587TrpGlu: 0.587 ± 0.028	0.461TrpPhe: 0.461 ± 0.021	0.986TrpGly: 0.986 ± 0.029	0.366TrpHis: 0.366 ± 0.017	0.532TrpIle: 0.532 ± 0.02	0.393TrpLys: 0.393 ± 0.019	1.812TrpLeu: 1.812 ± 0.047	0.376TrpMet: 0.376 ± 0.015	0.373TrpAsn: 0.373 ± 0.018	0.668TrpPro: 0.668 ± 0.024	0.758TrpGln: 0.758 ± 0.024	1.058TrpArg: 1.058 ± 0.03	0.865TrpSer: 0.865 ± 0.027	0.609TrpThr: 0.609 ± 0.022	0.876TrpVal: 0.876 ± 0.026	0.225TrpTrp: 0.225 ± 0.014	0.286TrpTyr: 0.286 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.3TyrAla: 2.3 ± 0.048	0.236TyrCys: 0.236 ± 0.014	1.377TyrAsp: 1.377 ± 0.032	1.034TyrGlu: 1.034 ± 0.031	0.775TyrPhe: 0.775 ± 0.024	2.129TyrGly: 2.129 ± 0.048	0.566TyrHis: 0.566 ± 0.021	0.807TyrIle: 0.807 ± 0.027	0.602TyrLys: 0.602 ± 0.022	2.285TyrLeu: 2.285 ± 0.038	0.46TyrMet: 0.46 ± 0.02	0.578TyrAsn: 0.578 ± 0.02	1.09TyrPro: 1.09 ± 0.031	1.054TyrGln: 1.054 ± 0.029	1.727TyrArg: 1.727 ± 0.033	1.206TyrSer: 1.206 ± 0.031	1.155TyrThr: 1.155 ± 0.032	1.483TyrVal: 1.483 ± 0.033	0.319TyrTrp: 0.319 ± 0.017	0.573TyrTyr: 0.573 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3976 proteins (1355373 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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