Amino acid dipepetide frequency for Parabacteroides sp. AM08-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.311AlaAla: 5.311 ± 0.097
0.961AlaCys: 0.961 ± 0.029
4.084AlaAsp: 4.084 ± 0.064
4.622AlaGlu: 4.622 ± 0.079
3.289AlaPhe: 3.289 ± 0.055
5.231AlaGly: 5.231 ± 0.07
1.114AlaHis: 1.114 ± 0.028
4.97AlaIle: 4.97 ± 0.073
4.139AlaLys: 4.139 ± 0.076
6.422AlaLeu: 6.422 ± 0.082
1.798AlaMet: 1.798 ± 0.043
3.201AlaAsn: 3.201 ± 0.061
2.192AlaPro: 2.192 ± 0.04
2.392AlaGln: 2.392 ± 0.049
2.854AlaArg: 2.854 ± 0.058
4.195AlaSer: 4.195 ± 0.06
3.809AlaThr: 3.809 ± 0.073
4.586AlaVal: 4.586 ± 0.066
0.764AlaTrp: 0.764 ± 0.025
2.889AlaTyr: 2.889 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.69CysAla: 0.69 ± 0.024
0.208CysCys: 0.208 ± 0.013
0.599CysAsp: 0.599 ± 0.021
0.615CysGlu: 0.615 ± 0.022
0.64CysPhe: 0.64 ± 0.02
0.953CysGly: 0.953 ± 0.029
0.272CysHis: 0.272 ± 0.015
0.883CysIle: 0.883 ± 0.029
0.701CysLys: 0.701 ± 0.026
1.114CysLeu: 1.114 ± 0.027
0.334CysMet: 0.334 ± 0.018
0.582CysAsn: 0.582 ± 0.024
0.528CysPro: 0.528 ± 0.022
0.32CysGln: 0.32 ± 0.016
0.59CysArg: 0.59 ± 0.024
0.81CysSer: 0.81 ± 0.027
0.597CysThr: 0.597 ± 0.022
0.719CysVal: 0.719 ± 0.027
0.163CysTrp: 0.163 ± 0.012
0.533CysTyr: 0.533 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.842AspAla: 3.842 ± 0.066
0.631AspCys: 0.631 ± 0.023
2.61AspAsp: 2.61 ± 0.046
3.893AspGlu: 3.893 ± 0.063
3.063AspPhe: 3.063 ± 0.055
3.89AspGly: 3.89 ± 0.066
0.703AspHis: 0.703 ± 0.023
4.395AspIle: 4.395 ± 0.07
4.409AspLys: 4.409 ± 0.062
4.584AspLeu: 4.584 ± 0.056
1.59AspMet: 1.59 ± 0.038
2.944AspAsn: 2.944 ± 0.049
1.766AspPro: 1.766 ± 0.036
1.131AspGln: 1.131 ± 0.035
2.225AspArg: 2.225 ± 0.042
3.038AspSer: 3.038 ± 0.061
2.92AspThr: 2.92 ± 0.06
3.539AspVal: 3.539 ± 0.052
0.848AspTrp: 0.848 ± 0.028
2.859AspTyr: 2.859 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
4.978GluAla: 4.978 ± 0.07
0.595GluCys: 0.595 ± 0.023
3.202GluAsp: 3.202 ± 0.057
5.177GluGlu: 5.177 ± 0.082
2.398GluPhe: 2.398 ± 0.044
4.05GluGly: 4.05 ± 0.059
1.21GluHis: 1.21 ± 0.03
4.865GluIle: 4.865 ± 0.066
5.695GluLys: 5.695 ± 0.064
6.28GluLeu: 6.28 ± 0.083
2.131GluMet: 2.131 ± 0.045
3.819GluAsn: 3.819 ± 0.056
1.871GluPro: 1.871 ± 0.041
2.779GluGln: 2.779 ± 0.052
3.179GluArg: 3.179 ± 0.053
2.994GluSer: 2.994 ± 0.054
3.616GluThr: 3.616 ± 0.056
4.262GluVal: 4.262 ± 0.061
0.853GluTrp: 0.853 ± 0.028
2.876GluTyr: 2.876 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
2.969PheAla: 2.969 ± 0.049
0.661PheCys: 0.661 ± 0.024
2.883PheAsp: 2.883 ± 0.048
2.608PheGlu: 2.608 ± 0.047
2.434PhePhe: 2.434 ± 0.054
3.219PheGly: 3.219 ± 0.056
0.891PheHis: 0.891 ± 0.031
3.439PheIle: 3.439 ± 0.057
2.607PheLys: 2.607 ± 0.056
4.25PheLeu: 4.25 ± 0.067
1.216PheMet: 1.216 ± 0.031
2.489PheAsn: 2.489 ± 0.045
1.82PhePro: 1.82 ± 0.04
1.265PheGln: 1.265 ± 0.033
2.256PheArg: 2.256 ± 0.041
3.563PheSer: 3.563 ± 0.059
2.887PheThr: 2.887 ± 0.049
3.023PheVal: 3.023 ± 0.052
0.588PheTrp: 0.588 ± 0.022
2.087PheTyr: 2.087 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.199GlyAla: 4.199 ± 0.068
0.906GlyCys: 0.906 ± 0.028
3.448GlyAsp: 3.448 ± 0.058
4.246GlyGlu: 4.246 ± 0.063
3.166GlyPhe: 3.166 ± 0.058
4.69GlyGly: 4.69 ± 0.086
1.236GlyHis: 1.236 ± 0.036
5.409GlyIle: 5.409 ± 0.064
5.51GlyLys: 5.51 ± 0.084
5.804GlyLeu: 5.804 ± 0.079
2.043GlyMet: 2.043 ± 0.046
3.688GlyAsn: 3.688 ± 0.065
1.422GlyPro: 1.422 ± 0.042
2.108GlyGln: 2.108 ± 0.044
2.753GlyArg: 2.753 ± 0.057
3.905GlySer: 3.905 ± 0.055
4.024GlyThr: 4.024 ± 0.05
4.503GlyVal: 4.503 ± 0.068
1.012GlyTrp: 1.012 ± 0.032
3.32GlyTyr: 3.32 ± 0.058
0.001GlyXaa: 0.001 ± 0.001
His
1.122HisAla: 1.122 ± 0.03
0.255HisCys: 0.255 ± 0.014
0.861HisAsp: 0.861 ± 0.024
0.961HisGlu: 0.961 ± 0.03
0.953HisPhe: 0.953 ± 0.027
1.073HisGly: 1.073 ± 0.029
0.422HisHis: 0.422 ± 0.021
1.489HisIle: 1.489 ± 0.033
0.951HisLys: 0.951 ± 0.028
1.78HisLeu: 1.78 ± 0.039
0.332HisMet: 0.332 ± 0.019
0.848HisAsn: 0.848 ± 0.028
1.063HisPro: 1.063 ± 0.027
0.595HisGln: 0.595 ± 0.024
0.785HisArg: 0.785 ± 0.027
1.099HisSer: 1.099 ± 0.033
0.996HisThr: 0.996 ± 0.029
1.039HisVal: 1.039 ± 0.031
0.248HisTrp: 0.248 ± 0.015
0.863HisTyr: 0.863 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.305IleAla: 5.305 ± 0.073
1.044IleCys: 1.044 ± 0.033
4.106IleAsp: 4.106 ± 0.05
4.658IleGlu: 4.658 ± 0.071
2.993IlePhe: 2.993 ± 0.056
4.897IleGly: 4.897 ± 0.079
1.436IleHis: 1.436 ± 0.04
4.875IleIle: 4.875 ± 0.078
4.391IleLys: 4.391 ± 0.057
6.418IleLeu: 6.418 ± 0.091
1.557IleMet: 1.557 ± 0.038
3.656IleAsn: 3.656 ± 0.06
3.442IlePro: 3.442 ± 0.055
2.497IleGln: 2.497 ± 0.049
3.592IleArg: 3.592 ± 0.056
4.913IleSer: 4.913 ± 0.07
4.23IleThr: 4.23 ± 0.066
4.408IleVal: 4.408 ± 0.064
0.726IleTrp: 0.726 ± 0.027
2.856IleTyr: 2.856 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.897LysAla: 4.897 ± 0.075
0.54LysCys: 0.54 ± 0.023
4.185LysAsp: 4.185 ± 0.058
6.252LysGlu: 6.252 ± 0.067
2.169LysPhe: 2.169 ± 0.042
4.691LysGly: 4.691 ± 0.064
1.141LysHis: 1.141 ± 0.026
4.592LysIle: 4.592 ± 0.071
5.412LysLys: 5.412 ± 0.076
5.532LysLeu: 5.532 ± 0.064
2.145LysMet: 2.145 ± 0.045
3.776LysAsn: 3.776 ± 0.062
2.34LysPro: 2.34 ± 0.045
2.769LysGln: 2.769 ± 0.057
3.148LysArg: 3.148 ± 0.048
3.515LysSer: 3.515 ± 0.061
3.612LysThr: 3.612 ± 0.059
4.325LysVal: 4.325 ± 0.065
0.751LysTrp: 0.751 ± 0.028
3.073LysTyr: 3.073 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
6.315LeuAla: 6.315 ± 0.085
1.192LeuCys: 1.192 ± 0.033
4.707LeuAsp: 4.707 ± 0.062
5.176LeuGlu: 5.176 ± 0.072
4.884LeuPhe: 4.884 ± 0.083
5.445LeuGly: 5.445 ± 0.073
1.653LeuHis: 1.653 ± 0.036
6.078LeuIle: 6.078 ± 0.094
6.507LeuLys: 6.507 ± 0.076
9.391LeuLeu: 9.391 ± 0.111
2.403LeuMet: 2.403 ± 0.049
4.762LeuAsn: 4.762 ± 0.057
4.134LeuPro: 4.134 ± 0.055
3.394LeuGln: 3.394 ± 0.059
4.022LeuArg: 4.022 ± 0.056
6.967LeuSer: 6.967 ± 0.085
5.233LeuThr: 5.233 ± 0.071
5.059LeuVal: 5.059 ± 0.067
0.934LeuTrp: 0.934 ± 0.025
3.809LeuTyr: 3.809 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
1.975MetAla: 1.975 ± 0.049
0.238MetCys: 0.238 ± 0.015
1.51MetAsp: 1.51 ± 0.038
1.868MetGlu: 1.868 ± 0.038
1.048MetPhe: 1.048 ± 0.029
1.767MetGly: 1.767 ± 0.037
0.407MetHis: 0.407 ± 0.016
1.627MetIle: 1.627 ± 0.034
2.427MetLys: 2.427 ± 0.046
2.497MetLeu: 2.497 ± 0.052
0.721MetMet: 0.721 ± 0.029
1.578MetAsn: 1.578 ± 0.034
1.102MetPro: 1.102 ± 0.033
1.071MetGln: 1.071 ± 0.027
1.245MetArg: 1.245 ± 0.034
1.462MetSer: 1.462 ± 0.036
1.34MetThr: 1.34 ± 0.033
1.516MetVal: 1.516 ± 0.041
0.22MetTrp: 0.22 ± 0.013
0.924MetTyr: 0.924 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.326AsnAla: 3.326 ± 0.055
0.557AsnCys: 0.557 ± 0.022
2.624AsnAsp: 2.624 ± 0.054
3.205AsnGlu: 3.205 ± 0.049
2.328AsnPhe: 2.328 ± 0.053
3.874AsnGly: 3.874 ± 0.058
0.947AsnHis: 0.947 ± 0.028
3.971AsnIle: 3.971 ± 0.064
3.515AsnLys: 3.515 ± 0.061
4.383AsnLeu: 4.383 ± 0.059
1.341AsnMet: 1.341 ± 0.027
2.775AsnAsn: 2.775 ± 0.053
2.642AsnPro: 2.642 ± 0.046
1.674AsnGln: 1.674 ± 0.039
2.479AsnArg: 2.479 ± 0.05
2.941AsnSer: 2.941 ± 0.051
2.867AsnThr: 2.867 ± 0.056
3.177AsnVal: 3.177 ± 0.053
0.698AsnTrp: 0.698 ± 0.028
2.411AsnTyr: 2.411 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.844ProAla: 2.844 ± 0.047
0.368ProCys: 0.368 ± 0.018
2.753ProAsp: 2.753 ± 0.05
3.659ProGlu: 3.659 ± 0.056
2.033ProPhe: 2.033 ± 0.04
2.566ProGly: 2.566 ± 0.052
0.702ProHis: 0.702 ± 0.024
2.414ProIle: 2.414 ± 0.04
2.004ProLys: 2.004 ± 0.037
3.339ProLeu: 3.339 ± 0.052
0.862ProMet: 0.862 ± 0.027
1.659ProAsn: 1.659 ± 0.041
0.914ProPro: 0.914 ± 0.031
1.217ProGln: 1.217 ± 0.03
1.246ProArg: 1.246 ± 0.036
2.25ProSer: 2.25 ± 0.038
1.929ProThr: 1.929 ± 0.039
3.289ProVal: 3.289 ± 0.053
0.433ProTrp: 0.433 ± 0.02
1.743ProTyr: 1.743 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.459GlnAla: 2.459 ± 0.048
0.263GlnCys: 0.263 ± 0.014
1.614GlnAsp: 1.614 ± 0.041
2.318GlnGlu: 2.318 ± 0.047
1.356GlnPhe: 1.356 ± 0.035
1.883GlnGly: 1.883 ± 0.04
0.573GlnHis: 0.573 ± 0.021
2.428GlnIle: 2.428 ± 0.04
2.468GlnLys: 2.468 ± 0.047
3.331GlnLeu: 3.331 ± 0.057
0.945GlnMet: 0.945 ± 0.031
1.706GlnAsn: 1.706 ± 0.038
1.332GlnPro: 1.332 ± 0.036
1.534GlnGln: 1.534 ± 0.039
1.429GlnArg: 1.429 ± 0.03
1.922GlnSer: 1.922 ± 0.041
2.048GlnThr: 2.048 ± 0.041
2.195GlnVal: 2.195 ± 0.047
0.427GlnTrp: 0.427 ± 0.019
1.517GlnTyr: 1.517 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.51ArgAla: 2.51 ± 0.045
0.433ArgCys: 0.433 ± 0.019
2.132ArgAsp: 2.132 ± 0.044
3.046ArgGlu: 3.046 ± 0.064
2.267ArgPhe: 2.267 ± 0.049
2.363ArgGly: 2.363 ± 0.052
0.793ArgHis: 0.793 ± 0.027
3.692ArgIle: 3.692 ± 0.06
3.418ArgLys: 3.418 ± 0.061
4.349ArgLeu: 4.349 ± 0.062
1.417ArgMet: 1.417 ± 0.034
2.478ArgAsn: 2.478 ± 0.046
1.571ArgPro: 1.571 ± 0.035
1.7ArgGln: 1.7 ± 0.042
2.078ArgArg: 2.078 ± 0.036
2.352ArgSer: 2.352 ± 0.044
2.418ArgThr: 2.418 ± 0.044
2.568ArgVal: 2.568 ± 0.047
0.535ArgTrp: 0.535 ± 0.026
2.191ArgTyr: 2.191 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
4.047SerAla: 4.047 ± 0.063
0.833SerCys: 0.833 ± 0.028
3.412SerAsp: 3.412 ± 0.047
3.683SerGlu: 3.683 ± 0.054
3.442SerPhe: 3.442 ± 0.068
4.7SerGly: 4.7 ± 0.067
1.061SerHis: 1.061 ± 0.028
4.491SerIle: 4.491 ± 0.072
3.45SerLys: 3.45 ± 0.053
6.143SerLeu: 6.143 ± 0.077
1.489SerMet: 1.489 ± 0.034
2.764SerAsn: 2.764 ± 0.054
2.389SerPro: 2.389 ± 0.04
1.743SerGln: 1.743 ± 0.037
2.657SerArg: 2.657 ± 0.047
3.981SerSer: 3.981 ± 0.068
3.202SerThr: 3.202 ± 0.051
4.202SerVal: 4.202 ± 0.059
0.774SerTrp: 0.774 ± 0.025
2.78SerTyr: 2.78 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
3.97ThrAla: 3.97 ± 0.069
0.57ThrCys: 0.57 ± 0.022
3.384ThrAsp: 3.384 ± 0.049
3.491ThrGlu: 3.491 ± 0.054
2.899ThrPhe: 2.899 ± 0.045
4.387ThrGly: 4.387 ± 0.061
1.031ThrHis: 1.031 ± 0.028
4.174ThrIle: 4.174 ± 0.067
2.923ThrLys: 2.923 ± 0.054
5.41ThrLeu: 5.41 ± 0.075
1.119ThrMet: 1.119 ± 0.029
2.457ThrAsn: 2.457 ± 0.054
2.811ThrPro: 2.811 ± 0.053
1.693ThrGln: 1.693 ± 0.036
2.191ThrArg: 2.191 ± 0.046
3.279ThrSer: 3.279 ± 0.058
3.268ThrThr: 3.268 ± 0.059
3.949ThrVal: 3.949 ± 0.062
0.628ThrTrp: 0.628 ± 0.022
2.404ThrTyr: 2.404 ± 0.045
0.002ThrXaa: 0.002 ± 0.001
Val
4.49ValAla: 4.49 ± 0.067
0.876ValCys: 0.876 ± 0.026
3.583ValAsp: 3.583 ± 0.061
4.112ValGlu: 4.112 ± 0.055
3.011ValPhe: 3.011 ± 0.051
3.927ValGly: 3.927 ± 0.072
1.017ValHis: 1.017 ± 0.028
4.418ValIle: 4.418 ± 0.057
4.437ValLys: 4.437 ± 0.069
5.799ValLeu: 5.799 ± 0.077
1.558ValMet: 1.558 ± 0.039
3.263ValAsn: 3.263 ± 0.057
2.574ValPro: 2.574 ± 0.047
1.857ValGln: 1.857 ± 0.041
2.837ValArg: 2.837 ± 0.052
4.586ValSer: 4.586 ± 0.07
3.727ValThr: 3.727 ± 0.072
4.295ValVal: 4.295 ± 0.074
0.749ValTrp: 0.749 ± 0.025
2.72ValTyr: 2.72 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.696TrpAla: 0.696 ± 0.022
0.168TrpCys: 0.168 ± 0.012
0.704TrpAsp: 0.704 ± 0.025
0.764TrpGlu: 0.764 ± 0.023
0.577TrpPhe: 0.577 ± 0.02
0.919TrpGly: 0.919 ± 0.029
0.263TrpHis: 0.263 ± 0.014
0.853TrpIle: 0.853 ± 0.028
0.922TrpLys: 0.922 ± 0.027
1.112TrpLeu: 1.112 ± 0.031
0.415TrpMet: 0.415 ± 0.022
0.749TrpAsn: 0.749 ± 0.027
0.296TrpPro: 0.296 ± 0.017
0.475TrpGln: 0.475 ± 0.022
0.534TrpArg: 0.534 ± 0.02
0.672TrpSer: 0.672 ± 0.025
0.613TrpThr: 0.613 ± 0.022
0.7TrpVal: 0.7 ± 0.025
0.192TrpTrp: 0.192 ± 0.012
0.529TrpTyr: 0.529 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.878TyrAla: 2.878 ± 0.051
0.552TyrCys: 0.552 ± 0.022
2.48TyrAsp: 2.48 ± 0.047
2.476TyrGlu: 2.476 ± 0.045
2.203TyrPhe: 2.203 ± 0.04
2.867TyrGly: 2.867 ± 0.062
0.864TyrHis: 0.864 ± 0.028
2.937TyrIle: 2.937 ± 0.048
2.977TyrLys: 2.977 ± 0.048
4.129TyrLeu: 4.129 ± 0.06
1.125TyrMet: 1.125 ± 0.031
2.543TyrAsn: 2.543 ± 0.051
2.018TyrPro: 2.018 ± 0.04
1.535TyrGln: 1.535 ± 0.034
2.208TyrArg: 2.208 ± 0.047
2.799TyrSer: 2.799 ± 0.051
2.706TyrThr: 2.706 ± 0.053
2.48TyrVal: 2.48 ± 0.047
0.608TyrTrp: 0.608 ± 0.025
2.189TyrTyr: 2.189 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.002XaaArg: 0.002 ± 0.001
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.003
Statistics based on 3426 proteins (1241278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski