Amino acid dipepetide frequency for Agromyces sp. KACC 19306

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.498AlaAla: 22.498 ± 0.235	0.635AlaCys: 0.635 ± 0.024	9.29AlaAsp: 9.29 ± 0.1	8.852AlaGlu: 8.852 ± 0.113	4.307AlaPhe: 4.307 ± 0.063	13.043AlaGly: 13.043 ± 0.111	2.488AlaHis: 2.488 ± 0.052	6.392AlaIle: 6.392 ± 0.082	2.481AlaLys: 2.481 ± 0.06	13.922AlaLeu: 13.922 ± 0.166	2.557AlaMet: 2.557 ± 0.049	2.373AlaAsn: 2.373 ± 0.054	7.242AlaPro: 7.242 ± 0.12	3.447AlaGln: 3.447 ± 0.057	10.127AlaArg: 10.127 ± 0.126	8.477AlaSer: 8.477 ± 0.086	7.823AlaThr: 7.823 ± 0.098	12.329AlaVal: 12.329 ± 0.132	2.054AlaTrp: 2.054 ± 0.048	2.402AlaTyr: 2.402 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.607CysAla: 0.607 ± 0.024	0.052CysCys: 0.052 ± 0.007	0.301CysAsp: 0.301 ± 0.02	0.254CysGlu: 0.254 ± 0.016	0.159CysPhe: 0.159 ± 0.012	0.502CysGly: 0.502 ± 0.02	0.1CysHis: 0.1 ± 0.01	0.164CysIle: 0.164 ± 0.01	0.047CysLys: 0.047 ± 0.006	0.401CysLeu: 0.401 ± 0.021	0.066CysMet: 0.066 ± 0.007	0.089CysAsn: 0.089 ± 0.01	0.266CysPro: 0.266 ± 0.016	0.094CysGln: 0.094 ± 0.01	0.328CysArg: 0.328 ± 0.018	0.35CysSer: 0.35 ± 0.019	0.33CysThr: 0.33 ± 0.02	0.387CysVal: 0.387 ± 0.019	0.073CysTrp: 0.073 ± 0.008	0.096CysTyr: 0.096 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	10.191AspAla: 10.191 ± 0.112	0.23AspCys: 0.23 ± 0.017	4.801AspAsp: 4.801 ± 0.077	4.876AspGlu: 4.876 ± 0.079	1.625AspPhe: 1.625 ± 0.044	6.56AspGly: 6.56 ± 0.097	1.158AspHis: 1.158 ± 0.032	1.969AspIle: 1.969 ± 0.041	0.696AspLys: 0.696 ± 0.032	6.69AspLeu: 6.69 ± 0.081	0.57AspMet: 0.57 ± 0.021	0.789AspAsn: 0.789 ± 0.028	4.605AspPro: 4.605 ± 0.062	1.493AspGln: 1.493 ± 0.043	5.231AspArg: 5.231 ± 0.095	2.326AspSer: 2.326 ± 0.042	2.751AspThr: 2.751 ± 0.053	5.428AspVal: 5.428 ± 0.076	1.041AspTrp: 1.041 ± 0.034	1.19AspTyr: 1.19 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.84GluAla: 7.84 ± 0.112	0.248GluCys: 0.248 ± 0.015	2.083GluAsp: 2.083 ± 0.036	2.421GluGlu: 2.421 ± 0.053	1.975GluPhe: 1.975 ± 0.04	3.965GluGly: 3.965 ± 0.062	1.648GluHis: 1.648 ± 0.038	2.521GluIle: 2.521 ± 0.053	0.905GluLys: 0.905 ± 0.037	7.111GluLeu: 7.111 ± 0.104	0.795GluMet: 0.795 ± 0.027	0.979GluAsn: 0.979 ± 0.026	3.695GluPro: 3.695 ± 0.069	2.341GluGln: 2.341 ± 0.049	5.718GluArg: 5.718 ± 0.079	2.725GluSer: 2.725 ± 0.051	2.904GluThr: 2.904 ± 0.049	5.109GluVal: 5.109 ± 0.066	0.95GluTrp: 0.95 ± 0.028	1.259GluTyr: 1.259 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.608PheAla: 4.608 ± 0.074	0.159PheCys: 0.159 ± 0.013	2.539PheAsp: 2.539 ± 0.058	1.91PheGlu: 1.91 ± 0.04	0.997PhePhe: 0.997 ± 0.032	3.535PheGly: 3.535 ± 0.061	0.562PheHis: 0.562 ± 0.022	1.172PheIle: 1.172 ± 0.037	0.392PheLys: 0.392 ± 0.02	2.745PheLeu: 2.745 ± 0.054	0.413PheMet: 0.413 ± 0.017	0.591PheAsn: 0.591 ± 0.024	1.38PhePro: 1.38 ± 0.033	0.734PheGln: 0.734 ± 0.023	1.911PheArg: 1.911 ± 0.05	1.591PheSer: 1.591 ± 0.042	2.116PheThr: 2.116 ± 0.049	2.804PheVal: 2.804 ± 0.06	0.509PheTrp: 0.509 ± 0.023	0.586PheTyr: 0.586 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.902GlyAla: 11.902 ± 0.119	0.605GlyCys: 0.605 ± 0.023	5.447GlyAsp: 5.447 ± 0.078	5.267GlyGlu: 5.267 ± 0.083	3.388GlyPhe: 3.388 ± 0.058	8.252GlyGly: 8.252 ± 0.118	1.784GlyHis: 1.784 ± 0.041	4.566GlyIle: 4.566 ± 0.068	1.72GlyLys: 1.72 ± 0.05	8.94GlyLeu: 8.94 ± 0.107	1.784GlyMet: 1.784 ± 0.04	1.504GlyAsn: 1.504 ± 0.041	4.034GlyPro: 4.034 ± 0.066	2.301GlyGln: 2.301 ± 0.05	7.047GlyArg: 7.047 ± 0.106	5.175GlySer: 5.175 ± 0.084	5.58GlyThr: 5.58 ± 0.087	8.462GlyVal: 8.462 ± 0.087	1.812GlyTrp: 1.812 ± 0.044	2.244GlyTyr: 2.244 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.404HisAla: 2.404 ± 0.05	0.1HisCys: 0.1 ± 0.009	1.479HisAsp: 1.479 ± 0.045	1.179HisGlu: 1.179 ± 0.032	0.505HisPhe: 0.505 ± 0.019	2.011HisGly: 2.011 ± 0.048	0.521HisHis: 0.521 ± 0.022	0.555HisIle: 0.555 ± 0.022	0.213HisLys: 0.213 ± 0.015	2.058HisLeu: 2.058 ± 0.045	0.254HisMet: 0.254 ± 0.017	0.319HisAsn: 0.319 ± 0.017	1.576HisPro: 1.576 ± 0.039	0.428HisGln: 0.428 ± 0.019	1.67HisArg: 1.67 ± 0.041	0.867HisSer: 0.867 ± 0.026	0.883HisThr: 0.883 ± 0.03	1.688HisVal: 1.688 ± 0.037	0.299HisTrp: 0.299 ± 0.015	0.394HisTyr: 0.394 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.322IleAla: 7.322 ± 0.08	0.214IleCys: 0.214 ± 0.013	3.493IleAsp: 3.493 ± 0.071	2.947IleGlu: 2.947 ± 0.053	0.991IlePhe: 0.991 ± 0.033	4.733IleGly: 4.733 ± 0.06	0.585IleHis: 0.585 ± 0.021	1.587IleIle: 1.587 ± 0.042	0.611IleLys: 0.611 ± 0.026	3.118IleLeu: 3.118 ± 0.062	0.545IleMet: 0.545 ± 0.025	0.725IleAsn: 0.725 ± 0.028	2.166IlePro: 2.166 ± 0.047	0.809IleGln: 0.809 ± 0.028	2.691IleArg: 2.691 ± 0.053	2.068IleSer: 2.068 ± 0.046	2.519IleThr: 2.519 ± 0.045	4.676IleVal: 4.676 ± 0.072	0.533IleTrp: 0.533 ± 0.021	0.616IleTyr: 0.616 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	1.975LysAla: 1.975 ± 0.059	0.062LysCys: 0.062 ± 0.008	0.791LysAsp: 0.791 ± 0.029	0.716LysGlu: 0.716 ± 0.024	0.429LysPhe: 0.429 ± 0.019	1.235LysGly: 1.235 ± 0.037	0.387LysHis: 0.387 ± 0.017	0.748LysIle: 0.748 ± 0.027	0.489LysLys: 0.489 ± 0.023	1.748LysLeu: 1.748 ± 0.05	0.271LysMet: 0.271 ± 0.016	0.376LysAsn: 0.376 ± 0.017	1.051LysPro: 1.051 ± 0.034	0.638LysGln: 0.638 ± 0.027	1.342LysArg: 1.342 ± 0.044	0.934LysSer: 0.934 ± 0.034	1.032LysThr: 1.032 ± 0.033	1.459LysVal: 1.459 ± 0.044	0.224LysTrp: 0.224 ± 0.013	0.377LysTyr: 0.377 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.958LeuAla: 15.958 ± 0.17	0.446LeuCys: 0.446 ± 0.02	7.351LeuAsp: 7.351 ± 0.095	5.476LeuGlu: 5.476 ± 0.087	2.763LeuPhe: 2.763 ± 0.061	9.407LeuGly: 9.407 ± 0.12	1.795LeuHis: 1.795 ± 0.045	4.118LeuIle: 4.118 ± 0.078	1.514LeuLys: 1.514 ± 0.047	9.675LeuLeu: 9.675 ± 0.139	1.378LeuMet: 1.378 ± 0.039	1.592LeuAsn: 1.592 ± 0.04	5.495LeuPro: 5.495 ± 0.075	2.301LeuGln: 2.301 ± 0.041	7.326LeuArg: 7.326 ± 0.096	4.918LeuSer: 4.918 ± 0.064	5.657LeuThr: 5.657 ± 0.072	10.15LeuVal: 10.15 ± 0.124	1.242LeuTrp: 1.242 ± 0.036	1.493LeuTyr: 1.493 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.883MetAla: 1.883 ± 0.047	0.081MetCys: 0.081 ± 0.011	0.628MetAsp: 0.628 ± 0.023	0.525MetGlu: 0.525 ± 0.022	0.478MetPhe: 0.478 ± 0.018	1.088MetGly: 1.088 ± 0.036	0.343MetHis: 0.343 ± 0.017	0.658MetIle: 0.658 ± 0.025	0.337MetLys: 0.337 ± 0.019	1.784MetLeu: 1.784 ± 0.047	0.245MetMet: 0.245 ± 0.016	0.41MetAsn: 0.41 ± 0.018	1.164MetPro: 1.164 ± 0.031	0.478MetGln: 0.478 ± 0.019	1.313MetArg: 1.313 ± 0.04	1.259MetSer: 1.259 ± 0.032	1.451MetThr: 1.451 ± 0.034	1.142MetVal: 1.142 ± 0.032	0.172MetTrp: 0.172 ± 0.013	0.218MetTyr: 0.218 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.307AsnAla: 2.307 ± 0.045	0.107AsnCys: 0.107 ± 0.011	1.088AsnAsp: 1.088 ± 0.033	0.857AsnGlu: 0.857 ± 0.029	0.547AsnPhe: 0.547 ± 0.022	1.826AsnGly: 1.826 ± 0.048	0.337AsnHis: 0.337 ± 0.017	0.704AsnIle: 0.704 ± 0.025	0.27AsnLys: 0.27 ± 0.017	1.807AsnLeu: 1.807 ± 0.046	0.241AsnMet: 0.241 ± 0.014	0.365AsnAsn: 0.365 ± 0.022	1.478AsnPro: 1.478 ± 0.035	0.536AsnGln: 0.536 ± 0.025	1.248AsnArg: 1.248 ± 0.034	0.844AsnSer: 0.844 ± 0.029	1.037AsnThr: 1.037 ± 0.036	1.502AsnVal: 1.502 ± 0.039	0.305AsnTrp: 0.305 ± 0.016	0.447AsnTyr: 0.447 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.002ProAla: 8.002 ± 0.12	0.176ProCys: 0.176 ± 0.012	4.42ProAsp: 4.42 ± 0.079	3.901ProGlu: 3.901 ± 0.064	1.704ProPhe: 1.704 ± 0.037	5.65ProGly: 5.65 ± 0.074	1.049ProHis: 1.049 ± 0.032	2.356ProIle: 2.356 ± 0.043	1.001ProLys: 1.001 ± 0.038	4.794ProLeu: 4.794 ± 0.071	0.84ProMet: 0.84 ± 0.029	1.146ProAsn: 1.146 ± 0.028	2.678ProPro: 2.678 ± 0.073	1.303ProGln: 1.303 ± 0.038	3.575ProArg: 3.575 ± 0.067	3.038ProSer: 3.038 ± 0.053	3.464ProThr: 3.464 ± 0.077	5.265ProVal: 5.265 ± 0.074	0.944ProTrp: 0.944 ± 0.032	1.047ProTyr: 1.047 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.523GlnAla: 3.523 ± 0.055	0.087GlnCys: 0.087 ± 0.009	0.996GlnAsp: 0.996 ± 0.031	1.055GlnGlu: 1.055 ± 0.033	0.805GlnPhe: 0.805 ± 0.03	2.003GlnGly: 2.003 ± 0.043	0.613GlnHis: 0.613 ± 0.024	1.099GlnIle: 1.099 ± 0.035	0.542GlnLys: 0.542 ± 0.024	2.97GlnLeu: 2.97 ± 0.048	0.384GlnMet: 0.384 ± 0.017	0.558GlnAsn: 0.558 ± 0.023	1.53GlnPro: 1.53 ± 0.04	1.143GlnGln: 1.143 ± 0.039	2.324GlnArg: 2.324 ± 0.048	1.312GlnSer: 1.312 ± 0.035	1.351GlnThr: 1.351 ± 0.033	2.406GlnVal: 2.406 ± 0.049	0.42GlnTrp: 0.42 ± 0.021	0.574GlnTyr: 0.574 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.815ArgAla: 9.815 ± 0.115	0.326ArgCys: 0.326 ± 0.019	4.526ArgAsp: 4.526 ± 0.075	4.439ArgGlu: 4.439 ± 0.073	2.655ArgPhe: 2.655 ± 0.05	5.797ArgGly: 5.797 ± 0.073	1.601ArgHis: 1.601 ± 0.039	3.753ArgIle: 3.753 ± 0.056	1.134ArgLys: 1.134 ± 0.035	7.846ArgLeu: 7.846 ± 0.108	1.677ArgMet: 1.677 ± 0.036	1.299ArgAsn: 1.299 ± 0.038	4.157ArgPro: 4.157 ± 0.07	1.841ArgGln: 1.841 ± 0.047	7.566ArgArg: 7.566 ± 0.115	4.123ArgSer: 4.123 ± 0.057	4.337ArgThr: 4.337 ± 0.073	6.803ArgVal: 6.803 ± 0.089	1.227ArgTrp: 1.227 ± 0.036	1.622ArgTyr: 1.622 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.86SerAla: 6.86 ± 0.091	0.232SerCys: 0.232 ± 0.015	3.095SerAsp: 3.095 ± 0.062	2.566SerGlu: 2.566 ± 0.049	1.775SerPhe: 1.775 ± 0.04	5.805SerGly: 5.805 ± 0.074	0.921SerHis: 0.921 ± 0.032	2.478SerIle: 2.478 ± 0.043	0.941SerLys: 0.941 ± 0.034	4.957SerLeu: 4.957 ± 0.07	0.992SerMet: 0.992 ± 0.027	1.049SerAsn: 1.049 ± 0.034	3.123SerPro: 3.123 ± 0.053	1.263SerGln: 1.263 ± 0.036	3.684SerArg: 3.684 ± 0.064	3.011SerSer: 3.011 ± 0.067	3.513SerThr: 3.513 ± 0.06	4.574SerVal: 4.574 ± 0.073	0.863SerTrp: 0.863 ± 0.03	1.06SerTyr: 1.06 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.935ThrAla: 7.935 ± 0.086	0.256ThrCys: 0.256 ± 0.018	3.537ThrAsp: 3.537 ± 0.067	2.909ThrGlu: 2.909 ± 0.055	1.781ThrPhe: 1.781 ± 0.043	5.905ThrGly: 5.905 ± 0.074	1.044ThrHis: 1.044 ± 0.029	2.675ThrIle: 2.675 ± 0.055	1.039ThrLys: 1.039 ± 0.032	5.626ThrLeu: 5.626 ± 0.083	0.878ThrMet: 0.878 ± 0.028	1.089ThrAsn: 1.089 ± 0.037	3.814ThrPro: 3.814 ± 0.069	1.216ThrGln: 1.216 ± 0.034	3.7ThrArg: 3.7 ± 0.056	3.138ThrSer: 3.138 ± 0.061	3.54ThrThr: 3.54 ± 0.07	5.64ThrVal: 5.64 ± 0.088	0.947ThrTrp: 0.947 ± 0.03	1.067ThrTyr: 1.067 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	12.912ValAla: 12.912 ± 0.144	0.456ValCys: 0.456 ± 0.02	6.227ValAsp: 6.227 ± 0.078	5.294ValGlu: 5.294 ± 0.076	3.037ValPhe: 3.037 ± 0.061	7.598ValGly: 7.598 ± 0.091	1.794ValHis: 1.794 ± 0.04	4.142ValIle: 4.142 ± 0.061	1.421ValLys: 1.421 ± 0.039	9.801ValLeu: 9.801 ± 0.102	1.231ValMet: 1.231 ± 0.033	1.761ValAsn: 1.761 ± 0.042	5.183ValPro: 5.183 ± 0.08	2.219ValGln: 2.219 ± 0.044	6.761ValArg: 6.761 ± 0.095	4.676ValSer: 4.676 ± 0.079	5.376ValThr: 5.376 ± 0.076	9.547ValVal: 9.547 ± 0.115	1.207ValTrp: 1.207 ± 0.033	1.585ValTyr: 1.585 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.741TrpAla: 1.741 ± 0.041	0.089TrpCys: 0.089 ± 0.009	0.773TrpAsp: 0.773 ± 0.028	0.653TrpGlu: 0.653 ± 0.025	0.653TrpPhe: 0.653 ± 0.028	1.103TrpGly: 1.103 ± 0.032	0.376TrpHis: 0.376 ± 0.016	0.749TrpIle: 0.749 ± 0.028	0.274TrpLys: 0.274 ± 0.018	1.835TrpLeu: 1.835 ± 0.046	0.322TrpMet: 0.322 ± 0.015	0.457TrpAsn: 0.457 ± 0.022	0.758TrpPro: 0.758 ± 0.025	0.581TrpGln: 0.581 ± 0.024	1.313TrpArg: 1.313 ± 0.04	0.964TrpSer: 0.964 ± 0.034	0.912TrpThr: 0.912 ± 0.035	1.272TrpVal: 1.272 ± 0.033	0.415TrpTrp: 0.415 ± 0.023	0.326TrpTyr: 0.326 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.456TyrAla: 2.456 ± 0.046	0.105TyrCys: 0.105 ± 0.009	1.354TyrAsp: 1.354 ± 0.036	1.095TyrGlu: 1.095 ± 0.032	0.679TyrPhe: 0.679 ± 0.022	1.797TyrGly: 1.797 ± 0.041	0.296TyrHis: 0.296 ± 0.016	0.546TyrIle: 0.546 ± 0.023	0.256TyrLys: 0.256 ± 0.017	2.228TyrLeu: 2.228 ± 0.046	0.212TyrMet: 0.212 ± 0.015	0.381TyrAsn: 0.381 ± 0.02	0.961TyrPro: 0.961 ± 0.029	0.53TyrGln: 0.53 ± 0.02	1.67TyrArg: 1.67 ± 0.044	0.968TyrSer: 0.968 ± 0.03	1.159TyrThr: 1.159 ± 0.038	1.584TyrVal: 1.584 ± 0.038	0.329TyrTrp: 0.329 ± 0.016	0.429TyrTyr: 0.429 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3349 proteins (1141035 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---