Amino acid dipepetide frequency for Lactococcus phage 1706

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.163AlaAla: 6.163 ± 1.612
0.291AlaCys: 0.291 ± 0.129
3.547AlaAsp: 3.547 ± 0.48
4.244AlaGlu: 4.244 ± 0.63
2.733AlaPhe: 2.733 ± 0.569
5.058AlaGly: 5.058 ± 1.312
1.163AlaHis: 1.163 ± 0.236
6.86AlaIle: 6.86 ± 0.94
5.523AlaLys: 5.523 ± 0.692
5.465AlaLeu: 5.465 ± 1.091
2.558AlaMet: 2.558 ± 0.648
4.186AlaAsn: 4.186 ± 0.487
1.86AlaPro: 1.86 ± 0.364
1.977AlaGln: 1.977 ± 0.371
2.151AlaArg: 2.151 ± 0.285
5.0AlaSer: 5.0 ± 1.066
4.419AlaThr: 4.419 ± 0.473
4.709AlaVal: 4.709 ± 0.887
0.872AlaTrp: 0.872 ± 0.249
2.442AlaTyr: 2.442 ± 0.44
0.0AlaXaa: 0.0 ± 0.0
Cys
0.291CysAla: 0.291 ± 0.127
0.0CysCys: 0.0 ± 0.0
0.116CysAsp: 0.116 ± 0.076
0.291CysGlu: 0.291 ± 0.151
0.174CysPhe: 0.174 ± 0.101
0.058CysGly: 0.058 ± 0.063
0.0CysHis: 0.0 ± 0.0
0.581CysIle: 0.581 ± 0.196
0.291CysLys: 0.291 ± 0.131
0.407CysLeu: 0.407 ± 0.169
0.116CysMet: 0.116 ± 0.071
0.116CysAsn: 0.116 ± 0.096
0.116CysPro: 0.116 ± 0.073
0.233CysGln: 0.233 ± 0.133
0.233CysArg: 0.233 ± 0.121
0.291CysSer: 0.291 ± 0.134
0.291CysThr: 0.291 ± 0.125
0.116CysVal: 0.116 ± 0.081
0.058CysTrp: 0.058 ± 0.053
0.116CysTyr: 0.116 ± 0.077
0.0CysXaa: 0.0 ± 0.0
Asp
4.186AspAla: 4.186 ± 0.656
0.174AspCys: 0.174 ± 0.107
4.128AspAsp: 4.128 ± 0.614
4.244AspGlu: 4.244 ± 0.602
3.198AspPhe: 3.198 ± 0.453
5.581AspGly: 5.581 ± 0.74
0.93AspHis: 0.93 ± 0.216
6.047AspIle: 6.047 ± 0.772
4.36AspLys: 4.36 ± 0.533
5.698AspLeu: 5.698 ± 0.639
2.384AspMet: 2.384 ± 0.346
3.953AspAsn: 3.953 ± 0.471
2.558AspPro: 2.558 ± 0.54
2.035AspGln: 2.035 ± 0.307
1.686AspArg: 1.686 ± 0.388
4.012AspSer: 4.012 ± 0.445
3.547AspThr: 3.547 ± 0.491
3.488AspVal: 3.488 ± 0.478
1.163AspTrp: 1.163 ± 0.241
3.256AspTyr: 3.256 ± 0.536
0.0AspXaa: 0.0 ± 0.0
Glu
4.535GluAla: 4.535 ± 0.554
0.174GluCys: 0.174 ± 0.105
3.605GluAsp: 3.605 ± 0.782
5.465GluGlu: 5.465 ± 0.835
2.326GluPhe: 2.326 ± 0.423
2.907GluGly: 2.907 ± 0.462
1.163GluHis: 1.163 ± 0.323
4.012GluIle: 4.012 ± 0.501
4.709GluLys: 4.709 ± 0.554
5.814GluLeu: 5.814 ± 0.887
1.686GluMet: 1.686 ± 0.321
3.721GluAsn: 3.721 ± 0.58
1.512GluPro: 1.512 ± 0.368
2.849GluGln: 2.849 ± 0.548
2.791GluArg: 2.791 ± 0.587
2.616GluSer: 2.616 ± 0.314
4.244GluThr: 4.244 ± 0.592
4.012GluVal: 4.012 ± 0.657
0.756GluTrp: 0.756 ± 0.245
2.965GluTyr: 2.965 ± 0.514
0.0GluXaa: 0.0 ± 0.0
Phe
2.558PheAla: 2.558 ± 0.49
0.291PheCys: 0.291 ± 0.116
3.14PheAsp: 3.14 ± 0.59
1.977PheGlu: 1.977 ± 0.432
1.453PhePhe: 1.453 ± 0.302
3.488PheGly: 3.488 ± 0.569
0.174PheHis: 0.174 ± 0.099
3.023PheIle: 3.023 ± 0.393
3.314PheLys: 3.314 ± 0.436
2.035PheLeu: 2.035 ± 0.331
0.756PheMet: 0.756 ± 0.203
2.384PheAsn: 2.384 ± 0.348
1.395PhePro: 1.395 ± 0.269
0.93PheGln: 0.93 ± 0.248
1.279PheArg: 1.279 ± 0.324
2.093PheSer: 2.093 ± 0.485
2.093PheThr: 2.093 ± 0.392
2.093PheVal: 2.093 ± 0.489
0.581PheTrp: 0.581 ± 0.202
1.395PheTyr: 1.395 ± 0.34
0.0PheXaa: 0.0 ± 0.0
Gly
5.465GlyAla: 5.465 ± 1.554
0.233GlyCys: 0.233 ± 0.14
3.663GlyAsp: 3.663 ± 0.423
3.953GlyGlu: 3.953 ± 0.532
2.384GlyPhe: 2.384 ± 0.411
3.895GlyGly: 3.895 ± 0.762
0.93GlyHis: 0.93 ± 0.214
5.349GlyIle: 5.349 ± 0.686
5.814GlyLys: 5.814 ± 0.594
5.233GlyLeu: 5.233 ± 0.958
2.326GlyMet: 2.326 ± 0.44
4.36GlyAsn: 4.36 ± 0.681
1.337GlyPro: 1.337 ± 0.303
2.791GlyGln: 2.791 ± 0.455
1.802GlyArg: 1.802 ± 0.288
3.953GlySer: 3.953 ± 0.741
4.477GlyThr: 4.477 ± 0.683
5.988GlyVal: 5.988 ± 0.776
1.163GlyTrp: 1.163 ± 0.239
2.267GlyTyr: 2.267 ± 0.391
0.058GlyXaa: 0.058 ± 0.052
His
0.814HisAla: 0.814 ± 0.289
0.058HisCys: 0.058 ± 0.062
1.163HisAsp: 1.163 ± 0.269
0.988HisGlu: 0.988 ± 0.294
0.698HisPhe: 0.698 ± 0.183
0.988HisGly: 0.988 ± 0.282
0.581HisHis: 0.581 ± 0.17
1.279HisIle: 1.279 ± 0.348
1.279HisLys: 1.279 ± 0.296
0.872HisLeu: 0.872 ± 0.222
0.523HisMet: 0.523 ± 0.153
1.337HisAsn: 1.337 ± 0.298
0.349HisPro: 0.349 ± 0.108
0.698HisGln: 0.698 ± 0.186
0.349HisArg: 0.349 ± 0.142
1.512HisSer: 1.512 ± 0.332
0.698HisThr: 0.698 ± 0.239
0.988HisVal: 0.988 ± 0.261
0.349HisTrp: 0.349 ± 0.15
0.698HisTyr: 0.698 ± 0.236
0.0HisXaa: 0.0 ± 0.0
Ile
4.709IleAla: 4.709 ± 0.576
0.407IleCys: 0.407 ± 0.174
5.698IleAsp: 5.698 ± 0.514
4.651IleGlu: 4.651 ± 0.689
1.919IlePhe: 1.919 ± 0.33
5.058IleGly: 5.058 ± 0.844
1.453IleHis: 1.453 ± 0.248
5.64IleIle: 5.64 ± 0.587
6.802IleLys: 6.802 ± 0.709
6.512IleLeu: 6.512 ± 0.707
1.221IleMet: 1.221 ± 0.25
5.291IleAsn: 5.291 ± 0.596
2.849IlePro: 2.849 ± 0.382
2.442IleGln: 2.442 ± 0.36
2.326IleArg: 2.326 ± 0.505
4.942IleSer: 4.942 ± 0.599
6.919IleThr: 6.919 ± 0.671
4.186IleVal: 4.186 ± 0.469
0.64IleTrp: 0.64 ± 0.261
2.093IleTyr: 2.093 ± 0.384
0.0IleXaa: 0.0 ± 0.0
Lys
5.116LysAla: 5.116 ± 0.699
0.116LysCys: 0.116 ± 0.084
5.988LysAsp: 5.988 ± 0.656
6.337LysGlu: 6.337 ± 0.856
2.5LysPhe: 2.5 ± 0.467
4.419LysGly: 4.419 ± 0.574
2.151LysHis: 2.151 ± 0.378
4.826LysIle: 4.826 ± 0.478
6.105LysLys: 6.105 ± 0.975
6.977LysLeu: 6.977 ± 0.705
2.442LysMet: 2.442 ± 0.391
3.953LysAsn: 3.953 ± 0.488
2.267LysPro: 2.267 ± 0.428
2.907LysGln: 2.907 ± 0.545
3.372LysArg: 3.372 ± 0.613
5.291LysSer: 5.291 ± 0.715
4.826LysThr: 4.826 ± 0.607
5.116LysVal: 5.116 ± 0.5
1.221LysTrp: 1.221 ± 0.323
4.302LysTyr: 4.302 ± 0.642
0.0LysXaa: 0.0 ± 0.0
Leu
6.105LeuAla: 6.105 ± 1.081
0.233LeuCys: 0.233 ± 0.114
5.64LeuAsp: 5.64 ± 0.594
3.779LeuGlu: 3.779 ± 0.621
3.14LeuPhe: 3.14 ± 0.413
5.756LeuGly: 5.756 ± 1.231
1.686LeuHis: 1.686 ± 0.314
5.0LeuIle: 5.0 ± 0.438
7.5LeuLys: 7.5 ± 0.924
5.523LeuLeu: 5.523 ± 0.601
2.151LeuMet: 2.151 ± 0.43
4.709LeuAsn: 4.709 ± 0.646
2.674LeuPro: 2.674 ± 0.432
3.314LeuGln: 3.314 ± 0.441
2.442LeuArg: 2.442 ± 0.463
5.698LeuSer: 5.698 ± 0.71
5.291LeuThr: 5.291 ± 0.595
4.884LeuVal: 4.884 ± 0.493
0.93LeuTrp: 0.93 ± 0.259
2.907LeuTyr: 2.907 ± 0.52
0.0LeuXaa: 0.0 ± 0.0
Met
2.674MetAla: 2.674 ± 0.605
0.058MetCys: 0.058 ± 0.051
1.628MetAsp: 1.628 ± 0.307
1.279MetGlu: 1.279 ± 0.229
0.872MetPhe: 0.872 ± 0.238
1.86MetGly: 1.86 ± 0.298
0.465MetHis: 0.465 ± 0.186
2.151MetIle: 2.151 ± 0.392
2.384MetLys: 2.384 ± 0.338
2.326MetLeu: 2.326 ± 0.419
0.756MetMet: 0.756 ± 0.222
1.86MetAsn: 1.86 ± 0.294
0.64MetPro: 0.64 ± 0.223
1.221MetGln: 1.221 ± 0.239
1.395MetArg: 1.395 ± 0.277
1.86MetSer: 1.86 ± 0.27
1.453MetThr: 1.453 ± 0.314
1.221MetVal: 1.221 ± 0.318
0.233MetTrp: 0.233 ± 0.108
0.872MetTyr: 0.872 ± 0.253
0.0MetXaa: 0.0 ± 0.0
Asn
4.186AsnAla: 4.186 ± 0.439
0.233AsnCys: 0.233 ± 0.116
4.593AsnAsp: 4.593 ± 0.551
4.593AsnGlu: 4.593 ± 0.657
2.326AsnPhe: 2.326 ± 0.386
5.0AsnGly: 5.0 ± 0.675
0.756AsnHis: 0.756 ± 0.231
5.523AsnIle: 5.523 ± 0.632
5.0AsnLys: 5.0 ± 0.666
4.302AsnLeu: 4.302 ± 0.566
1.395AsnMet: 1.395 ± 0.346
3.895AsnAsn: 3.895 ± 0.71
2.616AsnPro: 2.616 ± 0.334
2.965AsnGln: 2.965 ± 0.813
2.384AsnArg: 2.384 ± 0.39
3.663AsnSer: 3.663 ± 0.582
4.709AsnThr: 4.709 ± 0.702
3.081AsnVal: 3.081 ± 0.418
0.465AsnTrp: 0.465 ± 0.133
2.616AsnTyr: 2.616 ± 0.404
0.0AsnXaa: 0.0 ± 0.0
Pro
2.035ProAla: 2.035 ± 0.238
0.233ProCys: 0.233 ± 0.114
1.802ProAsp: 1.802 ± 0.298
2.733ProGlu: 2.733 ± 0.549
1.744ProPhe: 1.744 ± 0.243
2.907ProGly: 2.907 ± 0.493
0.581ProHis: 0.581 ± 0.16
2.442ProIle: 2.442 ± 0.346
2.674ProLys: 2.674 ± 0.523
1.57ProLeu: 1.57 ± 0.296
0.64ProMet: 0.64 ± 0.212
2.442ProAsn: 2.442 ± 0.446
0.756ProPro: 0.756 ± 0.189
1.221ProGln: 1.221 ± 0.252
0.93ProArg: 0.93 ± 0.253
1.628ProSer: 1.628 ± 0.231
2.209ProThr: 2.209 ± 0.405
2.151ProVal: 2.151 ± 0.381
0.64ProTrp: 0.64 ± 0.177
1.628ProTyr: 1.628 ± 0.369
0.0ProXaa: 0.0 ± 0.0
Gln
2.849GlnAla: 2.849 ± 0.653
0.116GlnCys: 0.116 ± 0.068
2.209GlnAsp: 2.209 ± 0.431
1.744GlnGlu: 1.744 ± 0.363
1.57GlnPhe: 1.57 ± 0.252
2.267GlnGly: 2.267 ± 0.435
0.581GlnHis: 0.581 ± 0.196
3.14GlnIle: 3.14 ± 0.475
2.209GlnLys: 2.209 ± 0.295
3.488GlnLeu: 3.488 ± 0.477
1.279GlnMet: 1.279 ± 0.241
2.907GlnAsn: 2.907 ± 0.387
1.628GlnPro: 1.628 ± 0.333
1.919GlnGln: 1.919 ± 0.426
1.279GlnArg: 1.279 ± 0.295
1.919GlnSer: 1.919 ± 0.258
1.744GlnThr: 1.744 ± 0.412
2.267GlnVal: 2.267 ± 0.479
0.523GlnTrp: 0.523 ± 0.163
1.802GlnTyr: 1.802 ± 0.383
0.0GlnXaa: 0.0 ± 0.0
Arg
2.5ArgAla: 2.5 ± 0.391
0.233ArgCys: 0.233 ± 0.1
1.919ArgAsp: 1.919 ± 0.322
1.919ArgGlu: 1.919 ± 0.365
1.279ArgPhe: 1.279 ± 0.346
1.802ArgGly: 1.802 ± 0.343
0.756ArgHis: 0.756 ± 0.317
2.035ArgIle: 2.035 ± 0.318
2.442ArgLys: 2.442 ± 0.523
3.023ArgLeu: 3.023 ± 0.547
0.988ArgMet: 0.988 ± 0.213
2.093ArgAsn: 2.093 ± 0.482
1.395ArgPro: 1.395 ± 0.316
1.512ArgGln: 1.512 ± 0.349
1.86ArgArg: 1.86 ± 0.389
2.035ArgSer: 2.035 ± 0.457
2.442ArgThr: 2.442 ± 0.381
1.86ArgVal: 1.86 ± 0.36
0.291ArgTrp: 0.291 ± 0.115
1.628ArgTyr: 1.628 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
3.953SerAla: 3.953 ± 0.774
0.174SerCys: 0.174 ± 0.099
3.488SerAsp: 3.488 ± 0.46
3.256SerGlu: 3.256 ± 0.421
2.849SerPhe: 2.849 ± 0.535
4.942SerGly: 4.942 ± 1.047
0.523SerHis: 0.523 ± 0.139
4.186SerIle: 4.186 ± 0.465
5.698SerLys: 5.698 ± 0.837
4.709SerLeu: 4.709 ± 0.71
1.57SerMet: 1.57 ± 0.287
4.419SerAsn: 4.419 ± 0.545
1.57SerPro: 1.57 ± 0.241
2.733SerGln: 2.733 ± 0.49
2.267SerArg: 2.267 ± 0.396
4.36SerSer: 4.36 ± 0.534
3.663SerThr: 3.663 ± 0.503
4.012SerVal: 4.012 ± 0.567
0.872SerTrp: 0.872 ± 0.225
2.267SerTyr: 2.267 ± 0.463
0.0SerXaa: 0.0 ± 0.0
Thr
4.884ThrAla: 4.884 ± 0.692
0.116ThrCys: 0.116 ± 0.073
4.244ThrAsp: 4.244 ± 0.484
3.547ThrGlu: 3.547 ± 0.522
2.442ThrPhe: 2.442 ± 0.491
4.244ThrGly: 4.244 ± 0.634
0.814ThrHis: 0.814 ± 0.294
5.116ThrIle: 5.116 ± 0.718
4.419ThrLys: 4.419 ± 0.43
5.872ThrLeu: 5.872 ± 0.623
1.221ThrMet: 1.221 ± 0.357
4.012ThrAsn: 4.012 ± 0.628
3.256ThrPro: 3.256 ± 0.374
1.802ThrGln: 1.802 ± 0.302
2.151ThrArg: 2.151 ± 0.412
3.895ThrSer: 3.895 ± 0.634
5.407ThrThr: 5.407 ± 1.09
5.233ThrVal: 5.233 ± 0.746
0.756ThrTrp: 0.756 ± 0.203
2.616ThrTyr: 2.616 ± 0.469
0.0ThrXaa: 0.0 ± 0.0
Val
4.535ValAla: 4.535 ± 0.671
0.174ValCys: 0.174 ± 0.102
4.826ValAsp: 4.826 ± 0.664
3.837ValGlu: 3.837 ± 0.57
1.395ValPhe: 1.395 ± 0.297
3.837ValGly: 3.837 ± 0.606
0.756ValHis: 0.756 ± 0.209
4.244ValIle: 4.244 ± 0.474
5.581ValLys: 5.581 ± 0.527
4.942ValLeu: 4.942 ± 0.537
1.628ValMet: 1.628 ± 0.337
4.651ValAsn: 4.651 ± 0.595
2.558ValPro: 2.558 ± 0.446
1.802ValGln: 1.802 ± 0.403
1.977ValArg: 1.977 ± 0.373
3.721ValSer: 3.721 ± 0.53
4.012ValThr: 4.012 ± 0.523
4.477ValVal: 4.477 ± 0.644
0.756ValTrp: 0.756 ± 0.207
2.965ValTyr: 2.965 ± 0.465
0.0ValXaa: 0.0 ± 0.0
Trp
1.105TrpAla: 1.105 ± 0.254
0.058TrpCys: 0.058 ± 0.054
1.105TrpAsp: 1.105 ± 0.307
0.814TrpGlu: 0.814 ± 0.249
0.349TrpPhe: 0.349 ± 0.135
0.581TrpGly: 0.581 ± 0.177
0.116TrpHis: 0.116 ± 0.083
0.872TrpIle: 0.872 ± 0.233
0.698TrpLys: 0.698 ± 0.206
1.337TrpLeu: 1.337 ± 0.368
0.349TrpMet: 0.349 ± 0.175
0.988TrpAsn: 0.988 ± 0.187
0.349TrpPro: 0.349 ± 0.129
0.523TrpGln: 0.523 ± 0.15
0.233TrpArg: 0.233 ± 0.118
0.581TrpSer: 0.581 ± 0.164
1.221TrpThr: 1.221 ± 0.465
0.756TrpVal: 0.756 ± 0.164
0.291TrpTrp: 0.291 ± 0.126
0.756TrpTyr: 0.756 ± 0.24
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.558TyrAla: 2.558 ± 0.455
0.523TyrCys: 0.523 ± 0.266
4.128TyrAsp: 4.128 ± 0.622
2.267TyrGlu: 2.267 ± 0.45
1.105TyrPhe: 1.105 ± 0.301
2.791TyrGly: 2.791 ± 0.428
0.64TyrHis: 0.64 ± 0.208
3.43TyrIle: 3.43 ± 0.467
3.43TyrLys: 3.43 ± 0.595
3.198TyrLeu: 3.198 ± 0.528
1.163TyrMet: 1.163 ± 0.3
3.023TyrAsn: 3.023 ± 0.562
1.279TyrPro: 1.279 ± 0.378
1.57TyrGln: 1.57 ± 0.289
1.105TyrArg: 1.105 ± 0.245
2.442TyrSer: 2.442 ± 0.386
2.384TyrThr: 2.384 ± 0.417
2.035TyrVal: 2.035 ± 0.493
0.523TyrTrp: 0.523 ± 0.21
2.035TyrTyr: 2.035 ± 0.397
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.058XaaLeu: 0.058 ± 0.052
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (17201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski