Amino acid dipepetide frequency for uncultured archaeon A07HR60

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.551AlaAla: 12.551 ± 0.203	0.759AlaCys: 0.759 ± 0.036	9.555AlaAsp: 9.555 ± 0.136	7.872AlaGlu: 7.872 ± 0.127	3.288AlaPhe: 3.288 ± 0.074	9.546AlaGly: 9.546 ± 0.14	1.894AlaHis: 1.894 ± 0.054	4.756AlaIle: 4.756 ± 0.084	1.847AlaLys: 1.847 ± 0.056	8.564AlaLeu: 8.564 ± 0.126	1.821AlaMet: 1.821 ± 0.052	2.595AlaAsn: 2.595 ± 0.063	3.808AlaPro: 3.808 ± 0.079	2.712AlaGln: 2.712 ± 0.07	5.886AlaArg: 5.886 ± 0.103	5.767AlaSer: 5.767 ± 0.109	6.942AlaThr: 6.942 ± 0.119	9.941AlaVal: 9.941 ± 0.148	0.996AlaTrp: 0.996 ± 0.036	2.32AlaTyr: 2.32 ± 0.055	0.019AlaXaa: 0.019 ± 0.006
Cys	0.644CysAla: 0.644 ± 0.028	0.11CysCys: 0.11 ± 0.013	0.665CysAsp: 0.665 ± 0.033	0.665CysGlu: 0.665 ± 0.032	0.203CysPhe: 0.203 ± 0.017	1.048CysGly: 1.048 ± 0.043	0.226CysHis: 0.226 ± 0.018	0.265CysIle: 0.265 ± 0.019	0.129CysLys: 0.129 ± 0.013	0.608CysLeu: 0.608 ± 0.033	0.119CysMet: 0.119 ± 0.011	0.202CysAsn: 0.202 ± 0.016	0.617CysPro: 0.617 ± 0.03	0.252CysGln: 0.252 ± 0.019	0.655CysArg: 0.655 ± 0.034	0.573CysSer: 0.573 ± 0.029	0.455CysThr: 0.455 ± 0.023	0.616CysVal: 0.616 ± 0.029	0.091CysTrp: 0.091 ± 0.012	0.175CysTyr: 0.175 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	8.185AspAla: 8.185 ± 0.111	0.654AspCys: 0.654 ± 0.031	6.519AspAsp: 6.519 ± 0.123	6.559AspGlu: 6.559 ± 0.109	1.899AspPhe: 1.899 ± 0.055	7.496AspGly: 7.496 ± 0.134	1.945AspHis: 1.945 ± 0.053	3.78AspIle: 3.78 ± 0.081	1.214AspLys: 1.214 ± 0.041	6.31AspLeu: 6.31 ± 0.105	1.336AspMet: 1.336 ± 0.049	1.673AspAsn: 1.673 ± 0.055	4.488AspPro: 4.488 ± 0.081	2.544AspGln: 2.544 ± 0.063	6.429AspArg: 6.429 ± 0.116	5.168AspSer: 5.168 ± 0.103	5.326AspThr: 5.326 ± 0.092	6.215AspVal: 6.215 ± 0.105	0.999AspTrp: 0.999 ± 0.038	1.681AspTyr: 1.681 ± 0.055	0.012AspXaa: 0.012 ± 0.004
Glu	7.665GluAla: 7.665 ± 0.11	0.681GluCys: 0.681 ± 0.037	4.537GluAsp: 4.537 ± 0.109	5.065GluGlu: 5.065 ± 0.122	2.939GluPhe: 2.939 ± 0.063	4.523GluGly: 4.523 ± 0.078	1.573GluHis: 1.573 ± 0.042	3.784GluIle: 3.784 ± 0.082	1.646GluLys: 1.646 ± 0.064	6.948GluLeu: 6.948 ± 0.118	1.81GluMet: 1.81 ± 0.051	2.025GluAsn: 2.025 ± 0.058	3.594GluPro: 3.594 ± 0.077	3.214GluGln: 3.214 ± 0.069	5.455GluArg: 5.455 ± 0.093	5.766GluSer: 5.766 ± 0.105	7.064GluThr: 7.064 ± 0.102	5.119GluVal: 5.119 ± 0.088	1.032GluTrp: 1.032 ± 0.043	2.671GluTyr: 2.671 ± 0.079	0.005GluXaa: 0.005 ± 0.003
Phe	3.233PheAla: 3.233 ± 0.076	0.264PheCys: 0.264 ± 0.021	3.068PheAsp: 3.068 ± 0.064	2.739PheGlu: 2.739 ± 0.066	0.937PhePhe: 0.937 ± 0.042	3.102PheGly: 3.102 ± 0.079	0.674PheHis: 0.674 ± 0.031	1.132PheIle: 1.132 ± 0.044	0.493PheLys: 0.493 ± 0.028	2.637PheLeu: 2.637 ± 0.072	0.482PheMet: 0.482 ± 0.028	0.781PheAsn: 0.781 ± 0.034	1.247PhePro: 1.247 ± 0.045	0.967PheGln: 0.967 ± 0.037	1.859PheArg: 1.859 ± 0.054	1.861PheSer: 1.861 ± 0.048	1.956PheThr: 1.956 ± 0.051	2.713PheVal: 2.713 ± 0.071	0.384PheTrp: 0.384 ± 0.025	0.801PheTyr: 0.801 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.011GlyAla: 8.011 ± 0.135	0.788GlyCys: 0.788 ± 0.034	6.479GlyAsp: 6.479 ± 0.117	6.261GlyGlu: 6.261 ± 0.096	3.149GlyPhe: 3.149 ± 0.067	7.168GlyGly: 7.168 ± 0.136	1.788GlyHis: 1.788 ± 0.052	4.554GlyIle: 4.554 ± 0.081	1.794GlyLys: 1.794 ± 0.053	7.439GlyLeu: 7.439 ± 0.113	1.657GlyMet: 1.657 ± 0.047	2.046GlyAsn: 2.046 ± 0.056	3.515GlyPro: 3.515 ± 0.079	2.764GlyGln: 2.764 ± 0.063	5.021GlyArg: 5.021 ± 0.072	5.608GlySer: 5.608 ± 0.101	5.647GlyThr: 5.647 ± 0.098	7.419GlyVal: 7.419 ± 0.123	1.076GlyTrp: 1.076 ± 0.035	2.51GlyTyr: 2.51 ± 0.063	0.014GlyXaa: 0.014 ± 0.005
His	2.024HisAla: 2.024 ± 0.058	0.217HisCys: 0.217 ± 0.016	1.828HisAsp: 1.828 ± 0.054	1.676HisGlu: 1.676 ± 0.045	0.481HisPhe: 0.481 ± 0.022	2.09HisGly: 2.09 ± 0.053	0.567HisHis: 0.567 ± 0.03	0.753HisIle: 0.753 ± 0.035	0.37HisLys: 0.37 ± 0.022	1.669HisLeu: 1.669 ± 0.044	0.306HisMet: 0.306 ± 0.017	0.539HisAsn: 0.539 ± 0.036	1.29HisPro: 1.29 ± 0.047	0.693HisGln: 0.693 ± 0.026	1.462HisArg: 1.462 ± 0.044	1.274HisSer: 1.274 ± 0.044	1.344HisThr: 1.344 ± 0.044	1.691HisVal: 1.691 ± 0.052	0.283HisTrp: 0.283 ± 0.021	0.535HisTyr: 0.535 ± 0.025	0.004HisXaa: 0.004 ± 0.002
Ile	5.029IleAla: 5.029 ± 0.093	0.389IleCys: 0.389 ± 0.022	4.197IleAsp: 4.197 ± 0.084	4.047IleGlu: 4.047 ± 0.087	0.961IlePhe: 0.961 ± 0.036	4.193IleGly: 4.193 ± 0.081	0.935IleHis: 0.935 ± 0.036	1.672IleIle: 1.672 ± 0.052	0.818IleLys: 0.818 ± 0.035	3.223IleLeu: 3.223 ± 0.083	0.54IleMet: 0.54 ± 0.026	1.074IleAsn: 1.074 ± 0.039	2.385IlePro: 2.385 ± 0.06	1.504IleGln: 1.504 ± 0.039	2.892IleArg: 2.892 ± 0.064	2.671IleSer: 2.671 ± 0.057	2.788IleThr: 2.788 ± 0.069	3.673IleVal: 3.673 ± 0.07	0.296IleTrp: 0.296 ± 0.024	0.796IleTyr: 0.796 ± 0.031	0.003IleXaa: 0.003 ± 0.002
Lys	1.772LysAla: 1.772 ± 0.056	0.153LysCys: 0.153 ± 0.015	1.057LysAsp: 1.057 ± 0.037	1.218LysGlu: 1.218 ± 0.049	0.505LysPhe: 0.505 ± 0.025	1.225LysGly: 1.225 ± 0.043	0.485LysHis: 0.485 ± 0.023	0.837LysIle: 0.837 ± 0.04	0.516LysLys: 0.516 ± 0.036	1.722LysLeu: 1.722 ± 0.048	0.413LysMet: 0.413 ± 0.024	0.582LysAsn: 0.582 ± 0.033	1.093LysPro: 1.093 ± 0.041	1.079LysGln: 1.079 ± 0.043	1.672LysArg: 1.672 ± 0.052	1.359LysSer: 1.359 ± 0.05	1.549LysThr: 1.549 ± 0.046	1.093LysVal: 1.093 ± 0.043	0.206LysTrp: 0.206 ± 0.017	0.6LysTyr: 0.6 ± 0.029	0.001LysXaa: 0.001 ± 0.001
Leu	9.485LeuAla: 9.485 ± 0.133	0.693LeuCys: 0.693 ± 0.03	6.766LeuAsp: 6.766 ± 0.091	6.477LeuGlu: 6.477 ± 0.119	2.919LeuPhe: 2.919 ± 0.077	7.217LeuGly: 7.217 ± 0.11	1.489LeuHis: 1.489 ± 0.046	3.299LeuIle: 3.299 ± 0.065	1.75LeuLys: 1.75 ± 0.052	7.636LeuLeu: 7.636 ± 0.128	1.358LeuMet: 1.358 ± 0.051	2.092LeuAsn: 2.092 ± 0.054	3.938LeuPro: 3.938 ± 0.075	2.568LeuGln: 2.568 ± 0.06	5.45LeuArg: 5.45 ± 0.104	6.157LeuSer: 6.157 ± 0.085	5.468LeuThr: 5.468 ± 0.087	7.289LeuVal: 7.289 ± 0.13	0.827LeuTrp: 0.827 ± 0.034	2.078LeuTyr: 2.078 ± 0.05	0.014LeuXaa: 0.014 ± 0.004
Met	1.768MetAla: 1.768 ± 0.052	0.154MetCys: 0.154 ± 0.013	1.244MetAsp: 1.244 ± 0.038	1.075MetGlu: 1.075 ± 0.042	0.502MetPhe: 0.502 ± 0.029	1.458MetGly: 1.458 ± 0.05	0.315MetHis: 0.315 ± 0.021	0.815MetIle: 0.815 ± 0.037	0.502MetLys: 0.502 ± 0.026	1.408MetLeu: 1.408 ± 0.049	0.34MetMet: 0.34 ± 0.025	0.64MetAsn: 0.64 ± 0.03	0.734MetPro: 0.734 ± 0.032	0.548MetGln: 0.548 ± 0.029	1.128MetArg: 1.128 ± 0.042	1.687MetSer: 1.687 ± 0.043	1.545MetThr: 1.545 ± 0.046	1.236MetVal: 1.236 ± 0.042	0.181MetTrp: 0.181 ± 0.016	0.421MetTyr: 0.421 ± 0.024	0.003MetXaa: 0.003 ± 0.002
Asn	2.511AsnAla: 2.511 ± 0.06	0.261AsnCys: 0.261 ± 0.02	1.561AsnAsp: 1.561 ± 0.051	1.692AsnGlu: 1.692 ± 0.056	0.676AsnPhe: 0.676 ± 0.031	1.998AsnGly: 1.998 ± 0.057	0.695AsnHis: 0.695 ± 0.033	1.106AsnIle: 1.106 ± 0.044	0.516AsnLys: 0.516 ± 0.026	2.212AsnLeu: 2.212 ± 0.059	0.46AsnMet: 0.46 ± 0.023	0.689AsnAsn: 0.689 ± 0.036	1.841AsnPro: 1.841 ± 0.052	0.88AsnGln: 0.88 ± 0.036	1.926AsnArg: 1.926 ± 0.052	1.412AsnSer: 1.412 ± 0.05	1.684AsnThr: 1.684 ± 0.05	2.084AsnVal: 2.084 ± 0.055	0.338AsnTrp: 0.338 ± 0.024	0.605AsnTyr: 0.605 ± 0.028	0.001AsnXaa: 0.001 ± 0.001
Pro	5.151ProAla: 5.151 ± 0.084	0.291ProCys: 0.291 ± 0.02	4.885ProAsp: 4.885 ± 0.079	4.358ProGlu: 4.358 ± 0.07	1.424ProPhe: 1.424 ± 0.05	4.098ProGly: 4.098 ± 0.078	0.969ProHis: 0.969 ± 0.04	1.829ProIle: 1.829 ± 0.047	0.759ProLys: 0.759 ± 0.034	3.72ProLeu: 3.72 ± 0.071	0.841ProMet: 0.841 ± 0.034	1.144ProAsn: 1.144 ± 0.041	2.197ProPro: 2.197 ± 0.054	1.393ProGln: 1.393 ± 0.046	2.467ProArg: 2.467 ± 0.056	3.104ProSer: 3.104 ± 0.065	3.386ProThr: 3.386 ± 0.066	4.381ProVal: 4.381 ± 0.072	0.462ProTrp: 0.462 ± 0.024	0.999ProTyr: 0.999 ± 0.037	0.011ProXaa: 0.011 ± 0.004
Gln	3.016GlnAla: 3.016 ± 0.064	0.256GlnCys: 0.256 ± 0.019	1.765GlnAsp: 1.765 ± 0.048	2.2GlnGlu: 2.2 ± 0.064	1.286GlnPhe: 1.286 ± 0.041	1.937GlnGly: 1.937 ± 0.057	0.703GlnHis: 0.703 ± 0.034	1.709GlnIle: 1.709 ± 0.054	0.759GlnLys: 0.759 ± 0.038	3.251GlnLeu: 3.251 ± 0.077	0.751GlnMet: 0.751 ± 0.033	0.919GlnAsn: 0.919 ± 0.043	1.657GlnPro: 1.657 ± 0.053	1.596GlnGln: 1.596 ± 0.051	2.477GlnArg: 2.477 ± 0.064	2.422GlnSer: 2.422 ± 0.06	2.601GlnThr: 2.601 ± 0.058	2.31GlnVal: 2.31 ± 0.053	0.424GlnTrp: 0.424 ± 0.025	1.028GlnTyr: 1.028 ± 0.037	0.007GlnXaa: 0.007 ± 0.003
Arg	6.089ArgAla: 6.089 ± 0.093	0.552ArgCys: 0.552 ± 0.03	5.287ArgAsp: 5.287 ± 0.094	5.907ArgGlu: 5.907 ± 0.108	2.264ArgPhe: 2.264 ± 0.056	4.584ArgGly: 4.584 ± 0.082	1.382ArgHis: 1.382 ± 0.04	2.988ArgIle: 2.988 ± 0.06	1.447ArgLys: 1.447 ± 0.049	6.446ArgLeu: 6.446 ± 0.109	1.247ArgMet: 1.247 ± 0.04	1.629ArgAsn: 1.629 ± 0.044	2.793ArgPro: 2.793 ± 0.058	2.51ArgGln: 2.51 ± 0.065	5.043ArgArg: 5.043 ± 0.089	3.902ArgSer: 3.902 ± 0.072	3.703ArgThr: 3.703 ± 0.082	5.536ArgVal: 5.536 ± 0.088	0.747ArgTrp: 0.747 ± 0.034	1.817ArgTyr: 1.817 ± 0.049	0.015ArgXaa: 0.015 ± 0.005
Ser	6.107SerAla: 6.107 ± 0.106	0.508SerCys: 0.508 ± 0.026	5.107SerAsp: 5.107 ± 0.093	4.799SerGlu: 4.799 ± 0.096	2.01SerPhe: 2.01 ± 0.053	6.247SerGly: 6.247 ± 0.109	1.438SerHis: 1.438 ± 0.045	2.584SerIle: 2.584 ± 0.061	1.351SerLys: 1.351 ± 0.043	5.357SerLeu: 5.357 ± 0.094	1.152SerMet: 1.152 ± 0.042	1.688SerAsn: 1.688 ± 0.057	3.374SerPro: 3.374 ± 0.064	2.339SerGln: 2.339 ± 0.055	4.496SerArg: 4.496 ± 0.08	3.898SerSer: 3.898 ± 0.101	4.01SerThr: 4.01 ± 0.083	5.666SerVal: 5.666 ± 0.098	0.707SerTrp: 0.707 ± 0.038	1.522SerTyr: 1.522 ± 0.05	0.023SerXaa: 0.023 ± 0.005
Thr	7.768ThrAla: 7.768 ± 0.121	0.441ThrCys: 0.441 ± 0.026	6.153ThrAsp: 6.153 ± 0.101	4.95ThrGlu: 4.95 ± 0.083	1.914ThrPhe: 1.914 ± 0.054	6.498ThrGly: 6.498 ± 0.111	1.538ThrHis: 1.538 ± 0.053	3.098ThrIle: 3.098 ± 0.061	1.023ThrLys: 1.023 ± 0.033	5.945ThrLeu: 5.945 ± 0.096	1.04ThrMet: 1.04 ± 0.038	1.561ThrAsn: 1.561 ± 0.049	3.781ThrPro: 3.781 ± 0.084	1.958ThrGln: 1.958 ± 0.058	4.036ThrArg: 4.036 ± 0.081	3.611ThrSer: 3.611 ± 0.072	4.694ThrThr: 4.694 ± 0.092	7.255ThrVal: 7.255 ± 0.127	0.573ThrTrp: 0.573 ± 0.028	1.484ThrTyr: 1.484 ± 0.05	0.008ThrXaa: 0.008 ± 0.003
Val	9.091ValAla: 9.091 ± 0.14	0.796ValCys: 0.796 ± 0.031	6.573ValAsp: 6.573 ± 0.093	6.658ValGlu: 6.658 ± 0.132	2.839ValPhe: 2.839 ± 0.07	7.455ValGly: 7.455 ± 0.132	1.585ValHis: 1.585 ± 0.045	3.862ValIle: 3.862 ± 0.079	1.438ValLys: 1.438 ± 0.044	6.332ValLeu: 6.332 ± 0.112	1.401ValMet: 1.401 ± 0.048	2.22ValAsn: 2.22 ± 0.055	3.804ValPro: 3.804 ± 0.072	2.228ValGln: 2.228 ± 0.052	4.897ValArg: 4.897 ± 0.088	6.085ValSer: 6.085 ± 0.093	6.865ValThr: 6.865 ± 0.105	7.864ValVal: 7.864 ± 0.14	0.827ValTrp: 0.827 ± 0.035	2.002ValTyr: 2.002 ± 0.052	0.009ValXaa: 0.009 ± 0.003
Trp	0.922TrpAla: 0.922 ± 0.035	0.095TrpCys: 0.095 ± 0.012	0.788TrpAsp: 0.788 ± 0.033	0.792TrpGlu: 0.792 ± 0.03	0.395TrpPhe: 0.395 ± 0.024	0.751TrpGly: 0.751 ± 0.028	0.248TrpHis: 0.248 ± 0.02	0.462TrpIle: 0.462 ± 0.025	0.309TrpLys: 0.309 ± 0.021	1.139TrpLeu: 1.139 ± 0.048	0.237TrpMet: 0.237 ± 0.017	0.372TrpAsn: 0.372 ± 0.023	0.452TrpPro: 0.452 ± 0.024	0.429TrpGln: 0.429 ± 0.026	0.785TrpArg: 0.785 ± 0.035	0.64TrpSer: 0.64 ± 0.032	0.741TrpThr: 0.741 ± 0.032	0.826TrpVal: 0.826 ± 0.033	0.191TrpTrp: 0.191 ± 0.017	0.359TrpTyr: 0.359 ± 0.024	0.003TrpXaa: 0.003 ± 0.002
Tyr	2.407TyrAla: 2.407 ± 0.06	0.248TyrCys: 0.248 ± 0.02	2.396TyrAsp: 2.396 ± 0.065	2.097TyrGlu: 2.097 ± 0.06	0.732TyrPhe: 0.732 ± 0.033	2.054TyrGly: 2.054 ± 0.056	0.642TyrHis: 0.642 ± 0.029	0.799TyrIle: 0.799 ± 0.033	0.454TyrLys: 0.454 ± 0.023	2.387TyrLeu: 2.387 ± 0.057	0.391TyrMet: 0.391 ± 0.024	0.674TyrAsn: 0.674 ± 0.032	1.251TyrPro: 1.251 ± 0.037	0.892TyrGln: 0.892 ± 0.036	1.832TyrArg: 1.832 ± 0.048	1.407TyrSer: 1.407 ± 0.052	1.551TyrThr: 1.551 ± 0.049	1.901TyrVal: 1.901 ± 0.055	0.29TyrTrp: 0.29 ± 0.017	0.666TyrTyr: 0.666 ± 0.033	0.004TyrXaa: 0.004 ± 0.002
Xaa	0.011XaaAla: 0.011 ± 0.004	0.007XaaCys: 0.007 ± 0.003	0.005XaaAsp: 0.005 ± 0.003	0.009XaaGlu: 0.009 ± 0.004	0.005XaaPhe: 0.005 ± 0.003	0.019XaaGly: 0.019 ± 0.005	0.003XaaHis: 0.003 ± 0.002	0.003XaaIle: 0.003 ± 0.002	0.001XaaLys: 0.001 ± 0.001	0.019XaaLeu: 0.019 ± 0.005	0.001XaaMet: 0.001 ± 0.001	0.004XaaAsn: 0.004 ± 0.002	0.011XaaPro: 0.011 ± 0.004	0.003XaaGln: 0.003 ± 0.002	0.018XaaArg: 0.018 ± 0.005	0.011XaaSer: 0.011 ± 0.004	0.009XaaThr: 0.009 ± 0.004	0.008XaaVal: 0.008 ± 0.003	0.004XaaTrp: 0.004 ± 0.002	0.004XaaTyr: 0.004 ± 0.002	0.972XaaXaa: 0.972 ± 0.09

Statistics based on 2853 proteins (738654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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