Amino acid dipepetide frequency for Candidatus Nitrosoglobus terrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.015AlaAla: 8.015 ± 0.158
0.999AlaCys: 0.999 ± 0.043
3.866AlaAsp: 3.866 ± 0.083
4.957AlaGlu: 4.957 ± 0.103
3.115AlaPhe: 3.115 ± 0.076
6.046AlaGly: 6.046 ± 0.114
2.063AlaHis: 2.063 ± 0.069
6.769AlaIle: 6.769 ± 0.114
4.16AlaLys: 4.16 ± 0.097
10.035AlaLeu: 10.035 ± 0.134
2.037AlaMet: 2.037 ± 0.067
3.137AlaAsn: 3.137 ± 0.091
2.807AlaPro: 2.807 ± 0.071
4.19AlaGln: 4.19 ± 0.082
4.711AlaArg: 4.711 ± 0.099
4.349AlaSer: 4.349 ± 0.09
4.433AlaThr: 4.433 ± 0.097
5.553AlaVal: 5.553 ± 0.107
1.159AlaTrp: 1.159 ± 0.045
2.66AlaTyr: 2.66 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.811CysAla: 0.811 ± 0.039
0.155CysCys: 0.155 ± 0.019
0.432CysAsp: 0.432 ± 0.027
0.458CysGlu: 0.458 ± 0.027
0.439CysPhe: 0.439 ± 0.025
0.835CysGly: 0.835 ± 0.043
0.369CysHis: 0.369 ± 0.027
0.644CysIle: 0.644 ± 0.034
0.353CysLys: 0.353 ± 0.024
1.146CysLeu: 1.146 ± 0.042
0.178CysMet: 0.178 ± 0.018
0.374CysAsn: 0.374 ± 0.026
0.541CysPro: 0.541 ± 0.035
0.56CysGln: 0.56 ± 0.033
0.553CysArg: 0.553 ± 0.03
0.644CysSer: 0.644 ± 0.035
0.569CysThr: 0.569 ± 0.036
0.562CysVal: 0.562 ± 0.033
0.125CysTrp: 0.125 ± 0.015
0.401CysTyr: 0.401 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.896AspAla: 2.896 ± 0.068
0.464AspCys: 0.464 ± 0.029
1.894AspAsp: 1.894 ± 0.058
2.805AspGlu: 2.805 ± 0.076
2.131AspPhe: 2.131 ± 0.064
2.821AspGly: 2.821 ± 0.095
1.194AspHis: 1.194 ± 0.051
3.62AspIle: 3.62 ± 0.074
2.536AspLys: 2.536 ± 0.066
5.57AspLeu: 5.57 ± 0.111
0.936AspMet: 0.936 ± 0.042
1.902AspAsn: 1.902 ± 0.063
2.787AspPro: 2.787 ± 0.068
2.297AspGln: 2.297 ± 0.059
2.968AspArg: 2.968 ± 0.073
2.911AspSer: 2.911 ± 0.066
2.45AspThr: 2.45 ± 0.079
2.491AspVal: 2.491 ± 0.068
0.755AspTrp: 0.755 ± 0.035
1.914AspTyr: 1.914 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.609GluAla: 5.609 ± 0.127
0.451GluCys: 0.451 ± 0.032
2.647GluAsp: 2.647 ± 0.07
3.89GluGlu: 3.89 ± 0.111
2.046GluPhe: 2.046 ± 0.063
4.119GluGly: 4.119 ± 0.084
1.303GluHis: 1.303 ± 0.047
5.157GluIle: 5.157 ± 0.108
3.442GluLys: 3.442 ± 0.102
5.674GluLeu: 5.674 ± 0.109
1.419GluMet: 1.419 ± 0.05
2.561GluAsn: 2.561 ± 0.081
1.755GluPro: 1.755 ± 0.05
3.231GluGln: 3.231 ± 0.098
3.704GluArg: 3.704 ± 0.087
3.425GluSer: 3.425 ± 0.08
2.99GluThr: 2.99 ± 0.063
3.938GluVal: 3.938 ± 0.089
0.688GluTrp: 0.688 ± 0.033
1.605GluTyr: 1.605 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.846PheAla: 2.846 ± 0.083
0.492PheCys: 0.492 ± 0.028
2.088PheAsp: 2.088 ± 0.064
2.073PheGlu: 2.073 ± 0.061
1.88PhePhe: 1.88 ± 0.079
2.918PheGly: 2.918 ± 0.083
0.999PheHis: 0.999 ± 0.043
3.075PheIle: 3.075 ± 0.073
1.69PheLys: 1.69 ± 0.056
4.059PheLeu: 4.059 ± 0.109
0.934PheMet: 0.934 ± 0.041
1.907PheAsn: 1.907 ± 0.059
1.781PhePro: 1.781 ± 0.054
1.496PheGln: 1.496 ± 0.052
1.933PheArg: 1.933 ± 0.066
3.104PheSer: 3.104 ± 0.075
2.442PheThr: 2.442 ± 0.065
1.926PheVal: 1.926 ± 0.062
0.517PheTrp: 0.517 ± 0.032
1.468PheTyr: 1.468 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
5.45GlyAla: 5.45 ± 0.112
0.859GlyCys: 0.859 ± 0.036
3.311GlyAsp: 3.311 ± 0.081
4.064GlyGlu: 4.064 ± 0.078
3.285GlyPhe: 3.285 ± 0.087
5.469GlyGly: 5.469 ± 0.18
1.692GlyHis: 1.692 ± 0.056
5.8GlyIle: 5.8 ± 0.121
3.871GlyLys: 3.871 ± 0.097
7.764GlyLeu: 7.764 ± 0.146
1.728GlyMet: 1.728 ± 0.074
2.618GlyAsn: 2.618 ± 0.085
1.906GlyPro: 1.906 ± 0.064
2.942GlyGln: 2.942 ± 0.079
3.857GlyArg: 3.857 ± 0.095
4.356GlySer: 4.356 ± 0.095
3.76GlyThr: 3.76 ± 0.111
5.071GlyVal: 5.071 ± 0.116
1.098GlyTrp: 1.098 ± 0.047
2.662GlyTyr: 2.662 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.624HisAla: 1.624 ± 0.053
0.362HisCys: 0.362 ± 0.024
0.966HisAsp: 0.966 ± 0.046
1.122HisGlu: 1.122 ± 0.045
1.043HisPhe: 1.043 ± 0.04
1.713HisGly: 1.713 ± 0.055
0.849HisHis: 0.849 ± 0.044
1.622HisIle: 1.622 ± 0.056
0.944HisLys: 0.944 ± 0.045
2.749HisLeu: 2.749 ± 0.071
0.451HisMet: 0.451 ± 0.032
0.896HisAsn: 0.896 ± 0.041
1.55HisPro: 1.55 ± 0.052
1.277HisGln: 1.277 ± 0.045
1.537HisArg: 1.537 ± 0.053
1.344HisSer: 1.344 ± 0.05
1.217HisThr: 1.217 ± 0.05
1.081HisVal: 1.081 ± 0.042
0.454HisTrp: 0.454 ± 0.025
1.059HisTyr: 1.059 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.938IleAla: 6.938 ± 0.118
0.779IleCys: 0.779 ± 0.039
3.994IleAsp: 3.994 ± 0.079
4.72IleGlu: 4.72 ± 0.123
2.72IlePhe: 2.72 ± 0.08
5.387IleGly: 5.387 ± 0.102
1.762IleHis: 1.762 ± 0.057
5.288IleIle: 5.288 ± 0.113
3.791IleLys: 3.791 ± 0.078
7.365IleLeu: 7.365 ± 0.131
1.393IleMet: 1.393 ± 0.049
3.207IleAsn: 3.207 ± 0.089
3.71IlePro: 3.71 ± 0.083
2.954IleGln: 2.954 ± 0.075
3.774IleArg: 3.774 ± 0.077
4.721IleSer: 4.721 ± 0.091
4.53IleThr: 4.53 ± 0.09
4.216IleVal: 4.216 ± 0.087
0.804IleTrp: 0.804 ± 0.038
2.266IleTyr: 2.266 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
4.342LysAla: 4.342 ± 0.094
0.292LysCys: 0.292 ± 0.02
2.428LysAsp: 2.428 ± 0.073
3.451LysGlu: 3.451 ± 0.093
1.388LysPhe: 1.388 ± 0.049
3.104LysGly: 3.104 ± 0.087
1.028LysHis: 1.028 ± 0.039
4.019LysIle: 4.019 ± 0.08
2.713LysLys: 2.713 ± 0.08
4.788LysLeu: 4.788 ± 0.097
1.086LysMet: 1.086 ± 0.044
2.092LysAsn: 2.092 ± 0.059
2.013LysPro: 2.013 ± 0.062
2.216LysGln: 2.216 ± 0.066
2.814LysArg: 2.814 ± 0.07
2.589LysSer: 2.589 ± 0.074
2.739LysThr: 2.739 ± 0.068
2.983LysVal: 2.983 ± 0.078
0.488LysTrp: 0.488 ± 0.03
1.294LysTyr: 1.294 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
10.798LeuAla: 10.798 ± 0.177
1.023LeuCys: 1.023 ± 0.043
5.404LeuAsp: 5.404 ± 0.111
6.813LeuGlu: 6.813 ± 0.133
4.243LeuPhe: 4.243 ± 0.109
8.217LeuGly: 8.217 ± 0.142
2.303LeuHis: 2.303 ± 0.062
7.658LeuIle: 7.658 ± 0.13
5.507LeuLys: 5.507 ± 0.11
11.949LeuLeu: 11.949 ± 0.183
2.268LeuMet: 2.268 ± 0.062
4.228LeuAsn: 4.228 ± 0.093
5.589LeuPro: 5.589 ± 0.096
4.783LeuGln: 4.783 ± 0.104
6.009LeuArg: 6.009 ± 0.103
7.414LeuSer: 7.414 ± 0.115
5.841LeuThr: 5.841 ± 0.099
6.456LeuVal: 6.456 ± 0.111
1.381LeuTrp: 1.381 ± 0.06
2.976LeuTyr: 2.976 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.102MetAla: 2.102 ± 0.061
0.133MetCys: 0.133 ± 0.016
1.079MetAsp: 1.079 ± 0.04
1.351MetGlu: 1.351 ± 0.054
0.594MetPhe: 0.594 ± 0.035
1.776MetGly: 1.776 ± 0.063
0.396MetHis: 0.396 ± 0.023
1.542MetIle: 1.542 ± 0.052
1.122MetLys: 1.122 ± 0.043
2.232MetLeu: 2.232 ± 0.059
0.565MetMet: 0.565 ± 0.034
0.949MetAsn: 0.949 ± 0.041
1.04MetPro: 1.04 ± 0.042
0.804MetGln: 0.804 ± 0.041
1.217MetArg: 1.217 ± 0.042
1.359MetSer: 1.359 ± 0.045
1.158MetThr: 1.158 ± 0.044
1.562MetVal: 1.562 ± 0.053
0.135MetTrp: 0.135 ± 0.015
0.441MetTyr: 0.441 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.785AsnAla: 2.785 ± 0.071
0.389AsnCys: 0.389 ± 0.029
1.634AsnAsp: 1.634 ± 0.05
2.006AsnGlu: 2.006 ± 0.058
1.721AsnPhe: 1.721 ± 0.062
2.525AsnGly: 2.525 ± 0.074
1.062AsnHis: 1.062 ± 0.038
3.01AsnIle: 3.01 ± 0.067
1.967AsnLys: 1.967 ± 0.062
4.46AsnLeu: 4.46 ± 0.089
0.828AsnMet: 0.828 ± 0.038
1.834AsnAsn: 1.834 ± 0.075
2.537AsnPro: 2.537 ± 0.066
1.994AsnGln: 1.994 ± 0.061
2.196AsnArg: 2.196 ± 0.062
2.297AsnSer: 2.297 ± 0.062
2.297AsnThr: 2.297 ± 0.066
1.936AsnVal: 1.936 ± 0.061
0.555AsnTrp: 0.555 ± 0.031
1.371AsnTyr: 1.371 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
3.251ProAla: 3.251 ± 0.08
0.394ProCys: 0.394 ± 0.027
2.553ProAsp: 2.553 ± 0.068
3.287ProGlu: 3.287 ± 0.078
1.762ProPhe: 1.762 ± 0.051
2.734ProGly: 2.734 ± 0.079
1.033ProHis: 1.033 ± 0.033
3.207ProIle: 3.207 ± 0.077
2.092ProLys: 2.092 ± 0.063
4.848ProLeu: 4.848 ± 0.086
0.953ProMet: 0.953 ± 0.04
1.976ProAsn: 1.976 ± 0.061
1.931ProPro: 1.931 ± 0.071
2.138ProGln: 2.138 ± 0.062
2.07ProArg: 2.07 ± 0.064
2.829ProSer: 2.829 ± 0.068
2.37ProThr: 2.37 ± 0.074
3.074ProVal: 3.074 ± 0.086
0.622ProTrp: 0.622 ± 0.032
1.535ProTyr: 1.535 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
4.803GlnAla: 4.803 ± 0.106
0.386GlnCys: 0.386 ± 0.024
1.959GlnAsp: 1.959 ± 0.062
2.925GlnGlu: 2.925 ± 0.079
1.523GlnPhe: 1.523 ± 0.053
3.441GlnGly: 3.441 ± 0.078
1.062GlnHis: 1.062 ± 0.04
3.364GlnIle: 3.364 ± 0.08
2.027GlnLys: 2.027 ± 0.071
5.222GlnLeu: 5.222 ± 0.109
0.919GlnMet: 0.919 ± 0.035
1.61GlnAsn: 1.61 ± 0.054
1.912GlnPro: 1.912 ± 0.061
3.101GlnGln: 3.101 ± 0.101
3.012GlnArg: 3.012 ± 0.087
2.372GlnSer: 2.372 ± 0.069
2.085GlnThr: 2.085 ± 0.059
3.422GlnVal: 3.422 ± 0.091
0.659GlnTrp: 0.659 ± 0.035
1.337GlnTyr: 1.337 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
4.298ArgAla: 4.298 ± 0.085
0.632ArgCys: 0.632 ± 0.036
2.664ArgAsp: 2.664 ± 0.074
3.567ArgGlu: 3.567 ± 0.08
2.566ArgPhe: 2.566 ± 0.058
3.383ArgGly: 3.383 ± 0.068
1.32ArgHis: 1.32 ± 0.053
4.031ArgIle: 4.031 ± 0.093
2.493ArgLys: 2.493 ± 0.06
6.717ArgLeu: 6.717 ± 0.114
1.192ArgMet: 1.192 ± 0.044
2.025ArgAsn: 2.025 ± 0.063
2.162ArgPro: 2.162 ± 0.057
2.87ArgGln: 2.87 ± 0.09
3.406ArgArg: 3.406 ± 0.084
3.273ArgSer: 3.273 ± 0.079
2.3ArgThr: 2.3 ± 0.063
3.683ArgVal: 3.683 ± 0.085
0.874ArgTrp: 0.874 ± 0.037
2.418ArgTyr: 2.418 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
4.854SerAla: 4.854 ± 0.09
0.652SerCys: 0.652 ± 0.036
2.626SerAsp: 2.626 ± 0.075
3.214SerGlu: 3.214 ± 0.081
2.614SerPhe: 2.614 ± 0.069
4.904SerGly: 4.904 ± 0.116
1.489SerHis: 1.489 ± 0.048
4.043SerIle: 4.043 ± 0.097
2.807SerLys: 2.807 ± 0.078
7.013SerLeu: 7.013 ± 0.111
1.376SerMet: 1.376 ± 0.053
2.346SerAsn: 2.346 ± 0.067
2.785SerPro: 2.785 ± 0.077
2.809SerGln: 2.809 ± 0.073
3.149SerArg: 3.149 ± 0.075
4.054SerSer: 4.054 ± 0.109
3.205SerThr: 3.205 ± 0.082
3.545SerVal: 3.545 ± 0.089
0.878SerTrp: 0.878 ± 0.042
1.996SerTyr: 1.996 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
4.723ThrAla: 4.723 ± 0.086
0.495ThrCys: 0.495 ± 0.032
2.455ThrAsp: 2.455 ± 0.067
2.86ThrGlu: 2.86 ± 0.068
1.877ThrPhe: 1.877 ± 0.057
4.393ThrGly: 4.393 ± 0.114
1.489ThrHis: 1.489 ± 0.052
3.622ThrIle: 3.622 ± 0.081
1.885ThrLys: 1.885 ± 0.055
6.775ThrLeu: 6.775 ± 0.125
0.987ThrMet: 0.987 ± 0.04
1.648ThrAsn: 1.648 ± 0.055
2.925ThrPro: 2.925 ± 0.074
2.462ThrGln: 2.462 ± 0.07
2.59ThrArg: 2.59 ± 0.066
2.928ThrSer: 2.928 ± 0.075
2.91ThrThr: 2.91 ± 0.078
3.637ThrVal: 3.637 ± 0.072
0.692ThrTrp: 0.692 ± 0.039
1.597ThrTyr: 1.597 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
5.736ValAla: 5.736 ± 0.096
0.604ValCys: 0.604 ± 0.03
3.307ValAsp: 3.307 ± 0.07
3.728ValGlu: 3.728 ± 0.092
2.572ValPhe: 2.572 ± 0.067
4.462ValGly: 4.462 ± 0.107
1.233ValHis: 1.233 ± 0.043
4.972ValIle: 4.972 ± 0.092
2.7ValLys: 2.7 ± 0.069
6.724ValLeu: 6.724 ± 0.131
1.46ValMet: 1.46 ± 0.052
2.471ValAsn: 2.471 ± 0.076
2.657ValPro: 2.657 ± 0.07
2.146ValGln: 2.146 ± 0.065
3.255ValArg: 3.255 ± 0.082
3.688ValSer: 3.688 ± 0.077
3.538ValThr: 3.538 ± 0.08
4.277ValVal: 4.277 ± 0.095
0.715ValTrp: 0.715 ± 0.035
1.716ValTyr: 1.716 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.954TrpAla: 0.954 ± 0.049
0.15TrpCys: 0.15 ± 0.016
0.579TrpAsp: 0.579 ± 0.032
0.775TrpGlu: 0.775 ± 0.036
0.56TrpPhe: 0.56 ± 0.034
0.891TrpGly: 0.891 ± 0.045
0.328TrpHis: 0.328 ± 0.025
0.949TrpIle: 0.949 ± 0.042
0.521TrpLys: 0.521 ± 0.028
1.83TrpLeu: 1.83 ± 0.062
0.266TrpMet: 0.266 ± 0.023
0.463TrpAsn: 0.463 ± 0.031
0.565TrpPro: 0.565 ± 0.034
0.787TrpGln: 0.787 ± 0.039
0.9TrpArg: 0.9 ± 0.045
0.726TrpSer: 0.726 ± 0.037
0.471TrpThr: 0.471 ± 0.029
0.951TrpVal: 0.951 ± 0.043
0.248TrpTrp: 0.248 ± 0.022
0.446TrpTyr: 0.446 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.223TyrAla: 2.223 ± 0.066
0.435TyrCys: 0.435 ± 0.03
1.455TyrAsp: 1.455 ± 0.052
1.588TyrGlu: 1.588 ± 0.056
1.55TyrPhe: 1.55 ± 0.052
2.426TyrGly: 2.426 ± 0.058
0.89TyrHis: 0.89 ± 0.039
1.924TyrIle: 1.924 ± 0.056
1.248TyrLys: 1.248 ± 0.042
3.941TyrLeu: 3.941 ± 0.088
0.581TyrMet: 0.581 ± 0.034
1.163TyrAsn: 1.163 ± 0.051
1.702TyrPro: 1.702 ± 0.057
2.081TyrGln: 2.081 ± 0.074
2.221TyrArg: 2.221 ± 0.059
1.976TyrSer: 1.976 ± 0.058
1.646TyrThr: 1.646 ± 0.065
1.597TyrVal: 1.597 ± 0.05
0.514TyrTrp: 0.514 ± 0.032
1.272TyrTyr: 1.272 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1841 proteins (585648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski