Amino acid dipepetide frequency for Paracoccus thiocyanatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.788AlaAla: 19.788 ± 0.22	1.12AlaCys: 1.12 ± 0.043	7.032AlaAsp: 7.032 ± 0.087	8.953AlaGlu: 8.953 ± 0.097	4.04AlaPhe: 4.04 ± 0.072	12.587AlaGly: 12.587 ± 0.115	2.475AlaHis: 2.475 ± 0.054	6.133AlaIle: 6.133 ± 0.087	3.144AlaLys: 3.144 ± 0.067	15.094AlaLeu: 15.094 ± 0.17	4.273AlaMet: 4.273 ± 0.078	2.501AlaAsn: 2.501 ± 0.05	6.573AlaPro: 6.573 ± 0.076	5.547AlaGln: 5.547 ± 0.087	10.826AlaArg: 10.826 ± 0.133	5.478AlaSer: 5.478 ± 0.086	5.812AlaThr: 5.812 ± 0.08	8.796AlaVal: 8.796 ± 0.108	1.645AlaTrp: 1.645 ± 0.046	2.381AlaTyr: 2.381 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.084CysAla: 1.084 ± 0.035	0.129CysCys: 0.129 ± 0.012	0.572CysAsp: 0.572 ± 0.025	0.409CysGlu: 0.409 ± 0.022	0.316CysPhe: 0.316 ± 0.02	0.994CysGly: 0.994 ± 0.038	0.287CysHis: 0.287 ± 0.02	0.386CysIle: 0.386 ± 0.018	0.201CysLys: 0.201 ± 0.015	0.794CysLeu: 0.794 ± 0.028	0.159CysMet: 0.159 ± 0.013	0.186CysAsn: 0.186 ± 0.014	0.506CysPro: 0.506 ± 0.024	0.231CysGln: 0.231 ± 0.015	0.652CysArg: 0.652 ± 0.026	0.44CysSer: 0.44 ± 0.022	0.397CysThr: 0.397 ± 0.022	0.465CysVal: 0.465 ± 0.025	0.141CysTrp: 0.141 ± 0.012	0.201CysTyr: 0.201 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.253AspAla: 7.253 ± 0.105	0.483AspCys: 0.483 ± 0.024	3.073AspAsp: 3.073 ± 0.072	3.473AspGlu: 3.473 ± 0.065	2.273AspPhe: 2.273 ± 0.049	5.372AspGly: 5.372 ± 0.086	1.408AspHis: 1.408 ± 0.037	2.729AspIle: 2.729 ± 0.052	1.478AspLys: 1.478 ± 0.05	6.385AspLeu: 6.385 ± 0.097	1.572AspMet: 1.572 ± 0.037	1.075AspAsn: 1.075 ± 0.035	3.977AspPro: 3.977 ± 0.079	1.991AspGln: 1.991 ± 0.049	4.798AspArg: 4.798 ± 0.074	2.19AspSer: 2.19 ± 0.059	2.269AspThr: 2.269 ± 0.055	3.352AspVal: 3.352 ± 0.057	1.259AspTrp: 1.259 ± 0.037	1.584AspTyr: 1.584 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.418GluAla: 7.418 ± 0.101	0.364GluCys: 0.364 ± 0.017	2.804GluAsp: 2.804 ± 0.054	2.791GluGlu: 2.791 ± 0.063	1.726GluPhe: 1.726 ± 0.044	4.45GluGly: 4.45 ± 0.078	1.061GluHis: 1.061 ± 0.033	3.468GluIle: 3.468 ± 0.058	1.773GluLys: 1.773 ± 0.043	5.3GluLeu: 5.3 ± 0.08	1.684GluMet: 1.684 ± 0.039	1.463GluAsn: 1.463 ± 0.043	2.742GluPro: 2.742 ± 0.051	2.004GluGln: 2.004 ± 0.051	4.533GluArg: 4.533 ± 0.068	2.359GluSer: 2.359 ± 0.053	3.204GluThr: 3.204 ± 0.06	3.781GluVal: 3.781 ± 0.07	0.757GluTrp: 0.757 ± 0.031	1.048GluTyr: 1.048 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.592PheAla: 4.592 ± 0.084	0.394PheCys: 0.394 ± 0.018	2.594PheAsp: 2.594 ± 0.063	1.727PheGlu: 1.727 ± 0.041	1.278PhePhe: 1.278 ± 0.037	3.662PheGly: 3.662 ± 0.067	0.817PheHis: 0.817 ± 0.03	1.525PheIle: 1.525 ± 0.044	0.713PheLys: 0.713 ± 0.026	3.481PheLeu: 3.481 ± 0.065	0.81PheMet: 0.81 ± 0.029	0.835PheAsn: 0.835 ± 0.029	1.583PhePro: 1.583 ± 0.037	1.06PheGln: 1.06 ± 0.036	2.339PheArg: 2.339 ± 0.054	1.954PheSer: 1.954 ± 0.047	1.829PheThr: 1.829 ± 0.047	2.528PheVal: 2.528 ± 0.058	0.568PheTrp: 0.568 ± 0.032	0.799PheTyr: 0.799 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.763GlyAla: 10.763 ± 0.107	0.862GlyCys: 0.862 ± 0.031	4.778GlyAsp: 4.778 ± 0.087	4.555GlyGlu: 4.555 ± 0.071	3.866GlyPhe: 3.866 ± 0.057	7.898GlyGly: 7.898 ± 0.122	2.102GlyHis: 2.102 ± 0.051	4.759GlyIle: 4.759 ± 0.072	3.011GlyLys: 3.011 ± 0.058	9.953GlyLeu: 9.953 ± 0.111	2.902GlyMet: 2.902 ± 0.054	2.146GlyAsn: 2.146 ± 0.069	4.209GlyPro: 4.209 ± 0.064	3.561GlyGln: 3.561 ± 0.062	7.25GlyArg: 7.25 ± 0.094	4.056GlySer: 4.056 ± 0.071	4.391GlyThr: 4.391 ± 0.075	6.31GlyVal: 6.31 ± 0.085	1.735GlyTrp: 1.735 ± 0.045	2.239GlyTyr: 2.239 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.455HisAla: 2.455 ± 0.048	0.206HisCys: 0.206 ± 0.014	1.388HisAsp: 1.388 ± 0.041	1.082HisGlu: 1.082 ± 0.035	0.809HisPhe: 0.809 ± 0.031	2.169HisGly: 2.169 ± 0.049	0.565HisHis: 0.565 ± 0.03	0.894HisIle: 0.894 ± 0.029	0.449HisLys: 0.449 ± 0.023	2.223HisLeu: 2.223 ± 0.051	0.573HisMet: 0.573 ± 0.026	0.408HisAsn: 0.408 ± 0.021	1.557HisPro: 1.557 ± 0.045	0.6HisGln: 0.6 ± 0.025	1.523HisArg: 1.523 ± 0.045	0.897HisSer: 0.897 ± 0.032	0.646HisThr: 0.646 ± 0.028	1.619HisVal: 1.619 ± 0.04	0.357HisTrp: 0.357 ± 0.018	0.568HisTyr: 0.568 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.372IleAla: 7.372 ± 0.095	0.617IleCys: 0.617 ± 0.025	3.281IleAsp: 3.281 ± 0.063	3.224IleGlu: 3.224 ± 0.061	1.63IlePhe: 1.63 ± 0.042	4.941IleGly: 4.941 ± 0.082	1.005IleHis: 1.005 ± 0.033	1.92IleIle: 1.92 ± 0.049	1.062IleLys: 1.062 ± 0.036	4.826IleLeu: 4.826 ± 0.081	1.073IleMet: 1.073 ± 0.035	1.124IleAsn: 1.124 ± 0.041	2.312IlePro: 2.312 ± 0.048	1.206IleGln: 1.206 ± 0.032	3.831IleArg: 3.831 ± 0.069	2.633IleSer: 2.633 ± 0.05	2.573IleThr: 2.573 ± 0.05	3.597IleVal: 3.597 ± 0.058	0.734IleTrp: 0.734 ± 0.03	0.986IleTyr: 0.986 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.477LysAla: 3.477 ± 0.069	0.145LysCys: 0.145 ± 0.012	1.419LysAsp: 1.419 ± 0.041	1.186LysGlu: 1.186 ± 0.039	0.759LysPhe: 0.759 ± 0.029	2.396LysGly: 2.396 ± 0.06	0.495LysHis: 0.495 ± 0.025	1.311LysIle: 1.311 ± 0.036	0.835LysLys: 0.835 ± 0.037	2.606LysLeu: 2.606 ± 0.05	0.675LysMet: 0.675 ± 0.027	0.602LysAsn: 0.602 ± 0.032	1.704LysPro: 1.704 ± 0.045	0.789LysGln: 0.789 ± 0.03	1.848LysArg: 1.848 ± 0.04	1.465LysSer: 1.465 ± 0.043	1.488LysThr: 1.488 ± 0.038	1.95LysVal: 1.95 ± 0.047	0.341LysTrp: 0.341 ± 0.019	0.523LysTyr: 0.523 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.854LeuAla: 15.854 ± 0.168	0.903LeuCys: 0.903 ± 0.031	6.342LeuAsp: 6.342 ± 0.1	4.806LeuGlu: 4.806 ± 0.071	3.283LeuPhe: 3.283 ± 0.072	9.227LeuGly: 9.227 ± 0.118	1.998LeuHis: 1.998 ± 0.044	5.063LeuIle: 5.063 ± 0.072	2.72LeuLys: 2.72 ± 0.061	9.33LeuLeu: 9.33 ± 0.138	2.711LeuMet: 2.711 ± 0.059	2.433LeuAsn: 2.433 ± 0.051	6.186LeuPro: 6.186 ± 0.082	2.493LeuGln: 2.493 ± 0.053	8.243LeuArg: 8.243 ± 0.112	5.891LeuSer: 5.891 ± 0.09	5.581LeuThr: 5.581 ± 0.076	7.539LeuVal: 7.539 ± 0.099	1.342LeuTrp: 1.342 ± 0.04	1.895LeuTyr: 1.895 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	4.035MetAla: 4.035 ± 0.066	0.138MetCys: 0.138 ± 0.013	1.401MetAsp: 1.401 ± 0.043	1.199MetGlu: 1.199 ± 0.039	0.791MetPhe: 0.791 ± 0.029	2.315MetGly: 2.315 ± 0.055	0.415MetHis: 0.415 ± 0.021	1.549MetIle: 1.549 ± 0.05	0.888MetLys: 0.888 ± 0.027	2.823MetLeu: 2.823 ± 0.06	0.71MetMet: 0.71 ± 0.031	0.775MetAsn: 0.775 ± 0.028	1.675MetPro: 1.675 ± 0.037	1.066MetGln: 1.066 ± 0.033	2.181MetArg: 2.181 ± 0.046	1.499MetSer: 1.499 ± 0.041	2.029MetThr: 2.029 ± 0.045	1.866MetVal: 1.866 ± 0.045	0.251MetTrp: 0.251 ± 0.018	0.286MetTyr: 0.286 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.843AsnAla: 2.843 ± 0.059	0.235AsnCys: 0.235 ± 0.015	1.231AsnAsp: 1.231 ± 0.055	0.966AsnGlu: 0.966 ± 0.034	0.819AsnPhe: 0.819 ± 0.029	2.053AsnGly: 2.053 ± 0.049	0.476AsnHis: 0.476 ± 0.024	1.206AsnIle: 1.206 ± 0.04	0.5AsnLys: 0.5 ± 0.021	2.298AsnLeu: 2.298 ± 0.048	0.614AsnMet: 0.614 ± 0.025	0.511AsnAsn: 0.511 ± 0.023	1.794AsnPro: 1.794 ± 0.043	0.691AsnGln: 0.691 ± 0.027	1.767AsnArg: 1.767 ± 0.045	0.991AsnSer: 0.991 ± 0.032	1.027AsnThr: 1.027 ± 0.033	1.564AsnVal: 1.564 ± 0.044	0.39AsnTrp: 0.39 ± 0.022	0.553AsnTyr: 0.553 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.642ProAla: 7.642 ± 0.096	0.399ProCys: 0.399 ± 0.019	3.97ProAsp: 3.97 ± 0.076	3.965ProGlu: 3.965 ± 0.064	1.932ProPhe: 1.932 ± 0.049	5.512ProGly: 5.512 ± 0.087	1.096ProHis: 1.096 ± 0.033	2.247ProIle: 2.247 ± 0.049	1.292ProLys: 1.292 ± 0.043	4.963ProLeu: 4.963 ± 0.071	1.47ProMet: 1.47 ± 0.041	1.146ProAsn: 1.146 ± 0.032	2.86ProPro: 2.86 ± 0.069	2.424ProGln: 2.424 ± 0.051	3.551ProArg: 3.551 ± 0.062	2.366ProSer: 2.366 ± 0.044	2.098ProThr: 2.098 ± 0.045	4.47ProVal: 4.47 ± 0.072	0.772ProTrp: 0.772 ± 0.031	1.04ProTyr: 1.04 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.226GlnAla: 5.226 ± 0.085	0.182GlnCys: 0.182 ± 0.015	1.948GlnAsp: 1.948 ± 0.052	1.65GlnGlu: 1.65 ± 0.044	1.0GlnPhe: 1.0 ± 0.029	3.697GlnGly: 3.697 ± 0.067	0.654GlnHis: 0.654 ± 0.028	1.953GlnIle: 1.953 ± 0.044	0.946GlnLys: 0.946 ± 0.032	2.684GlnLeu: 2.684 ± 0.052	1.1GlnMet: 1.1 ± 0.027	0.822GlnAsn: 0.822 ± 0.031	2.072GlnPro: 2.072 ± 0.049	1.243GlnGln: 1.243 ± 0.04	2.421GlnArg: 2.421 ± 0.052	1.65GlnSer: 1.65 ± 0.045	1.658GlnThr: 1.658 ± 0.039	2.701GlnVal: 2.701 ± 0.052	0.389GlnTrp: 0.389 ± 0.019	0.558GlnTyr: 0.558 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.583ArgAla: 9.583 ± 0.108	0.545ArgCys: 0.545 ± 0.023	4.797ArgAsp: 4.797 ± 0.076	4.024ArgGlu: 4.024 ± 0.07	2.841ArgPhe: 2.841 ± 0.054	5.662ArgGly: 5.662 ± 0.072	1.942ArgHis: 1.942 ± 0.044	4.658ArgIle: 4.658 ± 0.074	2.166ArgLys: 2.166 ± 0.049	8.901ArgLeu: 8.901 ± 0.122	2.305ArgMet: 2.305 ± 0.049	1.796ArgAsn: 1.796 ± 0.043	4.237ArgPro: 4.237 ± 0.076	2.942ArgGln: 2.942 ± 0.059	6.355ArgArg: 6.355 ± 0.1	3.376ArgSer: 3.376 ± 0.061	2.831ArgThr: 2.831 ± 0.063	4.841ArgVal: 4.841 ± 0.071	1.118ArgTrp: 1.118 ± 0.038	1.493ArgTyr: 1.493 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.706SerAla: 5.706 ± 0.075	0.438SerCys: 0.438 ± 0.023	2.758SerAsp: 2.758 ± 0.052	2.147SerGlu: 2.147 ± 0.054	2.095SerPhe: 2.095 ± 0.045	5.121SerGly: 5.121 ± 0.085	1.043SerHis: 1.043 ± 0.035	2.244SerIle: 2.244 ± 0.058	1.097SerLys: 1.097 ± 0.035	4.775SerLeu: 4.775 ± 0.08	1.245SerMet: 1.245 ± 0.036	1.045SerAsn: 1.045 ± 0.032	2.524SerPro: 2.524 ± 0.053	1.617SerGln: 1.617 ± 0.045	3.507SerArg: 3.507 ± 0.068	2.221SerSer: 2.221 ± 0.056	2.213SerThr: 2.213 ± 0.053	3.326SerVal: 3.326 ± 0.054	0.705SerTrp: 0.705 ± 0.027	1.106SerTyr: 1.106 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.886ThrAla: 5.886 ± 0.089	0.452ThrCys: 0.452 ± 0.022	2.657ThrAsp: 2.657 ± 0.061	2.564ThrGlu: 2.564 ± 0.052	1.631ThrPhe: 1.631 ± 0.042	5.037ThrGly: 5.037 ± 0.073	0.968ThrHis: 0.968 ± 0.031	2.35ThrIle: 2.35 ± 0.047	1.014ThrLys: 1.014 ± 0.031	5.348ThrLeu: 5.348 ± 0.075	1.123ThrMet: 1.123 ± 0.036	1.0ThrAsn: 1.0 ± 0.033	3.147ThrPro: 3.147 ± 0.058	1.458ThrGln: 1.458 ± 0.044	3.561ThrArg: 3.561 ± 0.063	2.102ThrSer: 2.102 ± 0.047	2.372ThrThr: 2.372 ± 0.049	3.906ThrVal: 3.906 ± 0.067	0.664ThrTrp: 0.664 ± 0.027	1.03ThrTyr: 1.03 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.315ValAla: 9.315 ± 0.108	0.575ValCys: 0.575 ± 0.026	3.649ValAsp: 3.649 ± 0.07	4.284ValGlu: 4.284 ± 0.069	2.634ValPhe: 2.634 ± 0.056	5.187ValGly: 5.187 ± 0.084	1.327ValHis: 1.327 ± 0.035	3.995ValIle: 3.995 ± 0.073	1.834ValLys: 1.834 ± 0.045	7.908ValLeu: 7.908 ± 0.1	2.062ValMet: 2.062 ± 0.047	1.788ValAsn: 1.788 ± 0.051	3.671ValPro: 3.671 ± 0.058	2.252ValGln: 2.252 ± 0.042	4.276ValArg: 4.276 ± 0.066	3.641ValSer: 3.641 ± 0.063	4.17ValThr: 4.17 ± 0.075	5.544ValVal: 5.544 ± 0.088	0.961ValTrp: 0.961 ± 0.033	1.304ValTyr: 1.304 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.466TrpAla: 1.466 ± 0.044	0.137TrpCys: 0.137 ± 0.012	0.822TrpAsp: 0.822 ± 0.028	0.612TrpGlu: 0.612 ± 0.029	0.578TrpPhe: 0.578 ± 0.023	1.053TrpGly: 1.053 ± 0.035	0.384TrpHis: 0.384 ± 0.02	0.775TrpIle: 0.775 ± 0.03	0.42TrpLys: 0.42 ± 0.019	1.941TrpLeu: 1.941 ± 0.052	0.381TrpMet: 0.381 ± 0.021	0.388TrpAsn: 0.388 ± 0.021	0.842TrpPro: 0.842 ± 0.031	0.74TrpGln: 0.74 ± 0.029	1.338TrpArg: 1.338 ± 0.042	0.757TrpSer: 0.757 ± 0.028	0.789TrpThr: 0.789 ± 0.03	0.809TrpVal: 0.809 ± 0.032	0.243TrpTrp: 0.243 ± 0.016	0.261TrpTyr: 0.261 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.438TyrAla: 2.438 ± 0.045	0.225TyrCys: 0.225 ± 0.015	1.477TyrAsp: 1.477 ± 0.039	1.114TyrGlu: 1.114 ± 0.037	0.788TyrPhe: 0.788 ± 0.028	2.014TyrGly: 2.014 ± 0.051	0.472TyrHis: 0.472 ± 0.021	0.784TyrIle: 0.784 ± 0.032	0.473TyrLys: 0.473 ± 0.02	2.208TyrLeu: 2.208 ± 0.047	0.449TyrMet: 0.449 ± 0.022	0.484TyrAsn: 0.484 ± 0.023	1.043TyrPro: 1.043 ± 0.033	0.638TyrGln: 0.638 ± 0.023	1.616TyrArg: 1.616 ± 0.045	0.966TyrSer: 0.966 ± 0.033	0.89TyrThr: 0.89 ± 0.03	1.413TyrVal: 1.413 ± 0.039	0.363TyrTrp: 0.363 ± 0.021	0.527TyrTyr: 0.527 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3285 proteins (956036 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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