Amino acid dipepetide frequency for Peptoniphilus sp. oral taxon 375 str. F0436

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.75AlaAla: 3.75 ± 0.105
0.953AlaCys: 0.953 ± 0.045
3.22AlaAsp: 3.22 ± 0.081
3.477AlaGlu: 3.477 ± 0.081
2.755AlaPhe: 2.755 ± 0.082
4.666AlaGly: 4.666 ± 0.106
1.137AlaHis: 1.137 ± 0.044
5.017AlaIle: 5.017 ± 0.109
5.454AlaLys: 5.454 ± 0.126
7.769AlaLeu: 7.769 ± 0.141
2.056AlaMet: 2.056 ± 0.073
2.596AlaAsn: 2.596 ± 0.067
1.753AlaPro: 1.753 ± 0.054
2.885AlaGln: 2.885 ± 0.093
2.755AlaArg: 2.755 ± 0.069
3.967AlaSer: 3.967 ± 0.083
2.803AlaThr: 2.803 ± 0.072
3.522AlaVal: 3.522 ± 0.105
0.529AlaTrp: 0.529 ± 0.025
2.855AlaTyr: 2.855 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.511CysAla: 0.511 ± 0.032
0.121CysCys: 0.121 ± 0.016
0.495CysAsp: 0.495 ± 0.03
0.42CysGlu: 0.42 ± 0.027
0.36CysPhe: 0.36 ± 0.025
0.866CysGly: 0.866 ± 0.041
0.261CysHis: 0.261 ± 0.025
0.688CysIle: 0.688 ± 0.043
0.575CysLys: 0.575 ± 0.031
1.263CysLeu: 1.263 ± 0.053
0.243CysMet: 0.243 ± 0.019
0.38CysAsn: 0.38 ± 0.029
0.541CysPro: 0.541 ± 0.037
0.509CysGln: 0.509 ± 0.034
0.41CysArg: 0.41 ± 0.03
0.525CysSer: 0.525 ± 0.032
0.335CysThr: 0.335 ± 0.027
0.53CysVal: 0.53 ± 0.028
0.057CysTrp: 0.057 ± 0.011
0.364CysTyr: 0.364 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.115AspAla: 3.115 ± 0.085
0.561AspCys: 0.561 ± 0.031
2.879AspAsp: 2.879 ± 0.081
3.979AspGlu: 3.979 ± 0.096
3.504AspPhe: 3.504 ± 0.076
3.979AspGly: 3.979 ± 0.097
1.481AspHis: 1.481 ± 0.051
4.329AspIle: 4.329 ± 0.097
4.7AspLys: 4.7 ± 0.115
9.087AspLeu: 9.087 ± 0.174
1.545AspMet: 1.545 ± 0.051
2.069AspAsn: 2.069 ± 0.067
2.661AspPro: 2.661 ± 0.07
4.297AspGln: 4.297 ± 0.107
2.918AspArg: 2.918 ± 0.084
2.961AspSer: 2.961 ± 0.065
2.358AspThr: 2.358 ± 0.08
3.392AspVal: 3.392 ± 0.081
0.539AspTrp: 0.539 ± 0.033
3.298AspTyr: 3.298 ± 0.091
0.0AspXaa: 0.0 ± 0.0
Glu
5.17GluAla: 5.17 ± 0.11
0.412GluCys: 0.412 ± 0.027
5.787GluAsp: 5.787 ± 0.128
7.79GluGlu: 7.79 ± 0.164
2.441GluPhe: 2.441 ± 0.067
4.7GluGly: 4.7 ± 0.108
0.669GluHis: 0.669 ± 0.042
6.082GluIle: 6.082 ± 0.101
7.849GluLys: 7.849 ± 0.132
5.537GluLeu: 5.537 ± 0.118
1.858GluMet: 1.858 ± 0.05
4.194GluAsn: 4.194 ± 0.092
1.464GluPro: 1.464 ± 0.058
1.483GluGln: 1.483 ± 0.053
2.821GluArg: 2.821 ± 0.079
3.742GluSer: 3.742 ± 0.081
2.996GluThr: 2.996 ± 0.086
4.941GluVal: 4.941 ± 0.112
0.41GluTrp: 0.41 ± 0.027
1.957GluTyr: 1.957 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
2.571PheAla: 2.571 ± 0.07
0.461PheCys: 0.461 ± 0.03
2.636PheAsp: 2.636 ± 0.071
2.262PheGlu: 2.262 ± 0.067
2.196PhePhe: 2.196 ± 0.07
2.741PheGly: 2.741 ± 0.081
0.8PheHis: 0.8 ± 0.035
3.538PheIle: 3.538 ± 0.095
3.149PheLys: 3.149 ± 0.082
4.515PheLeu: 4.515 ± 0.112
1.091PheMet: 1.091 ± 0.046
1.811PheAsn: 1.811 ± 0.058
1.322PhePro: 1.322 ± 0.047
1.657PheGln: 1.657 ± 0.055
1.442PheArg: 1.442 ± 0.049
3.144PheSer: 3.144 ± 0.085
2.219PheThr: 2.219 ± 0.077
2.718PheVal: 2.718 ± 0.083
0.334PheTrp: 0.334 ± 0.021
1.964PheTyr: 1.964 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
4.48GlyAla: 4.48 ± 0.118
0.662GlyCys: 0.662 ± 0.041
3.882GlyAsp: 3.882 ± 0.087
4.073GlyGlu: 4.073 ± 0.088
2.945GlyPhe: 2.945 ± 0.08
4.771GlyGly: 4.771 ± 0.149
1.4GlyHis: 1.4 ± 0.05
5.507GlyIle: 5.507 ± 0.133
5.791GlyLys: 5.791 ± 0.106
7.976GlyLeu: 7.976 ± 0.144
1.769GlyMet: 1.769 ± 0.072
2.667GlyAsn: 2.667 ± 0.078
2.021GlyPro: 2.021 ± 0.063
3.424GlyGln: 3.424 ± 0.081
3.137GlyArg: 3.137 ± 0.079
3.9GlySer: 3.9 ± 0.095
3.146GlyThr: 3.146 ± 0.091
4.469GlyVal: 4.469 ± 0.11
0.507GlyTrp: 0.507 ± 0.035
3.057GlyTyr: 3.057 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
0.937HisAla: 0.937 ± 0.041
0.215HisCys: 0.215 ± 0.018
0.884HisAsp: 0.884 ± 0.041
1.018HisGlu: 1.018 ± 0.047
0.821HisPhe: 0.821 ± 0.039
1.27HisGly: 1.27 ± 0.053
0.413HisHis: 0.413 ± 0.033
1.274HisIle: 1.274 ± 0.05
1.164HisLys: 1.164 ± 0.048
1.815HisLeu: 1.815 ± 0.06
0.444HisMet: 0.444 ± 0.026
0.568HisAsn: 0.568 ± 0.03
0.892HisPro: 0.892 ± 0.045
0.651HisGln: 0.651 ± 0.031
0.798HisArg: 0.798 ± 0.035
0.923HisSer: 0.923 ± 0.043
0.754HisThr: 0.754 ± 0.036
0.972HisVal: 0.972 ± 0.043
0.227HisTrp: 0.227 ± 0.02
0.827HisTyr: 0.827 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
4.673IleAla: 4.673 ± 0.119
0.743IleCys: 0.743 ± 0.035
4.641IleAsp: 4.641 ± 0.097
5.014IleGlu: 5.014 ± 0.096
3.396IlePhe: 3.396 ± 0.096
4.739IleGly: 4.739 ± 0.099
1.542IleHis: 1.542 ± 0.057
4.902IleIle: 4.902 ± 0.139
5.179IleLys: 5.179 ± 0.108
8.287IleLeu: 8.287 ± 0.166
1.632IleMet: 1.632 ± 0.061
3.261IleAsn: 3.261 ± 0.08
3.051IlePro: 3.051 ± 0.076
3.594IleGln: 3.594 ± 0.092
3.091IleArg: 3.091 ± 0.087
4.824IleSer: 4.824 ± 0.103
3.254IleThr: 3.254 ± 0.086
4.338IleVal: 4.338 ± 0.109
0.518IleTrp: 0.518 ± 0.033
3.11IleTyr: 3.11 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
5.278LysAla: 5.278 ± 0.121
0.396LysCys: 0.396 ± 0.027
6.832LysAsp: 6.832 ± 0.147
7.929LysGlu: 7.929 ± 0.147
2.305LysPhe: 2.305 ± 0.059
4.886LysGly: 4.886 ± 0.093
0.931LysHis: 0.931 ± 0.048
6.548LysIle: 6.548 ± 0.119
8.074LysLys: 8.074 ± 0.145
6.442LysLeu: 6.442 ± 0.11
2.17LysMet: 2.17 ± 0.057
4.778LysAsn: 4.778 ± 0.1
2.28LysPro: 2.28 ± 0.089
2.175LysGln: 2.175 ± 0.054
3.229LysArg: 3.229 ± 0.085
4.345LysSer: 4.345 ± 0.103
4.685LysThr: 4.685 ± 0.101
4.955LysVal: 4.955 ± 0.122
0.559LysTrp: 0.559 ± 0.039
2.894LysTyr: 2.894 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
8.271LeuAla: 8.271 ± 0.135
1.073LeuCys: 1.073 ± 0.047
7.217LeuAsp: 7.217 ± 0.122
8.07LeuGlu: 8.07 ± 0.131
4.114LeuPhe: 4.114 ± 0.105
7.689LeuGly: 7.689 ± 0.137
1.348LeuHis: 1.348 ± 0.052
6.612LeuIle: 6.612 ± 0.139
8.532LeuLys: 8.532 ± 0.129
9.767LeuLeu: 9.767 ± 0.205
2.704LeuMet: 2.704 ± 0.076
4.418LeuAsn: 4.418 ± 0.097
3.653LeuPro: 3.653 ± 0.072
2.821LeuGln: 2.821 ± 0.081
3.99LeuArg: 3.99 ± 0.098
7.063LeuSer: 7.063 ± 0.135
5.14LeuThr: 5.14 ± 0.101
7.403LeuVal: 7.403 ± 0.144
0.772LeuTrp: 0.772 ± 0.037
3.424LeuTyr: 3.424 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.182MetAla: 2.182 ± 0.064
0.154MetCys: 0.154 ± 0.015
2.216MetAsp: 2.216 ± 0.062
2.274MetGlu: 2.274 ± 0.063
0.679MetPhe: 0.679 ± 0.037
1.932MetGly: 1.932 ± 0.061
0.296MetHis: 0.296 ± 0.024
1.732MetIle: 1.732 ± 0.057
2.448MetLys: 2.448 ± 0.071
1.87MetLeu: 1.87 ± 0.069
0.711MetMet: 0.711 ± 0.045
1.347MetAsn: 1.347 ± 0.053
0.85MetPro: 0.85 ± 0.041
0.649MetGln: 0.649 ± 0.035
0.978MetArg: 0.978 ± 0.048
1.428MetSer: 1.428 ± 0.054
1.641MetThr: 1.641 ± 0.061
1.957MetVal: 1.957 ± 0.061
0.121MetTrp: 0.121 ± 0.014
0.653MetTyr: 0.653 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.177AsnAla: 2.177 ± 0.077
0.42AsnCys: 0.42 ± 0.03
1.937AsnAsp: 1.937 ± 0.061
2.478AsnGlu: 2.478 ± 0.07
2.12AsnPhe: 2.12 ± 0.066
2.656AsnGly: 2.656 ± 0.08
0.979AsnHis: 0.979 ± 0.041
3.417AsnIle: 3.417 ± 0.083
3.582AsnLys: 3.582 ± 0.074
5.046AsnLeu: 5.046 ± 0.105
1.111AsnMet: 1.111 ± 0.042
1.769AsnAsn: 1.769 ± 0.063
2.296AsnPro: 2.296 ± 0.077
2.097AsnGln: 2.097 ± 0.065
2.161AsnArg: 2.161 ± 0.063
2.285AsnSer: 2.285 ± 0.067
1.982AsnThr: 1.982 ± 0.066
2.301AsnVal: 2.301 ± 0.055
0.374AsnTrp: 0.374 ± 0.027
2.077AsnTyr: 2.077 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
1.925ProAla: 1.925 ± 0.078
0.309ProCys: 0.309 ± 0.026
2.173ProAsp: 2.173 ± 0.065
2.526ProGlu: 2.526 ± 0.085
1.481ProPhe: 1.481 ± 0.051
2.663ProGly: 2.663 ± 0.086
0.6ProHis: 0.6 ± 0.034
2.516ProIle: 2.516 ± 0.074
2.713ProLys: 2.713 ± 0.078
3.474ProLeu: 3.474 ± 0.087
0.949ProMet: 0.949 ± 0.039
1.355ProAsn: 1.355 ± 0.052
0.811ProPro: 0.811 ± 0.055
1.497ProGln: 1.497 ± 0.056
1.212ProArg: 1.212 ± 0.045
2.312ProSer: 2.312 ± 0.068
1.636ProThr: 1.636 ± 0.06
2.319ProVal: 2.319 ± 0.066
0.348ProTrp: 0.348 ± 0.025
1.508ProTyr: 1.508 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.619GlnAla: 3.619 ± 0.083
0.275GlnCys: 0.275 ± 0.022
3.438GlnAsp: 3.438 ± 0.102
4.318GlnGlu: 4.318 ± 0.12
1.135GlnPhe: 1.135 ± 0.041
3.662GlnGly: 3.662 ± 0.097
0.381GlnHis: 0.381 ± 0.026
2.441GlnIle: 2.441 ± 0.07
3.0GlnLys: 3.0 ± 0.086
3.099GlnLeu: 3.099 ± 0.091
1.036GlnMet: 1.036 ± 0.042
1.384GlnAsn: 1.384 ± 0.048
0.923GlnPro: 0.923 ± 0.043
0.763GlnGln: 0.763 ± 0.042
1.659GlnArg: 1.659 ± 0.06
1.999GlnSer: 1.999 ± 0.066
1.639GlnThr: 1.639 ± 0.059
3.413GlnVal: 3.413 ± 0.091
0.358GlnTrp: 0.358 ± 0.026
1.119GlnTyr: 1.119 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.594ArgAla: 2.594 ± 0.068
0.413ArgCys: 0.413 ± 0.029
2.732ArgAsp: 2.732 ± 0.068
3.502ArgGlu: 3.502 ± 0.086
1.643ArgPhe: 1.643 ± 0.056
2.817ArgGly: 2.817 ± 0.076
0.628ArgHis: 0.628 ± 0.033
3.174ArgIle: 3.174 ± 0.078
3.378ArgLys: 3.378 ± 0.086
4.052ArgLeu: 4.052 ± 0.087
1.144ArgMet: 1.144 ± 0.046
1.63ArgAsn: 1.63 ± 0.056
1.625ArgPro: 1.625 ± 0.054
1.806ArgGln: 1.806 ± 0.071
2.111ArgArg: 2.111 ± 0.066
2.173ArgSer: 2.173 ± 0.064
1.843ArgThr: 1.843 ± 0.059
2.816ArgVal: 2.816 ± 0.074
0.275ArgTrp: 0.275 ± 0.022
1.574ArgTyr: 1.574 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
2.934SerAla: 2.934 ± 0.07
0.569SerCys: 0.569 ± 0.029
2.7SerAsp: 2.7 ± 0.071
2.792SerGlu: 2.792 ± 0.076
3.231SerPhe: 3.231 ± 0.076
4.036SerGly: 4.036 ± 0.1
1.137SerHis: 1.137 ± 0.041
4.764SerIle: 4.764 ± 0.1
4.464SerLys: 4.464 ± 0.086
7.368SerLeu: 7.368 ± 0.131
1.717SerMet: 1.717 ± 0.052
2.468SerAsn: 2.468 ± 0.073
2.219SerPro: 2.219 ± 0.067
2.828SerGln: 2.828 ± 0.073
2.629SerArg: 2.629 ± 0.073
3.708SerSer: 3.708 ± 0.095
2.585SerThr: 2.585 ± 0.077
3.16SerVal: 3.16 ± 0.083
0.607SerTrp: 0.607 ± 0.033
2.938SerTyr: 2.938 ± 0.084
0.0SerXaa: 0.0 ± 0.0
Thr
2.846ThrAla: 2.846 ± 0.083
0.561ThrCys: 0.561 ± 0.029
2.706ThrAsp: 2.706 ± 0.079
2.723ThrGlu: 2.723 ± 0.095
2.184ThrPhe: 2.184 ± 0.074
3.839ThrGly: 3.839 ± 0.09
0.738ThrHis: 0.738 ± 0.032
3.774ThrIle: 3.774 ± 0.087
3.465ThrLys: 3.465 ± 0.102
4.584ThrLeu: 4.584 ± 0.1
1.306ThrMet: 1.306 ± 0.054
1.886ThrAsn: 1.886 ± 0.054
2.005ThrPro: 2.005 ± 0.072
1.473ThrGln: 1.473 ± 0.061
1.889ThrArg: 1.889 ± 0.061
3.126ThrSer: 3.126 ± 0.079
2.507ThrThr: 2.507 ± 0.085
3.114ThrVal: 3.114 ± 0.096
0.445ThrTrp: 0.445 ± 0.029
1.845ThrTyr: 1.845 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
4.08ValAla: 4.08 ± 0.101
0.648ValCys: 0.648 ± 0.032
4.439ValAsp: 4.439 ± 0.087
4.528ValGlu: 4.528 ± 0.102
3.012ValPhe: 3.012 ± 0.079
4.231ValGly: 4.231 ± 0.112
1.173ValHis: 1.173 ± 0.046
4.137ValIle: 4.137 ± 0.08
4.721ValLys: 4.721 ± 0.099
7.001ValLeu: 7.001 ± 0.128
1.43ValMet: 1.43 ± 0.055
2.643ValAsn: 2.643 ± 0.078
2.166ValPro: 2.166 ± 0.075
2.507ValGln: 2.507 ± 0.074
2.39ValArg: 2.39 ± 0.071
3.672ValSer: 3.672 ± 0.083
3.089ValThr: 3.089 ± 0.107
4.169ValVal: 4.169 ± 0.104
0.428ValTrp: 0.428 ± 0.028
2.615ValTyr: 2.615 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.61TrpAla: 0.61 ± 0.041
0.067TrpCys: 0.067 ± 0.012
0.456TrpAsp: 0.456 ± 0.031
0.527TrpGlu: 0.527 ± 0.036
0.284TrpPhe: 0.284 ± 0.021
0.575TrpGly: 0.575 ± 0.033
0.101TrpHis: 0.101 ± 0.017
0.656TrpIle: 0.656 ± 0.036
0.548TrpLys: 0.548 ± 0.033
0.69TrpLeu: 0.69 ± 0.044
0.279TrpMet: 0.279 ± 0.022
0.326TrpAsn: 0.326 ± 0.025
0.24TrpPro: 0.24 ± 0.023
0.309TrpGln: 0.309 ± 0.021
0.335TrpArg: 0.335 ± 0.025
0.479TrpSer: 0.479 ± 0.032
0.525TrpThr: 0.525 ± 0.035
0.467TrpVal: 0.467 ± 0.031
0.067TrpTrp: 0.067 ± 0.011
0.264TrpTyr: 0.264 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.195TyrAla: 2.195 ± 0.064
0.442TyrCys: 0.442 ± 0.029
2.383TyrAsp: 2.383 ± 0.067
2.597TyrGlu: 2.597 ± 0.063
1.964TyrPhe: 1.964 ± 0.066
2.865TyrGly: 2.865 ± 0.068
0.85TyrHis: 0.85 ± 0.04
2.681TyrIle: 2.681 ± 0.075
2.906TyrLys: 2.906 ± 0.079
4.439TyrLeu: 4.439 ± 0.098
0.923TyrMet: 0.923 ± 0.042
1.717TyrAsn: 1.717 ± 0.057
1.554TyrPro: 1.554 ± 0.052
2.239TyrGln: 2.239 ± 0.075
1.976TyrArg: 1.976 ± 0.056
2.28TyrSer: 2.28 ± 0.064
1.877TyrThr: 1.877 ± 0.06
2.124TyrVal: 2.124 ± 0.076
0.332TyrTrp: 0.332 ± 0.024
1.694TyrTyr: 1.694 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2117 proteins (563660 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski