Amino acid dipepetide frequency for Salinispira pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.398AlaAla: 8.398 ± 0.113	0.482AlaCys: 0.482 ± 0.022	4.603AlaAsp: 4.603 ± 0.066	5.757AlaGlu: 5.757 ± 0.083	2.901AlaPhe: 2.901 ± 0.059	7.659AlaGly: 7.659 ± 0.11	1.412AlaHis: 1.412 ± 0.033	4.05AlaIle: 4.05 ± 0.062	2.406AlaLys: 2.406 ± 0.062	8.269AlaLeu: 8.269 ± 0.113	2.094AlaMet: 2.094 ± 0.052	2.03AlaAsn: 2.03 ± 0.044	2.716AlaPro: 2.716 ± 0.057	2.472AlaGln: 2.472 ± 0.05	4.893AlaArg: 4.893 ± 0.077	5.058AlaSer: 5.058 ± 0.077	2.468AlaThr: 2.468 ± 0.055	6.195AlaVal: 6.195 ± 0.088	0.816AlaTrp: 0.816 ± 0.029	2.251AlaTyr: 2.251 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.021	0.079CysCys: 0.079 ± 0.009	0.359CysAsp: 0.359 ± 0.018	0.365CysGlu: 0.365 ± 0.016	0.288CysPhe: 0.288 ± 0.016	0.646CysGly: 0.646 ± 0.027	0.161CysHis: 0.161 ± 0.013	0.489CysIle: 0.489 ± 0.021	0.231CysLys: 0.231 ± 0.016	0.498CysLeu: 0.498 ± 0.021	0.189CysMet: 0.189 ± 0.012	0.215CysAsn: 0.215 ± 0.015	0.38CysPro: 0.38 ± 0.022	0.149CysGln: 0.149 ± 0.01	0.568CysArg: 0.568 ± 0.025	0.636CysSer: 0.636 ± 0.024	0.322CysThr: 0.322 ± 0.018	0.338CysVal: 0.338 ± 0.016	0.056CysTrp: 0.056 ± 0.007	0.196CysTyr: 0.196 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.406AspAla: 4.406 ± 0.075	0.344AspCys: 0.344 ± 0.02	3.292AspAsp: 3.292 ± 0.082	4.59AspGlu: 4.59 ± 0.084	2.961AspPhe: 2.961 ± 0.064	4.334AspGly: 4.334 ± 0.086	1.095AspHis: 1.095 ± 0.034	4.209AspIle: 4.209 ± 0.06	1.652AspLys: 1.652 ± 0.051	5.715AspLeu: 5.715 ± 0.079	1.47AspMet: 1.47 ± 0.038	1.886AspAsn: 1.886 ± 0.046	3.13AspPro: 3.13 ± 0.06	1.992AspGln: 1.992 ± 0.045	3.268AspArg: 3.268 ± 0.062	4.209AspSer: 4.209 ± 0.079	2.523AspThr: 2.523 ± 0.055	3.378AspVal: 3.378 ± 0.059	0.71AspTrp: 0.71 ± 0.029	2.057AspTyr: 2.057 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.456GluAla: 5.456 ± 0.085	0.345GluCys: 0.345 ± 0.017	4.394GluAsp: 4.394 ± 0.075	5.978GluGlu: 5.978 ± 0.105	2.902GluPhe: 2.902 ± 0.057	4.664GluGly: 4.664 ± 0.081	1.69GluHis: 1.69 ± 0.039	5.515GluIle: 5.515 ± 0.075	3.911GluLys: 3.911 ± 0.08	7.848GluLeu: 7.848 ± 0.094	2.011GluMet: 2.011 ± 0.041	3.47GluAsn: 3.47 ± 0.061	2.415GluPro: 2.415 ± 0.057	3.287GluGln: 3.287 ± 0.065	3.931GluArg: 3.931 ± 0.069	4.695GluSer: 4.695 ± 0.072	3.524GluThr: 3.524 ± 0.06	3.803GluVal: 3.803 ± 0.064	0.714GluTrp: 0.714 ± 0.026	2.738GluTyr: 2.738 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.238PheAla: 3.238 ± 0.058	0.334PheCys: 0.334 ± 0.018	2.298PheAsp: 2.298 ± 0.048	2.207PheGlu: 2.207 ± 0.047	2.266PhePhe: 2.266 ± 0.051	2.949PheGly: 2.949 ± 0.059	1.117PheHis: 1.117 ± 0.031	2.953PheIle: 2.953 ± 0.057	1.212PheLys: 1.212 ± 0.035	4.521PheLeu: 4.521 ± 0.083	0.958PheMet: 0.958 ± 0.03	1.581PheAsn: 1.581 ± 0.045	2.181PhePro: 2.181 ± 0.049	1.791PheGln: 1.791 ± 0.044	2.895PheArg: 2.895 ± 0.054	4.219PheSer: 4.219 ± 0.068	2.758PheThr: 2.758 ± 0.048	2.193PheVal: 2.193 ± 0.049	0.513PheTrp: 0.513 ± 0.023	1.401PheTyr: 1.401 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.308GlyAla: 5.308 ± 0.093	0.586GlyCys: 0.586 ± 0.024	4.498GlyAsp: 4.498 ± 0.083	5.824GlyGlu: 5.824 ± 0.073	3.647GlyPhe: 3.647 ± 0.06	6.102GlyGly: 6.102 ± 0.117	1.338GlyHis: 1.338 ± 0.036	5.991GlyIle: 5.991 ± 0.082	3.828GlyLys: 3.828 ± 0.068	7.379GlyLeu: 7.379 ± 0.098	2.369GlyMet: 2.369 ± 0.054	3.204GlyAsn: 3.204 ± 0.075	2.302GlyPro: 2.302 ± 0.05	2.125GlyGln: 2.125 ± 0.051	4.752GlyArg: 4.752 ± 0.08	5.819GlySer: 5.819 ± 0.099	4.058GlyThr: 4.058 ± 0.102	4.798GlyVal: 4.798 ± 0.072	0.921GlyTrp: 0.921 ± 0.03	2.729GlyTyr: 2.729 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.455HisAla: 1.455 ± 0.036	0.217HisCys: 0.217 ± 0.015	1.097HisAsp: 1.097 ± 0.032	1.292HisGlu: 1.292 ± 0.035	0.975HisPhe: 0.975 ± 0.033	1.579HisGly: 1.579 ± 0.041	0.596HisHis: 0.596 ± 0.023	1.529HisIle: 1.529 ± 0.037	0.666HisLys: 0.666 ± 0.027	2.043HisLeu: 2.043 ± 0.044	0.529HisMet: 0.529 ± 0.021	0.733HisAsn: 0.733 ± 0.03	1.395HisPro: 1.395 ± 0.033	0.765HisGln: 0.765 ± 0.028	1.552HisArg: 1.552 ± 0.038	1.587HisSer: 1.587 ± 0.039	0.9HisThr: 0.9 ± 0.032	1.121HisVal: 1.121 ± 0.03	0.28HisTrp: 0.28 ± 0.015	0.657HisTyr: 0.657 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.193IleAla: 5.193 ± 0.076	0.525IleCys: 0.525 ± 0.019	3.635IleAsp: 3.635 ± 0.069	4.072IleGlu: 4.072 ± 0.061	2.826IlePhe: 2.826 ± 0.052	3.989IleGly: 3.989 ± 0.075	1.738IleHis: 1.738 ± 0.039	4.779IleIle: 4.779 ± 0.071	2.113IleLys: 2.113 ± 0.061	7.37IleLeu: 7.37 ± 0.102	1.441IleMet: 1.441 ± 0.038	2.369IleAsn: 2.369 ± 0.055	3.886IlePro: 3.886 ± 0.067	3.019IleGln: 3.019 ± 0.055	5.083IleArg: 5.083 ± 0.068	6.06IleSer: 6.06 ± 0.082	3.333IleThr: 3.333 ± 0.053	3.518IleVal: 3.518 ± 0.055	0.63IleTrp: 0.63 ± 0.023	1.819IleTyr: 1.819 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.163LysAla: 3.163 ± 0.061	0.188LysCys: 0.188 ± 0.015	2.475LysAsp: 2.475 ± 0.06	3.247LysGlu: 3.247 ± 0.066	1.227LysPhe: 1.227 ± 0.033	2.691LysGly: 2.691 ± 0.053	0.908LysHis: 0.908 ± 0.028	2.913LysIle: 2.913 ± 0.06	2.849LysLys: 2.849 ± 0.057	3.76LysLeu: 3.76 ± 0.066	1.113LysMet: 1.113 ± 0.037	1.988LysAsn: 1.988 ± 0.047	1.725LysPro: 1.725 ± 0.039	1.569LysGln: 1.569 ± 0.044	2.454LysArg: 2.454 ± 0.052	2.674LysSer: 2.674 ± 0.054	2.464LysThr: 2.464 ± 0.05	2.277LysVal: 2.277 ± 0.057	0.329LysTrp: 0.329 ± 0.019	1.225LysTyr: 1.225 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.503LeuAla: 7.503 ± 0.095	0.69LeuCys: 0.69 ± 0.028	5.821LeuAsp: 5.821 ± 0.077	8.124LeuGlu: 8.124 ± 0.105	4.732LeuPhe: 4.732 ± 0.089	7.347LeuGly: 7.347 ± 0.085	2.12LeuHis: 2.12 ± 0.052	6.581LeuIle: 6.581 ± 0.094	5.068LeuLys: 5.068 ± 0.074	10.61LeuLeu: 10.61 ± 0.135	2.552LeuMet: 2.552 ± 0.06	4.271LeuAsn: 4.271 ± 0.068	5.002LeuPro: 5.002 ± 0.086	3.879LeuGln: 3.879 ± 0.064	5.859LeuArg: 5.859 ± 0.077	8.198LeuSer: 8.198 ± 0.09	4.346LeuThr: 4.346 ± 0.073	5.708LeuVal: 5.708 ± 0.09	1.017LeuTrp: 1.017 ± 0.032	3.26LeuTyr: 3.26 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.001MetAla: 2.001 ± 0.049	0.116MetCys: 0.116 ± 0.01	1.595MetAsp: 1.595 ± 0.042	2.1MetGlu: 2.1 ± 0.045	0.963MetPhe: 0.963 ± 0.029	1.888MetGly: 1.888 ± 0.046	0.443MetHis: 0.443 ± 0.022	1.721MetIle: 1.721 ± 0.041	1.78MetLys: 1.78 ± 0.042	2.509MetLeu: 2.509 ± 0.052	0.635MetMet: 0.635 ± 0.025	1.456MetAsn: 1.456 ± 0.035	1.045MetPro: 1.045 ± 0.033	0.857MetGln: 0.857 ± 0.03	1.253MetArg: 1.253 ± 0.035	1.736MetSer: 1.736 ± 0.036	1.134MetThr: 1.134 ± 0.034	1.744MetVal: 1.744 ± 0.045	0.177MetTrp: 0.177 ± 0.012	0.742MetTyr: 0.742 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.687AsnAla: 2.687 ± 0.055	0.276AsnCys: 0.276 ± 0.017	1.794AsnAsp: 1.794 ± 0.048	2.29AsnGlu: 2.29 ± 0.046	1.63AsnPhe: 1.63 ± 0.039	2.973AsnGly: 2.973 ± 0.08	0.772AsnHis: 0.772 ± 0.025	2.865AsnIle: 2.865 ± 0.053	1.191AsnLys: 1.191 ± 0.04	4.042AsnLeu: 4.042 ± 0.066	1.052AsnMet: 1.052 ± 0.031	1.363AsnAsn: 1.363 ± 0.043	2.369AsnPro: 2.369 ± 0.052	1.362AsnGln: 1.362 ± 0.036	2.853AsnArg: 2.853 ± 0.047	2.887AsnSer: 2.887 ± 0.055	1.944AsnThr: 1.944 ± 0.046	1.903AsnVal: 1.903 ± 0.052	0.464AsnTrp: 0.464 ± 0.019	1.302AsnTyr: 1.302 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.738ProAla: 3.738 ± 0.063	0.229ProCys: 0.229 ± 0.014	3.377ProAsp: 3.377 ± 0.059	4.512ProGlu: 4.512 ± 0.074	1.79ProPhe: 1.79 ± 0.044	5.374ProGly: 5.374 ± 0.085	0.922ProHis: 0.922 ± 0.032	1.728ProIle: 1.728 ± 0.045	1.156ProLys: 1.156 ± 0.036	4.009ProLeu: 4.009 ± 0.063	0.99ProMet: 0.99 ± 0.034	1.083ProAsn: 1.083 ± 0.032	1.875ProPro: 1.875 ± 0.05	1.37ProGln: 1.37 ± 0.04	2.884ProArg: 2.884 ± 0.059	2.827ProSer: 2.827 ± 0.063	1.27ProThr: 1.27 ± 0.038	3.743ProVal: 3.743 ± 0.063	0.627ProTrp: 0.627 ± 0.024	1.228ProTyr: 1.228 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.042GlnAla: 3.042 ± 0.062	0.188GlnCys: 0.188 ± 0.013	2.054GlnAsp: 2.054 ± 0.037	2.797GlnGlu: 2.797 ± 0.063	1.42GlnPhe: 1.42 ± 0.037	2.857GlnGly: 2.857 ± 0.055	0.646GlnHis: 0.646 ± 0.027	2.468GlnIle: 2.468 ± 0.051	1.828GlnLys: 1.828 ± 0.05	3.848GlnLeu: 3.848 ± 0.066	0.939GlnMet: 0.939 ± 0.029	1.599GlnAsn: 1.599 ± 0.041	1.299GlnPro: 1.299 ± 0.034	1.581GlnGln: 1.581 ± 0.044	2.329GlnArg: 2.329 ± 0.05	2.361GlnSer: 2.361 ± 0.058	1.641GlnThr: 1.641 ± 0.042	2.083GlnVal: 2.083 ± 0.048	0.395GlnTrp: 0.395 ± 0.019	0.982GlnTyr: 0.982 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.794ArgAla: 3.794 ± 0.052	0.402ArgCys: 0.402 ± 0.019	3.633ArgAsp: 3.633 ± 0.063	5.558ArgGlu: 5.558 ± 0.085	2.914ArgPhe: 2.914 ± 0.055	4.396ArgGly: 4.396 ± 0.065	1.33ArgHis: 1.33 ± 0.035	5.073ArgIle: 5.073 ± 0.068	3.475ArgLys: 3.475 ± 0.059	6.546ArgLeu: 6.546 ± 0.094	1.784ArgMet: 1.784 ± 0.04	2.861ArgAsn: 2.861 ± 0.056	2.275ArgPro: 2.275 ± 0.048	2.433ArgGln: 2.433 ± 0.052	4.609ArgArg: 4.609 ± 0.093	4.45ArgSer: 4.45 ± 0.071	2.649ArgThr: 2.649 ± 0.045	3.663ArgVal: 3.663 ± 0.065	0.683ArgTrp: 0.683 ± 0.026	2.117ArgTyr: 2.117 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.975SerAla: 5.975 ± 0.092	0.634SerCys: 0.634 ± 0.022	3.984SerAsp: 3.984 ± 0.07	4.481SerGlu: 4.481 ± 0.067	3.365SerPhe: 3.365 ± 0.046	7.18SerGly: 7.18 ± 0.098	1.419SerHis: 1.419 ± 0.035	4.704SerIle: 4.704 ± 0.067	2.195SerLys: 2.195 ± 0.049	7.473SerLeu: 7.473 ± 0.092	2.161SerMet: 2.161 ± 0.046	2.154SerAsn: 2.154 ± 0.057	3.594SerPro: 3.594 ± 0.064	2.44SerGln: 2.44 ± 0.059	5.827SerArg: 5.827 ± 0.091	6.024SerSer: 6.024 ± 0.094	3.102SerThr: 3.102 ± 0.064	4.381SerVal: 4.381 ± 0.069	0.938SerTrp: 0.938 ± 0.033	2.375SerTyr: 2.375 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.322ThrAla: 4.322 ± 0.057	0.251ThrCys: 0.251 ± 0.015	2.46ThrAsp: 2.46 ± 0.054	2.85ThrGlu: 2.85 ± 0.053	1.621ThrPhe: 1.621 ± 0.042	4.457ThrGly: 4.457 ± 0.075	0.9ThrHis: 0.9 ± 0.025	2.86ThrIle: 2.86 ± 0.054	1.334ThrLys: 1.334 ± 0.043	4.833ThrLeu: 4.833 ± 0.073	1.122ThrMet: 1.122 ± 0.031	1.356ThrAsn: 1.356 ± 0.041	2.424ThrPro: 2.424 ± 0.055	1.37ThrGln: 1.37 ± 0.036	3.006ThrArg: 3.006 ± 0.056	2.964ThrSer: 2.964 ± 0.057	1.998ThrThr: 1.998 ± 0.056	3.445ThrVal: 3.445 ± 0.081	0.461ThrTrp: 0.461 ± 0.022	1.194ThrTyr: 1.194 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	3.839ValAla: 3.839 ± 0.076	0.452ValCys: 0.452 ± 0.02	3.528ValAsp: 3.528 ± 0.067	4.378ValGlu: 4.378 ± 0.076	3.09ValPhe: 3.09 ± 0.055	3.462ValGly: 3.462 ± 0.066	1.428ValHis: 1.428 ± 0.04	4.243ValIle: 4.243 ± 0.072	2.718ValLys: 2.718 ± 0.055	6.869ValLeu: 6.869 ± 0.096	1.48ValMet: 1.48 ± 0.036	2.597ValAsn: 2.597 ± 0.048	2.715ValPro: 2.715 ± 0.049	2.32ValGln: 2.32 ± 0.043	3.434ValArg: 3.434 ± 0.058	4.687ValSer: 4.687 ± 0.07	2.734ValThr: 2.734 ± 0.067	3.78ValVal: 3.78 ± 0.073	0.582ValTrp: 0.582 ± 0.023	2.095ValTyr: 2.095 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.695TrpAla: 0.695 ± 0.027	0.067TrpCys: 0.067 ± 0.007	0.627TrpAsp: 0.627 ± 0.028	0.806TrpGlu: 0.806 ± 0.028	0.507TrpPhe: 0.507 ± 0.021	0.691TrpGly: 0.691 ± 0.026	0.2TrpHis: 0.2 ± 0.015	0.718TrpIle: 0.718 ± 0.028	0.691TrpLys: 0.691 ± 0.024	1.095TrpLeu: 1.095 ± 0.032	0.327TrpMet: 0.327 ± 0.015	0.625TrpAsn: 0.625 ± 0.021	0.378TrpPro: 0.378 ± 0.018	0.418TrpGln: 0.418 ± 0.022	0.555TrpArg: 0.555 ± 0.02	0.709TrpSer: 0.709 ± 0.025	0.5TrpThr: 0.5 ± 0.024	0.649TrpVal: 0.649 ± 0.025	0.132TrpTrp: 0.132 ± 0.011	0.415TrpTyr: 0.415 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.232TyrAla: 2.232 ± 0.047	0.248TyrCys: 0.248 ± 0.016	1.697TyrAsp: 1.697 ± 0.047	2.061TyrGlu: 2.061 ± 0.049	1.561TyrPhe: 1.561 ± 0.046	2.34TyrGly: 2.34 ± 0.051	0.733TyrHis: 0.733 ± 0.026	2.006TyrIle: 2.006 ± 0.044	0.934TyrLys: 0.934 ± 0.035	3.45TyrLeu: 3.45 ± 0.049	0.679TyrMet: 0.679 ± 0.028	1.182TyrAsn: 1.182 ± 0.032	1.627TyrPro: 1.627 ± 0.042	1.156TyrGln: 1.156 ± 0.033	2.641TyrArg: 2.641 ± 0.054	2.604TyrSer: 2.604 ± 0.056	1.558TyrThr: 1.558 ± 0.039	1.711TyrVal: 1.711 ± 0.041	0.361TyrTrp: 0.361 ± 0.02	1.154TyrTyr: 1.154 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3350 proteins (1098157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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