Amino acid dipepetide frequency for Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.439AlaAla: 11.439 ± 0.986
1.497AlaCys: 1.497 ± 0.144
4.184AlaAsp: 4.184 ± 0.26
3.782AlaGlu: 3.782 ± 0.275
2.717AlaPhe: 2.717 ± 0.198
4.971AlaGly: 4.971 ± 0.411
1.451AlaHis: 1.451 ± 0.18
3.474AlaIle: 3.474 ± 0.221
2.393AlaLys: 2.393 ± 0.211
6.638AlaLeu: 6.638 ± 0.381
1.714AlaMet: 1.714 ± 0.14
2.13AlaAsn: 2.13 ± 0.148
4.153AlaPro: 4.153 ± 0.328
1.961AlaGln: 1.961 ± 0.176
5.619AlaArg: 5.619 ± 0.339
6.731AlaSer: 6.731 ± 0.382
5.974AlaThr: 5.974 ± 0.352
6.376AlaVal: 6.376 ± 0.402
0.695AlaTrp: 0.695 ± 0.142
1.667AlaTyr: 1.667 ± 0.138
0.0AlaXaa: 0.0 ± 0.0
Cys
1.575CysAla: 1.575 ± 0.177
0.587CysCys: 0.587 ± 0.121
1.513CysAsp: 1.513 ± 0.158
1.112CysGlu: 1.112 ± 0.126
0.88CysPhe: 0.88 ± 0.117
1.467CysGly: 1.467 ± 0.183
0.448CysHis: 0.448 ± 0.082
0.973CysIle: 0.973 ± 0.134
0.695CysLys: 0.695 ± 0.103
2.269CysLeu: 2.269 ± 0.239
0.401CysMet: 0.401 ± 0.071
0.664CysAsn: 0.664 ± 0.118
0.988CysPro: 0.988 ± 0.119
0.756CysGln: 0.756 ± 0.138
2.146CysArg: 2.146 ± 0.184
1.312CysSer: 1.312 ± 0.193
1.235CysThr: 1.235 ± 0.155
2.316CysVal: 2.316 ± 0.242
0.201CysTrp: 0.201 ± 0.059
0.679CysTyr: 0.679 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
5.002AspAla: 5.002 ± 0.316
0.648AspCys: 0.648 ± 0.098
5.666AspAsp: 5.666 ± 0.556
4.57AspGlu: 4.57 ± 0.367
2.115AspPhe: 2.115 ± 0.192
4.662AspGly: 4.662 ± 0.368
1.019AspHis: 1.019 ± 0.12
2.47AspIle: 2.47 ± 0.202
1.389AspLys: 1.389 ± 0.127
5.172AspLeu: 5.172 ± 0.326
1.25AspMet: 1.25 ± 0.162
2.038AspAsn: 2.038 ± 0.146
3.474AspPro: 3.474 ± 0.294
1.528AspGln: 1.528 ± 0.168
4.384AspArg: 4.384 ± 0.299
4.076AspSer: 4.076 ± 0.281
3.381AspThr: 3.381 ± 0.278
4.168AspVal: 4.168 ± 0.298
0.371AspTrp: 0.371 ± 0.074
1.328AspTyr: 1.328 ± 0.145
0.0AspXaa: 0.0 ± 0.0
Glu
3.273GluAla: 3.273 ± 0.296
1.173GluCys: 1.173 ± 0.155
4.106GluAsp: 4.106 ± 0.34
4.199GluGlu: 4.199 ± 0.449
1.744GluPhe: 1.744 ± 0.151
2.81GluGly: 2.81 ± 0.2
1.065GluHis: 1.065 ± 0.13
2.64GluIle: 2.64 ± 0.213
2.115GluLys: 2.115 ± 0.22
4.462GluLeu: 4.462 ± 0.306
1.328GluMet: 1.328 ± 0.143
2.038GluAsn: 2.038 ± 0.177
2.902GluPro: 2.902 ± 0.381
1.266GluGln: 1.266 ± 0.142
4.431GluArg: 4.431 ± 0.301
4.184GluSer: 4.184 ± 0.237
3.798GluThr: 3.798 ± 0.257
2.702GluVal: 2.702 ± 0.225
0.525GluTrp: 0.525 ± 0.096
1.575GluTyr: 1.575 ± 0.173
0.0GluXaa: 0.0 ± 0.0
Phe
2.81PheAla: 2.81 ± 0.202
1.034PheCys: 1.034 ± 0.122
2.223PheAsp: 2.223 ± 0.166
1.837PheGlu: 1.837 ± 0.171
1.976PhePhe: 1.976 ± 0.185
2.439PheGly: 2.439 ± 0.193
0.865PheHis: 0.865 ± 0.128
1.436PheIle: 1.436 ± 0.193
1.266PheLys: 1.266 ± 0.138
3.767PheLeu: 3.767 ± 0.256
0.756PheMet: 0.756 ± 0.126
1.127PheAsn: 1.127 ± 0.115
1.714PhePro: 1.714 ± 0.166
0.787PheGln: 0.787 ± 0.127
2.686PheArg: 2.686 ± 0.217
3.458PheSer: 3.458 ± 0.259
2.161PheThr: 2.161 ± 0.193
3.474PheVal: 3.474 ± 0.256
0.494PheTrp: 0.494 ± 0.076
1.575PheTyr: 1.575 ± 0.19
0.0PheXaa: 0.0 ± 0.0
Gly
5.187GlyAla: 5.187 ± 0.328
1.235GlyCys: 1.235 ± 0.159
3.998GlyAsp: 3.998 ± 0.311
3.551GlyGlu: 3.551 ± 0.257
2.424GlyPhe: 2.424 ± 0.206
7.92GlyGly: 7.92 ± 0.643
1.359GlyHis: 1.359 ± 0.151
2.377GlyIle: 2.377 ± 0.23
1.976GlyLys: 1.976 ± 0.181
4.971GlyLeu: 4.971 ± 0.302
1.25GlyMet: 1.25 ± 0.176
1.868GlyAsn: 1.868 ± 0.186
3.072GlyPro: 3.072 ± 0.247
1.698GlyGln: 1.698 ± 0.169
5.681GlyArg: 5.681 ± 0.326
5.588GlySer: 5.588 ± 0.563
4.353GlyThr: 4.353 ± 0.341
4.801GlyVal: 4.801 ± 0.284
0.865GlyTrp: 0.865 ± 0.113
2.053GlyTyr: 2.053 ± 0.226
0.0GlyXaa: 0.0 ± 0.0
His
1.59HisAla: 1.59 ± 0.193
0.324HisCys: 0.324 ± 0.077
1.281HisAsp: 1.281 ± 0.137
1.019HisGlu: 1.019 ± 0.12
0.71HisPhe: 0.71 ± 0.101
1.405HisGly: 1.405 ± 0.159
1.25HisHis: 1.25 ± 0.414
0.942HisIle: 0.942 ± 0.115
0.679HisLys: 0.679 ± 0.102
1.976HisLeu: 1.976 ± 0.179
0.417HisMet: 0.417 ± 0.089
0.726HisAsn: 0.726 ± 0.1
1.528HisPro: 1.528 ± 0.185
0.695HisGln: 0.695 ± 0.1
2.038HisArg: 2.038 ± 0.205
1.312HisSer: 1.312 ± 0.146
1.482HisThr: 1.482 ± 0.146
1.59HisVal: 1.59 ± 0.148
0.154HisTrp: 0.154 ± 0.044
0.633HisTyr: 0.633 ± 0.09
0.0HisXaa: 0.0 ± 0.0
Ile
3.18IleAla: 3.18 ± 0.216
1.127IleCys: 1.127 ± 0.15
2.238IleAsp: 2.238 ± 0.156
2.1IleGlu: 2.1 ± 0.185
1.914IlePhe: 1.914 ± 0.203
2.686IleGly: 2.686 ± 0.221
1.081IleHis: 1.081 ± 0.112
1.822IleIle: 1.822 ± 0.194
1.436IleLys: 1.436 ± 0.167
3.983IleLeu: 3.983 ± 0.234
0.942IleMet: 0.942 ± 0.115
1.883IleAsn: 1.883 ± 0.181
2.779IlePro: 2.779 ± 0.222
1.204IleGln: 1.204 ± 0.14
3.412IleArg: 3.412 ± 0.273
3.767IleSer: 3.767 ± 0.279
2.995IleThr: 2.995 ± 0.295
3.551IleVal: 3.551 ± 0.228
0.355IleTrp: 0.355 ± 0.078
1.791IleTyr: 1.791 ± 0.194
0.0IleXaa: 0.0 ± 0.0
Lys
1.868LysAla: 1.868 ± 0.171
0.818LysCys: 0.818 ± 0.127
1.714LysAsp: 1.714 ± 0.149
1.76LysGlu: 1.76 ± 0.175
1.019LysPhe: 1.019 ± 0.126
1.497LysGly: 1.497 ± 0.138
0.926LysHis: 0.926 ± 0.128
2.347LysIle: 2.347 ± 0.194
2.377LysLys: 2.377 ± 0.254
2.964LysLeu: 2.964 ± 0.214
1.065LysMet: 1.065 ± 0.128
1.683LysAsn: 1.683 ± 0.17
1.621LysPro: 1.621 ± 0.189
0.957LysGln: 0.957 ± 0.119
3.149LysArg: 3.149 ± 0.241
2.748LysSer: 2.748 ± 0.204
2.516LysThr: 2.516 ± 0.212
2.115LysVal: 2.115 ± 0.233
0.371LysTrp: 0.371 ± 0.079
1.096LysTyr: 1.096 ± 0.137
0.0LysXaa: 0.0 ± 0.0
Leu
6.438LeuAla: 6.438 ± 0.286
2.856LeuCys: 2.856 ± 0.243
4.338LeuAsp: 4.338 ± 0.327
4.014LeuGlu: 4.014 ± 0.309
3.597LeuPhe: 3.597 ± 0.216
4.77LeuGly: 4.77 ± 0.307
1.976LeuHis: 1.976 ± 0.143
3.906LeuIle: 3.906 ± 0.246
3.149LeuLys: 3.149 ± 0.317
8.182LeuLeu: 8.182 ± 0.459
1.791LeuMet: 1.791 ± 0.202
2.439LeuAsn: 2.439 ± 0.199
5.203LeuPro: 5.203 ± 0.3
2.516LeuGln: 2.516 ± 0.189
7.179LeuArg: 7.179 ± 0.347
7.487LeuSer: 7.487 ± 0.348
5.82LeuThr: 5.82 ± 0.305
5.959LeuVal: 5.959 ± 0.398
0.865LeuTrp: 0.865 ± 0.126
2.779LeuTyr: 2.779 ± 0.249
0.0LeuXaa: 0.0 ± 0.0
Met
1.652MetAla: 1.652 ± 0.178
0.463MetCys: 0.463 ± 0.077
1.204MetAsp: 1.204 ± 0.141
1.096MetGlu: 1.096 ± 0.127
0.988MetPhe: 0.988 ± 0.138
0.895MetGly: 0.895 ± 0.129
0.355MetHis: 0.355 ± 0.065
1.235MetIle: 1.235 ± 0.155
0.756MetLys: 0.756 ± 0.121
2.007MetLeu: 2.007 ± 0.176
0.648MetMet: 0.648 ± 0.103
0.88MetAsn: 0.88 ± 0.106
1.034MetPro: 1.034 ± 0.127
0.571MetGln: 0.571 ± 0.079
1.636MetArg: 1.636 ± 0.175
2.007MetSer: 2.007 ± 0.203
1.59MetThr: 1.59 ± 0.161
1.25MetVal: 1.25 ± 0.161
0.293MetTrp: 0.293 ± 0.065
0.865MetTyr: 0.865 ± 0.142
0.0MetXaa: 0.0 ± 0.0
Asn
2.902AsnAla: 2.902 ± 0.249
0.602AsnCys: 0.602 ± 0.102
1.667AsnAsp: 1.667 ± 0.162
1.698AsnGlu: 1.698 ± 0.166
0.973AsnPhe: 0.973 ± 0.123
2.594AsnGly: 2.594 ± 0.209
0.618AsnHis: 0.618 ± 0.094
1.667AsnIle: 1.667 ± 0.172
1.235AsnLys: 1.235 ± 0.147
2.671AsnLeu: 2.671 ± 0.202
0.741AsnMet: 0.741 ± 0.11
1.822AsnAsn: 1.822 ± 0.19
1.667AsnPro: 1.667 ± 0.146
0.726AsnGln: 0.726 ± 0.114
2.316AsnArg: 2.316 ± 0.171
2.624AsnSer: 2.624 ± 0.216
2.501AsnThr: 2.501 ± 0.216
2.501AsnVal: 2.501 ± 0.236
0.293AsnTrp: 0.293 ± 0.071
1.019AsnTyr: 1.019 ± 0.116
0.0AsnXaa: 0.0 ± 0.0
Pro
4.863ProAla: 4.863 ± 0.386
0.895ProCys: 0.895 ± 0.127
3.257ProAsp: 3.257 ± 0.239
3.288ProGlu: 3.288 ± 0.334
1.961ProPhe: 1.961 ± 0.2
3.628ProGly: 3.628 ± 0.25
1.266ProHis: 1.266 ± 0.168
2.408ProIle: 2.408 ± 0.245
1.899ProLys: 1.899 ± 0.187
4.847ProLeu: 4.847 ± 0.269
1.034ProMet: 1.034 ± 0.129
1.42ProAsn: 1.42 ± 0.171
7.333ProPro: 7.333 ± 0.69
1.976ProGln: 1.976 ± 0.17
4.786ProArg: 4.786 ± 0.37
5.341ProSer: 5.341 ± 0.376
3.875ProThr: 3.875 ± 0.361
4.369ProVal: 4.369 ± 0.326
0.587ProTrp: 0.587 ± 0.101
1.513ProTyr: 1.513 ± 0.163
0.015ProXaa: 0.015 ± 0.016
Gln
1.528GlnAla: 1.528 ± 0.203
0.648GlnCys: 0.648 ± 0.106
1.359GlnAsp: 1.359 ± 0.126
1.451GlnGlu: 1.451 ± 0.156
0.942GlnPhe: 0.942 ± 0.117
1.204GlnGly: 1.204 ± 0.151
0.834GlnHis: 0.834 ± 0.109
1.42GlnIle: 1.42 ± 0.141
1.297GlnLys: 1.297 ± 0.125
2.547GlnLeu: 2.547 ± 0.26
0.602GlnMet: 0.602 ± 0.093
1.034GlnAsn: 1.034 ± 0.11
1.636GlnPro: 1.636 ± 0.184
2.362GlnGln: 2.362 ± 0.391
2.702GlnArg: 2.702 ± 0.209
2.177GlnSer: 2.177 ± 0.203
2.3GlnThr: 2.3 ± 0.171
1.59GlnVal: 1.59 ± 0.146
0.216GlnTrp: 0.216 ± 0.076
0.679GlnTyr: 0.679 ± 0.091
0.0GlnXaa: 0.0 ± 0.0
Arg
5.743ArgAla: 5.743 ± 0.299
2.069ArgCys: 2.069 ± 0.192
5.064ArgAsp: 5.064 ± 0.309
4.076ArgGlu: 4.076 ± 0.277
3.18ArgPhe: 3.18 ± 0.267
5.542ArgGly: 5.542 ± 0.373
2.038ArgHis: 2.038 ± 0.2
2.979ArgIle: 2.979 ± 0.237
2.871ArgLys: 2.871 ± 0.212
7.055ArgLeu: 7.055 ± 0.393
1.976ArgMet: 1.976 ± 0.178
2.563ArgAsn: 2.563 ± 0.234
5.295ArgPro: 5.295 ± 0.421
2.47ArgGln: 2.47 ± 0.194
9.834ArgArg: 9.834 ± 0.616
6.669ArgSer: 6.669 ± 0.382
4.23ArgThr: 4.23 ± 0.247
5.372ArgVal: 5.372 ± 0.292
1.112ArgTrp: 1.112 ± 0.134
2.485ArgTyr: 2.485 ± 0.211
0.0ArgXaa: 0.0 ± 0.0
Ser
6.098SerAla: 6.098 ± 0.393
1.93SerCys: 1.93 ± 0.166
5.079SerAsp: 5.079 ± 0.417
4.585SerGlu: 4.585 ± 0.296
2.979SerPhe: 2.979 ± 0.221
6.021SerGly: 6.021 ± 0.475
1.606SerHis: 1.606 ± 0.144
3.443SerIle: 3.443 ± 0.243
2.47SerLys: 2.47 ± 0.193
6.314SerLeu: 6.314 ± 0.337
1.559SerMet: 1.559 ± 0.18
2.47SerAsn: 2.47 ± 0.218
5.434SerPro: 5.434 ± 0.392
2.238SerGln: 2.238 ± 0.218
7.117SerArg: 7.117 ± 0.422
11.038SerSer: 11.038 ± 1.049
6.113SerThr: 6.113 ± 0.413
6.283SerVal: 6.283 ± 0.394
0.942SerTrp: 0.942 ± 0.153
2.377SerTyr: 2.377 ± 0.22
0.0SerXaa: 0.0 ± 0.0
Thr
6.082ThrAla: 6.082 ± 0.354
1.297ThrCys: 1.297 ± 0.156
3.551ThrAsp: 3.551 ± 0.239
3.242ThrGlu: 3.242 ± 0.252
2.624ThrPhe: 2.624 ± 0.202
4.384ThrGly: 4.384 ± 0.336
1.297ThrHis: 1.297 ± 0.125
3.396ThrIle: 3.396 ± 0.291
2.455ThrLys: 2.455 ± 0.223
5.264ThrLeu: 5.264 ± 0.326
1.575ThrMet: 1.575 ± 0.185
2.007ThrAsn: 2.007 ± 0.173
4.523ThrPro: 4.523 ± 0.296
1.853ThrGln: 1.853 ± 0.198
4.184ThrArg: 4.184 ± 0.266
5.681ThrSer: 5.681 ± 0.339
7.04ThrThr: 7.04 ± 0.765
6.468ThrVal: 6.468 ± 0.328
0.88ThrTrp: 0.88 ± 0.139
1.791ThrTyr: 1.791 ± 0.155
0.0ThrXaa: 0.0 ± 0.0
Val
5.588ValAla: 5.588 ± 0.318
2.022ValCys: 2.022 ± 0.189
4.122ValAsp: 4.122 ± 0.277
3.057ValGlu: 3.057 ± 0.211
3.535ValPhe: 3.535 ± 0.27
4.925ValGly: 4.925 ± 0.328
1.312ValHis: 1.312 ± 0.145
3.427ValIle: 3.427 ± 0.279
2.547ValLys: 2.547 ± 0.221
6.499ValLeu: 6.499 ± 0.348
1.482ValMet: 1.482 ± 0.145
2.455ValAsn: 2.455 ± 0.194
4.338ValPro: 4.338 ± 0.357
1.991ValGln: 1.991 ± 0.174
5.311ValArg: 5.311 ± 0.32
6.824ValSer: 6.824 ± 0.347
5.203ValThr: 5.203 ± 0.341
6.237ValVal: 6.237 ± 0.343
0.973ValTrp: 0.973 ± 0.132
2.578ValTyr: 2.578 ± 0.212
0.0ValXaa: 0.0 ± 0.0
Trp
0.602TrpAla: 0.602 ± 0.111
0.278TrpCys: 0.278 ± 0.065
0.417TrpAsp: 0.417 ± 0.077
0.401TrpGlu: 0.401 ± 0.104
0.479TrpPhe: 0.479 ± 0.091
0.509TrpGly: 0.509 ± 0.082
0.293TrpHis: 0.293 ± 0.066
0.571TrpIle: 0.571 ± 0.106
0.525TrpLys: 0.525 ± 0.096
0.988TrpLeu: 0.988 ± 0.138
0.293TrpMet: 0.293 ± 0.068
0.324TrpAsn: 0.324 ± 0.081
0.618TrpPro: 0.618 ± 0.097
0.324TrpGln: 0.324 ± 0.083
1.081TrpArg: 1.081 ± 0.133
0.88TrpSer: 0.88 ± 0.134
0.895TrpThr: 0.895 ± 0.11
0.664TrpVal: 0.664 ± 0.099
0.34TrpTrp: 0.34 ± 0.079
0.463TrpTyr: 0.463 ± 0.088
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.146TyrAla: 2.146 ± 0.192
0.71TyrCys: 0.71 ± 0.098
1.729TyrAsp: 1.729 ± 0.165
1.497TyrGlu: 1.497 ± 0.143
1.112TyrPhe: 1.112 ± 0.138
1.899TyrGly: 1.899 ± 0.19
0.695TyrHis: 0.695 ± 0.126
1.312TyrIle: 1.312 ± 0.168
1.081TyrLys: 1.081 ± 0.135
2.686TyrLeu: 2.686 ± 0.214
0.587TyrMet: 0.587 ± 0.09
1.266TyrAsn: 1.266 ± 0.188
1.25TyrPro: 1.25 ± 0.156
0.648TyrGln: 0.648 ± 0.111
2.949TyrArg: 2.949 ± 0.231
2.192TyrSer: 2.192 ± 0.219
2.13TyrThr: 2.13 ± 0.203
2.64TyrVal: 2.64 ± 0.233
0.417TyrTrp: 0.417 ± 0.096
1.158TyrTyr: 1.158 ± 0.133
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.015XaaPhe: 0.015 ± 0.016
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.031XaaXaa: 0.031 ± 0.032
Statistics based on 166 proteins (64777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski