Amino acid dipepetide frequency for Ursus maritimus (Polar bear) (Thalarctos maritimus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.937AlaAla: 5.937 ± 0.031	1.425AlaCys: 1.425 ± 0.013	2.852AlaAsp: 2.852 ± 0.017	4.538AlaGlu: 4.538 ± 0.025	2.762AlaPhe: 2.762 ± 0.017	4.473AlaGly: 4.473 ± 0.026	1.561AlaHis: 1.561 ± 0.011	2.792AlaIle: 2.792 ± 0.017	3.33AlaLys: 3.33 ± 0.021	7.04AlaLeu: 7.04 ± 0.032	1.463AlaMet: 1.463 ± 0.011	1.988AlaAsn: 1.988 ± 0.013	4.005AlaPro: 4.005 ± 0.029	3.179AlaGln: 3.179 ± 0.019	3.493AlaArg: 3.493 ± 0.02	5.691AlaSer: 5.691 ± 0.027	3.434AlaThr: 3.434 ± 0.02	4.726AlaVal: 4.726 ± 0.022	0.808AlaTrp: 0.808 ± 0.009	1.531AlaTyr: 1.531 ± 0.011	0.02AlaXaa: 0.02 ± 0.001
Cys	1.28CysAla: 1.28 ± 0.013	0.634CysCys: 0.634 ± 0.01	1.047CysAsp: 1.047 ± 0.011	1.28CysGlu: 1.28 ± 0.014	0.902CysPhe: 0.902 ± 0.01	1.947CysGly: 1.947 ± 0.024	0.685CysHis: 0.685 ± 0.007	0.968CysIle: 0.968 ± 0.01	1.187CysLys: 1.187 ± 0.014	2.204CysLeu: 2.204 ± 0.018	0.437CysMet: 0.437 ± 0.006	0.829CysAsn: 0.829 ± 0.011	1.416CysPro: 1.416 ± 0.016	1.077CysGln: 1.077 ± 0.011	1.305CysArg: 1.305 ± 0.011	2.087CysSer: 2.087 ± 0.018	1.134CysThr: 1.134 ± 0.011	1.348CysVal: 1.348 ± 0.013	0.301CysTrp: 0.301 ± 0.004	0.593CysTyr: 0.593 ± 0.007	0.006CysXaa: 0.006 ± 0.001
Asp	2.731AspAla: 2.731 ± 0.016	1.034AspCys: 1.034 ± 0.012	2.524AspAsp: 2.524 ± 0.02	3.305AspGlu: 3.305 ± 0.019	2.123AspPhe: 2.123 ± 0.014	3.168AspGly: 3.168 ± 0.026	1.134AspHis: 1.134 ± 0.01	2.551AspIle: 2.551 ± 0.017	2.478AspLys: 2.478 ± 0.015	4.975AspLeu: 4.975 ± 0.021	1.096AspMet: 1.096 ± 0.01	1.655AspAsn: 1.655 ± 0.013	2.913AspPro: 2.913 ± 0.017	1.821AspGln: 1.821 ± 0.015	2.479AspArg: 2.479 ± 0.016	4.104AspSer: 4.104 ± 0.023	2.47AspThr: 2.47 ± 0.017	3.052AspVal: 3.052 ± 0.019	0.623AspTrp: 0.623 ± 0.007	1.443AspTyr: 1.443 ± 0.012	0.007AspXaa: 0.007 ± 0.001
Glu	5.035GluAla: 5.035 ± 0.025	1.607GluCys: 1.607 ± 0.024	4.347GluAsp: 4.347 ± 0.024	7.727GluGlu: 7.727 ± 0.05	2.056GluPhe: 2.056 ± 0.014	4.2GluGly: 4.2 ± 0.02	1.493GluHis: 1.493 ± 0.012	3.146GluIle: 3.146 ± 0.02	5.512GluLys: 5.512 ± 0.036	6.339GluLeu: 6.339 ± 0.029	1.662GluMet: 1.662 ± 0.012	3.14GluAsn: 3.14 ± 0.019	3.149GluPro: 3.149 ± 0.026	3.084GluGln: 3.084 ± 0.023	3.884GluArg: 3.884 ± 0.026	4.35GluSer: 4.35 ± 0.021	3.388GluThr: 3.388 ± 0.02	4.144GluVal: 4.144 ± 0.023	0.703GluTrp: 0.703 ± 0.007	1.542GluTyr: 1.542 ± 0.016	0.011GluXaa: 0.011 ± 0.001
Phe	1.974PheAla: 1.974 ± 0.013	1.044PheCys: 1.044 ± 0.009	1.643PheAsp: 1.643 ± 0.011	1.994PheGlu: 1.994 ± 0.013	1.824PhePhe: 1.824 ± 0.015	2.263PheGly: 2.263 ± 0.018	1.055PheHis: 1.055 ± 0.009	1.985PheIle: 1.985 ± 0.015	1.763PheLys: 1.763 ± 0.012	4.369PheLeu: 4.369 ± 0.026	0.792PheMet: 0.792 ± 0.01	1.358PheAsn: 1.358 ± 0.01	2.072PhePro: 2.072 ± 0.015	1.828PheGln: 1.828 ± 0.013	2.002PheArg: 2.002 ± 0.015	3.589PheSer: 3.589 ± 0.02	2.102PheThr: 2.102 ± 0.016	2.207PheVal: 2.207 ± 0.014	0.524PheTrp: 0.524 ± 0.007	1.259PheTyr: 1.259 ± 0.011	0.008PheXaa: 0.008 ± 0.001
Gly	4.283GlyAla: 4.283 ± 0.025	1.318GlyCys: 1.318 ± 0.012	3.079GlyAsp: 3.079 ± 0.02	4.211GlyGlu: 4.211 ± 0.029	2.462GlyPhe: 2.462 ± 0.017	4.646GlyGly: 4.646 ± 0.036	1.707GlyHis: 1.707 ± 0.014	2.768GlyIle: 2.768 ± 0.018	3.905GlyLys: 3.905 ± 0.025	5.913GlyLeu: 5.913 ± 0.023	1.284GlyMet: 1.284 ± 0.011	2.398GlyAsn: 2.398 ± 0.014	4.181GlyPro: 4.181 ± 0.05	2.788GlyGln: 2.788 ± 0.022	3.709GlyArg: 3.709 ± 0.022	5.704GlySer: 5.704 ± 0.033	3.595GlyThr: 3.595 ± 0.021	3.597GlyVal: 3.597 ± 0.021	0.797GlyTrp: 0.797 ± 0.009	1.683GlyTyr: 1.683 ± 0.015	0.021GlyXaa: 0.021 ± 0.001
His	1.314HisAla: 1.314 ± 0.01	0.72HisCys: 0.72 ± 0.008	0.862HisAsp: 0.862 ± 0.008	1.319HisGlu: 1.319 ± 0.011	1.128HisPhe: 1.128 ± 0.01	1.557HisGly: 1.557 ± 0.014	0.868HisHis: 0.868 ± 0.011	1.254HisIle: 1.254 ± 0.01	1.244HisLys: 1.244 ± 0.009	3.005HisLeu: 3.005 ± 0.017	0.603HisMet: 0.603 ± 0.007	0.839HisAsn: 0.839 ± 0.008	1.681HisPro: 1.681 ± 0.013	1.453HisGln: 1.453 ± 0.017	1.622HisArg: 1.622 ± 0.013	2.312HisSer: 2.312 ± 0.014	1.703HisThr: 1.703 ± 0.02	1.544HisVal: 1.544 ± 0.012	0.355HisTrp: 0.355 ± 0.005	0.83HisTyr: 0.83 ± 0.009	0.006HisXaa: 0.006 ± 0.001
Ile	2.566IleAla: 2.566 ± 0.016	1.157IleCys: 1.157 ± 0.011	1.964IleAsp: 1.964 ± 0.015	2.514IleGlu: 2.514 ± 0.016	2.008IlePhe: 2.008 ± 0.015	2.2IleGly: 2.2 ± 0.016	1.447IleHis: 1.447 ± 0.015	2.427IleIle: 2.427 ± 0.021	2.562IleLys: 2.562 ± 0.016	4.785IleLeu: 4.785 ± 0.03	1.024IleMet: 1.024 ± 0.009	1.777IleAsn: 1.777 ± 0.012	2.663IlePro: 2.663 ± 0.017	2.286IleGln: 2.286 ± 0.012	2.383IleArg: 2.383 ± 0.013	3.786IleSer: 3.786 ± 0.02	2.588IleThr: 2.588 ± 0.022	2.568IleVal: 2.568 ± 0.017	0.525IleTrp: 0.525 ± 0.007	1.448IleTyr: 1.448 ± 0.015	0.007IleXaa: 0.007 ± 0.001
Lys	4.083LysAla: 4.083 ± 0.023	1.191LysCys: 1.191 ± 0.015	3.138LysAsp: 3.138 ± 0.019	5.112LysGlu: 5.112 ± 0.032	1.713LysPhe: 1.713 ± 0.012	3.218LysGly: 3.218 ± 0.026	1.427LysHis: 1.427 ± 0.012	2.779LysIle: 2.779 ± 0.016	4.715LysLys: 4.715 ± 0.032	5.106LysLeu: 5.106 ± 0.024	1.491LysMet: 1.491 ± 0.013	2.407LysAsn: 2.407 ± 0.016	3.25LysPro: 3.25 ± 0.025	2.581LysGln: 2.581 ± 0.018	3.27LysArg: 3.27 ± 0.021	3.982LysSer: 3.982 ± 0.024	3.156LysThr: 3.156 ± 0.017	3.449LysVal: 3.449 ± 0.023	0.598LysTrp: 0.598 ± 0.008	1.535LysTyr: 1.535 ± 0.013	0.012LysXaa: 0.012 ± 0.001
Leu	6.75LeuAla: 6.75 ± 0.032	2.237LeuCys: 2.237 ± 0.017	4.645LeuAsp: 4.645 ± 0.024	7.117LeuGlu: 7.117 ± 0.037	3.535LeuPhe: 3.535 ± 0.023	6.0LeuGly: 6.0 ± 0.026	2.773LeuHis: 2.773 ± 0.017	4.067LeuIle: 4.067 ± 0.025	5.797LeuLys: 5.797 ± 0.026	10.797LeuLeu: 10.797 ± 0.051	2.05LeuMet: 2.05 ± 0.014	3.501LeuAsn: 3.501 ± 0.02	5.986LeuPro: 5.986 ± 0.03	5.675LeuGln: 5.675 ± 0.031	5.926LeuArg: 5.926 ± 0.025	8.198LeuSer: 8.198 ± 0.03	5.245LeuThr: 5.245 ± 0.022	5.634LeuVal: 5.634 ± 0.025	1.172LeuTrp: 1.172 ± 0.011	2.549LeuTyr: 2.549 ± 0.016	0.024LeuXaa: 0.024 ± 0.001
Met	1.895MetAla: 1.895 ± 0.014	0.407MetCys: 0.407 ± 0.006	1.239MetAsp: 1.239 ± 0.011	1.82MetGlu: 1.82 ± 0.012	0.749MetPhe: 0.749 ± 0.008	1.333MetGly: 1.333 ± 0.011	0.455MetHis: 0.455 ± 0.005	0.862MetIle: 0.862 ± 0.009	1.44MetLys: 1.44 ± 0.011	2.029MetLeu: 2.029 ± 0.015	0.574MetMet: 0.574 ± 0.007	0.915MetAsn: 0.915 ± 0.009	1.067MetPro: 1.067 ± 0.012	0.911MetGln: 0.911 ± 0.009	1.048MetArg: 1.048 ± 0.009	1.595MetSer: 1.595 ± 0.012	1.16MetThr: 1.16 ± 0.01	1.421MetVal: 1.421 ± 0.011	0.247MetTrp: 0.247 ± 0.004	0.663MetTyr: 0.663 ± 0.009	0.003MetXaa: 0.003 ± 0.001
Asn	2.019AsnAla: 2.019 ± 0.012	0.834AsnCys: 0.834 ± 0.009	1.5AsnAsp: 1.5 ± 0.013	2.227AsnGlu: 2.227 ± 0.016	1.486AsnPhe: 1.486 ± 0.012	2.37AsnGly: 2.37 ± 0.017	0.98AsnHis: 0.98 ± 0.008	2.098AsnIle: 2.098 ± 0.016	2.214AsnLys: 2.214 ± 0.013	3.736AsnLeu: 3.736 ± 0.021	0.909AsnMet: 0.909 ± 0.008	1.494AsnAsn: 1.494 ± 0.013	2.259AsnPro: 2.259 ± 0.015	1.647AsnGln: 1.647 ± 0.012	1.816AsnArg: 1.816 ± 0.012	3.11AsnSer: 3.11 ± 0.018	1.976AsnThr: 1.976 ± 0.014	2.216AsnVal: 2.216 ± 0.014	0.442AsnTrp: 0.442 ± 0.006	1.101AsnTyr: 1.101 ± 0.01	0.005AsnXaa: 0.005 ± 0.001
Pro	4.635ProAla: 4.635 ± 0.029	1.172ProCys: 1.172 ± 0.015	2.721ProAsp: 2.721 ± 0.017	4.426ProGlu: 4.426 ± 0.027	2.048ProPhe: 2.048 ± 0.015	5.088ProGly: 5.088 ± 0.063	1.474ProHis: 1.474 ± 0.012	1.861ProIle: 1.861 ± 0.017	2.846ProLys: 2.846 ± 0.022	5.334ProLeu: 5.334 ± 0.025	1.131ProMet: 1.131 ± 0.01	1.803ProAsn: 1.803 ± 0.013	5.664ProPro: 5.664 ± 0.055	2.843ProGln: 2.843 ± 0.02	3.343ProArg: 3.343 ± 0.02	5.73ProSer: 5.73 ± 0.032	3.115ProThr: 3.115 ± 0.027	3.852ProVal: 3.852 ± 0.024	0.731ProTrp: 0.731 ± 0.009	1.588ProTyr: 1.588 ± 0.017	0.017ProXaa: 0.017 ± 0.001
Gln	3.427GlnAla: 3.427 ± 0.022	0.936GlnCys: 0.936 ± 0.011	2.323GlnAsp: 2.323 ± 0.013	3.871GlnGlu: 3.871 ± 0.025	1.332GlnPhe: 1.332 ± 0.01	2.874GlnGly: 2.874 ± 0.019	1.324GlnHis: 1.324 ± 0.011	2.008GlnIle: 2.008 ± 0.012	2.988GlnLys: 2.988 ± 0.02	4.671GlnLeu: 4.671 ± 0.027	1.137GlnMet: 1.137 ± 0.011	1.876GlnAsn: 1.876 ± 0.013	2.726GlnPro: 2.726 ± 0.02	2.852GlnGln: 2.852 ± 0.031	3.037GlnArg: 3.037 ± 0.021	3.142GlnSer: 3.142 ± 0.02	2.368GlnThr: 2.368 ± 0.017	2.832GlnVal: 2.832 ± 0.018	0.539GlnTrp: 0.539 ± 0.007	1.115GlnTyr: 1.115 ± 0.009	0.009GlnXaa: 0.009 ± 0.001
Arg	3.73ArgAla: 3.73 ± 0.023	1.209ArgCys: 1.209 ± 0.014	2.7ArgAsp: 2.7 ± 0.015	3.967ArgGlu: 3.967 ± 0.025	1.836ArgPhe: 1.836 ± 0.014	3.575ArgGly: 3.575 ± 0.028	1.547ArgHis: 1.547 ± 0.012	2.482ArgIle: 2.482 ± 0.015	3.764ArgLys: 3.764 ± 0.022	5.284ArgLeu: 5.284 ± 0.025	1.185ArgMet: 1.185 ± 0.011	2.161ArgAsn: 2.161 ± 0.014	3.197ArgPro: 3.197 ± 0.022	2.558ArgGln: 2.558 ± 0.018	4.128ArgArg: 4.128 ± 0.03	4.245ArgSer: 4.245 ± 0.034	2.893ArgThr: 2.893 ± 0.018	3.154ArgVal: 3.154 ± 0.019	0.699ArgTrp: 0.699 ± 0.008	1.5ArgTyr: 1.5 ± 0.01	0.018ArgXaa: 0.018 ± 0.001
Ser	5.245SerAla: 5.245 ± 0.022	1.897SerCys: 1.897 ± 0.017	3.82SerAsp: 3.82 ± 0.025	5.207SerGlu: 5.207 ± 0.028	3.191SerPhe: 3.191 ± 0.017	5.57SerGly: 5.57 ± 0.036	2.232SerHis: 2.232 ± 0.016	3.222SerIle: 3.222 ± 0.019	4.115SerLys: 4.115 ± 0.021	8.37SerLeu: 8.37 ± 0.031	1.596SerMet: 1.596 ± 0.012	2.684SerAsn: 2.684 ± 0.016	6.018SerPro: 6.018 ± 0.037	3.944SerGln: 3.944 ± 0.022	4.558SerArg: 4.558 ± 0.036	9.346SerSer: 9.346 ± 0.055	4.514SerThr: 4.514 ± 0.028	5.012SerVal: 5.012 ± 0.022	1.121SerTrp: 1.121 ± 0.011	2.149SerTyr: 2.149 ± 0.014	0.019SerXaa: 0.019 ± 0.001
Thr	3.676ThrAla: 3.676 ± 0.021	1.388ThrCys: 1.388 ± 0.013	2.455ThrAsp: 2.455 ± 0.017	3.56ThrGlu: 3.56 ± 0.019	2.219ThrPhe: 2.219 ± 0.013	3.667ThrGly: 3.667 ± 0.023	1.392ThrHis: 1.392 ± 0.015	2.426ThrIle: 2.426 ± 0.016	2.635ThrLys: 2.635 ± 0.016	5.371ThrLeu: 5.371 ± 0.02	1.112ThrMet: 1.112 ± 0.01	1.728ThrAsn: 1.728 ± 0.012	3.614ThrPro: 3.614 ± 0.032	2.361ThrGln: 2.361 ± 0.015	2.5ThrArg: 2.5 ± 0.015	4.685ThrSer: 4.685 ± 0.027	3.025ThrThr: 3.025 ± 0.039	4.008ThrVal: 4.008 ± 0.027	0.702ThrTrp: 0.702 ± 0.01	1.44ThrTyr: 1.44 ± 0.012	0.012ThrXaa: 0.012 ± 0.001
Val	4.257ValAla: 4.257 ± 0.021	1.511ValCys: 1.511 ± 0.013	2.871ValAsp: 2.871 ± 0.015	3.755ValGlu: 3.755 ± 0.023	2.518ValPhe: 2.518 ± 0.016	3.413ValGly: 3.413 ± 0.022	1.612ValHis: 1.612 ± 0.015	3.037ValIle: 3.037 ± 0.022	3.406ValLys: 3.406 ± 0.018	6.417ValLeu: 6.417 ± 0.028	1.383ValMet: 1.383 ± 0.011	2.254ValAsn: 2.254 ± 0.015	3.701ValPro: 3.701 ± 0.025	2.714ValGln: 2.714 ± 0.015	3.026ValArg: 3.026 ± 0.016	5.016ValSer: 5.016 ± 0.022	3.875ValThr: 3.875 ± 0.026	4.047ValVal: 4.047 ± 0.021	0.727ValTrp: 0.727 ± 0.009	1.646ValTyr: 1.646 ± 0.012	0.014ValXaa: 0.014 ± 0.001
Trp	0.802TrpAla: 0.802 ± 0.009	0.254TrpCys: 0.254 ± 0.005	0.663TrpAsp: 0.663 ± 0.009	0.819TrpGlu: 0.819 ± 0.008	0.46TrpPhe: 0.46 ± 0.006	0.781TrpGly: 0.781 ± 0.009	0.309TrpHis: 0.309 ± 0.005	0.553TrpIle: 0.553 ± 0.007	0.824TrpLys: 0.824 ± 0.008	1.209TrpLeu: 1.209 ± 0.011	0.309TrpMet: 0.309 ± 0.005	0.549TrpAsn: 0.549 ± 0.006	0.544TrpPro: 0.544 ± 0.006	0.533TrpGln: 0.533 ± 0.006	0.729TrpArg: 0.729 ± 0.008	0.89TrpSer: 0.89 ± 0.009	0.688TrpThr: 0.688 ± 0.009	0.708TrpVal: 0.708 ± 0.007	0.193TrpTrp: 0.193 ± 0.004	0.341TrpTyr: 0.341 ± 0.006	0.004TrpXaa: 0.004 ± 0.001
Tyr	1.389TyrAla: 1.389 ± 0.01	0.688TyrCys: 0.688 ± 0.008	1.282TyrAsp: 1.282 ± 0.012	1.737TyrGlu: 1.737 ± 0.014	1.291TyrPhe: 1.291 ± 0.011	1.684TyrGly: 1.684 ± 0.014	0.74TyrHis: 0.74 ± 0.009	1.393TyrIle: 1.393 ± 0.013	1.474TyrLys: 1.474 ± 0.017	2.703TyrLeu: 2.703 ± 0.016	0.592TyrMet: 0.592 ± 0.006	1.078TyrAsn: 1.078 ± 0.01	1.297TyrPro: 1.297 ± 0.012	1.244TyrGln: 1.244 ± 0.01	1.56TyrArg: 1.56 ± 0.012	2.247TyrSer: 2.247 ± 0.014	1.541TyrThr: 1.541 ± 0.014	1.663TyrVal: 1.663 ± 0.013	0.351TyrTrp: 0.351 ± 0.006	0.944TyrTyr: 0.944 ± 0.01	0.004TyrXaa: 0.004 ± 0.001
Xaa	0.018XaaAla: 0.018 ± 0.001	0.006XaaCys: 0.006 ± 0.001	0.008XaaAsp: 0.008 ± 0.001	0.015XaaGlu: 0.015 ± 0.001	0.009XaaPhe: 0.009 ± 0.001	0.021XaaGly: 0.021 ± 0.001	0.006XaaHis: 0.006 ± 0.001	0.007XaaIle: 0.007 ± 0.001	0.013XaaLys: 0.013 ± 0.001	0.021XaaLeu: 0.021 ± 0.001	0.004XaaMet: 0.004 ± 0.001	0.007XaaAsn: 0.007 ± 0.001	0.018XaaPro: 0.018 ± 0.001	0.009XaaGln: 0.009 ± 0.001	0.017XaaArg: 0.017 ± 0.001	0.019XaaSer: 0.019 ± 0.001	0.008XaaThr: 0.008 ± 0.001	0.015XaaVal: 0.015 ± 0.001	0.003XaaTrp: 0.003 ± 0.0	0.005XaaTyr: 0.005 ± 0.001	0.377XaaXaa: 0.377 ± 0.014

Statistics based on 25970 proteins (14166585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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