Amino acid dipepetide frequency for Actinocrispum wychmicini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.311AlaAla: 18.311 ± 0.103	1.053AlaCys: 1.053 ± 0.017	8.241AlaAsp: 8.241 ± 0.057	7.803AlaGlu: 7.803 ± 0.063	3.421AlaPhe: 3.421 ± 0.036	12.08AlaGly: 12.08 ± 0.063	2.642AlaHis: 2.642 ± 0.034	4.477AlaIle: 4.477 ± 0.043	2.957AlaLys: 2.957 ± 0.035	12.955AlaLeu: 12.955 ± 0.078	2.713AlaMet: 2.713 ± 0.028	2.713AlaAsn: 2.713 ± 0.033	5.426AlaPro: 5.426 ± 0.046	3.713AlaGln: 3.713 ± 0.033	8.894AlaArg: 8.894 ± 0.056	5.713AlaSer: 5.713 ± 0.042	7.517AlaThr: 7.517 ± 0.045	11.63AlaVal: 11.63 ± 0.062	1.816AlaTrp: 1.816 ± 0.025	2.341AlaTyr: 2.341 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.047CysAla: 1.047 ± 0.017	0.107CysCys: 0.107 ± 0.006	0.53CysAsp: 0.53 ± 0.011	0.386CysGlu: 0.386 ± 0.011	0.233CysPhe: 0.233 ± 0.008	0.916CysGly: 0.916 ± 0.018	0.208CysHis: 0.208 ± 0.009	0.142CysIle: 0.142 ± 0.006	0.122CysLys: 0.122 ± 0.006	0.782CysLeu: 0.782 ± 0.014	0.133CysMet: 0.133 ± 0.006	0.142CysAsn: 0.142 ± 0.007	0.53CysPro: 0.53 ± 0.013	0.238CysGln: 0.238 ± 0.008	0.649CysArg: 0.649 ± 0.014	0.48CysSer: 0.48 ± 0.011	0.508CysThr: 0.508 ± 0.012	0.773CysVal: 0.773 ± 0.016	0.149CysTrp: 0.149 ± 0.006	0.2CysTyr: 0.2 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.931AspAla: 6.931 ± 0.05	0.443AspCys: 0.443 ± 0.012	3.734AspAsp: 3.734 ± 0.038	3.719AspGlu: 3.719 ± 0.036	1.733AspPhe: 1.733 ± 0.024	5.971AspGly: 5.971 ± 0.045	1.598AspHis: 1.598 ± 0.023	2.266AspIle: 2.266 ± 0.025	1.338AspLys: 1.338 ± 0.023	6.821AspLeu: 6.821 ± 0.047	0.985AspMet: 0.985 ± 0.016	1.35AspAsn: 1.35 ± 0.022	4.519AspPro: 4.519 ± 0.04	2.115AspGln: 2.115 ± 0.026	5.015AspArg: 5.015 ± 0.043	2.842AspSer: 2.842 ± 0.027	3.51AspThr: 3.51 ± 0.036	5.528AspVal: 5.528 ± 0.039	1.022AspTrp: 1.022 ± 0.021	1.291AspTyr: 1.291 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.583GluAla: 5.583 ± 0.047	0.395GluCys: 0.395 ± 0.011	2.395GluAsp: 2.395 ± 0.026	2.213GluGlu: 2.213 ± 0.024	1.662GluPhe: 1.662 ± 0.024	2.853GluGly: 2.853 ± 0.033	1.506GluHis: 1.506 ± 0.022	2.382GluIle: 2.382 ± 0.028	1.035GluLys: 1.035 ± 0.018	6.516GluLeu: 6.516 ± 0.051	0.927GluMet: 0.927 ± 0.017	1.011GluAsn: 1.011 ± 0.015	3.116GluPro: 3.116 ± 0.034	2.144GluGln: 2.144 ± 0.024	4.51GluArg: 4.51 ± 0.041	2.407GluSer: 2.407 ± 0.026	2.568GluThr: 2.568 ± 0.025	4.245GluVal: 4.245 ± 0.039	0.83GluTrp: 0.83 ± 0.016	1.063GluTyr: 1.063 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.883PheAla: 3.883 ± 0.036	0.281PheCys: 0.281 ± 0.009	2.348PheAsp: 2.348 ± 0.028	1.402PheGlu: 1.402 ± 0.021	0.911PhePhe: 0.911 ± 0.017	3.265PheGly: 3.265 ± 0.036	0.672PheHis: 0.672 ± 0.012	0.757PheIle: 0.757 ± 0.015	0.472PheLys: 0.472 ± 0.011	2.601PheLeu: 2.601 ± 0.03	0.427PheMet: 0.427 ± 0.012	0.653PheAsn: 0.653 ± 0.012	1.483PhePro: 1.483 ± 0.02	0.83PheGln: 0.83 ± 0.016	1.877PheArg: 1.877 ± 0.022	1.571PheSer: 1.571 ± 0.021	2.201PheThr: 2.201 ± 0.025	2.676PheVal: 2.676 ± 0.026	0.428PheTrp: 0.428 ± 0.011	0.632PheTyr: 0.632 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	8.913GlyAla: 8.913 ± 0.056	0.834GlyCys: 0.834 ± 0.019	5.016GlyAsp: 5.016 ± 0.042	4.238GlyGlu: 4.238 ± 0.038	2.941GlyPhe: 2.941 ± 0.029	7.615GlyGly: 7.615 ± 0.068	2.234GlyHis: 2.234 ± 0.029	3.589GlyIle: 3.589 ± 0.034	2.363GlyLys: 2.363 ± 0.032	9.056GlyLeu: 9.056 ± 0.062	2.15GlyMet: 2.15 ± 0.026	2.051GlyAsn: 2.051 ± 0.029	4.7GlyPro: 4.7 ± 0.045	3.076GlyGln: 3.076 ± 0.034	6.712GlyArg: 6.712 ± 0.049	4.919GlySer: 4.919 ± 0.044	5.888GlyThr: 5.888 ± 0.051	7.85GlyVal: 7.85 ± 0.06	1.698GlyTrp: 1.698 ± 0.027	2.324GlyTyr: 2.324 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.525HisAla: 2.525 ± 0.03	0.226HisCys: 0.226 ± 0.008	1.403HisAsp: 1.403 ± 0.024	1.131HisGlu: 1.131 ± 0.017	0.63HisPhe: 0.63 ± 0.014	2.246HisGly: 2.246 ± 0.027	0.688HisHis: 0.688 ± 0.016	0.739HisIle: 0.739 ± 0.016	0.383HisLys: 0.383 ± 0.011	2.339HisLeu: 2.339 ± 0.029	0.385HisMet: 0.385 ± 0.01	0.535HisAsn: 0.535 ± 0.012	1.738HisPro: 1.738 ± 0.026	0.786HisGln: 0.786 ± 0.016	1.971HisArg: 1.971 ± 0.027	1.126HisSer: 1.126 ± 0.019	1.357HisThr: 1.357 ± 0.023	1.897HisVal: 1.897 ± 0.024	0.373HisTrp: 0.373 ± 0.011	0.5HisTyr: 0.5 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.277IleAla: 5.277 ± 0.045	0.306IleCys: 0.306 ± 0.009	2.608IleAsp: 2.608 ± 0.028	2.138IleGlu: 2.138 ± 0.027	0.828IlePhe: 0.828 ± 0.016	3.846IleGly: 3.846 ± 0.034	0.72IleHis: 0.72 ± 0.016	1.04IleIle: 1.04 ± 0.019	0.754IleLys: 0.754 ± 0.016	2.749IleLeu: 2.749 ± 0.03	0.516IleMet: 0.516 ± 0.013	0.844IleAsn: 0.844 ± 0.017	2.103IlePro: 2.103 ± 0.024	0.956IleGln: 0.956 ± 0.016	2.713IleArg: 2.713 ± 0.029	1.933IleSer: 1.933 ± 0.025	2.705IleThr: 2.705 ± 0.028	3.291IleVal: 3.291 ± 0.032	0.458IleTrp: 0.458 ± 0.013	0.656IleTyr: 0.656 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	2.687LysAla: 2.687 ± 0.036	0.132LysCys: 0.132 ± 0.006	1.247LysAsp: 1.247 ± 0.023	0.926LysGlu: 0.926 ± 0.019	0.601LysPhe: 0.601 ± 0.013	1.472LysGly: 1.472 ± 0.025	0.466LysHis: 0.466 ± 0.012	0.962LysIle: 0.962 ± 0.019	0.534LysLys: 0.534 ± 0.017	2.162LysLeu: 2.162 ± 0.028	0.406LysMet: 0.406 ± 0.01	0.469LysAsn: 0.469 ± 0.013	1.446LysPro: 1.446 ± 0.022	0.728LysGln: 0.728 ± 0.016	1.415LysArg: 1.415 ± 0.02	1.107LysSer: 1.107 ± 0.02	1.259LysThr: 1.259 ± 0.021	2.006LysVal: 2.006 ± 0.027	0.324LysTrp: 0.324 ± 0.01	0.501LysTyr: 0.501 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.398LeuAla: 15.398 ± 0.078	0.854LeuCys: 0.854 ± 0.015	6.872LeuAsp: 6.872 ± 0.05	3.901LeuGlu: 3.901 ± 0.033	2.75LeuPhe: 2.75 ± 0.031	9.002LeuGly: 9.002 ± 0.059	2.174LeuHis: 2.174 ± 0.027	3.49LeuIle: 3.49 ± 0.044	1.794LeuLys: 1.794 ± 0.026	10.572LeuLeu: 10.572 ± 0.073	1.613LeuMet: 1.613 ± 0.02	1.966LeuAsn: 1.966 ± 0.024	6.188LeuPro: 6.188 ± 0.046	2.225LeuGln: 2.225 ± 0.027	8.662LeuArg: 8.662 ± 0.053	5.684LeuSer: 5.684 ± 0.036	6.988LeuThr: 6.988 ± 0.049	9.73LeuVal: 9.73 ± 0.057	1.351LeuTrp: 1.351 ± 0.02	1.826LeuTyr: 1.826 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.485MetAla: 2.485 ± 0.028	0.151MetCys: 0.151 ± 0.007	0.993MetAsp: 0.993 ± 0.016	0.614MetGlu: 0.614 ± 0.014	0.588MetPhe: 0.588 ± 0.013	1.265MetGly: 1.265 ± 0.021	0.375MetHis: 0.375 ± 0.01	0.846MetIle: 0.846 ± 0.014	0.38MetLys: 0.38 ± 0.011	1.939MetLeu: 1.939 ± 0.028	0.331MetMet: 0.331 ± 0.01	0.456MetAsn: 0.456 ± 0.012	1.2MetPro: 1.2 ± 0.023	0.424MetGln: 0.424 ± 0.01	1.619MetArg: 1.619 ± 0.021	1.412MetSer: 1.412 ± 0.021	1.68MetThr: 1.68 ± 0.02	1.608MetVal: 1.608 ± 0.022	0.245MetTrp: 0.245 ± 0.009	0.351MetTyr: 0.351 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.625AsnAla: 2.625 ± 0.029	0.207AsnCys: 0.207 ± 0.007	1.197AsnAsp: 1.197 ± 0.022	0.965AsnGlu: 0.965 ± 0.015	0.581AsnPhe: 0.581 ± 0.012	2.404AsnGly: 2.404 ± 0.037	0.467AsnHis: 0.467 ± 0.012	0.764AsnIle: 0.764 ± 0.016	0.475AsnLys: 0.475 ± 0.013	2.061AsnLeu: 2.061 ± 0.027	0.335AsnMet: 0.335 ± 0.01	0.589AsnAsn: 0.589 ± 0.018	1.67AsnPro: 1.67 ± 0.027	0.749AsnGln: 0.749 ± 0.016	1.534AsnArg: 1.534 ± 0.021	1.138AsnSer: 1.138 ± 0.02	1.417AsnThr: 1.417 ± 0.023	1.798AsnVal: 1.798 ± 0.022	0.35AsnTrp: 0.35 ± 0.01	0.508AsnTyr: 0.508 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.629ProAla: 7.629 ± 0.05	0.369ProCys: 0.369 ± 0.011	4.788ProAsp: 4.788 ± 0.046	3.395ProGlu: 3.395 ± 0.032	1.589ProPhe: 1.589 ± 0.02	5.836ProGly: 5.836 ± 0.047	1.227ProHis: 1.227 ± 0.019	1.845ProIle: 1.845 ± 0.023	1.253ProLys: 1.253 ± 0.02	4.947ProLeu: 4.947 ± 0.036	1.142ProMet: 1.142 ± 0.018	1.402ProAsn: 1.402 ± 0.021	3.721ProPro: 3.721 ± 0.061	1.719ProGln: 1.719 ± 0.026	3.596ProArg: 3.596 ± 0.037	3.142ProSer: 3.142 ± 0.033	3.809ProThr: 3.809 ± 0.039	5.499ProVal: 5.499 ± 0.044	0.949ProTrp: 0.949 ± 0.016	1.141ProTyr: 1.141 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	4.095GlnAla: 4.095 ± 0.039	0.222GlnCys: 0.222 ± 0.007	1.584GlnAsp: 1.584 ± 0.023	1.249GlnGlu: 1.249 ± 0.018	0.915GlnPhe: 0.915 ± 0.016	2.124GlnGly: 2.124 ± 0.024	0.745GlnHis: 0.745 ± 0.015	1.248GlnIle: 1.248 ± 0.018	0.536GlnLys: 0.536 ± 0.014	3.457GlnLeu: 3.457 ± 0.032	0.552GlnMet: 0.552 ± 0.012	0.622GlnAsn: 0.622 ± 0.016	2.062GlnPro: 2.062 ± 0.031	1.389GlnGln: 1.389 ± 0.028	2.786GlnArg: 2.786 ± 0.026	1.435GlnSer: 1.435 ± 0.022	1.553GlnThr: 1.553 ± 0.024	2.989GlnVal: 2.989 ± 0.032	0.558GlnTrp: 0.558 ± 0.014	0.643GlnTyr: 0.643 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	8.882ArgAla: 8.882 ± 0.067	0.643ArgCys: 0.643 ± 0.013	4.472ArgAsp: 4.472 ± 0.037	3.863ArgGlu: 3.863 ± 0.037	2.527ArgPhe: 2.527 ± 0.026	5.171ArgGly: 5.171 ± 0.039	2.054ArgHis: 2.054 ± 0.028	3.25ArgIle: 3.25 ± 0.032	1.694ArgLys: 1.694 ± 0.026	8.69ArgLeu: 8.69 ± 0.063	1.889ArgMet: 1.889 ± 0.023	1.594ArgAsn: 1.594 ± 0.021	4.504ArgPro: 4.504 ± 0.045	2.634ArgGln: 2.634 ± 0.029	7.123ArgArg: 7.123 ± 0.052	3.966ArgSer: 3.966 ± 0.035	4.92ArgThr: 4.92 ± 0.041	6.063ArgVal: 6.063 ± 0.048	1.415ArgTrp: 1.415 ± 0.022	1.876ArgTyr: 1.876 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.43SerAla: 6.43 ± 0.041	0.462SerCys: 0.462 ± 0.012	2.858SerAsp: 2.858 ± 0.034	2.177SerGlu: 2.177 ± 0.026	1.689SerPhe: 1.689 ± 0.021	5.57SerGly: 5.57 ± 0.043	1.0SerHis: 1.0 ± 0.019	1.791SerIle: 1.791 ± 0.021	1.016SerLys: 1.016 ± 0.017	5.1SerLeu: 5.1 ± 0.042	1.209SerMet: 1.209 ± 0.016	1.077SerAsn: 1.077 ± 0.021	3.228SerPro: 3.228 ± 0.029	1.455SerGln: 1.455 ± 0.019	3.759SerArg: 3.759 ± 0.032	3.027SerSer: 3.027 ± 0.037	3.667SerThr: 3.667 ± 0.038	4.746SerVal: 4.746 ± 0.037	0.968SerTrp: 0.968 ± 0.017	1.216SerTyr: 1.216 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	8.259ThrAla: 8.259 ± 0.054	0.519ThrCys: 0.519 ± 0.013	3.878ThrAsp: 3.878 ± 0.032	3.207ThrGlu: 3.207 ± 0.032	1.875ThrPhe: 1.875 ± 0.024	6.446ThrGly: 6.446 ± 0.048	1.321ThrHis: 1.321 ± 0.018	2.3ThrIle: 2.3 ± 0.025	1.368ThrLys: 1.368 ± 0.022	5.988ThrLeu: 5.988 ± 0.045	1.191ThrMet: 1.191 ± 0.018	1.402ThrAsn: 1.402 ± 0.024	4.056ThrPro: 4.056 ± 0.035	1.693ThrGln: 1.693 ± 0.023	4.084ThrArg: 4.084 ± 0.037	3.59ThrSer: 3.59 ± 0.035	4.34ThrThr: 4.34 ± 0.051	6.572ThrVal: 6.572 ± 0.053	1.022ThrTrp: 1.022 ± 0.022	1.434ThrTyr: 1.434 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.513ValAla: 11.513 ± 0.062	0.727ValCys: 0.727 ± 0.014	6.32ValAsp: 6.32 ± 0.045	4.417ValGlu: 4.417 ± 0.041	2.673ValPhe: 2.673 ± 0.029	7.072ValGly: 7.072 ± 0.046	1.984ValHis: 1.984 ± 0.025	3.405ValIle: 3.405 ± 0.033	1.734ValLys: 1.734 ± 0.028	10.045ValLeu: 10.045 ± 0.062	1.46ValMet: 1.46 ± 0.02	2.068ValAsn: 2.068 ± 0.026	5.185ValPro: 5.185 ± 0.044	2.358ValGln: 2.358 ± 0.027	6.952ValArg: 6.952 ± 0.05	4.887ValSer: 4.887 ± 0.043	6.254ValThr: 6.254 ± 0.048	8.988ValVal: 8.988 ± 0.064	1.162ValTrp: 1.162 ± 0.019	1.591ValTyr: 1.591 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.606TrpAla: 1.606 ± 0.023	0.166TrpCys: 0.166 ± 0.007	0.859TrpAsp: 0.859 ± 0.016	0.627TrpGlu: 0.627 ± 0.012	0.54TrpPhe: 0.54 ± 0.012	1.028TrpGly: 1.028 ± 0.019	0.415TrpHis: 0.415 ± 0.011	0.632TrpIle: 0.632 ± 0.016	0.29TrpLys: 0.29 ± 0.009	1.97TrpLeu: 1.97 ± 0.026	0.317TrpMet: 0.317 ± 0.009	0.429TrpAsn: 0.429 ± 0.012	0.903TrpPro: 0.903 ± 0.017	0.7TrpGln: 0.7 ± 0.015	1.448TrpArg: 1.448 ± 0.021	0.982TrpSer: 0.982 ± 0.017	1.105TrpThr: 1.105 ± 0.016	1.137TrpVal: 1.137 ± 0.02	0.372TrpTrp: 0.372 ± 0.011	0.343TrpTyr: 0.343 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.337TyrAla: 2.337 ± 0.027	0.179TyrCys: 0.179 ± 0.007	1.388TyrAsp: 1.388 ± 0.029	0.988TyrGlu: 0.988 ± 0.016	0.682TyrPhe: 0.682 ± 0.015	1.985TyrGly: 1.985 ± 0.026	0.482TyrHis: 0.482 ± 0.012	0.518TyrIle: 0.518 ± 0.013	0.351TyrLys: 0.351 ± 0.011	2.292TyrLeu: 2.292 ± 0.026	0.28TyrMet: 0.28 ± 0.01	0.46TyrAsn: 0.46 ± 0.012	1.219TyrPro: 1.219 ± 0.017	0.83TyrGln: 0.83 ± 0.017	1.913TyrArg: 1.913 ± 0.027	1.083TyrSer: 1.083 ± 0.018	1.299TyrThr: 1.299 ± 0.021	1.768TyrVal: 1.768 ± 0.024	0.38TyrTrp: 0.38 ± 0.009	0.496TyrTyr: 0.496 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10734 proteins (3650074 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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