Amino acid dipepetide frequency for Streptococcus phage Javan210

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.145AlaAla: 4.145 ± 1.573
0.259AlaCys: 0.259 ± 0.154
4.405AlaAsp: 4.405 ± 0.673
6.477AlaGlu: 6.477 ± 0.988
3.714AlaPhe: 3.714 ± 0.935
6.045AlaGly: 6.045 ± 1.253
0.864AlaHis: 0.864 ± 0.281
6.045AlaIle: 6.045 ± 0.844
6.564AlaLys: 6.564 ± 0.728
6.564AlaLeu: 6.564 ± 1.429
2.073AlaMet: 2.073 ± 0.836
5.009AlaAsn: 5.009 ± 0.717
2.85AlaPro: 2.85 ± 0.397
3.368AlaGln: 3.368 ± 0.789
1.986AlaArg: 1.986 ± 0.404
3.973AlaSer: 3.973 ± 0.871
4.664AlaThr: 4.664 ± 0.997
4.491AlaVal: 4.491 ± 1.064
0.777AlaTrp: 0.777 ± 0.238
3.195AlaTyr: 3.195 ± 0.482
0.0AlaXaa: 0.0 ± 0.0
Cys
0.086CysAla: 0.086 ± 0.084
0.086CysCys: 0.086 ± 0.074
0.259CysAsp: 0.259 ± 0.155
0.432CysGlu: 0.432 ± 0.187
0.173CysPhe: 0.173 ± 0.13
0.605CysGly: 0.605 ± 0.227
0.173CysHis: 0.173 ± 0.119
0.173CysIle: 0.173 ± 0.139
0.345CysLys: 0.345 ± 0.171
0.259CysLeu: 0.259 ± 0.129
0.0CysMet: 0.0 ± 0.0
0.259CysAsn: 0.259 ± 0.171
0.0CysPro: 0.0 ± 0.0
0.345CysGln: 0.345 ± 0.169
0.259CysArg: 0.259 ± 0.148
0.173CysSer: 0.173 ± 0.133
0.259CysThr: 0.259 ± 0.151
0.259CysVal: 0.259 ± 0.143
0.0CysTrp: 0.0 ± 0.0
0.345CysTyr: 0.345 ± 0.167
0.0CysXaa: 0.0 ± 0.0
Asp
4.059AspAla: 4.059 ± 0.634
0.518AspCys: 0.518 ± 0.218
4.664AspAsp: 4.664 ± 0.898
5.182AspGlu: 5.182 ± 0.934
3.8AspPhe: 3.8 ± 0.535
6.045AspGly: 6.045 ± 0.754
0.691AspHis: 0.691 ± 0.205
3.8AspIle: 3.8 ± 0.774
4.75AspLys: 4.75 ± 0.637
4.405AspLeu: 4.405 ± 0.652
1.814AspMet: 1.814 ± 0.303
3.8AspAsn: 3.8 ± 0.565
1.123AspPro: 1.123 ± 0.439
1.727AspGln: 1.727 ± 0.336
2.159AspArg: 2.159 ± 0.356
3.627AspSer: 3.627 ± 0.53
3.627AspThr: 3.627 ± 0.629
3.541AspVal: 3.541 ± 0.671
0.432AspTrp: 0.432 ± 0.236
3.023AspTyr: 3.023 ± 0.545
0.0AspXaa: 0.0 ± 0.0
Glu
4.664GluAla: 4.664 ± 0.666
0.173GluCys: 0.173 ± 0.117
4.405GluAsp: 4.405 ± 0.793
5.7GluGlu: 5.7 ± 0.915
3.282GluPhe: 3.282 ± 0.5
2.85GluGly: 2.85 ± 0.422
0.777GluHis: 0.777 ± 0.223
5.095GluIle: 5.095 ± 0.927
4.232GluLys: 4.232 ± 0.657
6.218GluLeu: 6.218 ± 1.066
2.245GluMet: 2.245 ± 0.471
4.145GluAsn: 4.145 ± 0.746
1.9GluPro: 1.9 ± 0.493
3.714GluGln: 3.714 ± 0.607
3.455GluArg: 3.455 ± 0.738
1.986GluSer: 1.986 ± 0.418
4.491GluThr: 4.491 ± 0.878
5.095GluVal: 5.095 ± 0.699
0.864GluTrp: 0.864 ± 0.27
2.936GluTyr: 2.936 ± 0.511
0.0GluXaa: 0.0 ± 0.0
Phe
2.332PheAla: 2.332 ± 0.446
0.345PheCys: 0.345 ± 0.161
3.714PheAsp: 3.714 ± 0.514
3.714PheGlu: 3.714 ± 0.686
1.641PhePhe: 1.641 ± 0.392
3.195PheGly: 3.195 ± 0.586
0.345PheHis: 0.345 ± 0.171
2.159PheIle: 2.159 ± 0.359
4.75PheLys: 4.75 ± 0.606
2.418PheLeu: 2.418 ± 0.575
1.036PheMet: 1.036 ± 0.284
3.886PheAsn: 3.886 ± 0.539
0.691PhePro: 0.691 ± 0.24
1.641PheGln: 1.641 ± 0.398
1.036PheArg: 1.036 ± 0.267
2.85PheSer: 2.85 ± 0.468
2.677PheThr: 2.677 ± 0.587
2.591PheVal: 2.591 ± 0.379
0.864PheTrp: 0.864 ± 0.371
1.555PheTyr: 1.555 ± 0.442
0.0PheXaa: 0.0 ± 0.0
Gly
5.009GlyAla: 5.009 ± 1.721
0.345GlyCys: 0.345 ± 0.15
2.764GlyAsp: 2.764 ± 0.522
3.282GlyGlu: 3.282 ± 0.37
3.195GlyPhe: 3.195 ± 0.505
5.095GlyGly: 5.095 ± 0.864
1.468GlyHis: 1.468 ± 0.43
4.75GlyIle: 4.75 ± 1.043
6.305GlyLys: 6.305 ± 0.9
4.836GlyLeu: 4.836 ± 0.65
1.555GlyMet: 1.555 ± 0.432
5.182GlyAsn: 5.182 ± 1.014
0.173GlyPro: 0.173 ± 0.108
3.541GlyGln: 3.541 ± 0.708
3.541GlyArg: 3.541 ± 0.506
4.577GlySer: 4.577 ± 0.9
5.009GlyThr: 5.009 ± 0.836
4.75GlyVal: 4.75 ± 0.671
0.864GlyTrp: 0.864 ± 0.316
2.505GlyTyr: 2.505 ± 0.606
0.0GlyXaa: 0.0 ± 0.0
His
0.518HisAla: 0.518 ± 0.232
0.173HisCys: 0.173 ± 0.112
0.95HisAsp: 0.95 ± 0.3
0.864HisGlu: 0.864 ± 0.248
0.432HisPhe: 0.432 ± 0.18
0.864HisGly: 0.864 ± 0.273
0.345HisHis: 0.345 ± 0.183
0.95HisIle: 0.95 ± 0.385
0.95HisLys: 0.95 ± 0.291
1.036HisLeu: 1.036 ± 0.269
0.345HisMet: 0.345 ± 0.197
0.95HisAsn: 0.95 ± 0.265
0.605HisPro: 0.605 ± 0.308
0.777HisGln: 0.777 ± 0.34
0.518HisArg: 0.518 ± 0.2
0.864HisSer: 0.864 ± 0.273
0.691HisThr: 0.691 ± 0.322
1.123HisVal: 1.123 ± 0.323
0.173HisTrp: 0.173 ± 0.115
0.518HisTyr: 0.518 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
5.527IleAla: 5.527 ± 1.193
0.086IleCys: 0.086 ± 0.086
4.577IleAsp: 4.577 ± 0.549
4.923IleGlu: 4.923 ± 0.675
2.418IlePhe: 2.418 ± 0.54
4.145IleGly: 4.145 ± 0.732
0.95IleHis: 0.95 ± 0.268
3.541IleIle: 3.541 ± 0.556
6.045IleLys: 6.045 ± 0.664
3.8IleLeu: 3.8 ± 0.545
1.209IleMet: 1.209 ± 0.299
4.923IleAsn: 4.923 ± 0.782
1.468IlePro: 1.468 ± 0.436
2.073IleGln: 2.073 ± 0.365
2.245IleArg: 2.245 ± 0.48
4.145IleSer: 4.145 ± 0.562
4.836IleThr: 4.836 ± 0.723
3.973IleVal: 3.973 ± 0.703
0.864IleTrp: 0.864 ± 0.257
2.591IleTyr: 2.591 ± 0.587
0.0IleXaa: 0.0 ± 0.0
Lys
8.205LysAla: 8.205 ± 0.956
0.691LysCys: 0.691 ± 0.244
5.095LysAsp: 5.095 ± 0.882
5.786LysGlu: 5.786 ± 0.864
2.245LysPhe: 2.245 ± 0.372
4.75LysGly: 4.75 ± 0.419
1.295LysHis: 1.295 ± 0.324
5.182LysIle: 5.182 ± 0.574
5.873LysLys: 5.873 ± 0.987
6.909LysLeu: 6.909 ± 0.92
2.677LysMet: 2.677 ± 0.412
4.405LysAsn: 4.405 ± 0.711
2.591LysPro: 2.591 ± 0.527
3.282LysGln: 3.282 ± 0.568
3.627LysArg: 3.627 ± 0.889
5.527LysSer: 5.527 ± 0.704
5.527LysThr: 5.527 ± 0.662
5.614LysVal: 5.614 ± 0.771
0.95LysTrp: 0.95 ± 0.244
3.195LysTyr: 3.195 ± 0.64
0.0LysXaa: 0.0 ± 0.0
Leu
6.045LeuAla: 6.045 ± 0.835
0.259LeuCys: 0.259 ± 0.148
4.836LeuAsp: 4.836 ± 0.783
5.009LeuGlu: 5.009 ± 0.733
2.332LeuPhe: 2.332 ± 0.422
5.614LeuGly: 5.614 ± 0.956
1.382LeuHis: 1.382 ± 0.432
3.368LeuIle: 3.368 ± 0.62
7.514LeuLys: 7.514 ± 0.879
4.491LeuLeu: 4.491 ± 0.673
1.555LeuMet: 1.555 ± 0.528
3.8LeuAsn: 3.8 ± 0.604
2.677LeuPro: 2.677 ± 0.492
2.85LeuGln: 2.85 ± 0.565
2.332LeuArg: 2.332 ± 0.551
6.045LeuSer: 6.045 ± 0.818
5.441LeuThr: 5.441 ± 0.811
5.182LeuVal: 5.182 ± 0.685
0.432LeuTrp: 0.432 ± 0.229
2.245LeuTyr: 2.245 ± 0.572
0.0LeuXaa: 0.0 ± 0.0
Met
1.9MetAla: 1.9 ± 0.729
0.086MetCys: 0.086 ± 0.084
1.295MetAsp: 1.295 ± 0.262
1.036MetGlu: 1.036 ± 0.322
1.036MetPhe: 1.036 ± 0.245
1.555MetGly: 1.555 ± 0.365
0.345MetHis: 0.345 ± 0.233
1.382MetIle: 1.382 ± 0.28
2.159MetLys: 2.159 ± 0.486
1.641MetLeu: 1.641 ± 0.365
0.691MetMet: 0.691 ± 0.198
1.209MetAsn: 1.209 ± 0.387
0.691MetPro: 0.691 ± 0.216
1.9MetGln: 1.9 ± 0.431
1.036MetArg: 1.036 ± 0.348
1.814MetSer: 1.814 ± 0.52
2.505MetThr: 2.505 ± 0.504
1.209MetVal: 1.209 ± 0.358
0.345MetTrp: 0.345 ± 0.147
0.95MetTyr: 0.95 ± 0.316
0.0MetXaa: 0.0 ± 0.0
Asn
5.614AsnAla: 5.614 ± 0.818
0.0AsnCys: 0.0 ± 0.0
3.886AsnAsp: 3.886 ± 0.628
4.75AsnGlu: 4.75 ± 0.805
2.85AsnPhe: 2.85 ± 0.595
5.7AsnGly: 5.7 ± 1.028
0.605AsnHis: 0.605 ± 0.2
3.023AsnIle: 3.023 ± 0.565
4.145AsnLys: 4.145 ± 0.624
4.75AsnLeu: 4.75 ± 0.594
1.382AsnMet: 1.382 ± 0.349
2.936AsnAsn: 2.936 ± 0.556
2.677AsnPro: 2.677 ± 0.562
2.677AsnGln: 2.677 ± 0.639
1.209AsnArg: 1.209 ± 0.279
3.714AsnSer: 3.714 ± 0.717
4.577AsnThr: 4.577 ± 0.9
4.405AsnVal: 4.405 ± 0.762
0.777AsnTrp: 0.777 ± 0.451
1.727AsnTyr: 1.727 ± 0.413
0.0AsnXaa: 0.0 ± 0.0
Pro
2.505ProAla: 2.505 ± 0.515
0.086ProCys: 0.086 ± 0.076
1.555ProAsp: 1.555 ± 0.413
2.85ProGlu: 2.85 ± 0.575
1.727ProPhe: 1.727 ± 0.331
0.864ProGly: 0.864 ± 0.223
0.345ProHis: 0.345 ± 0.16
1.641ProIle: 1.641 ± 0.315
1.814ProLys: 1.814 ± 0.389
1.986ProLeu: 1.986 ± 0.429
0.432ProMet: 0.432 ± 0.157
1.555ProAsn: 1.555 ± 0.385
0.605ProPro: 0.605 ± 0.202
0.864ProGln: 0.864 ± 0.286
0.864ProArg: 0.864 ± 0.253
1.814ProSer: 1.814 ± 0.361
1.641ProThr: 1.641 ± 0.441
2.245ProVal: 2.245 ± 0.389
0.0ProTrp: 0.0 ± 0.0
1.123ProTyr: 1.123 ± 0.297
0.0ProXaa: 0.0 ± 0.0
Gln
4.059GlnAla: 4.059 ± 0.656
0.173GlnCys: 0.173 ± 0.126
2.245GlnAsp: 2.245 ± 0.438
2.85GlnGlu: 2.85 ± 0.637
1.9GlnPhe: 1.9 ± 0.371
3.023GlnGly: 3.023 ± 0.692
0.432GlnHis: 0.432 ± 0.168
3.541GlnIle: 3.541 ± 0.622
3.541GlnLys: 3.541 ± 0.631
3.973GlnLeu: 3.973 ± 0.464
1.9GlnMet: 1.9 ± 0.435
1.986GlnAsn: 1.986 ± 0.741
1.036GlnPro: 1.036 ± 0.328
1.986GlnGln: 1.986 ± 0.541
1.468GlnArg: 1.468 ± 0.397
2.591GlnSer: 2.591 ± 0.454
2.073GlnThr: 2.073 ± 0.626
2.418GlnVal: 2.418 ± 0.437
0.605GlnTrp: 0.605 ± 0.177
1.555GlnTyr: 1.555 ± 0.413
0.0GlnXaa: 0.0 ± 0.0
Arg
3.714ArgAla: 3.714 ± 0.643
0.0ArgCys: 0.0 ± 0.0
2.505ArgAsp: 2.505 ± 0.579
1.727ArgGlu: 1.727 ± 0.431
1.209ArgPhe: 1.209 ± 0.331
1.727ArgGly: 1.727 ± 0.397
0.259ArgHis: 0.259 ± 0.163
2.332ArgIle: 2.332 ± 0.39
4.059ArgLys: 4.059 ± 0.635
3.109ArgLeu: 3.109 ± 0.477
0.95ArgMet: 0.95 ± 0.296
2.418ArgAsn: 2.418 ± 0.394
1.209ArgPro: 1.209 ± 0.31
1.295ArgGln: 1.295 ± 0.381
1.382ArgArg: 1.382 ± 0.366
1.209ArgSer: 1.209 ± 0.29
2.159ArgThr: 2.159 ± 0.34
1.814ArgVal: 1.814 ± 0.474
0.864ArgTrp: 0.864 ± 0.256
1.555ArgTyr: 1.555 ± 0.363
0.0ArgXaa: 0.0 ± 0.0
Ser
4.75SerAla: 4.75 ± 1.271
0.173SerCys: 0.173 ± 0.131
4.577SerAsp: 4.577 ± 0.605
4.145SerGlu: 4.145 ± 0.7
2.591SerPhe: 2.591 ± 0.483
4.836SerGly: 4.836 ± 0.862
1.209SerHis: 1.209 ± 0.345
4.577SerIle: 4.577 ± 0.638
3.973SerLys: 3.973 ± 0.614
3.627SerLeu: 3.627 ± 0.514
1.9SerMet: 1.9 ± 0.505
3.109SerAsn: 3.109 ± 0.502
1.468SerPro: 1.468 ± 0.314
3.282SerGln: 3.282 ± 0.68
1.986SerArg: 1.986 ± 0.325
4.145SerSer: 4.145 ± 0.827
5.095SerThr: 5.095 ± 0.648
4.059SerVal: 4.059 ± 0.691
1.036SerTrp: 1.036 ± 0.255
2.764SerTyr: 2.764 ± 0.37
0.0SerXaa: 0.0 ± 0.0
Thr
6.477ThrAla: 6.477 ± 0.807
0.345ThrCys: 0.345 ± 0.178
3.282ThrAsp: 3.282 ± 0.644
3.282ThrGlu: 3.282 ± 0.358
3.627ThrPhe: 3.627 ± 0.711
4.059ThrGly: 4.059 ± 0.816
0.691ThrHis: 0.691 ± 0.324
4.923ThrIle: 4.923 ± 0.573
4.836ThrLys: 4.836 ± 0.986
5.182ThrLeu: 5.182 ± 0.703
1.123ThrMet: 1.123 ± 0.321
4.836ThrAsn: 4.836 ± 1.004
2.159ThrPro: 2.159 ± 0.361
3.455ThrGln: 3.455 ± 0.641
1.727ThrArg: 1.727 ± 0.374
4.059ThrSer: 4.059 ± 0.7
3.8ThrThr: 3.8 ± 0.845
5.355ThrVal: 5.355 ± 0.825
0.691ThrTrp: 0.691 ± 0.277
3.109ThrTyr: 3.109 ± 0.574
0.0ThrXaa: 0.0 ± 0.0
Val
4.232ValAla: 4.232 ± 0.823
0.173ValCys: 0.173 ± 0.122
3.973ValAsp: 3.973 ± 0.494
3.455ValGlu: 3.455 ± 0.732
2.591ValPhe: 2.591 ± 0.469
5.182ValGly: 5.182 ± 1.177
0.777ValHis: 0.777 ± 0.249
4.059ValIle: 4.059 ± 0.609
6.132ValLys: 6.132 ± 0.858
3.973ValLeu: 3.973 ± 0.587
1.036ValMet: 1.036 ± 0.346
3.541ValAsn: 3.541 ± 0.605
1.641ValPro: 1.641 ± 0.432
2.505ValGln: 2.505 ± 0.592
1.9ValArg: 1.9 ± 0.404
6.218ValSer: 6.218 ± 0.749
4.577ValThr: 4.577 ± 0.479
4.836ValVal: 4.836 ± 0.488
0.864ValTrp: 0.864 ± 0.285
2.936ValTyr: 2.936 ± 0.477
0.0ValXaa: 0.0 ± 0.0
Trp
0.777TrpAla: 0.777 ± 0.207
0.086TrpCys: 0.086 ± 0.083
0.777TrpAsp: 0.777 ± 0.237
0.605TrpGlu: 0.605 ± 0.239
0.518TrpPhe: 0.518 ± 0.234
0.777TrpGly: 0.777 ± 0.242
0.345TrpHis: 0.345 ± 0.181
0.605TrpIle: 0.605 ± 0.277
1.555TrpLys: 1.555 ± 0.398
0.95TrpLeu: 0.95 ± 0.326
0.259TrpMet: 0.259 ± 0.131
0.518TrpAsn: 0.518 ± 0.197
0.0TrpPro: 0.0 ± 0.0
0.518TrpGln: 0.518 ± 0.222
0.691TrpArg: 0.691 ± 0.322
0.864TrpSer: 0.864 ± 0.237
0.864TrpThr: 0.864 ± 0.269
0.432TrpVal: 0.432 ± 0.189
0.173TrpTrp: 0.173 ± 0.111
0.864TrpTyr: 0.864 ± 0.343
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.85TyrAla: 2.85 ± 0.582
0.432TyrCys: 0.432 ± 0.255
3.023TyrAsp: 3.023 ± 0.643
2.159TyrGlu: 2.159 ± 0.557
2.159TyrPhe: 2.159 ± 0.538
1.814TyrGly: 1.814 ± 0.465
0.345TyrHis: 0.345 ± 0.191
3.195TyrIle: 3.195 ± 0.501
3.886TyrLys: 3.886 ± 0.528
3.282TyrLeu: 3.282 ± 0.547
0.518TyrMet: 0.518 ± 0.191
2.936TyrAsn: 2.936 ± 0.553
0.95TyrPro: 0.95 ± 0.306
1.555TyrGln: 1.555 ± 0.408
2.073TyrArg: 2.073 ± 0.419
3.109TyrSer: 3.109 ± 0.457
2.505TyrThr: 2.505 ± 0.625
1.295TyrVal: 1.295 ± 0.355
0.605TyrTrp: 0.605 ± 0.212
2.677TyrTyr: 2.677 ± 0.742
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski