Amino acid dipepetide frequency for Strongyloides stercoralis (Threadworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.313AlaAla: 2.313 ± 0.036	0.766AlaCys: 0.766 ± 0.015	1.755AlaAsp: 1.755 ± 0.021	2.295AlaGlu: 2.295 ± 0.032	2.058AlaPhe: 2.058 ± 0.024	1.839AlaGly: 1.839 ± 0.025	0.734AlaHis: 0.734 ± 0.013	3.43AlaIle: 3.43 ± 0.03	2.945AlaLys: 2.945 ± 0.033	3.797AlaLeu: 3.797 ± 0.038	0.924AlaMet: 0.924 ± 0.016	2.141AlaAsn: 2.141 ± 0.02	1.547AlaPro: 1.547 ± 0.023	1.234AlaGln: 1.234 ± 0.017	1.559AlaArg: 1.559 ± 0.023	3.066AlaSer: 3.066 ± 0.029	2.331AlaThr: 2.331 ± 0.051	2.295AlaVal: 2.295 ± 0.024	0.354AlaTrp: 0.354 ± 0.009	1.461AlaTyr: 1.461 ± 0.019	0.001AlaXaa: 0.001 ± 0.0
Cys	0.691CysAla: 0.691 ± 0.013	0.569CysCys: 0.569 ± 0.014	1.184CysAsp: 1.184 ± 0.02	1.172CysGlu: 1.172 ± 0.022	1.049CysPhe: 1.049 ± 0.018	1.211CysGly: 1.211 ± 0.023	0.48CysHis: 0.48 ± 0.012	1.645CysIle: 1.645 ± 0.021	1.608CysLys: 1.608 ± 0.022	1.86CysLeu: 1.86 ± 0.025	0.415CysMet: 0.415 ± 0.009	1.437CysAsn: 1.437 ± 0.023	0.945CysPro: 0.945 ± 0.025	0.862CysGln: 0.862 ± 0.015	0.798CysArg: 0.798 ± 0.013	1.686CysSer: 1.686 ± 0.026	0.992CysThr: 0.992 ± 0.018	0.966CysVal: 0.966 ± 0.017	0.186CysTrp: 0.186 ± 0.006	0.919CysTyr: 0.919 ± 0.015	0.001CysXaa: 0.001 ± 0.0
Asp	1.873AspAla: 1.873 ± 0.021	1.074AspCys: 1.074 ± 0.017	3.894AspAsp: 3.894 ± 0.039	4.424AspGlu: 4.424 ± 0.045	2.68AspPhe: 2.68 ± 0.022	2.777AspGly: 2.777 ± 0.034	0.891AspHis: 0.891 ± 0.014	4.928AspIle: 4.928 ± 0.034	4.708AspLys: 4.708 ± 0.042	4.274AspLeu: 4.274 ± 0.038	1.154AspMet: 1.154 ± 0.016	4.261AspAsn: 4.261 ± 0.039	1.752AspPro: 1.752 ± 0.018	1.416AspGln: 1.416 ± 0.018	1.8AspArg: 1.8 ± 0.016	4.107AspSer: 4.107 ± 0.04	2.516AspThr: 2.516 ± 0.023	3.067AspVal: 3.067 ± 0.027	0.475AspTrp: 0.475 ± 0.01	2.336AspTyr: 2.336 ± 0.031	0.001AspXaa: 0.001 ± 0.0
Glu	2.882GluAla: 2.882 ± 0.047	1.347GluCys: 1.347 ± 0.025	3.895GluAsp: 3.895 ± 0.036	5.993GluGlu: 5.993 ± 0.066	2.52GluPhe: 2.52 ± 0.021	2.665GluGly: 2.665 ± 0.023	1.162GluHis: 1.162 ± 0.015	5.61GluIle: 5.61 ± 0.043	7.059GluLys: 7.059 ± 0.071	5.08GluLeu: 5.08 ± 0.039	1.638GluMet: 1.638 ± 0.018	5.492GluAsn: 5.492 ± 0.046	1.652GluPro: 1.652 ± 0.039	1.897GluGln: 1.897 ± 0.022	2.714GluArg: 2.714 ± 0.03	4.595GluSer: 4.595 ± 0.069	3.583GluThr: 3.583 ± 0.081	3.283GluVal: 3.283 ± 0.026	0.605GluTrp: 0.605 ± 0.011	2.606GluTyr: 2.606 ± 0.024	0.001GluXaa: 0.001 ± 0.001
Phe	1.897PheAla: 1.897 ± 0.021	1.077PheCys: 1.077 ± 0.015	2.887PheAsp: 2.887 ± 0.025	2.873PheGlu: 2.873 ± 0.024	2.746PhePhe: 2.746 ± 0.027	2.632PheGly: 2.632 ± 0.025	0.965PheHis: 0.965 ± 0.013	4.418PheIle: 4.418 ± 0.033	3.689PheLys: 3.689 ± 0.032	4.587PheLeu: 4.587 ± 0.04	1.06PheMet: 1.06 ± 0.016	3.582PheAsn: 3.582 ± 0.031	1.724PhePro: 1.724 ± 0.021	1.531PheGln: 1.531 ± 0.019	1.562PheArg: 1.562 ± 0.017	3.94PheSer: 3.94 ± 0.031	2.595PheThr: 2.595 ± 0.02	2.65PheVal: 2.65 ± 0.021	0.484PheTrp: 0.484 ± 0.011	2.24PheTyr: 2.24 ± 0.021	0.002PheXaa: 0.002 ± 0.001
Gly	1.956GlyAla: 1.956 ± 0.027	1.021GlyCys: 1.021 ± 0.019	2.376GlyAsp: 2.376 ± 0.024	2.893GlyGlu: 2.893 ± 0.05	2.249GlyPhe: 2.249 ± 0.023	2.924GlyGly: 2.924 ± 0.054	0.959GlyHis: 0.959 ± 0.016	4.009GlyIle: 4.009 ± 0.034	4.031GlyLys: 4.031 ± 0.037	3.607GlyLeu: 3.607 ± 0.036	1.097GlyMet: 1.097 ± 0.018	3.247GlyAsn: 3.247 ± 0.029	1.573GlyPro: 1.573 ± 0.037	1.491GlyGln: 1.491 ± 0.022	2.047GlyArg: 2.047 ± 0.024	3.566GlySer: 3.566 ± 0.033	2.609GlyThr: 2.609 ± 0.027	2.527GlyVal: 2.527 ± 0.021	0.446GlyTrp: 0.446 ± 0.011	2.168GlyTyr: 2.168 ± 0.027	0.001GlyXaa: 0.001 ± 0.0
His	0.725HisAla: 0.725 ± 0.013	0.465HisCys: 0.465 ± 0.009	0.966HisAsp: 0.966 ± 0.015	1.152HisGlu: 1.152 ± 0.015	1.075HisPhe: 1.075 ± 0.014	0.994HisGly: 0.994 ± 0.015	0.562HisHis: 0.562 ± 0.014	1.536HisIle: 1.536 ± 0.019	1.338HisLys: 1.338 ± 0.014	1.884HisLeu: 1.884 ± 0.018	0.416HisMet: 0.416 ± 0.009	1.226HisAsn: 1.226 ± 0.015	0.876HisPro: 0.876 ± 0.013	0.737HisGln: 0.737 ± 0.015	0.818HisArg: 0.818 ± 0.014	1.618HisSer: 1.618 ± 0.019	0.96HisThr: 0.96 ± 0.014	1.022HisVal: 1.022 ± 0.015	0.196HisTrp: 0.196 ± 0.006	0.913HisTyr: 0.913 ± 0.014	0.001HisXaa: 0.001 ± 0.0
Ile	3.249IleAla: 3.249 ± 0.029	1.786IleCys: 1.786 ± 0.023	4.757IleAsp: 4.757 ± 0.035	5.488IleGlu: 5.488 ± 0.041	4.645IlePhe: 4.645 ± 0.042	3.792IleGly: 3.792 ± 0.027	1.681IleHis: 1.681 ± 0.019	7.522IleIle: 7.522 ± 0.062	7.134IleLys: 7.134 ± 0.049	7.601IleLeu: 7.601 ± 0.053	1.623IleMet: 1.623 ± 0.019	6.717IleAsn: 6.717 ± 0.048	3.73IlePro: 3.73 ± 0.029	2.769IleGln: 2.769 ± 0.025	2.9IleArg: 2.9 ± 0.027	6.969IleSer: 6.969 ± 0.04	4.634IleThr: 4.634 ± 0.034	4.394IleVal: 4.394 ± 0.034	0.714IleTrp: 0.714 ± 0.012	3.301IleTyr: 3.301 ± 0.031	0.002IleXaa: 0.002 ± 0.001
Lys	3.054LysAla: 3.054 ± 0.032	1.842LysCys: 1.842 ± 0.025	4.699LysAsp: 4.699 ± 0.049	6.65LysGlu: 6.65 ± 0.051	3.57LysPhe: 3.57 ± 0.031	3.167LysGly: 3.167 ± 0.033	1.667LysHis: 1.667 ± 0.02	7.495LysIle: 7.495 ± 0.047	9.61LysLys: 9.61 ± 0.077	7.127LysLeu: 7.127 ± 0.047	2.004LysMet: 2.004 ± 0.022	7.986LysAsn: 7.986 ± 0.055	2.73LysPro: 2.73 ± 0.044	2.676LysGln: 2.676 ± 0.029	3.741LysArg: 3.741 ± 0.032	5.984LysSer: 5.984 ± 0.045	4.339LysThr: 4.339 ± 0.036	4.181LysVal: 4.181 ± 0.033	0.801LysTrp: 0.801 ± 0.011	3.706LysTyr: 3.706 ± 0.031	0.004LysXaa: 0.004 ± 0.001
Leu	3.689LeuAla: 3.689 ± 0.038	1.678LeuCys: 1.678 ± 0.02	4.208LeuAsp: 4.208 ± 0.038	5.451LeuGlu: 5.451 ± 0.044	4.415LeuPhe: 4.415 ± 0.032	3.507LeuGly: 3.507 ± 0.031	1.802LeuHis: 1.802 ± 0.022	6.871LeuIle: 6.871 ± 0.042	7.736LeuLys: 7.736 ± 0.046	8.328LeuLeu: 8.328 ± 0.05	1.873LeuMet: 1.873 ± 0.018	6.068LeuAsn: 6.068 ± 0.04	3.955LeuPro: 3.955 ± 0.034	3.269LeuGln: 3.269 ± 0.03	3.496LeuArg: 3.496 ± 0.032	7.471LeuSer: 7.471 ± 0.047	4.88LeuThr: 4.88 ± 0.03	3.868LeuVal: 3.868 ± 0.03	0.764LeuTrp: 0.764 ± 0.013	3.301LeuTyr: 3.301 ± 0.024	0.002LeuXaa: 0.002 ± 0.001
Met	1.182MetAla: 1.182 ± 0.018	0.372MetCys: 0.372 ± 0.009	1.222MetAsp: 1.222 ± 0.015	1.531MetGlu: 1.531 ± 0.019	1.006MetPhe: 1.006 ± 0.014	1.0MetGly: 1.0 ± 0.016	0.395MetHis: 0.395 ± 0.009	1.76MetIle: 1.76 ± 0.021	1.964MetLys: 1.964 ± 0.02	1.892MetLeu: 1.892 ± 0.02	0.546MetMet: 0.546 ± 0.011	1.559MetAsn: 1.559 ± 0.019	0.849MetPro: 0.849 ± 0.015	0.567MetGln: 0.567 ± 0.011	0.784MetArg: 0.784 ± 0.011	1.692MetSer: 1.692 ± 0.016	1.197MetThr: 1.197 ± 0.016	1.121MetVal: 1.121 ± 0.015	0.19MetTrp: 0.19 ± 0.005	0.833MetTyr: 0.833 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	2.33AsnAla: 2.33 ± 0.022	1.58AsnCys: 1.58 ± 0.021	4.984AsnAsp: 4.984 ± 0.043	5.667AsnGlu: 5.667 ± 0.051	3.776AsnPhe: 3.776 ± 0.029	3.727AsnGly: 3.727 ± 0.034	1.321AsnHis: 1.321 ± 0.018	7.181AsnIle: 7.181 ± 0.052	6.251AsnLys: 6.251 ± 0.048	6.058AsnLeu: 6.058 ± 0.042	1.51AsnMet: 1.51 ± 0.02	7.6AsnAsn: 7.6 ± 0.07	2.379AsnPro: 2.379 ± 0.024	2.393AsnGln: 2.393 ± 0.029	2.326AsnArg: 2.326 ± 0.023	5.968AsnSer: 5.968 ± 0.048	3.827AsnThr: 3.827 ± 0.036	4.038AsnVal: 4.038 ± 0.03	0.578AsnTrp: 0.578 ± 0.009	3.276AsnTyr: 3.276 ± 0.029	0.002AsnXaa: 0.002 ± 0.001
Pro	1.301ProAla: 1.301 ± 0.021	0.619ProCys: 0.619 ± 0.014	1.81ProAsp: 1.81 ± 0.021	2.37ProGlu: 2.37 ± 0.034	1.808ProPhe: 1.808 ± 0.019	2.015ProGly: 2.015 ± 0.074	0.736ProHis: 0.736 ± 0.012	3.24ProIle: 3.24 ± 0.029	3.0ProLys: 3.0 ± 0.029	3.303ProLeu: 3.303 ± 0.03	0.723ProMet: 0.723 ± 0.014	2.513ProAsn: 2.513 ± 0.024	2.205ProPro: 2.205 ± 0.038	1.461ProGln: 1.461 ± 0.023	1.329ProArg: 1.329 ± 0.016	3.497ProSer: 3.497 ± 0.035	2.497ProThr: 2.497 ± 0.031	1.916ProVal: 1.916 ± 0.023	0.321ProTrp: 0.321 ± 0.009	1.602ProTyr: 1.602 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	1.283GlnAla: 1.283 ± 0.019	0.747GlnCys: 0.747 ± 0.019	1.326GlnAsp: 1.326 ± 0.02	1.877GlnGlu: 1.877 ± 0.024	1.58GlnPhe: 1.58 ± 0.018	1.316GlnGly: 1.316 ± 0.019	0.726GlnHis: 0.726 ± 0.013	2.678GlnIle: 2.678 ± 0.023	2.983GlnLys: 2.983 ± 0.025	3.231GlnLeu: 3.231 ± 0.031	0.885GlnMet: 0.885 ± 0.015	2.673GlnAsn: 2.673 ± 0.03	1.314GlnPro: 1.314 ± 0.021	1.927GlnGln: 1.927 ± 0.048	1.5GlnArg: 1.5 ± 0.019	2.462GlnSer: 2.462 ± 0.025	1.782GlnThr: 1.782 ± 0.02	1.505GlnVal: 1.505 ± 0.016	0.335GlnTrp: 0.335 ± 0.007	1.376GlnTyr: 1.376 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	1.459ArgAla: 1.459 ± 0.023	0.809ArgCys: 0.809 ± 0.016	1.814ArgAsp: 1.814 ± 0.023	2.351ArgGlu: 2.351 ± 0.025	1.783ArgPhe: 1.783 ± 0.018	1.735ArgGly: 1.735 ± 0.023	0.88ArgHis: 0.88 ± 0.012	3.003ArgIle: 3.003 ± 0.026	3.742ArgLys: 3.742 ± 0.03	3.28ArgLeu: 3.28 ± 0.028	0.879ArgMet: 0.879 ± 0.012	2.816ArgAsn: 2.816 ± 0.025	1.358ArgPro: 1.358 ± 0.019	1.488ArgGln: 1.488 ± 0.02	2.421ArgArg: 2.421 ± 0.03	2.821ArgSer: 2.821 ± 0.03	1.794ArgThr: 1.794 ± 0.018	1.762ArgVal: 1.762 ± 0.019	0.388ArgTrp: 0.388 ± 0.009	1.601ArgTyr: 1.601 ± 0.02	0.002ArgXaa: 0.002 ± 0.0
Ser	2.682SerAla: 2.682 ± 0.027	1.547SerCys: 1.547 ± 0.025	4.14SerAsp: 4.14 ± 0.042	4.546SerGlu: 4.546 ± 0.057	4.012SerPhe: 4.012 ± 0.031	3.76SerGly: 3.76 ± 0.034	1.488SerHis: 1.488 ± 0.018	6.871SerIle: 6.871 ± 0.044	6.56SerLys: 6.56 ± 0.044	7.156SerLeu: 7.156 ± 0.044	1.62SerMet: 1.62 ± 0.019	6.326SerAsn: 6.326 ± 0.05	3.156SerPro: 3.156 ± 0.038	2.799SerGln: 2.799 ± 0.027	2.934SerArg: 2.934 ± 0.027	8.041SerSer: 8.041 ± 0.08	5.243SerThr: 5.243 ± 0.071	3.69SerVal: 3.69 ± 0.026	0.624SerTrp: 0.624 ± 0.011	3.006SerTyr: 3.006 ± 0.03	0.001SerXaa: 0.001 ± 0.0
Thr	2.149ThrAla: 2.149 ± 0.022	1.105ThrCys: 1.105 ± 0.02	2.51ThrAsp: 2.51 ± 0.027	3.175ThrGlu: 3.175 ± 0.071	3.031ThrPhe: 3.031 ± 0.025	2.688ThrGly: 2.688 ± 0.052	0.936ThrHis: 0.936 ± 0.015	5.107ThrIle: 5.107 ± 0.036	4.392ThrLys: 4.392 ± 0.054	4.888ThrLeu: 4.888 ± 0.028	1.066ThrMet: 1.066 ± 0.015	3.974ThrAsn: 3.974 ± 0.037	2.528ThrPro: 2.528 ± 0.026	1.573ThrGln: 1.573 ± 0.018	1.71ThrArg: 1.71 ± 0.021	5.063ThrSer: 5.063 ± 0.055	4.626ThrThr: 4.626 ± 0.093	3.06ThrVal: 3.06 ± 0.044	0.46ThrTrp: 0.46 ± 0.009	1.979ThrTyr: 1.979 ± 0.022	0.001ThrXaa: 0.001 ± 0.0
Val	2.282ValAla: 2.282 ± 0.028	1.059ValCys: 1.059 ± 0.017	2.999ValAsp: 2.999 ± 0.03	3.397ValGlu: 3.397 ± 0.04	2.413ValPhe: 2.413 ± 0.026	2.441ValGly: 2.441 ± 0.028	0.936ValHis: 0.936 ± 0.015	4.06ValIle: 4.06 ± 0.031	4.29ValLys: 4.29 ± 0.033	4.218ValLeu: 4.218 ± 0.034	1.132ValMet: 1.132 ± 0.015	3.417ValAsn: 3.417 ± 0.028	2.154ValPro: 2.154 ± 0.021	1.565ValGln: 1.565 ± 0.017	1.821ValArg: 1.821 ± 0.019	3.969ValSer: 3.969 ± 0.029	3.096ValThr: 3.096 ± 0.051	3.035ValVal: 3.035 ± 0.031	0.494ValTrp: 0.494 ± 0.011	1.92ValTyr: 1.92 ± 0.021	0.001ValXaa: 0.001 ± 0.0
Trp	0.348TrpAla: 0.348 ± 0.007	0.189TrpCys: 0.189 ± 0.006	0.487TrpAsp: 0.487 ± 0.01	0.509TrpGlu: 0.509 ± 0.01	0.437TrpPhe: 0.437 ± 0.01	0.397TrpGly: 0.397 ± 0.009	0.194TrpHis: 0.194 ± 0.006	0.798TrpIle: 0.798 ± 0.013	0.868TrpLys: 0.868 ± 0.014	0.804TrpLeu: 0.804 ± 0.013	0.247TrpMet: 0.247 ± 0.007	0.656TrpAsn: 0.656 ± 0.012	0.295TrpPro: 0.295 ± 0.008	0.303TrpGln: 0.303 ± 0.009	0.416TrpArg: 0.416 ± 0.008	0.663TrpSer: 0.663 ± 0.012	0.433TrpThr: 0.433 ± 0.009	0.397TrpVal: 0.397 ± 0.008	0.121TrpTrp: 0.121 ± 0.005	0.382TrpTyr: 0.382 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.498TyrAla: 1.498 ± 0.019	1.023TyrCys: 1.023 ± 0.018	2.495TyrAsp: 2.495 ± 0.027	2.465TyrGlu: 2.465 ± 0.024	2.284TyrPhe: 2.284 ± 0.026	2.211TyrGly: 2.211 ± 0.022	0.963TyrHis: 0.963 ± 0.014	3.243TyrIle: 3.243 ± 0.029	3.126TyrLys: 3.126 ± 0.028	3.655TyrLeu: 3.655 ± 0.033	0.849TyrMet: 0.849 ± 0.014	3.079TyrAsn: 3.079 ± 0.03	1.545TyrPro: 1.545 ± 0.022	1.548TyrGln: 1.548 ± 0.02	1.51TyrArg: 1.51 ± 0.019	3.024TyrSer: 3.024 ± 0.023	2.084TyrThr: 2.084 ± 0.022	1.919TyrVal: 1.919 ± 0.02	0.407TyrTrp: 0.407 ± 0.009	2.085TyrTyr: 2.085 ± 0.028	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.003XaaPhe: 0.003 ± 0.001	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 12851 proteins (5840225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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