Amino acid dipepetide frequency for Trichinella sp. T9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.569AlaAla: 5.569 ± 0.048
1.509AlaCys: 1.509 ± 0.014
3.593AlaAsp: 3.593 ± 0.023
4.583AlaGlu: 4.583 ± 0.03
2.785AlaPhe: 2.785 ± 0.019
3.306AlaGly: 3.306 ± 0.028
1.316AlaHis: 1.316 ± 0.011
3.45AlaIle: 3.45 ± 0.021
3.606AlaLys: 3.606 ± 0.024
6.157AlaLeu: 6.157 ± 0.038
1.559AlaMet: 1.559 ± 0.016
2.942AlaAsn: 2.942 ± 0.018
2.375AlaPro: 2.375 ± 0.023
2.289AlaGln: 2.289 ± 0.018
2.978AlaArg: 2.978 ± 0.021
5.287AlaSer: 5.287 ± 0.032
3.525AlaThr: 3.525 ± 0.023
5.095AlaVal: 5.095 ± 0.025
0.707AlaTrp: 0.707 ± 0.01
1.852AlaTyr: 1.852 ± 0.014
0.001AlaXaa: 0.001 ± 0.0
Cys
1.472CysAla: 1.472 ± 0.018
0.897CysCys: 0.897 ± 0.014
1.358CysAsp: 1.358 ± 0.02
1.517CysGlu: 1.517 ± 0.021
1.275CysPhe: 1.275 ± 0.012
1.411CysGly: 1.411 ± 0.015
0.684CysHis: 0.684 ± 0.011
1.563CysIle: 1.563 ± 0.019
1.492CysLys: 1.492 ± 0.022
2.563CysLeu: 2.563 ± 0.022
0.573CysMet: 0.573 ± 0.008
1.249CysAsn: 1.249 ± 0.015
1.218CysPro: 1.218 ± 0.024
1.13CysGln: 1.13 ± 0.015
1.595CysArg: 1.595 ± 0.018
2.491CysSer: 2.491 ± 0.023
1.361CysThr: 1.361 ± 0.016
1.498CysVal: 1.498 ± 0.015
0.351CysTrp: 0.351 ± 0.007
0.777CysTyr: 0.777 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.321AspAla: 3.321 ± 0.022
1.41AspCys: 1.41 ± 0.02
3.949AspAsp: 3.949 ± 0.029
4.262AspGlu: 4.262 ± 0.027
2.414AspPhe: 2.414 ± 0.02
3.174AspGly: 3.174 ± 0.03
1.201AspHis: 1.201 ± 0.012
2.816AspIle: 2.816 ± 0.024
2.528AspLys: 2.528 ± 0.018
4.683AspLeu: 4.683 ± 0.025
1.144AspMet: 1.144 ± 0.013
2.342AspAsn: 2.342 ± 0.015
2.06AspPro: 2.06 ± 0.017
2.06AspGln: 2.06 ± 0.018
2.733AspArg: 2.733 ± 0.021
4.201AspSer: 4.201 ± 0.023
2.196AspThr: 2.196 ± 0.014
3.711AspVal: 3.711 ± 0.021
0.69AspTrp: 0.69 ± 0.012
1.646AspTyr: 1.646 ± 0.014
0.002AspXaa: 0.002 ± 0.0
Glu
3.915GluAla: 3.915 ± 0.033
1.382GluCys: 1.382 ± 0.024
3.2GluAsp: 3.2 ± 0.025
5.48GluGlu: 5.48 ± 0.043
2.507GluPhe: 2.507 ± 0.019
2.316GluGly: 2.316 ± 0.021
1.442GluHis: 1.442 ± 0.014
4.001GluIle: 4.001 ± 0.026
4.964GluLys: 4.964 ± 0.031
5.762GluLeu: 5.762 ± 0.03
1.932GluMet: 1.932 ± 0.016
4.106GluAsn: 4.106 ± 0.024
2.15GluPro: 2.15 ± 0.022
3.076GluGln: 3.076 ± 0.023
3.51GluArg: 3.51 ± 0.029
4.512GluSer: 4.512 ± 0.029
3.306GluThr: 3.306 ± 0.023
3.507GluVal: 3.507 ± 0.024
0.715GluTrp: 0.715 ± 0.011
1.771GluTyr: 1.771 ± 0.017
0.001GluXaa: 0.001 ± 0.0
Phe
2.809PheAla: 2.809 ± 0.02
1.414PheCys: 1.414 ± 0.015
2.615PheAsp: 2.615 ± 0.017
2.655PheGlu: 2.655 ± 0.02
2.186PhePhe: 2.186 ± 0.02
2.603PheGly: 2.603 ± 0.021
1.322PheHis: 1.322 ± 0.014
2.606PheIle: 2.606 ± 0.021
2.189PheLys: 2.189 ± 0.016
4.345PheLeu: 4.345 ± 0.029
0.889PheMet: 0.889 ± 0.01
2.102PheAsn: 2.102 ± 0.016
2.001PhePro: 2.001 ± 0.017
1.95PheGln: 1.95 ± 0.015
2.331PheArg: 2.331 ± 0.02
3.922PheSer: 3.922 ± 0.019
2.415PheThr: 2.415 ± 0.016
3.083PheVal: 3.083 ± 0.022
0.587PheTrp: 0.587 ± 0.009
1.713PheTyr: 1.713 ± 0.014
0.001PheXaa: 0.001 ± 0.0
Gly
2.726GlyAla: 2.726 ± 0.023
1.232GlyCys: 1.232 ± 0.013
2.617GlyAsp: 2.617 ± 0.02
2.95GlyGlu: 2.95 ± 0.024
2.237GlyPhe: 2.237 ± 0.019
3.277GlyGly: 3.277 ± 0.036
1.295GlyHis: 1.295 ± 0.013
2.925GlyIle: 2.925 ± 0.023
3.35GlyLys: 3.35 ± 0.025
4.033GlyLeu: 4.033 ± 0.033
1.214GlyMet: 1.214 ± 0.012
2.529GlyAsn: 2.529 ± 0.021
1.775GlyPro: 1.775 ± 0.025
2.06GlyGln: 2.06 ± 0.019
3.227GlyArg: 3.227 ± 0.027
4.24GlySer: 4.24 ± 0.032
2.582GlyThr: 2.582 ± 0.019
3.035GlyVal: 3.035 ± 0.023
0.63GlyTrp: 0.63 ± 0.008
1.764GlyTyr: 1.764 ± 0.024
0.002GlyXaa: 0.002 ± 0.0
His
1.428HisAla: 1.428 ± 0.014
0.895HisCys: 0.895 ± 0.011
1.015HisAsp: 1.015 ± 0.009
1.233HisGlu: 1.233 ± 0.012
1.376HisPhe: 1.376 ± 0.013
1.325HisGly: 1.325 ± 0.013
0.952HisHis: 0.952 ± 0.016
1.286HisIle: 1.286 ± 0.013
0.982HisLys: 0.982 ± 0.012
2.722HisLeu: 2.722 ± 0.018
0.535HisMet: 0.535 ± 0.007
0.968HisAsn: 0.968 ± 0.01
1.23HisPro: 1.23 ± 0.012
1.11HisGln: 1.11 ± 0.013
1.534HisArg: 1.534 ± 0.014
2.095HisSer: 2.095 ± 0.015
1.091HisThr: 1.091 ± 0.012
1.595HisVal: 1.595 ± 0.013
0.352HisTrp: 0.352 ± 0.007
0.874HisTyr: 0.874 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
3.719IleAla: 3.719 ± 0.022
1.719IleCys: 1.719 ± 0.023
3.011IleAsp: 3.011 ± 0.019
3.317IleGlu: 3.317 ± 0.024
2.853IlePhe: 2.853 ± 0.023
2.885IleGly: 2.885 ± 0.023
1.326IleHis: 1.326 ± 0.013
3.118IleIle: 3.118 ± 0.025
2.856IleLys: 2.856 ± 0.02
5.37IleLeu: 5.37 ± 0.028
1.207IleMet: 1.207 ± 0.012
2.46IleAsn: 2.46 ± 0.017
2.596IlePro: 2.596 ± 0.019
2.203IleGln: 2.203 ± 0.016
3.158IleArg: 3.158 ± 0.019
4.817IleSer: 4.817 ± 0.027
2.877IleThr: 2.877 ± 0.028
3.701IleVal: 3.701 ± 0.023
0.659IleTrp: 0.659 ± 0.009
1.941IleTyr: 1.941 ± 0.016
0.001IleXaa: 0.001 ± 0.0
Lys
3.569LysAla: 3.569 ± 0.022
1.531LysCys: 1.531 ± 0.022
2.65LysAsp: 2.65 ± 0.021
3.923LysGlu: 3.923 ± 0.025
2.541LysPhe: 2.541 ± 0.018
2.247LysGly: 2.247 ± 0.022
1.526LysHis: 1.526 ± 0.014
3.615LysIle: 3.615 ± 0.025
4.562LysLys: 4.562 ± 0.042
6.122LysLeu: 6.122 ± 0.035
1.743LysMet: 1.743 ± 0.014
3.192LysAsn: 3.192 ± 0.021
2.477LysPro: 2.477 ± 0.025
2.826LysGln: 2.826 ± 0.02
3.803LysArg: 3.803 ± 0.027
4.622LysSer: 4.622 ± 0.025
2.973LysThr: 2.973 ± 0.02
3.329LysVal: 3.329 ± 0.019
0.734LysTrp: 0.734 ± 0.01
1.891LysTyr: 1.891 ± 0.015
0.001LysXaa: 0.001 ± 0.0
Leu
6.018LeuAla: 6.018 ± 0.033
2.493LeuCys: 2.493 ± 0.022
4.562LeuAsp: 4.562 ± 0.027
5.769LeuGlu: 5.769 ± 0.033
4.609LeuPhe: 4.609 ± 0.033
3.802LeuGly: 3.802 ± 0.024
2.663LeuHis: 2.663 ± 0.017
5.431LeuIle: 5.431 ± 0.031
6.583LeuLys: 6.583 ± 0.032
10.644LeuLeu: 10.644 ± 0.056
2.231LeuMet: 2.231 ± 0.02
4.988LeuAsn: 4.988 ± 0.028
4.715LeuPro: 4.715 ± 0.025
4.559LeuGln: 4.559 ± 0.024
5.406LeuArg: 5.406 ± 0.034
7.7LeuSer: 7.7 ± 0.032
4.983LeuThr: 4.983 ± 0.026
5.481LeuVal: 5.481 ± 0.028
1.065LeuTrp: 1.065 ± 0.012
2.942LeuTyr: 2.942 ± 0.02
0.001LeuXaa: 0.001 ± 0.0
Met
1.632MetAla: 1.632 ± 0.015
0.495MetCys: 0.495 ± 0.007
1.286MetAsp: 1.286 ± 0.013
1.636MetGlu: 1.636 ± 0.015
1.012MetPhe: 1.012 ± 0.012
0.903MetGly: 0.903 ± 0.01
0.66MetHis: 0.66 ± 0.007
1.296MetIle: 1.296 ± 0.013
1.775MetLys: 1.775 ± 0.014
2.462MetLeu: 2.462 ± 0.016
0.678MetMet: 0.678 ± 0.01
1.353MetAsn: 1.353 ± 0.013
1.14MetPro: 1.14 ± 0.011
1.17MetGln: 1.17 ± 0.012
1.252MetArg: 1.252 ± 0.013
1.696MetSer: 1.696 ± 0.015
1.231MetThr: 1.231 ± 0.01
1.353MetVal: 1.353 ± 0.014
0.229MetTrp: 0.229 ± 0.006
0.678MetTyr: 0.678 ± 0.008
0.001MetXaa: 0.001 ± 0.0
Asn
3.286AsnAla: 3.286 ± 0.022
1.424AsnCys: 1.424 ± 0.017
2.797AsnAsp: 2.797 ± 0.02
3.262AsnGlu: 3.262 ± 0.021
2.51AsnPhe: 2.51 ± 0.019
3.048AsnGly: 3.048 ± 0.023
1.056AsnHis: 1.056 ± 0.012
2.81AsnIle: 2.81 ± 0.021
2.543AsnLys: 2.543 ± 0.018
4.558AsnLeu: 4.558 ± 0.025
1.128AsnMet: 1.128 ± 0.012
2.982AsnAsn: 2.982 ± 0.029
1.929AsnPro: 1.929 ± 0.015
1.804AsnGln: 1.804 ± 0.015
2.598AsnArg: 2.598 ± 0.016
4.266AsnSer: 4.266 ± 0.029
2.235AsnThr: 2.235 ± 0.018
3.509AsnVal: 3.509 ± 0.02
0.629AsnTrp: 0.629 ± 0.009
1.716AsnTyr: 1.716 ± 0.017
0.002AsnXaa: 0.002 ± 0.0
Pro
2.872ProAla: 2.872 ± 0.02
0.964ProCys: 0.964 ± 0.015
2.268ProAsp: 2.268 ± 0.016
2.607ProGlu: 2.607 ± 0.022
1.916ProPhe: 1.916 ± 0.016
2.352ProGly: 2.352 ± 0.051
0.903ProHis: 0.903 ± 0.012
2.177ProIle: 2.177 ± 0.017
2.386ProLys: 2.386 ± 0.018
4.098ProLeu: 4.098 ± 0.027
0.955ProMet: 0.955 ± 0.01
2.123ProAsn: 2.123 ± 0.016
3.026ProPro: 3.026 ± 0.04
1.481ProGln: 1.481 ± 0.016
1.927ProArg: 1.927 ± 0.018
3.777ProSer: 3.777 ± 0.028
2.634ProThr: 2.634 ± 0.019
3.139ProVal: 3.139 ± 0.02
0.482ProTrp: 0.482 ± 0.009
1.391ProTyr: 1.391 ± 0.014
0.001ProXaa: 0.001 ± 0.0
Gln
2.65GlnAla: 2.65 ± 0.021
1.152GlnCys: 1.152 ± 0.016
1.489GlnAsp: 1.489 ± 0.015
2.22GlnGlu: 2.22 ± 0.017
1.946GlnPhe: 1.946 ± 0.016
1.467GlnGly: 1.467 ± 0.015
1.217GlnHis: 1.217 ± 0.013
2.422GlnIle: 2.422 ± 0.017
2.523GlnLys: 2.523 ± 0.02
4.865GlnLeu: 4.865 ± 0.029
1.219GlnMet: 1.219 ± 0.011
2.115GlnAsn: 2.115 ± 0.015
1.899GlnPro: 1.899 ± 0.017
3.722GlnGln: 3.722 ± 0.061
2.643GlnArg: 2.643 ± 0.019
3.32GlnSer: 3.32 ± 0.022
2.109GlnThr: 2.109 ± 0.016
2.093GlnVal: 2.093 ± 0.017
0.596GlnTrp: 0.596 ± 0.009
1.313GlnTyr: 1.313 ± 0.014
0.001GlnXaa: 0.001 ± 0.0
Arg
3.023ArgAla: 3.023 ± 0.022
1.585ArgCys: 1.585 ± 0.02
2.453ArgAsp: 2.453 ± 0.022
2.97ArgGlu: 2.97 ± 0.02
2.564ArgPhe: 2.564 ± 0.02
2.472ArgGly: 2.472 ± 0.024
1.55ArgHis: 1.55 ± 0.014
3.261ArgIle: 3.261 ± 0.022
3.711ArgLys: 3.711 ± 0.026
5.809ArgLeu: 5.809 ± 0.033
1.438ArgMet: 1.438 ± 0.014
2.692ArgAsn: 2.692 ± 0.018
2.323ArgPro: 2.323 ± 0.018
2.615ArgGln: 2.615 ± 0.021
4.672ArgArg: 4.672 ± 0.042
4.446ArgSer: 4.446 ± 0.035
2.747ArgThr: 2.747 ± 0.02
2.983ArgVal: 2.983 ± 0.02
0.799ArgTrp: 0.799 ± 0.01
1.715ArgTyr: 1.715 ± 0.017
0.001ArgXaa: 0.001 ± 0.0
Ser
5.555SerAla: 5.555 ± 0.03
2.087SerCys: 2.087 ± 0.019
4.546SerAsp: 4.546 ± 0.029
4.934SerGlu: 4.934 ± 0.033
3.652SerPhe: 3.652 ± 0.02
4.615SerGly: 4.615 ± 0.029
1.652SerHis: 1.652 ± 0.014
4.204SerIle: 4.204 ± 0.027
4.687SerLys: 4.687 ± 0.025
7.444SerLeu: 7.444 ± 0.034
1.792SerMet: 1.792 ± 0.014
4.177SerAsn: 4.177 ± 0.028
3.602SerPro: 3.602 ± 0.028
2.86SerGln: 2.86 ± 0.021
4.35SerArg: 4.35 ± 0.032
9.634SerSer: 9.634 ± 0.073
5.202SerThr: 5.202 ± 0.03
5.705SerVal: 5.705 ± 0.031
0.935SerTrp: 0.935 ± 0.012
2.255SerTyr: 2.255 ± 0.02
0.001SerXaa: 0.001 ± 0.0
Thr
4.143ThrAla: 4.143 ± 0.026
1.292ThrCys: 1.292 ± 0.02
2.818ThrAsp: 2.818 ± 0.019
3.15ThrGlu: 3.15 ± 0.023
2.394ThrPhe: 2.394 ± 0.016
2.908ThrGly: 2.908 ± 0.023
0.958ThrHis: 0.958 ± 0.012
2.853ThrIle: 2.853 ± 0.017
2.72ThrLys: 2.72 ± 0.017
4.973ThrLeu: 4.973 ± 0.028
1.244ThrMet: 1.244 ± 0.012
2.472ThrAsn: 2.472 ± 0.02
2.372ThrPro: 2.372 ± 0.018
1.503ThrGln: 1.503 ± 0.015
2.215ThrArg: 2.215 ± 0.017
4.5ThrSer: 4.5 ± 0.028
3.793ThrThr: 3.793 ± 0.038
4.509ThrVal: 4.509 ± 0.025
0.559ThrTrp: 0.559 ± 0.009
1.389ThrTyr: 1.389 ± 0.014
0.002ThrXaa: 0.002 ± 0.0
Val
4.27ValAla: 4.27 ± 0.025
1.704ValCys: 1.704 ± 0.02
4.136ValAsp: 4.136 ± 0.027
4.684ValGlu: 4.684 ± 0.032
2.646ValPhe: 2.646 ± 0.019
3.382ValGly: 3.382 ± 0.022
1.757ValHis: 1.757 ± 0.015
3.537ValIle: 3.537 ± 0.02
3.793ValLys: 3.793 ± 0.025
5.74ValLeu: 5.74 ± 0.029
1.384ValMet: 1.384 ± 0.013
3.041ValAsn: 3.041 ± 0.02
2.749ValPro: 2.749 ± 0.02
2.801ValGln: 2.801 ± 0.018
3.375ValArg: 3.375 ± 0.02
4.818ValSer: 4.818 ± 0.024
3.323ValThr: 3.323 ± 0.023
4.579ValVal: 4.579 ± 0.027
0.742ValTrp: 0.742 ± 0.01
1.863ValTyr: 1.863 ± 0.016
0.001ValXaa: 0.001 ± 0.0
Trp
0.608TrpAla: 0.608 ± 0.009
0.278TrpCys: 0.278 ± 0.006
0.546TrpAsp: 0.546 ± 0.009
0.572TrpGlu: 0.572 ± 0.008
0.545TrpPhe: 0.545 ± 0.009
0.392TrpGly: 0.392 ± 0.008
0.307TrpHis: 0.307 ± 0.006
0.812TrpIle: 0.812 ± 0.011
0.941TrpLys: 0.941 ± 0.011
1.313TrpLeu: 1.313 ± 0.013
0.339TrpMet: 0.339 ± 0.007
0.778TrpAsn: 0.778 ± 0.009
0.508TrpPro: 0.508 ± 0.008
0.553TrpGln: 0.553 ± 0.007
0.73TrpArg: 0.73 ± 0.009
1.037TrpSer: 1.037 ± 0.015
0.714TrpThr: 0.714 ± 0.01
0.513TrpVal: 0.513 ± 0.008
0.183TrpTrp: 0.183 ± 0.005
0.402TrpTyr: 0.402 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.899TyrAla: 1.899 ± 0.015
1.013TyrCys: 1.013 ± 0.014
1.636TyrAsp: 1.636 ± 0.015
1.83TyrGlu: 1.83 ± 0.016
1.772TyrPhe: 1.772 ± 0.014
1.812TyrGly: 1.812 ± 0.016
0.809TyrHis: 0.809 ± 0.011
1.611TyrIle: 1.611 ± 0.013
1.682TyrLys: 1.682 ± 0.015
2.98TyrLeu: 2.98 ± 0.018
0.731TyrMet: 0.731 ± 0.009
1.48TyrAsn: 1.48 ± 0.013
1.332TyrPro: 1.332 ± 0.014
1.208TyrGln: 1.208 ± 0.013
1.79TyrArg: 1.79 ± 0.015
2.508TyrSer: 2.508 ± 0.019
1.466TyrThr: 1.466 ± 0.015
1.905TyrVal: 1.905 ± 0.016
0.427TyrTrp: 0.427 ± 0.007
1.24TyrTyr: 1.24 ± 0.014
0.001TyrXaa: 0.001 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.001XaaCys: 0.001 ± 0.0
0.001XaaAsp: 0.001 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.001XaaPhe: 0.001 ± 0.0
0.001XaaGly: 0.001 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.001XaaLys: 0.001 ± 0.0
0.002XaaLeu: 0.002 ± 0.001
0.001XaaMet: 0.001 ± 0.0
0.001XaaAsn: 0.001 ± 0.0
0.001XaaPro: 0.001 ± 0.0
0.001XaaGln: 0.001 ± 0.0
0.002XaaArg: 0.002 ± 0.0
0.002XaaSer: 0.002 ± 0.0
0.002XaaThr: 0.002 ± 0.0
0.001XaaVal: 0.001 ± 0.0
0.001XaaTrp: 0.001 ± 0.0
0.001XaaTyr: 0.001 ± 0.0
0.071XaaXaa: 0.071 ± 0.009
Statistics based on 17770 proteins (9363422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski