Amino acid dipepetide frequency for Scophthalmus maximus reovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.734AlaAla: 11.734 ± 1.218
1.032AlaCys: 1.032 ± 0.342
4.126AlaAsp: 4.126 ± 0.788
3.353AlaGlu: 3.353 ± 0.542
4.126AlaPhe: 4.126 ± 0.753
6.576AlaGly: 6.576 ± 0.924
2.579AlaHis: 2.579 ± 0.422
5.416AlaIle: 5.416 ± 0.704
1.934AlaLys: 1.934 ± 0.55
9.413AlaLeu: 9.413 ± 0.773
2.837AlaMet: 2.837 ± 0.674
3.74AlaAsn: 3.74 ± 0.873
5.803AlaPro: 5.803 ± 0.645
3.353AlaGln: 3.353 ± 0.945
5.416AlaArg: 5.416 ± 0.807
8.64AlaSer: 8.64 ± 1.438
8.511AlaThr: 8.511 ± 0.912
6.061AlaVal: 6.061 ± 0.532
1.289AlaTrp: 1.289 ± 0.314
3.482AlaTyr: 3.482 ± 0.527
0.0AlaXaa: 0.0 ± 0.0
Cys
1.032CysAla: 1.032 ± 0.356
0.903CysCys: 0.903 ± 0.961
1.161CysAsp: 1.161 ± 0.368
0.516CysGlu: 0.516 ± 0.297
0.516CysPhe: 0.516 ± 0.354
1.161CysGly: 1.161 ± 0.238
0.774CysHis: 0.774 ± 0.235
0.645CysIle: 0.645 ± 0.285
0.258CysLys: 0.258 ± 0.18
0.645CysLeu: 0.645 ± 0.304
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.774CysPro: 0.774 ± 0.428
0.903CysGln: 0.903 ± 0.26
0.258CysArg: 0.258 ± 0.217
0.258CysSer: 0.258 ± 0.206
0.903CysThr: 0.903 ± 0.352
0.645CysVal: 0.645 ± 0.272
0.258CysTrp: 0.258 ± 0.171
0.387CysTyr: 0.387 ± 0.285
0.0CysXaa: 0.0 ± 0.0
Asp
5.803AspAla: 5.803 ± 0.766
0.516AspCys: 0.516 ± 0.206
2.708AspAsp: 2.708 ± 0.402
1.289AspGlu: 1.289 ± 0.288
1.289AspPhe: 1.289 ± 0.355
3.868AspGly: 3.868 ± 0.631
1.032AspHis: 1.032 ± 0.28
1.934AspIle: 1.934 ± 0.39
0.903AspLys: 0.903 ± 0.343
6.705AspLeu: 6.705 ± 0.842
0.903AspMet: 0.903 ± 0.239
1.418AspAsn: 1.418 ± 0.293
5.287AspPro: 5.287 ± 0.934
2.063AspGln: 2.063 ± 0.55
2.192AspArg: 2.192 ± 0.504
5.158AspSer: 5.158 ± 0.724
2.837AspThr: 2.837 ± 0.441
4.513AspVal: 4.513 ± 0.649
1.161AspTrp: 1.161 ± 0.318
1.676AspTyr: 1.676 ± 0.397
0.0AspXaa: 0.0 ± 0.0
Glu
3.353GluAla: 3.353 ± 0.762
0.516GluCys: 0.516 ± 0.287
1.805GluAsp: 1.805 ± 0.382
1.032GluGlu: 1.032 ± 0.411
0.903GluPhe: 0.903 ± 0.259
1.805GluGly: 1.805 ± 0.325
0.903GluHis: 0.903 ± 0.25
1.805GluIle: 1.805 ± 0.488
0.774GluLys: 0.774 ± 0.433
3.611GluLeu: 3.611 ± 0.625
1.418GluMet: 1.418 ± 0.482
1.032GluAsn: 1.032 ± 0.298
2.192GluPro: 2.192 ± 0.413
0.387GluGln: 0.387 ± 0.179
1.934GluArg: 1.934 ± 0.325
1.547GluSer: 1.547 ± 0.388
2.837GluThr: 2.837 ± 0.691
2.837GluVal: 2.837 ± 0.546
0.516GluTrp: 0.516 ± 0.209
1.289GluTyr: 1.289 ± 0.66
0.0GluXaa: 0.0 ± 0.0
Phe
2.45PheAla: 2.45 ± 0.537
0.129PheCys: 0.129 ± 0.145
1.934PheAsp: 1.934 ± 0.291
1.032PheGlu: 1.032 ± 0.373
0.903PhePhe: 0.903 ± 0.369
2.063PheGly: 2.063 ± 0.393
0.516PheHis: 0.516 ± 0.153
2.708PheIle: 2.708 ± 0.554
1.161PheLys: 1.161 ± 0.407
4.384PheLeu: 4.384 ± 0.888
0.774PheMet: 0.774 ± 0.298
1.418PheAsn: 1.418 ± 0.305
2.321PhePro: 2.321 ± 0.679
1.418PheGln: 1.418 ± 0.359
1.547PheArg: 1.547 ± 0.3
3.611PheSer: 3.611 ± 0.54
1.676PheThr: 1.676 ± 0.422
2.063PheVal: 2.063 ± 0.474
0.387PheTrp: 0.387 ± 0.259
1.418PheTyr: 1.418 ± 0.394
0.0PheXaa: 0.0 ± 0.0
Gly
6.576GlyAla: 6.576 ± 0.938
0.516GlyCys: 0.516 ± 0.196
2.708GlyAsp: 2.708 ± 0.529
1.289GlyGlu: 1.289 ± 0.402
2.966GlyPhe: 2.966 ± 0.312
3.611GlyGly: 3.611 ± 0.848
1.161GlyHis: 1.161 ± 0.57
2.321GlyIle: 2.321 ± 0.554
1.934GlyLys: 1.934 ± 0.533
4.255GlyLeu: 4.255 ± 0.403
1.161GlyMet: 1.161 ± 0.417
2.579GlyAsn: 2.579 ± 0.687
4.384GlyPro: 4.384 ± 0.642
2.192GlyGln: 2.192 ± 0.325
3.74GlyArg: 3.74 ± 0.595
4.642GlySer: 4.642 ± 0.604
2.321GlyThr: 2.321 ± 0.574
5.416GlyVal: 5.416 ± 0.647
0.645GlyTrp: 0.645 ± 0.253
1.676GlyTyr: 1.676 ± 0.362
0.0GlyXaa: 0.0 ± 0.0
His
2.45HisAla: 2.45 ± 0.426
0.258HisCys: 0.258 ± 0.145
1.289HisAsp: 1.289 ± 0.418
0.774HisGlu: 0.774 ± 0.254
0.645HisPhe: 0.645 ± 0.189
1.418HisGly: 1.418 ± 0.416
0.387HisHis: 0.387 ± 0.247
1.676HisIle: 1.676 ± 0.298
0.129HisLys: 0.129 ± 0.129
2.579HisLeu: 2.579 ± 0.539
0.387HisMet: 0.387 ± 0.189
0.645HisAsn: 0.645 ± 0.207
2.063HisPro: 2.063 ± 0.514
0.774HisGln: 0.774 ± 0.246
0.903HisArg: 0.903 ± 0.245
2.063HisSer: 2.063 ± 0.653
1.418HisThr: 1.418 ± 0.371
2.579HisVal: 2.579 ± 0.554
0.645HisTrp: 0.645 ± 0.202
0.645HisTyr: 0.645 ± 0.202
0.0HisXaa: 0.0 ± 0.0
Ile
5.416IleAla: 5.416 ± 0.835
1.032IleCys: 1.032 ± 0.363
3.353IleAsp: 3.353 ± 0.298
2.579IleGlu: 2.579 ± 0.469
1.161IlePhe: 1.161 ± 0.337
1.547IleGly: 1.547 ± 0.301
1.289IleHis: 1.289 ± 0.362
1.676IleIle: 1.676 ± 0.482
1.418IleLys: 1.418 ± 0.407
3.997IleLeu: 3.997 ± 0.498
1.289IleMet: 1.289 ± 0.381
2.45IleAsn: 2.45 ± 0.385
4.642IlePro: 4.642 ± 1.203
1.547IleGln: 1.547 ± 0.384
2.45IleArg: 2.45 ± 0.491
3.74IleSer: 3.74 ± 0.701
4.384IleThr: 4.384 ± 0.637
4.513IleVal: 4.513 ± 0.708
1.161IleTrp: 1.161 ± 0.272
1.161IleTyr: 1.161 ± 0.274
0.0IleXaa: 0.0 ± 0.0
Lys
2.192LysAla: 2.192 ± 0.474
0.258LysCys: 0.258 ± 0.194
1.676LysAsp: 1.676 ± 0.512
0.774LysGlu: 0.774 ± 0.172
0.387LysPhe: 0.387 ± 0.17
1.547LysGly: 1.547 ± 0.405
0.516LysHis: 0.516 ± 0.174
1.032LysIle: 1.032 ± 0.37
0.516LysLys: 0.516 ± 0.248
2.45LysLeu: 2.45 ± 0.78
0.258LysMet: 0.258 ± 0.156
0.903LysAsn: 0.903 ± 0.421
1.934LysPro: 1.934 ± 0.46
0.387LysGln: 0.387 ± 0.197
1.032LysArg: 1.032 ± 0.202
2.063LysSer: 2.063 ± 0.592
1.032LysThr: 1.032 ± 0.354
2.192LysVal: 2.192 ± 0.693
0.903LysTrp: 0.903 ± 0.329
1.161LysTyr: 1.161 ± 0.253
0.0LysXaa: 0.0 ± 0.0
Leu
10.832LeuAla: 10.832 ± 0.776
1.289LeuCys: 1.289 ± 0.513
5.545LeuAsp: 5.545 ± 0.636
3.868LeuGlu: 3.868 ± 0.986
2.45LeuPhe: 2.45 ± 0.392
4.771LeuGly: 4.771 ± 0.547
2.45LeuHis: 2.45 ± 0.524
4.771LeuIle: 4.771 ± 0.661
3.611LeuLys: 3.611 ± 0.637
9.8LeuLeu: 9.8 ± 1.067
2.579LeuMet: 2.579 ± 0.563
5.158LeuAsn: 5.158 ± 1.141
6.447LeuPro: 6.447 ± 0.83
3.482LeuGln: 3.482 ± 0.378
6.061LeuArg: 6.061 ± 0.529
9.8LeuSer: 9.8 ± 1.001
8.382LeuThr: 8.382 ± 1.018
5.029LeuVal: 5.029 ± 0.908
1.032LeuTrp: 1.032 ± 0.33
2.966LeuTyr: 2.966 ± 0.465
0.0LeuXaa: 0.0 ± 0.0
Met
1.934MetAla: 1.934 ± 0.4
0.258MetCys: 0.258 ± 0.136
1.161MetAsp: 1.161 ± 0.359
1.289MetGlu: 1.289 ± 0.435
1.032MetPhe: 1.032 ± 0.343
1.547MetGly: 1.547 ± 0.4
0.516MetHis: 0.516 ± 0.152
1.934MetIle: 1.934 ± 0.55
0.645MetLys: 0.645 ± 0.305
1.934MetLeu: 1.934 ± 0.522
0.774MetMet: 0.774 ± 0.265
1.032MetAsn: 1.032 ± 0.284
1.547MetPro: 1.547 ± 0.277
0.774MetGln: 0.774 ± 0.241
0.903MetArg: 0.903 ± 0.319
2.579MetSer: 2.579 ± 0.715
1.676MetThr: 1.676 ± 0.314
1.161MetVal: 1.161 ± 0.404
0.387MetTrp: 0.387 ± 0.301
0.645MetTyr: 0.645 ± 0.183
0.0MetXaa: 0.0 ± 0.0
Asn
3.997AsnAla: 3.997 ± 0.424
0.516AsnCys: 0.516 ± 0.26
1.934AsnAsp: 1.934 ± 0.457
0.903AsnGlu: 0.903 ± 0.337
0.645AsnPhe: 0.645 ± 0.204
2.321AsnGly: 2.321 ± 0.708
0.516AsnHis: 0.516 ± 0.217
2.063AsnIle: 2.063 ± 0.433
1.161AsnLys: 1.161 ± 0.263
4.126AsnLeu: 4.126 ± 0.536
0.387AsnMet: 0.387 ± 0.194
2.192AsnAsn: 2.192 ± 0.564
5.029AsnPro: 5.029 ± 0.742
2.579AsnGln: 2.579 ± 0.509
2.708AsnArg: 2.708 ± 0.558
2.45AsnSer: 2.45 ± 0.557
2.192AsnThr: 2.192 ± 0.594
4.126AsnVal: 4.126 ± 0.615
0.516AsnTrp: 0.516 ± 0.224
1.032AsnTyr: 1.032 ± 0.32
0.0AsnXaa: 0.0 ± 0.0
Pro
8.64ProAla: 8.64 ± 1.442
0.387ProCys: 0.387 ± 0.195
3.868ProAsp: 3.868 ± 0.623
3.224ProGlu: 3.224 ± 0.886
3.868ProPhe: 3.868 ± 0.721
3.74ProGly: 3.74 ± 0.585
1.934ProHis: 1.934 ± 0.527
4.126ProIle: 4.126 ± 0.375
0.903ProLys: 0.903 ± 0.463
8.511ProLeu: 8.511 ± 1.11
1.418ProMet: 1.418 ± 0.473
2.966ProAsn: 2.966 ± 0.64
6.447ProPro: 6.447 ± 1.022
2.45ProGln: 2.45 ± 0.626
3.224ProArg: 3.224 ± 0.783
7.737ProSer: 7.737 ± 0.933
7.221ProThr: 7.221 ± 0.877
6.19ProVal: 6.19 ± 0.85
0.903ProTrp: 0.903 ± 0.393
1.547ProTyr: 1.547 ± 0.337
0.0ProXaa: 0.0 ± 0.0
Gln
3.353GlnAla: 3.353 ± 0.662
0.774GlnCys: 0.774 ± 0.269
1.805GlnAsp: 1.805 ± 0.377
0.774GlnGlu: 0.774 ± 0.306
2.063GlnPhe: 2.063 ± 0.449
1.418GlnGly: 1.418 ± 0.294
1.289GlnHis: 1.289 ± 0.203
2.063GlnIle: 2.063 ± 0.296
0.387GlnLys: 0.387 ± 0.216
5.029GlnLeu: 5.029 ± 0.703
0.387GlnMet: 0.387 ± 0.135
1.418GlnAsn: 1.418 ± 0.463
3.095GlnPro: 3.095 ± 0.596
1.032GlnGln: 1.032 ± 0.367
2.966GlnArg: 2.966 ± 0.559
1.805GlnSer: 1.805 ± 0.342
3.611GlnThr: 3.611 ± 0.691
2.966GlnVal: 2.966 ± 0.667
0.516GlnTrp: 0.516 ± 0.211
1.547GlnTyr: 1.547 ± 0.288
0.0GlnXaa: 0.0 ± 0.0
Arg
4.642ArgAla: 4.642 ± 0.555
0.774ArgCys: 0.774 ± 0.262
3.224ArgAsp: 3.224 ± 0.607
1.805ArgGlu: 1.805 ± 0.278
1.418ArgPhe: 1.418 ± 0.356
2.837ArgGly: 2.837 ± 0.49
1.161ArgHis: 1.161 ± 0.472
3.095ArgIle: 3.095 ± 0.634
0.516ArgLys: 0.516 ± 0.248
6.447ArgLeu: 6.447 ± 1.079
1.676ArgMet: 1.676 ± 0.257
2.192ArgAsn: 2.192 ± 0.572
3.74ArgPro: 3.74 ± 0.659
2.579ArgGln: 2.579 ± 0.512
3.611ArgArg: 3.611 ± 0.526
5.158ArgSer: 5.158 ± 0.902
3.482ArgThr: 3.482 ± 0.439
4.9ArgVal: 4.9 ± 0.762
1.032ArgTrp: 1.032 ± 0.218
1.547ArgTyr: 1.547 ± 0.472
0.0ArgXaa: 0.0 ± 0.0
Ser
9.026SerAla: 9.026 ± 1.498
0.645SerCys: 0.645 ± 0.281
3.74SerAsp: 3.74 ± 0.8
2.45SerGlu: 2.45 ± 0.747
3.224SerPhe: 3.224 ± 0.481
4.513SerGly: 4.513 ± 0.714
1.934SerHis: 1.934 ± 0.66
3.482SerIle: 3.482 ± 0.664
1.934SerLys: 1.934 ± 0.26
8.897SerLeu: 8.897 ± 1.304
2.192SerMet: 2.192 ± 0.484
2.45SerAsn: 2.45 ± 0.562
5.545SerPro: 5.545 ± 0.458
3.74SerGln: 3.74 ± 0.581
6.319SerArg: 6.319 ± 0.998
7.35SerSer: 7.35 ± 1.453
6.963SerThr: 6.963 ± 0.732
6.319SerVal: 6.319 ± 1.12
1.161SerTrp: 1.161 ± 0.295
2.063SerTyr: 2.063 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
6.061ThrAla: 6.061 ± 1.058
0.387ThrCys: 0.387 ± 0.208
3.997ThrAsp: 3.997 ± 0.535
2.192ThrGlu: 2.192 ± 0.365
2.966ThrPhe: 2.966 ± 0.866
4.126ThrGly: 4.126 ± 0.51
1.289ThrHis: 1.289 ± 0.344
3.611ThrIle: 3.611 ± 0.499
1.934ThrLys: 1.934 ± 0.536
6.576ThrLeu: 6.576 ± 0.873
2.063ThrMet: 2.063 ± 0.379
3.095ThrAsn: 3.095 ± 0.432
6.705ThrPro: 6.705 ± 0.809
2.708ThrGln: 2.708 ± 0.552
3.997ThrArg: 3.997 ± 0.819
7.221ThrSer: 7.221 ± 0.994
5.416ThrThr: 5.416 ± 0.833
6.19ThrVal: 6.19 ± 0.857
0.903ThrTrp: 0.903 ± 0.322
1.934ThrTyr: 1.934 ± 0.434
0.0ThrXaa: 0.0 ± 0.0
Val
6.705ValAla: 6.705 ± 1.051
1.418ValCys: 1.418 ± 0.381
4.255ValAsp: 4.255 ± 0.6
2.321ValGlu: 2.321 ± 0.418
2.063ValPhe: 2.063 ± 0.609
4.384ValGly: 4.384 ± 0.517
1.805ValHis: 1.805 ± 0.655
3.353ValIle: 3.353 ± 0.523
1.418ValLys: 1.418 ± 0.324
6.705ValLeu: 6.705 ± 1.314
1.934ValMet: 1.934 ± 0.264
4.384ValAsn: 4.384 ± 0.647
7.092ValPro: 7.092 ± 0.817
3.482ValGln: 3.482 ± 0.682
3.868ValArg: 3.868 ± 0.437
4.9ValSer: 4.9 ± 0.573
6.576ValThr: 6.576 ± 0.701
4.255ValVal: 4.255 ± 0.524
1.418ValTrp: 1.418 ± 0.421
2.192ValTyr: 2.192 ± 0.58
0.0ValXaa: 0.0 ± 0.0
Trp
1.161TrpAla: 1.161 ± 0.399
0.129TrpCys: 0.129 ± 0.129
0.774TrpAsp: 0.774 ± 0.293
0.645TrpGlu: 0.645 ± 0.296
0.516TrpPhe: 0.516 ± 0.291
0.516TrpGly: 0.516 ± 0.267
0.516TrpHis: 0.516 ± 0.224
0.774TrpIle: 0.774 ± 0.31
0.645TrpLys: 0.645 ± 0.266
2.063TrpLeu: 2.063 ± 0.456
0.645TrpMet: 0.645 ± 0.217
0.774TrpAsn: 0.774 ± 0.275
1.418TrpPro: 1.418 ± 0.476
0.903TrpGln: 0.903 ± 0.337
0.903TrpArg: 0.903 ± 0.369
0.903TrpSer: 0.903 ± 0.294
0.903TrpThr: 0.903 ± 0.311
0.645TrpVal: 0.645 ± 0.212
0.387TrpTrp: 0.387 ± 0.204
0.258TrpTyr: 0.258 ± 0.157
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.063TyrAla: 2.063 ± 0.625
0.258TyrCys: 0.258 ± 0.136
2.192TyrAsp: 2.192 ± 0.716
0.516TyrGlu: 0.516 ± 0.211
0.774TyrPhe: 0.774 ± 0.192
2.321TyrGly: 2.321 ± 0.287
1.161TyrHis: 1.161 ± 0.303
2.321TyrIle: 2.321 ± 0.746
1.032TyrLys: 1.032 ± 0.406
2.192TyrLeu: 2.192 ± 0.472
0.516TyrMet: 0.516 ± 0.218
1.547TyrAsn: 1.547 ± 0.293
2.837TyrPro: 2.837 ± 0.433
1.547TyrGln: 1.547 ± 0.352
1.805TyrArg: 1.805 ± 0.344
2.321TyrSer: 2.321 ± 0.372
1.032TyrThr: 1.032 ± 0.298
1.934TyrVal: 1.934 ± 0.49
0.258TyrTrp: 0.258 ± 0.194
0.258TyrTyr: 0.258 ± 0.141
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (7756 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski