Amino acid dipepetide frequency for Wenzhou tombus-like virus 18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.764AlaAla: 5.764 ± 1.412
3.602AlaCys: 3.602 ± 1.362
6.484AlaAsp: 6.484 ± 1.64
0.0AlaGlu: 0.0 ± 0.0
3.602AlaPhe: 3.602 ± 0.981
5.043AlaGly: 5.043 ± 1.096
1.441AlaHis: 1.441 ± 0.929
2.882AlaIle: 2.882 ± 1.275
5.043AlaLys: 5.043 ± 1.096
10.086AlaLeu: 10.086 ± 0.524
1.441AlaMet: 1.441 ± 0.555
4.323AlaAsn: 4.323 ± 1.0
6.484AlaPro: 6.484 ± 1.64
5.043AlaGln: 5.043 ± 1.096
5.043AlaArg: 5.043 ± 0.759
4.323AlaSer: 4.323 ± 1.161
5.764AlaThr: 5.764 ± 1.246
5.043AlaVal: 5.043 ± 0.759
1.441AlaTrp: 1.441 ± 0.428
1.441AlaTyr: 1.441 ± 0.428
0.0AlaXaa: 0.0 ± 0.0
Cys
0.72CysAla: 0.72 ± 0.626
1.441CysCys: 1.441 ± 0.929
5.043CysAsp: 5.043 ± 1.623
0.72CysGlu: 0.72 ± 0.464
0.72CysPhe: 0.72 ± 0.626
2.882CysGly: 2.882 ± 0.26
0.72CysHis: 0.72 ± 0.464
0.72CysIle: 0.72 ± 0.626
0.0CysLys: 0.0 ± 0.0
1.441CysLeu: 1.441 ± 0.929
0.0CysMet: 0.0 ± 0.0
0.72CysAsn: 0.72 ± 0.464
1.441CysPro: 1.441 ± 0.428
0.72CysGln: 0.72 ± 0.611
2.161CysArg: 2.161 ± 0.637
1.441CysSer: 1.441 ± 1.252
0.0CysThr: 0.0 ± 0.0
2.161CysVal: 2.161 ± 0.966
0.0CysTrp: 0.0 ± 0.0
0.72CysTyr: 0.72 ± 0.626
0.0CysXaa: 0.0 ± 0.0
Asp
7.205AspAla: 7.205 ± 1.057
0.0AspCys: 0.0 ± 0.0
2.161AspAsp: 2.161 ± 0.881
2.161AspGlu: 2.161 ± 0.966
2.161AspPhe: 2.161 ± 0.881
2.882AspGly: 2.882 ± 1.571
0.72AspHis: 0.72 ± 0.464
0.72AspIle: 0.72 ± 0.464
2.161AspLys: 2.161 ± 1.198
5.764AspLeu: 5.764 ± 1.534
2.161AspMet: 2.161 ± 1.118
2.882AspAsn: 2.882 ± 0.26
5.043AspPro: 5.043 ± 1.139
1.441AspGln: 1.441 ± 0.428
6.484AspArg: 6.484 ± 2.182
5.043AspSer: 5.043 ± 0.757
2.161AspThr: 2.161 ± 0.273
1.441AspVal: 1.441 ± 1.252
1.441AspTrp: 1.441 ± 0.6
2.882AspTyr: 2.882 ± 1.199
0.0AspXaa: 0.0 ± 0.0
Glu
2.882GluAla: 2.882 ± 0.26
2.161GluCys: 2.161 ± 0.881
1.441GluAsp: 1.441 ± 0.929
3.602GluGlu: 3.602 ± 2.321
1.441GluPhe: 1.441 ± 0.929
2.882GluGly: 2.882 ± 0.26
1.441GluHis: 1.441 ± 0.428
0.72GluIle: 0.72 ± 0.464
2.161GluLys: 2.161 ± 0.637
0.72GluLeu: 0.72 ± 0.611
0.0GluMet: 0.0 ± 0.0
1.441GluAsn: 1.441 ± 0.6
2.161GluPro: 2.161 ± 0.637
0.72GluGln: 0.72 ± 0.626
3.602GluArg: 3.602 ± 1.704
1.441GluSer: 1.441 ± 0.6
5.043GluThr: 5.043 ± 1.766
1.441GluVal: 1.441 ± 0.428
0.72GluTrp: 0.72 ± 0.464
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
2.882PheAla: 2.882 ± 0.26
1.441PheCys: 1.441 ± 0.929
0.72PheAsp: 0.72 ± 0.464
1.441PheGlu: 1.441 ± 0.929
1.441PhePhe: 1.441 ± 0.6
0.0PheGly: 0.0 ± 0.0
2.882PheHis: 2.882 ± 1.029
1.441PheIle: 1.441 ± 0.6
1.441PheLys: 1.441 ± 0.929
2.161PheLeu: 2.161 ± 1.393
0.72PheMet: 0.72 ± 0.464
2.161PheAsn: 2.161 ± 1.175
2.161PhePro: 2.161 ± 0.881
2.161PheGln: 2.161 ± 1.198
4.323PheArg: 4.323 ± 0.546
0.72PheSer: 0.72 ± 0.464
1.441PheThr: 1.441 ± 0.716
2.882PheVal: 2.882 ± 1.275
0.72PheTrp: 0.72 ± 0.464
0.72PheTyr: 0.72 ± 0.626
0.0PheXaa: 0.0 ± 0.0
Gly
3.602GlyAla: 3.602 ± 2.188
0.72GlyCys: 0.72 ± 0.611
4.323GlyAsp: 4.323 ± 0.377
0.72GlyGlu: 0.72 ± 0.464
2.161GlyPhe: 2.161 ± 0.273
5.043GlyGly: 5.043 ± 2.543
0.72GlyHis: 0.72 ± 0.626
2.882GlyIle: 2.882 ± 1.857
2.882GlyLys: 2.882 ± 0.26
2.161GlyLeu: 2.161 ± 0.637
1.441GlyMet: 1.441 ± 0.839
2.161GlyAsn: 2.161 ± 1.175
6.484GlyPro: 6.484 ± 1.718
1.441GlyGln: 1.441 ± 0.428
5.043GlyArg: 5.043 ± 1.625
6.484GlySer: 6.484 ± 2.408
5.764GlyThr: 5.764 ± 0.764
2.882GlyVal: 2.882 ± 1.199
1.441GlyTrp: 1.441 ± 0.428
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
2.882HisAla: 2.882 ± 0.856
1.441HisCys: 1.441 ± 0.929
1.441HisAsp: 1.441 ± 0.428
2.161HisGlu: 2.161 ± 1.393
0.0HisPhe: 0.0 ± 0.0
1.441HisGly: 1.441 ± 0.428
1.441HisHis: 1.441 ± 0.428
0.72HisIle: 0.72 ± 0.464
0.72HisLys: 0.72 ± 0.464
3.602HisLeu: 3.602 ± 0.701
0.0HisMet: 0.0 ± 0.0
1.441HisAsn: 1.441 ± 0.6
1.441HisPro: 1.441 ± 0.929
0.0HisGln: 0.0 ± 0.0
0.72HisArg: 0.72 ± 0.464
2.882HisSer: 2.882 ± 1.571
2.882HisThr: 2.882 ± 1.029
0.0HisVal: 0.0 ± 0.0
0.72HisTrp: 0.72 ± 0.626
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.161IleAla: 2.161 ± 0.881
0.72IleCys: 0.72 ± 0.464
0.72IleAsp: 0.72 ± 0.611
2.882IleGlu: 2.882 ± 1.275
0.0IlePhe: 0.0 ± 0.0
1.441IleGly: 1.441 ± 0.929
1.441IleHis: 1.441 ± 0.6
1.441IleIle: 1.441 ± 0.929
2.161IleLys: 2.161 ± 0.881
1.441IleLeu: 1.441 ± 0.716
0.72IleMet: 0.72 ± 0.464
0.0IleAsn: 0.0 ± 0.0
2.161IlePro: 2.161 ± 0.637
1.441IleGln: 1.441 ± 1.222
1.441IleArg: 1.441 ± 0.929
2.882IleSer: 2.882 ± 1.857
1.441IleThr: 1.441 ± 0.929
0.72IleVal: 0.72 ± 0.626
1.441IleTrp: 1.441 ± 0.428
1.441IleTyr: 1.441 ± 0.929
0.0IleXaa: 0.0 ± 0.0
Lys
2.161LysAla: 2.161 ± 0.966
1.441LysCys: 1.441 ± 0.428
1.441LysAsp: 1.441 ± 0.6
0.72LysGlu: 0.72 ± 0.611
2.161LysPhe: 2.161 ± 0.881
0.72LysGly: 0.72 ± 0.464
0.0LysHis: 0.0 ± 0.0
0.72LysIle: 0.72 ± 0.464
1.441LysLys: 1.441 ± 1.252
4.323LysLeu: 4.323 ± 0.377
0.0LysMet: 0.0 ± 0.0
1.441LysAsn: 1.441 ± 0.428
3.602LysPro: 3.602 ± 1.687
3.602LysGln: 3.602 ± 0.981
1.441LysArg: 1.441 ± 0.6
1.441LysSer: 1.441 ± 1.252
4.323LysThr: 4.323 ± 0.377
6.484LysVal: 6.484 ± 2.29
0.72LysTrp: 0.72 ± 0.626
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
9.366LeuAla: 9.366 ± 0.22
1.441LeuCys: 1.441 ± 1.252
5.043LeuAsp: 5.043 ± 0.759
4.323LeuGlu: 4.323 ± 0.819
0.0LeuPhe: 0.0 ± 0.0
5.764LeuGly: 5.764 ± 1.534
2.882LeuHis: 2.882 ± 0.856
2.882LeuIle: 2.882 ± 0.856
1.441LeuLys: 1.441 ± 0.929
7.205LeuLeu: 7.205 ± 1.403
2.161LeuMet: 2.161 ± 0.637
1.441LeuAsn: 1.441 ± 0.929
8.646LeuPro: 8.646 ± 1.601
1.441LeuGln: 1.441 ± 0.428
5.764LeuArg: 5.764 ± 1.339
7.205LeuSer: 7.205 ± 1.403
9.366LeuThr: 9.366 ± 2.296
9.366LeuVal: 9.366 ± 0.22
1.441LeuTrp: 1.441 ± 0.716
3.602LeuTyr: 3.602 ± 0.69
0.0LeuXaa: 0.0 ± 0.0
Met
1.441MetAla: 1.441 ± 0.428
1.441MetCys: 1.441 ± 0.428
0.72MetAsp: 0.72 ± 0.464
2.161MetGlu: 2.161 ± 0.273
0.72MetPhe: 0.72 ± 0.464
1.441MetGly: 1.441 ± 0.428
1.441MetHis: 1.441 ± 0.6
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.441MetLeu: 1.441 ± 0.428
0.0MetMet: 0.0 ± 0.0
0.72MetAsn: 0.72 ± 0.611
0.72MetPro: 0.72 ± 0.464
0.0MetGln: 0.0 ± 0.0
2.161MetArg: 2.161 ± 0.881
2.161MetSer: 2.161 ± 0.881
2.882MetThr: 2.882 ± 1.199
0.72MetVal: 0.72 ± 0.611
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.161AsnAla: 2.161 ± 1.118
0.0AsnCys: 0.0 ± 0.0
0.72AsnAsp: 0.72 ± 0.611
0.0AsnGlu: 0.0 ± 0.0
2.882AsnPhe: 2.882 ± 0.757
3.602AsnGly: 3.602 ± 0.979
0.72AsnHis: 0.72 ± 0.464
0.72AsnIle: 0.72 ± 0.464
0.0AsnLys: 0.0 ± 0.0
4.323AsnLeu: 4.323 ± 1.0
1.441AsnMet: 1.441 ± 0.6
0.0AsnAsn: 0.0 ± 0.0
5.043AsnPro: 5.043 ± 1.693
3.602AsnGln: 3.602 ± 0.69
2.161AsnArg: 2.161 ± 0.273
1.441AsnSer: 1.441 ± 1.222
2.161AsnThr: 2.161 ± 0.273
0.72AsnVal: 0.72 ± 0.464
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.043ProAla: 5.043 ± 1.625
0.0ProCys: 0.0 ± 0.0
2.882ProAsp: 2.882 ± 0.856
2.882ProGlu: 2.882 ± 1.029
5.043ProPhe: 5.043 ± 2.368
3.602ProGly: 3.602 ± 1.847
0.72ProHis: 0.72 ± 0.464
2.161ProIle: 2.161 ± 0.881
5.764ProLys: 5.764 ± 0.861
7.205ProLeu: 7.205 ± 0.486
0.72ProMet: 0.72 ± 0.464
2.882ProAsn: 2.882 ± 0.757
4.323ProPro: 4.323 ± 1.274
3.602ProGln: 3.602 ± 1.448
9.366ProArg: 9.366 ± 0.72
9.366ProSer: 9.366 ± 0.72
5.764ProThr: 5.764 ± 0.5
5.043ProVal: 5.043 ± 0.262
0.72ProTrp: 0.72 ± 0.464
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.882GlnAla: 2.882 ± 1.699
0.0GlnCys: 0.0 ± 0.0
2.161GlnAsp: 2.161 ± 1.118
0.0GlnGlu: 0.0 ± 0.0
1.441GlnPhe: 1.441 ± 0.716
5.043GlnGly: 5.043 ± 0.262
0.0GlnHis: 0.0 ± 0.0
2.161GlnIle: 2.161 ± 1.118
0.72GlnLys: 0.72 ± 0.626
5.043GlnLeu: 5.043 ± 0.757
2.882GlnMet: 2.882 ± 0.844
1.441GlnAsn: 1.441 ± 0.716
5.764GlnPro: 5.764 ± 1.514
4.323GlnGln: 4.323 ± 1.277
2.161GlnArg: 2.161 ± 1.198
1.441GlnSer: 1.441 ± 1.252
2.161GlnThr: 2.161 ± 1.175
5.043GlnVal: 5.043 ± 1.096
1.441GlnTrp: 1.441 ± 0.6
2.161GlnTyr: 2.161 ± 0.637
0.0GlnXaa: 0.0 ± 0.0
Arg
5.764ArgAla: 5.764 ± 1.412
2.882ArgCys: 2.882 ± 0.856
3.602ArgAsp: 3.602 ± 0.981
4.323ArgGlu: 4.323 ± 1.284
3.602ArgPhe: 3.602 ± 0.701
4.323ArgGly: 4.323 ± 1.933
3.602ArgHis: 3.602 ± 2.321
0.72ArgIle: 0.72 ± 0.611
3.602ArgLys: 3.602 ± 1.448
6.484ArgLeu: 6.484 ± 1.102
0.72ArgMet: 0.72 ± 0.626
2.161ArgAsn: 2.161 ± 0.637
4.323ArgPro: 4.323 ± 1.0
6.484ArgGln: 6.484 ± 1.718
7.205ArgArg: 7.205 ± 1.403
4.323ArgSer: 4.323 ± 1.161
3.602ArgThr: 3.602 ± 1.357
6.484ArgVal: 6.484 ± 2.602
0.0ArgTrp: 0.0 ± 0.0
2.882ArgTyr: 2.882 ± 1.199
0.0ArgXaa: 0.0 ± 0.0
Ser
10.086SerAla: 10.086 ± 1.786
0.72SerCys: 0.72 ± 0.464
5.043SerAsp: 5.043 ± 1.693
0.72SerGlu: 0.72 ± 0.626
1.441SerPhe: 1.441 ± 0.6
4.323SerGly: 4.323 ± 1.284
1.441SerHis: 1.441 ± 0.428
1.441SerIle: 1.441 ± 0.929
1.441SerLys: 1.441 ± 0.929
6.484SerLeu: 6.484 ± 1.96
0.72SerMet: 0.72 ± 0.464
2.882SerAsn: 2.882 ± 1.699
5.043SerPro: 5.043 ± 1.623
2.882SerGln: 2.882 ± 0.844
2.161SerArg: 2.161 ± 0.637
10.807SerSer: 10.807 ± 2.941
5.764SerThr: 5.764 ± 2.317
8.646SerVal: 8.646 ± 1.638
2.882SerTrp: 2.882 ± 1.571
2.161SerTyr: 2.161 ± 0.966
0.0SerXaa: 0.0 ± 0.0
Thr
7.925ThrAla: 7.925 ± 2.345
2.161ThrCys: 2.161 ± 0.637
5.764ThrAsp: 5.764 ± 2.086
2.161ThrGlu: 2.161 ± 0.637
2.161ThrPhe: 2.161 ± 0.881
4.323ThrGly: 4.323 ± 1.277
1.441ThrHis: 1.441 ± 0.428
2.161ThrIle: 2.161 ± 0.637
0.72ThrLys: 0.72 ± 0.626
5.764ThrLeu: 5.764 ± 3.06
0.72ThrMet: 0.72 ± 0.464
1.441ThrAsn: 1.441 ± 1.252
2.882ThrPro: 2.882 ± 1.199
4.323ThrGln: 4.323 ± 0.546
8.646ThrArg: 8.646 ± 1.99
6.484ThrSer: 6.484 ± 1.782
2.882ThrThr: 2.882 ± 2.503
5.764ThrVal: 5.764 ± 1.514
1.441ThrTrp: 1.441 ± 0.929
1.441ThrTyr: 1.441 ± 1.252
0.0ThrXaa: 0.0 ± 0.0
Val
7.925ValAla: 7.925 ± 0.594
1.441ValCys: 1.441 ± 0.428
4.323ValAsp: 4.323 ± 0.546
2.882ValGlu: 2.882 ± 1.275
1.441ValPhe: 1.441 ± 0.6
2.161ValGly: 2.161 ± 1.175
2.161ValHis: 2.161 ± 0.966
2.882ValIle: 2.882 ± 1.199
3.602ValLys: 3.602 ± 0.69
8.646ValLeu: 8.646 ± 2.908
3.602ValMet: 3.602 ± 0.357
1.441ValAsn: 1.441 ± 1.222
7.925ValPro: 7.925 ± 0.712
2.882ValGln: 2.882 ± 0.844
4.323ValArg: 4.323 ± 1.41
6.484ValSer: 6.484 ± 1.47
5.043ValThr: 5.043 ± 0.759
7.925ValVal: 7.925 ± 1.696
0.72ValTrp: 0.72 ± 0.611
2.161ValTyr: 2.161 ± 1.175
0.0ValXaa: 0.0 ± 0.0
Trp
1.441TrpAla: 1.441 ± 0.428
0.72TrpCys: 0.72 ± 0.626
1.441TrpAsp: 1.441 ± 0.428
1.441TrpGlu: 1.441 ± 0.6
0.0TrpPhe: 0.0 ± 0.0
0.72TrpGly: 0.72 ± 0.626
0.72TrpHis: 0.72 ± 0.626
0.0TrpIle: 0.0 ± 0.0
2.882TrpLys: 2.882 ± 1.571
3.602TrpLeu: 3.602 ± 0.701
0.0TrpMet: 0.0 ± 0.0
0.72TrpAsn: 0.72 ± 0.611
0.72TrpPro: 0.72 ± 0.464
0.0TrpGln: 0.0 ± 0.0
1.441TrpArg: 1.441 ± 0.929
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
2.161TrpVal: 2.161 ± 0.881
0.0TrpTrp: 0.0 ± 0.0
0.72TrpTyr: 0.72 ± 0.626
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
1.441TyrAsp: 1.441 ± 0.428
0.72TyrGlu: 0.72 ± 0.626
1.441TyrPhe: 1.441 ± 0.6
1.441TyrGly: 1.441 ± 0.428
0.0TyrHis: 0.0 ± 0.0
0.72TyrIle: 0.72 ± 0.464
0.0TyrLys: 0.0 ± 0.0
2.882TyrLeu: 2.882 ± 1.275
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
0.72TyrPro: 0.72 ± 0.464
2.161TyrGln: 2.161 ± 0.273
1.441TyrArg: 1.441 ± 0.428
0.72TyrSer: 0.72 ± 0.464
2.161TyrThr: 2.161 ± 1.175
5.043TyrVal: 5.043 ± 2.568
1.441TyrTrp: 1.441 ± 0.428
0.72TyrTyr: 0.72 ± 0.611
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski