Amino acid dipepetide frequency for Labrys okinawensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.847AlaAla: 17.847 ± 0.146	1.124AlaCys: 1.124 ± 0.027	6.942AlaAsp: 6.942 ± 0.071	7.376AlaGlu: 7.376 ± 0.067	4.916AlaPhe: 4.916 ± 0.052	11.849AlaGly: 11.849 ± 0.095	2.159AlaHis: 2.159 ± 0.031	6.96AlaIle: 6.96 ± 0.073	4.265AlaLys: 4.265 ± 0.062	14.338AlaLeu: 14.338 ± 0.116	3.57AlaMet: 3.57 ± 0.044	2.932AlaAsn: 2.932 ± 0.038	5.661AlaPro: 5.661 ± 0.07	3.854AlaGln: 3.854 ± 0.051	9.013AlaArg: 9.013 ± 0.086	6.922AlaSer: 6.922 ± 0.069	5.918AlaThr: 5.918 ± 0.064	9.095AlaVal: 9.095 ± 0.085	1.649AlaTrp: 1.649 ± 0.031	2.755AlaTyr: 2.755 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.024	0.112CysCys: 0.112 ± 0.008	0.472CysAsp: 0.472 ± 0.017	0.392CysGlu: 0.392 ± 0.014	0.326CysPhe: 0.326 ± 0.014	0.883CysGly: 0.883 ± 0.022	0.218CysHis: 0.218 ± 0.011	0.365CysIle: 0.365 ± 0.014	0.184CysLys: 0.184 ± 0.01	0.893CysLeu: 0.893 ± 0.025	0.131CysMet: 0.131 ± 0.009	0.196CysAsn: 0.196 ± 0.01	0.4CysPro: 0.4 ± 0.017	0.224CysGln: 0.224 ± 0.012	0.625CysArg: 0.625 ± 0.021	0.452CysSer: 0.452 ± 0.017	0.375CysThr: 0.375 ± 0.015	0.6CysVal: 0.6 ± 0.02	0.114CysTrp: 0.114 ± 0.008	0.209CysTyr: 0.209 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.369AspAla: 6.369 ± 0.068	0.452AspCys: 0.452 ± 0.019	2.712AspAsp: 2.712 ± 0.041	3.212AspGlu: 3.212 ± 0.041	2.149AspPhe: 2.149 ± 0.032	5.022AspGly: 5.022 ± 0.059	1.205AspHis: 1.205 ± 0.031	3.16AspIle: 3.16 ± 0.04	1.91AspLys: 1.91 ± 0.033	5.985AspLeu: 5.985 ± 0.058	1.2AspMet: 1.2 ± 0.024	1.29AspAsn: 1.29 ± 0.028	3.362AspPro: 3.362 ± 0.043	1.591AspGln: 1.591 ± 0.03	4.088AspArg: 4.088 ± 0.055	2.084AspSer: 2.084 ± 0.033	2.407AspThr: 2.407 ± 0.038	3.775AspVal: 3.775 ± 0.046	0.949AspTrp: 0.949 ± 0.023	1.59AspTyr: 1.59 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.174GluAla: 8.174 ± 0.081	0.321GluCys: 0.321 ± 0.015	2.592GluAsp: 2.592 ± 0.04	3.15GluGlu: 3.15 ± 0.048	1.645GluPhe: 1.645 ± 0.031	4.242GluGly: 4.242 ± 0.047	1.173GluHis: 1.173 ± 0.027	3.506GluIle: 3.506 ± 0.044	2.109GluLys: 2.109 ± 0.035	5.068GluLeu: 5.068 ± 0.053	1.299GluMet: 1.299 ± 0.026	1.447GluAsn: 1.447 ± 0.03	2.785GluPro: 2.785 ± 0.044	1.857GluGln: 1.857 ± 0.033	4.825GluArg: 4.825 ± 0.057	2.066GluSer: 2.066 ± 0.034	3.222GluThr: 3.222 ± 0.045	3.596GluVal: 3.596 ± 0.053	0.624GluTrp: 0.624 ± 0.019	0.843GluTyr: 0.843 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	4.752PheAla: 4.752 ± 0.051	0.377PheCys: 0.377 ± 0.015	2.619PheAsp: 2.619 ± 0.037	2.21PheGlu: 2.21 ± 0.034	1.441PhePhe: 1.441 ± 0.034	3.799PheGly: 3.799 ± 0.052	0.758PheHis: 0.758 ± 0.019	1.772PheIle: 1.772 ± 0.032	1.042PheLys: 1.042 ± 0.025	3.683PheLeu: 3.683 ± 0.051	0.812PheMet: 0.812 ± 0.021	1.026PheAsn: 1.026 ± 0.026	1.61PhePro: 1.61 ± 0.031	1.081PheGln: 1.081 ± 0.025	2.244PheArg: 2.244 ± 0.038	2.194PheSer: 2.194 ± 0.036	1.917PheThr: 1.917 ± 0.034	2.916PheVal: 2.916 ± 0.042	0.547PheTrp: 0.547 ± 0.018	0.961PheTyr: 0.961 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.404GlyAla: 9.404 ± 0.072	0.796GlyCys: 0.796 ± 0.021	4.207GlyAsp: 4.207 ± 0.047	4.874GlyGlu: 4.874 ± 0.057	3.661GlyPhe: 3.661 ± 0.048	7.422GlyGly: 7.422 ± 0.074	1.953GlyHis: 1.953 ± 0.04	4.846GlyIle: 4.846 ± 0.049	3.445GlyLys: 3.445 ± 0.053	9.787GlyLeu: 9.787 ± 0.074	2.26GlyMet: 2.26 ± 0.031	2.179GlyAsn: 2.179 ± 0.041	3.648GlyPro: 3.648 ± 0.048	2.994GlyGln: 2.994 ± 0.045	6.399GlyArg: 6.399 ± 0.058	4.964GlySer: 4.964 ± 0.056	4.569GlyThr: 4.569 ± 0.06	6.285GlyVal: 6.285 ± 0.062	1.509GlyTrp: 1.509 ± 0.03	2.262GlyTyr: 2.262 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.384HisAla: 2.384 ± 0.039	0.215HisCys: 0.215 ± 0.012	1.186HisAsp: 1.186 ± 0.025	0.991HisGlu: 0.991 ± 0.022	0.863HisPhe: 0.863 ± 0.022	2.003HisGly: 2.003 ± 0.035	0.57HisHis: 0.57 ± 0.021	0.904HisIle: 0.904 ± 0.024	0.516HisLys: 0.516 ± 0.017	2.145HisLeu: 2.145 ± 0.034	0.471HisMet: 0.471 ± 0.015	0.453HisAsn: 0.453 ± 0.017	1.295HisPro: 1.295 ± 0.031	0.617HisGln: 0.617 ± 0.021	1.492HisArg: 1.492 ± 0.031	0.883HisSer: 0.883 ± 0.024	0.774HisThr: 0.774 ± 0.022	1.484HisVal: 1.484 ± 0.032	0.354HisTrp: 0.354 ± 0.015	0.574HisTyr: 0.574 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.733IleAla: 7.733 ± 0.072	0.506IleCys: 0.506 ± 0.016	3.538IleAsp: 3.538 ± 0.042	3.588IleGlu: 3.588 ± 0.049	1.718IlePhe: 1.718 ± 0.035	5.461IleGly: 5.461 ± 0.063	0.955IleHis: 0.955 ± 0.023	2.246IleIle: 2.246 ± 0.04	1.472IleLys: 1.472 ± 0.027	4.784IleLeu: 4.784 ± 0.061	0.909IleMet: 0.909 ± 0.024	1.282IleAsn: 1.282 ± 0.028	2.352IlePro: 2.352 ± 0.034	1.245IleGln: 1.245 ± 0.028	3.444IleArg: 3.444 ± 0.046	2.797IleSer: 2.797 ± 0.044	2.565IleThr: 2.565 ± 0.043	4.338IleVal: 4.338 ± 0.056	0.647IleTrp: 0.647 ± 0.019	1.161IleTyr: 1.161 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.904LysAla: 4.904 ± 0.065	0.142LysCys: 0.142 ± 0.009	1.71LysAsp: 1.71 ± 0.035	1.529LysGlu: 1.529 ± 0.029	0.897LysPhe: 0.897 ± 0.021	2.79LysGly: 2.79 ± 0.049	0.544LysHis: 0.544 ± 0.017	1.714LysIle: 1.714 ± 0.032	1.179LysLys: 1.179 ± 0.03	3.351LysLeu: 3.351 ± 0.049	0.716LysMet: 0.716 ± 0.02	0.789LysAsn: 0.789 ± 0.022	2.299LysPro: 2.299 ± 0.042	1.047LysGln: 1.047 ± 0.023	2.25LysArg: 2.25 ± 0.034	1.764LysSer: 1.764 ± 0.034	1.859LysThr: 1.859 ± 0.036	2.486LysVal: 2.486 ± 0.041	0.35LysTrp: 0.35 ± 0.015	0.599LysTyr: 0.599 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.42LeuAla: 15.42 ± 0.114	0.902LeuCys: 0.902 ± 0.023	6.155LeuAsp: 6.155 ± 0.062	5.137LeuGlu: 5.137 ± 0.06	3.808LeuPhe: 3.808 ± 0.047	8.972LeuGly: 8.972 ± 0.068	1.9LeuHis: 1.9 ± 0.035	5.238LeuIle: 5.238 ± 0.059	3.611LeuLys: 3.611 ± 0.052	9.996LeuLeu: 9.996 ± 0.101	2.261LeuMet: 2.261 ± 0.037	2.427LeuAsn: 2.427 ± 0.037	5.943LeuPro: 5.943 ± 0.06	2.958LeuGln: 2.958 ± 0.042	6.839LeuArg: 6.839 ± 0.069	6.487LeuSer: 6.487 ± 0.063	5.6LeuThr: 5.6 ± 0.053	7.96LeuVal: 7.96 ± 0.069	1.19LeuTrp: 1.19 ± 0.028	2.181LeuTyr: 2.181 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.156MetAla: 3.156 ± 0.044	0.118MetCys: 0.118 ± 0.008	0.977MetAsp: 0.977 ± 0.025	0.962MetGlu: 0.962 ± 0.026	0.641MetPhe: 0.641 ± 0.02	1.649MetGly: 1.649 ± 0.031	0.388MetHis: 0.388 ± 0.014	1.265MetIle: 1.265 ± 0.025	0.889MetLys: 0.889 ± 0.023	2.443MetLeu: 2.443 ± 0.032	0.584MetMet: 0.584 ± 0.018	0.672MetAsn: 0.672 ± 0.018	1.522MetPro: 1.522 ± 0.027	0.786MetGln: 0.786 ± 0.021	1.777MetArg: 1.777 ± 0.037	1.605MetSer: 1.605 ± 0.028	1.726MetThr: 1.726 ± 0.032	1.632MetVal: 1.632 ± 0.026	0.195MetTrp: 0.195 ± 0.01	0.277MetTyr: 0.277 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.117AsnAla: 3.117 ± 0.046	0.216AsnCys: 0.216 ± 0.011	1.192AsnAsp: 1.192 ± 0.026	1.183AsnGlu: 1.183 ± 0.028	0.978AsnPhe: 0.978 ± 0.022	2.328AsnGly: 2.328 ± 0.042	0.495AsnHis: 0.495 ± 0.017	1.3AsnIle: 1.3 ± 0.029	0.731AsnLys: 0.731 ± 0.021	2.591AsnLeu: 2.591 ± 0.042	0.54AsnMet: 0.54 ± 0.018	0.651AsnAsn: 0.651 ± 0.02	1.719AsnPro: 1.719 ± 0.029	0.772AsnGln: 0.772 ± 0.019	1.663AsnArg: 1.663 ± 0.031	1.164AsnSer: 1.164 ± 0.028	1.172AsnThr: 1.172 ± 0.026	1.839AsnVal: 1.839 ± 0.03	0.422AsnTrp: 0.422 ± 0.016	0.696AsnTyr: 0.696 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.137ProAla: 7.137 ± 0.074	0.312ProCys: 0.312 ± 0.015	3.654ProAsp: 3.654 ± 0.043	3.397ProGlu: 3.397 ± 0.043	2.047ProPhe: 2.047 ± 0.033	4.78ProGly: 4.78 ± 0.055	1.097ProHis: 1.097 ± 0.029	2.352ProIle: 2.352 ± 0.04	1.671ProLys: 1.671 ± 0.034	5.025ProLeu: 5.025 ± 0.053	1.155ProMet: 1.155 ± 0.025	1.28ProAsn: 1.28 ± 0.026	2.907ProPro: 2.907 ± 0.051	1.709ProGln: 1.709 ± 0.031	3.132ProArg: 3.132 ± 0.048	2.971ProSer: 2.971 ± 0.04	2.421ProThr: 2.421 ± 0.036	4.289ProVal: 4.289 ± 0.046	0.683ProTrp: 0.683 ± 0.02	1.225ProTyr: 1.225 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.871GlnAla: 4.871 ± 0.063	0.197GlnCys: 0.197 ± 0.01	1.493GlnAsp: 1.493 ± 0.03	1.473GlnGlu: 1.473 ± 0.03	1.063GlnPhe: 1.063 ± 0.022	2.477GlnGly: 2.477 ± 0.037	0.625GlnHis: 0.625 ± 0.019	1.765GlnIle: 1.765 ± 0.035	1.053GlnLys: 1.053 ± 0.023	2.841GlnLeu: 2.841 ± 0.041	0.748GlnMet: 0.748 ± 0.021	0.793GlnAsn: 0.793 ± 0.023	1.823GlnPro: 1.823 ± 0.039	1.186GlnGln: 1.186 ± 0.028	2.443GlnArg: 2.443 ± 0.036	1.759GlnSer: 1.759 ± 0.032	1.602GlnThr: 1.602 ± 0.031	2.08GlnVal: 2.08 ± 0.03	0.434GlnTrp: 0.434 ± 0.014	0.574GlnTyr: 0.574 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.59ArgAla: 7.59 ± 0.072	0.507ArgCys: 0.507 ± 0.017	3.836ArgAsp: 3.836 ± 0.05	4.045ArgGlu: 4.045 ± 0.058	3.025ArgPhe: 3.025 ± 0.044	4.88ArgGly: 4.88 ± 0.063	1.847ArgHis: 1.847 ± 0.033	4.019ArgIle: 4.019 ± 0.041	2.275ArgLys: 2.275 ± 0.037	8.488ArgLeu: 8.488 ± 0.08	1.657ArgMet: 1.657 ± 0.03	1.859ArgAsn: 1.859 ± 0.03	3.795ArgPro: 3.795 ± 0.055	2.828ArgGln: 2.828 ± 0.044	5.947ArgArg: 5.947 ± 0.066	3.895ArgSer: 3.895 ± 0.049	3.195ArgThr: 3.195 ± 0.04	4.437ArgVal: 4.437 ± 0.047	1.02ArgTrp: 1.02 ± 0.026	1.739ArgTyr: 1.739 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.213SerAla: 6.213 ± 0.06	0.418SerCys: 0.418 ± 0.016	2.68SerAsp: 2.68 ± 0.044	2.584SerGlu: 2.584 ± 0.041	2.414SerPhe: 2.414 ± 0.034	5.34SerGly: 5.34 ± 0.054	1.178SerHis: 1.178 ± 0.022	2.845SerIle: 2.845 ± 0.036	1.622SerLys: 1.622 ± 0.033	5.896SerLeu: 5.896 ± 0.059	1.249SerMet: 1.249 ± 0.027	1.327SerAsn: 1.327 ± 0.028	3.11SerPro: 3.11 ± 0.043	1.776SerGln: 1.776 ± 0.035	3.735SerArg: 3.735 ± 0.054	3.037SerSer: 3.037 ± 0.047	2.624SerThr: 2.624 ± 0.042	3.845SerVal: 3.845 ± 0.053	0.835SerTrp: 0.835 ± 0.021	1.353SerTyr: 1.353 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.17ThrAla: 6.17 ± 0.062	0.402ThrCys: 0.402 ± 0.016	2.449ThrAsp: 2.449 ± 0.039	2.204ThrGlu: 2.204 ± 0.037	1.925ThrPhe: 1.925 ± 0.036	4.883ThrGly: 4.883 ± 0.052	0.968ThrHis: 0.968 ± 0.022	2.918ThrIle: 2.918 ± 0.042	1.487ThrLys: 1.487 ± 0.031	5.854ThrLeu: 5.854 ± 0.059	1.151ThrMet: 1.151 ± 0.025	1.204ThrAsn: 1.204 ± 0.028	3.332ThrPro: 3.332 ± 0.046	1.495ThrGln: 1.495 ± 0.031	3.21ThrArg: 3.21 ± 0.037	2.75ThrSer: 2.75 ± 0.041	2.674ThrThr: 2.674 ± 0.048	4.048ThrVal: 4.048 ± 0.056	0.616ThrTrp: 0.616 ± 0.019	1.118ThrTyr: 1.118 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	9.103ValAla: 9.103 ± 0.079	0.614ValCys: 0.614 ± 0.019	4.013ValAsp: 4.013 ± 0.049	4.502ValGlu: 4.502 ± 0.053	2.745ValPhe: 2.745 ± 0.041	5.56ValGly: 5.56 ± 0.061	1.323ValHis: 1.323 ± 0.026	4.049ValIle: 4.049 ± 0.054	2.375ValLys: 2.375 ± 0.039	7.715ValLeu: 7.715 ± 0.078	1.814ValMet: 1.814 ± 0.03	1.897ValAsn: 1.897 ± 0.035	3.824ValPro: 3.824 ± 0.046	1.942ValGln: 1.942 ± 0.036	4.615ValArg: 4.615 ± 0.049	4.274ValSer: 4.274 ± 0.051	4.421ValThr: 4.421 ± 0.043	5.92ValVal: 5.92 ± 0.072	0.852ValTrp: 0.852 ± 0.021	1.515ValTyr: 1.515 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.203TrpAla: 1.203 ± 0.03	0.118TrpCys: 0.118 ± 0.008	0.633TrpAsp: 0.633 ± 0.02	0.526TrpGlu: 0.526 ± 0.018	0.56TrpPhe: 0.56 ± 0.019	0.951TrpGly: 0.951 ± 0.025	0.359TrpHis: 0.359 ± 0.015	0.674TrpIle: 0.674 ± 0.019	0.455TrpLys: 0.455 ± 0.015	1.741TrpLeu: 1.741 ± 0.035	0.336TrpMet: 0.336 ± 0.014	0.481TrpAsn: 0.481 ± 0.015	0.765TrpPro: 0.765 ± 0.019	0.628TrpGln: 0.628 ± 0.022	1.225TrpArg: 1.225 ± 0.024	0.856TrpSer: 0.856 ± 0.021	0.762TrpThr: 0.762 ± 0.02	0.793TrpVal: 0.793 ± 0.024	0.244TrpTrp: 0.244 ± 0.012	0.303TrpTyr: 0.303 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.673TyrAla: 2.673 ± 0.039	0.246TyrCys: 0.246 ± 0.012	1.45TyrAsp: 1.45 ± 0.031	1.208TyrGlu: 1.208 ± 0.028	0.939TyrPhe: 0.939 ± 0.025	2.176TyrGly: 2.176 ± 0.033	0.46TyrHis: 0.46 ± 0.015	0.844TyrIle: 0.844 ± 0.023	0.626TyrLys: 0.626 ± 0.021	2.363TyrLeu: 2.363 ± 0.035	0.399TyrMet: 0.399 ± 0.015	0.586TyrAsn: 0.586 ± 0.019	1.092TyrPro: 1.092 ± 0.021	0.713TyrGln: 0.713 ± 0.02	1.917TyrArg: 1.917 ± 0.032	1.156TyrSer: 1.156 ± 0.026	1.056TyrThr: 1.056 ± 0.024	1.653TyrVal: 1.653 ± 0.031	0.381TyrTrp: 0.381 ± 0.015	0.638TyrTyr: 0.638 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5818 proteins (1849414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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