Amino acid dipepetide frequency for Methylocucumis oryzae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.358AlaAla: 8.358 ± 0.148	1.138AlaCys: 1.138 ± 0.048	5.249AlaAsp: 5.249 ± 0.088	6.187AlaGlu: 6.187 ± 0.101	3.455AlaPhe: 3.455 ± 0.066	6.268AlaGly: 6.268 ± 0.119	1.987AlaHis: 1.987 ± 0.054	6.069AlaIle: 6.069 ± 0.102	4.965AlaLys: 4.965 ± 0.099	11.222AlaLeu: 11.222 ± 0.143	2.407AlaMet: 2.407 ± 0.053	4.227AlaAsn: 4.227 ± 0.093	2.98AlaPro: 2.98 ± 0.075	4.237AlaGln: 4.237 ± 0.107	3.619AlaArg: 3.619 ± 0.074	5.63AlaSer: 5.63 ± 0.093	5.165AlaThr: 5.165 ± 0.097	5.942AlaVal: 5.942 ± 0.095	1.329AlaTrp: 1.329 ± 0.041	2.928AlaTyr: 2.928 ± 0.069	0.003AlaXaa: 0.003 ± 0.001
Cys	0.988CysAla: 0.988 ± 0.038	0.196CysCys: 0.196 ± 0.016	0.504CysAsp: 0.504 ± 0.025	0.485CysGlu: 0.485 ± 0.024	0.518CysPhe: 0.518 ± 0.025	0.823CysGly: 0.823 ± 0.031	0.394CysHis: 0.394 ± 0.024	0.569CysIle: 0.569 ± 0.027	0.425CysLys: 0.425 ± 0.024	1.362CysLeu: 1.362 ± 0.046	0.263CysMet: 0.263 ± 0.017	0.382CysAsn: 0.382 ± 0.025	0.495CysPro: 0.495 ± 0.026	0.595CysGln: 0.595 ± 0.028	0.605CysArg: 0.605 ± 0.03	0.774CysSer: 0.774 ± 0.029	0.55CysThr: 0.55 ± 0.025	0.717CysVal: 0.717 ± 0.03	0.157CysTrp: 0.157 ± 0.013	0.453CysTyr: 0.453 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	5.25AspAla: 5.25 ± 0.089	0.66AspCys: 0.66 ± 0.03	3.271AspAsp: 3.271 ± 0.093	3.32AspGlu: 3.32 ± 0.073	2.577AspPhe: 2.577 ± 0.054	3.982AspGly: 3.982 ± 0.113	0.908AspHis: 0.908 ± 0.035	3.879AspIle: 3.879 ± 0.082	2.947AspLys: 2.947 ± 0.065	5.392AspLeu: 5.392 ± 0.093	1.176AspMet: 1.176 ± 0.041	2.631AspAsn: 2.631 ± 0.069	1.809AspPro: 1.809 ± 0.053	1.529AspGln: 1.529 ± 0.041	1.853AspArg: 1.853 ± 0.051	3.479AspSer: 3.479 ± 0.075	3.313AspThr: 3.313 ± 0.107	3.749AspVal: 3.749 ± 0.085	0.921AspTrp: 0.921 ± 0.033	2.254AspTyr: 2.254 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.963GluAla: 4.963 ± 0.093	0.536GluCys: 0.536 ± 0.023	2.247GluAsp: 2.247 ± 0.061	2.441GluGlu: 2.441 ± 0.065	2.23GluPhe: 2.23 ± 0.054	2.746GluGly: 2.746 ± 0.073	1.781GluHis: 1.781 ± 0.052	3.658GluIle: 3.658 ± 0.085	2.757GluLys: 2.757 ± 0.075	7.258GluLeu: 7.258 ± 0.108	1.158GluMet: 1.158 ± 0.042	2.186GluAsn: 2.186 ± 0.065	2.04GluPro: 2.04 ± 0.057	4.338GluGln: 4.338 ± 0.099	3.019GluArg: 3.019 ± 0.072	2.859GluSer: 2.859 ± 0.06	3.13GluThr: 3.13 ± 0.074	3.142GluVal: 3.142 ± 0.081	0.689GluTrp: 0.689 ± 0.029	1.485GluTyr: 1.485 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.515PheAla: 3.515 ± 0.08	0.519PheCys: 0.519 ± 0.026	2.619PheAsp: 2.619 ± 0.063	2.128PheGlu: 2.128 ± 0.054	1.776PhePhe: 1.776 ± 0.058	2.733PheGly: 2.733 ± 0.063	0.812PheHis: 0.812 ± 0.033	2.739PheIle: 2.739 ± 0.066	1.941PheLys: 1.941 ± 0.048	3.555PheLeu: 3.555 ± 0.085	0.88PheMet: 0.88 ± 0.034	2.197PheAsn: 2.197 ± 0.058	1.408PhePro: 1.408 ± 0.049	1.276PheGln: 1.276 ± 0.042	1.604PheArg: 1.604 ± 0.049	3.226PheSer: 3.226 ± 0.078	2.472PheThr: 2.472 ± 0.069	2.469PheVal: 2.469 ± 0.061	0.531PheTrp: 0.531 ± 0.027	1.416PheTyr: 1.416 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.157GlyAla: 5.157 ± 0.111	0.888GlyCys: 0.888 ± 0.041	3.674GlyAsp: 3.674 ± 0.105	3.491GlyGlu: 3.491 ± 0.074	3.313GlyPhe: 3.313 ± 0.075	4.866GlyGly: 4.866 ± 0.14	1.581GlyHis: 1.581 ± 0.052	4.427GlyIle: 4.427 ± 0.09	3.467GlyLys: 3.467 ± 0.079	7.424GlyLeu: 7.424 ± 0.097	1.699GlyMet: 1.699 ± 0.051	3.117GlyAsn: 3.117 ± 0.117	1.439GlyPro: 1.439 ± 0.049	2.996GlyGln: 2.996 ± 0.07	2.973GlyArg: 2.973 ± 0.072	4.229GlySer: 4.229 ± 0.115	3.493GlyThr: 3.493 ± 0.109	4.787GlyVal: 4.787 ± 0.095	0.899GlyTrp: 0.899 ± 0.035	2.314GlyTyr: 2.314 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.095HisAla: 2.095 ± 0.054	0.408HisCys: 0.408 ± 0.026	1.373HisAsp: 1.373 ± 0.041	1.293HisGlu: 1.293 ± 0.039	1.058HisPhe: 1.058 ± 0.044	1.557HisGly: 1.557 ± 0.049	0.803HisHis: 0.803 ± 0.039	1.568HisIle: 1.568 ± 0.047	1.066HisLys: 1.066 ± 0.039	2.413HisLeu: 2.413 ± 0.063	0.447HisMet: 0.447 ± 0.026	0.927HisAsn: 0.927 ± 0.037	1.217HisPro: 1.217 ± 0.042	1.07HisGln: 1.07 ± 0.036	1.087HisArg: 1.087 ± 0.039	1.561HisSer: 1.561 ± 0.047	1.215HisThr: 1.215 ± 0.041	1.396HisVal: 1.396 ± 0.045	0.43HisTrp: 0.43 ± 0.027	1.102HisTyr: 1.102 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	6.854IleAla: 6.854 ± 0.111	0.587IleCys: 0.587 ± 0.03	4.231IleAsp: 4.231 ± 0.085	4.107IleGlu: 4.107 ± 0.084	2.091IlePhe: 2.091 ± 0.06	4.334IleGly: 4.334 ± 0.09	1.378IleHis: 1.378 ± 0.041	3.815IleIle: 3.815 ± 0.079	3.56IleLys: 3.56 ± 0.077	5.101IleLeu: 5.101 ± 0.089	1.177IleMet: 1.177 ± 0.044	3.51IleAsn: 3.51 ± 0.085	2.818IlePro: 2.818 ± 0.055	2.384IleGln: 2.384 ± 0.058	2.719IleArg: 2.719 ± 0.063	4.16IleSer: 4.16 ± 0.076	4.278IleThr: 4.278 ± 0.082	3.889IleVal: 3.889 ± 0.081	0.576IleTrp: 0.576 ± 0.028	1.766IleTyr: 1.766 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.55LysAla: 4.55 ± 0.085	0.34LysCys: 0.34 ± 0.022	2.253LysAsp: 2.253 ± 0.056	2.262LysGlu: 2.262 ± 0.069	1.392LysPhe: 1.392 ± 0.037	2.514LysGly: 2.514 ± 0.068	1.412LysHis: 1.412 ± 0.047	3.27LysIle: 3.27 ± 0.082	2.538LysLys: 2.538 ± 0.078	5.295LysLeu: 5.295 ± 0.083	0.978LysMet: 0.978 ± 0.041	2.235LysAsn: 2.235 ± 0.063	2.873LysPro: 2.873 ± 0.07	3.159LysGln: 3.159 ± 0.071	2.429LysArg: 2.429 ± 0.066	2.739LysSer: 2.739 ± 0.067	3.454LysThr: 3.454 ± 0.065	2.683LysVal: 2.683 ± 0.062	0.453LysTrp: 0.453 ± 0.024	1.106LysTyr: 1.106 ± 0.047	0.004LysXaa: 0.004 ± 0.002
Leu	12.132LeuAla: 12.132 ± 0.155	1.242LeuCys: 1.242 ± 0.044	5.587LeuAsp: 5.587 ± 0.089	5.34LeuGlu: 5.34 ± 0.106	4.087LeuPhe: 4.087 ± 0.083	6.793LeuGly: 6.793 ± 0.098	2.371LeuHis: 2.371 ± 0.06	6.905LeuIle: 6.905 ± 0.106	5.529LeuLys: 5.529 ± 0.084	12.078LeuLeu: 12.078 ± 0.176	2.306LeuMet: 2.306 ± 0.061	5.328LeuAsn: 5.328 ± 0.082	5.342LeuPro: 5.342 ± 0.097	4.428LeuGln: 4.428 ± 0.092	4.788LeuArg: 4.788 ± 0.082	8.389LeuSer: 8.389 ± 0.133	8.044LeuThr: 8.044 ± 0.143	6.455LeuVal: 6.455 ± 0.089	1.16LeuTrp: 1.16 ± 0.045	2.752LeuTyr: 2.752 ± 0.064	0.003LeuXaa: 0.003 ± 0.002
Met	2.214MetAla: 2.214 ± 0.054	0.182MetCys: 0.182 ± 0.017	0.929MetAsp: 0.929 ± 0.034	0.933MetGlu: 0.933 ± 0.039	0.67MetPhe: 0.67 ± 0.026	1.248MetGly: 1.248 ± 0.044	0.522MetHis: 0.522 ± 0.027	1.217MetIle: 1.217 ± 0.036	1.089MetLys: 1.089 ± 0.038	2.554MetLeu: 2.554 ± 0.066	0.526MetMet: 0.526 ± 0.03	1.014MetAsn: 1.014 ± 0.039	1.219MetPro: 1.219 ± 0.036	1.148MetGln: 1.148 ± 0.043	1.191MetArg: 1.191 ± 0.039	1.467MetSer: 1.467 ± 0.044	1.469MetThr: 1.469 ± 0.04	1.377MetVal: 1.377 ± 0.045	0.149MetTrp: 0.149 ± 0.014	0.415MetTyr: 0.415 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.254AsnAla: 4.254 ± 0.088	0.433AsnCys: 0.433 ± 0.028	2.804AsnAsp: 2.804 ± 0.108	2.289AsnGlu: 2.289 ± 0.06	1.517AsnPhe: 1.517 ± 0.049	3.299AsnGly: 3.299 ± 0.078	1.138AsnHis: 1.138 ± 0.036	2.63AsnIle: 2.63 ± 0.068	2.164AsnLys: 2.164 ± 0.057	4.148AsnLeu: 4.148 ± 0.076	0.828AsnMet: 0.828 ± 0.035	2.273AsnAsn: 2.273 ± 0.078	2.508AsnPro: 2.508 ± 0.062	2.375AsnGln: 2.375 ± 0.053	2.062AsnArg: 2.062 ± 0.054	2.914AsnSer: 2.914 ± 0.076	2.919AsnThr: 2.919 ± 0.081	2.579AsnVal: 2.579 ± 0.066	0.599AsnTrp: 0.599 ± 0.03	1.369AsnTyr: 1.369 ± 0.053	0.001AsnXaa: 0.001 ± 0.001
Pro	3.53ProAla: 3.53 ± 0.074	0.396ProCys: 0.396 ± 0.024	2.822ProAsp: 2.822 ± 0.063	3.3ProGlu: 3.3 ± 0.076	1.627ProPhe: 1.627 ± 0.048	2.881ProGly: 2.881 ± 0.069	0.815ProHis: 0.815 ± 0.035	2.663ProIle: 2.663 ± 0.059	1.995ProLys: 1.995 ± 0.052	4.131ProLeu: 4.131 ± 0.08	0.961ProMet: 0.961 ± 0.035	1.973ProAsn: 1.973 ± 0.053	1.487ProPro: 1.487 ± 0.048	1.319ProGln: 1.319 ± 0.044	1.446ProArg: 1.446 ± 0.051	2.691ProSer: 2.691 ± 0.065	2.336ProThr: 2.336 ± 0.062	3.293ProVal: 3.293 ± 0.073	0.514ProTrp: 0.514 ± 0.029	1.308ProTyr: 1.308 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	5.15GlnAla: 5.15 ± 0.118	0.499GlnCys: 0.499 ± 0.028	2.164GlnAsp: 2.164 ± 0.048	2.158GlnGlu: 2.158 ± 0.064	1.711GlnPhe: 1.711 ± 0.054	3.089GlnGly: 3.089 ± 0.063	1.646GlnHis: 1.646 ± 0.052	2.607GlnIle: 2.607 ± 0.063	1.91GlnLys: 1.91 ± 0.05	5.635GlnLeu: 5.635 ± 0.111	0.884GlnMet: 0.884 ± 0.036	1.704GlnAsn: 1.704 ± 0.056	2.269GlnPro: 2.269 ± 0.063	3.838GlnGln: 3.838 ± 0.103	2.835GlnArg: 2.835 ± 0.081	2.445GlnSer: 2.445 ± 0.058	2.681GlnThr: 2.681 ± 0.06	2.804GlnVal: 2.804 ± 0.066	0.613GlnTrp: 0.613 ± 0.027	1.335GlnTyr: 1.335 ± 0.046	0.001GlnXaa: 0.001 ± 0.001
Arg	3.296ArgAla: 3.296 ± 0.06	0.551ArgCys: 0.551 ± 0.029	2.296ArgAsp: 2.296 ± 0.065	2.458ArgGlu: 2.458 ± 0.057	2.295ArgPhe: 2.295 ± 0.059	2.237ArgGly: 2.237 ± 0.062	1.175ArgHis: 1.175 ± 0.043	3.19ArgIle: 3.19 ± 0.064	2.012ArgLys: 2.012 ± 0.055	5.996ArgLeu: 5.996 ± 0.109	1.235ArgMet: 1.235 ± 0.042	1.888ArgAsn: 1.888 ± 0.055	1.577ArgPro: 1.577 ± 0.048	2.381ArgGln: 2.381 ± 0.071	2.278ArgArg: 2.278 ± 0.064	2.363ArgSer: 2.363 ± 0.07	2.016ArgThr: 2.016 ± 0.055	3.025ArgVal: 3.025 ± 0.063	0.684ArgTrp: 0.684 ± 0.032	2.026ArgTyr: 2.026 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.283SerAla: 6.283 ± 0.119	0.737SerCys: 0.737 ± 0.033	3.697SerAsp: 3.697 ± 0.087	3.677SerGlu: 3.677 ± 0.071	2.586SerPhe: 2.586 ± 0.063	5.231SerGly: 5.231 ± 0.124	1.566SerHis: 1.566 ± 0.049	3.84SerIle: 3.84 ± 0.075	2.53SerLys: 2.53 ± 0.06	7.065SerLeu: 7.065 ± 0.1	1.223SerMet: 1.223 ± 0.038	2.577SerAsn: 2.577 ± 0.07	2.533SerPro: 2.533 ± 0.066	2.607SerGln: 2.607 ± 0.061	2.644SerArg: 2.644 ± 0.069	4.265SerSer: 4.265 ± 0.093	3.427SerThr: 3.427 ± 0.074	4.581SerVal: 4.581 ± 0.088	0.769SerTrp: 0.769 ± 0.032	2.055SerTyr: 2.055 ± 0.052	0.001SerXaa: 0.001 ± 0.001
Thr	5.581ThrAla: 5.581 ± 0.099	0.547ThrCys: 0.547 ± 0.028	3.352ThrAsp: 3.352 ± 0.08	3.437ThrGlu: 3.437 ± 0.063	2.062ThrPhe: 2.062 ± 0.066	5.023ThrGly: 5.023 ± 0.12	1.346ThrHis: 1.346 ± 0.044	3.759ThrIle: 3.759 ± 0.093	2.238ThrLys: 2.238 ± 0.059	7.205ThrLeu: 7.205 ± 0.13	1.09ThrMet: 1.09 ± 0.046	2.056ThrAsn: 2.056 ± 0.066	3.191ThrPro: 3.191 ± 0.084	2.608ThrGln: 2.608 ± 0.054	2.48ThrArg: 2.48 ± 0.063	3.438ThrSer: 3.438 ± 0.085	3.819ThrThr: 3.819 ± 0.106	4.488ThrVal: 4.488 ± 0.103	0.749ThrTrp: 0.749 ± 0.036	1.592ThrTyr: 1.592 ± 0.054	0.001ThrXaa: 0.001 ± 0.002
Val	5.599ValAla: 5.599 ± 0.104	0.798ValCys: 0.798 ± 0.031	3.543ValAsp: 3.543 ± 0.073	3.388ValGlu: 3.388 ± 0.088	2.895ValPhe: 2.895 ± 0.064	3.773ValGly: 3.773 ± 0.074	1.215ValHis: 1.215 ± 0.048	4.464ValIle: 4.464 ± 0.092	3.208ValLys: 3.208 ± 0.07	7.528ValLeu: 7.528 ± 0.122	1.556ValMet: 1.556 ± 0.049	3.327ValAsn: 3.327 ± 0.077	2.291ValPro: 2.291 ± 0.054	2.285ValGln: 2.285 ± 0.062	2.666ValArg: 2.666 ± 0.063	4.451ValSer: 4.451 ± 0.087	4.108ValThr: 4.108 ± 0.094	4.507ValVal: 4.507 ± 0.086	0.803ValTrp: 0.803 ± 0.033	2.019ValTyr: 2.019 ± 0.057	0.001ValXaa: 0.001 ± 0.001
Trp	0.848TrpAla: 0.848 ± 0.037	0.135TrpCys: 0.135 ± 0.015	0.599TrpAsp: 0.599 ± 0.032	0.481TrpGlu: 0.481 ± 0.026	0.512TrpPhe: 0.512 ± 0.028	0.627TrpGly: 0.627 ± 0.034	0.401TrpHis: 0.401 ± 0.026	0.518TrpIle: 0.518 ± 0.027	0.392TrpLys: 0.392 ± 0.023	2.238TrpLeu: 2.238 ± 0.067	0.236TrpMet: 0.236 ± 0.019	0.413TrpAsn: 0.413 ± 0.026	0.548TrpPro: 0.548 ± 0.026	1.159TrpGln: 1.159 ± 0.041	0.877TrpArg: 0.877 ± 0.04	0.811TrpSer: 0.811 ± 0.032	0.556TrpThr: 0.556 ± 0.032	0.79TrpVal: 0.79 ± 0.037	0.203TrpTrp: 0.203 ± 0.016	0.393TrpTyr: 0.393 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.746TyrAla: 2.746 ± 0.062	0.463TyrCys: 0.463 ± 0.026	1.687TyrAsp: 1.687 ± 0.054	1.492TyrGlu: 1.492 ± 0.046	1.434TyrPhe: 1.434 ± 0.042	2.212TyrGly: 2.212 ± 0.057	0.834TyrHis: 0.834 ± 0.038	1.548TyrIle: 1.548 ± 0.045	1.204TyrLys: 1.204 ± 0.045	3.458TyrLeu: 3.458 ± 0.076	0.502TyrMet: 0.502 ± 0.029	1.136TyrAsn: 1.136 ± 0.045	1.443TyrPro: 1.443 ± 0.047	2.246TyrGln: 2.246 ± 0.056	1.803TyrArg: 1.803 ± 0.051	2.003TyrSer: 2.003 ± 0.054	1.614TyrThr: 1.614 ± 0.054	1.751TyrVal: 1.751 ± 0.042	0.511TyrTrp: 0.511 ± 0.025	1.045TyrTyr: 1.045 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.008XaaPhe: 0.008 ± 0.003	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.003XaaLys: 0.003 ± 0.002	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 2947 proteins (753327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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