Amino acid dipepetide frequency for Wallemia mellicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.915AlaAla: 5.915 ± 0.078	0.739AlaCys: 0.739 ± 0.019	3.53AlaAsp: 3.53 ± 0.039	4.07AlaGlu: 4.07 ± 0.043	2.991AlaPhe: 2.991 ± 0.045	4.264AlaGly: 4.264 ± 0.053	1.57AlaHis: 1.57 ± 0.027	4.58AlaIle: 4.58 ± 0.051	4.295AlaLys: 4.295 ± 0.049	7.06AlaLeu: 7.06 ± 0.081	1.513AlaMet: 1.513 ± 0.03	3.167AlaAsn: 3.167 ± 0.038	3.435AlaPro: 3.435 ± 0.057	3.095AlaGln: 3.095 ± 0.045	3.553AlaArg: 3.553 ± 0.044	5.893AlaSer: 5.893 ± 0.063	4.185AlaThr: 4.185 ± 0.048	4.098AlaVal: 4.098 ± 0.05	0.721AlaTrp: 0.721 ± 0.019	2.125AlaTyr: 2.125 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.684CysAla: 0.684 ± 0.021	0.178CysCys: 0.178 ± 0.01	0.573CysAsp: 0.573 ± 0.016	0.505CysGlu: 0.505 ± 0.017	0.422CysPhe: 0.422 ± 0.014	0.7CysGly: 0.7 ± 0.025	0.249CysHis: 0.249 ± 0.012	0.634CysIle: 0.634 ± 0.018	0.553CysLys: 0.553 ± 0.016	1.052CysLeu: 1.052 ± 0.022	0.201CysMet: 0.201 ± 0.009	0.444CysAsn: 0.444 ± 0.016	0.467CysPro: 0.467 ± 0.019	0.358CysGln: 0.358 ± 0.012	0.508CysArg: 0.508 ± 0.017	0.755CysSer: 0.755 ± 0.02	0.584CysThr: 0.584 ± 0.019	0.667CysVal: 0.667 ± 0.02	0.14CysTrp: 0.14 ± 0.008	0.341CysTyr: 0.341 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.181AspAla: 4.181 ± 0.043	0.558AspCys: 0.558 ± 0.015	5.258AspAsp: 5.258 ± 0.07	5.341AspGlu: 5.341 ± 0.059	2.324AspPhe: 2.324 ± 0.037	3.485AspGly: 3.485 ± 0.041	1.14AspHis: 1.14 ± 0.023	4.056AspIle: 4.056 ± 0.046	3.868AspLys: 3.868 ± 0.048	5.528AspLeu: 5.528 ± 0.051	1.194AspMet: 1.194 ± 0.023	3.318AspAsn: 3.318 ± 0.043	2.505AspPro: 2.505 ± 0.036	2.151AspGln: 2.151 ± 0.035	2.647AspArg: 2.647 ± 0.042	4.542AspSer: 4.542 ± 0.057	3.023AspThr: 3.023 ± 0.037	4.023AspVal: 4.023 ± 0.047	0.76AspTrp: 0.76 ± 0.02	2.035AspTyr: 2.035 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	4.572GluAla: 4.572 ± 0.053	0.643GluCys: 0.643 ± 0.019	4.66GluAsp: 4.66 ± 0.061	6.209GluGlu: 6.209 ± 0.093	2.233GluPhe: 2.233 ± 0.03	3.302GluGly: 3.302 ± 0.042	1.398GluHis: 1.398 ± 0.028	3.883GluIle: 3.883 ± 0.042	4.735GluLys: 4.735 ± 0.058	5.919GluLeu: 5.919 ± 0.057	1.463GluMet: 1.463 ± 0.029	3.323GluAsn: 3.323 ± 0.043	2.284GluPro: 2.284 ± 0.034	2.931GluGln: 2.931 ± 0.044	3.852GluArg: 3.852 ± 0.06	4.934GluSer: 4.934 ± 0.051	3.255GluThr: 3.255 ± 0.035	3.44GluVal: 3.44 ± 0.043	0.75GluTrp: 0.75 ± 0.024	1.939GluTyr: 1.939 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	2.679PheAla: 2.679 ± 0.04	0.472PheCys: 0.472 ± 0.017	2.716PheAsp: 2.716 ± 0.037	2.443PheGlu: 2.443 ± 0.035	1.491PhePhe: 1.491 ± 0.032	2.741PheGly: 2.741 ± 0.054	0.756PheHis: 0.756 ± 0.018	2.357PheIle: 2.357 ± 0.035	2.422PheLys: 2.422 ± 0.034	3.132PheLeu: 3.132 ± 0.044	0.728PheMet: 0.728 ± 0.021	2.268PheAsn: 2.268 ± 0.033	1.496PhePro: 1.496 ± 0.029	1.201PheGln: 1.201 ± 0.023	1.645PheArg: 1.645 ± 0.026	3.073PheSer: 3.073 ± 0.04	2.212PheThr: 2.212 ± 0.035	2.353PheVal: 2.353 ± 0.036	0.486PheTrp: 0.486 ± 0.015	1.248PheTyr: 1.248 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	3.787GlyAla: 3.787 ± 0.053	0.698GlyCys: 0.698 ± 0.021	3.158GlyAsp: 3.158 ± 0.042	3.184GlyGlu: 3.184 ± 0.037	2.445GlyPhe: 2.445 ± 0.035	4.159GlyGly: 4.159 ± 0.074	1.355GlyHis: 1.355 ± 0.033	3.394GlyIle: 3.394 ± 0.046	3.503GlyLys: 3.503 ± 0.045	5.409GlyLeu: 5.409 ± 0.06	1.274GlyMet: 1.274 ± 0.029	2.398GlyAsn: 2.398 ± 0.032	2.043GlyPro: 2.043 ± 0.038	2.17GlyGln: 2.17 ± 0.032	2.856GlyArg: 2.856 ± 0.038	4.497GlySer: 4.497 ± 0.053	3.082GlyThr: 3.082 ± 0.038	3.838GlyVal: 3.838 ± 0.047	0.847GlyTrp: 0.847 ± 0.02	1.97GlyTyr: 1.97 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.45HisAla: 1.45 ± 0.025	0.248HisCys: 0.248 ± 0.013	1.231HisAsp: 1.231 ± 0.025	1.241HisGlu: 1.241 ± 0.029	0.912HisPhe: 0.912 ± 0.019	1.211HisGly: 1.211 ± 0.032	0.737HisHis: 0.737 ± 0.033	1.361HisIle: 1.361 ± 0.026	1.294HisLys: 1.294 ± 0.024	2.344HisLeu: 2.344 ± 0.032	0.407HisMet: 0.407 ± 0.013	1.087HisAsn: 1.087 ± 0.024	1.405HisPro: 1.405 ± 0.026	1.009HisGln: 1.009 ± 0.021	1.145HisArg: 1.145 ± 0.024	2.029HisSer: 2.029 ± 0.034	1.282HisThr: 1.282 ± 0.027	1.242HisVal: 1.242 ± 0.026	0.255HisTrp: 0.255 ± 0.01	0.738HisTyr: 0.738 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.403IleAla: 4.403 ± 0.051	0.703IleCys: 0.703 ± 0.019	4.14IleAsp: 4.14 ± 0.043	4.074IleGlu: 4.074 ± 0.054	2.076IlePhe: 2.076 ± 0.038	3.386IleGly: 3.386 ± 0.04	1.367IleHis: 1.367 ± 0.025	3.423IleIle: 3.423 ± 0.043	3.722IleLys: 3.722 ± 0.044	5.25IleLeu: 5.25 ± 0.059	1.068IleMet: 1.068 ± 0.023	3.155IleAsn: 3.155 ± 0.043	3.347IlePro: 3.347 ± 0.04	2.347IleGln: 2.347 ± 0.033	2.886IleArg: 2.886 ± 0.036	4.906IleSer: 4.906 ± 0.05	3.214IleThr: 3.214 ± 0.045	3.502IleVal: 3.502 ± 0.038	0.684IleTrp: 0.684 ± 0.019	1.797IleTyr: 1.797 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.615LysAla: 4.615 ± 0.059	0.57LysCys: 0.57 ± 0.018	3.878LysAsp: 3.878 ± 0.043	4.818LysGlu: 4.818 ± 0.061	2.068LysPhe: 2.068 ± 0.034	3.109LysGly: 3.109 ± 0.039	1.512LysHis: 1.512 ± 0.028	3.215LysIle: 3.215 ± 0.045	4.82LysLys: 4.82 ± 0.082	5.996LysLeu: 5.996 ± 0.067	1.255LysMet: 1.255 ± 0.022	2.892LysAsn: 2.892 ± 0.039	3.256LysPro: 3.256 ± 0.049	2.937LysGln: 2.937 ± 0.038	3.947LysArg: 3.947 ± 0.049	5.447LysSer: 5.447 ± 0.06	3.334LysThr: 3.334 ± 0.039	3.55LysVal: 3.55 ± 0.044	0.665LysTrp: 0.665 ± 0.017	1.945LysTyr: 1.945 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	6.797LeuAla: 6.797 ± 0.064	0.985LeuCys: 0.985 ± 0.024	5.877LeuAsp: 5.877 ± 0.058	6.042LeuGlu: 6.042 ± 0.067	3.509LeuPhe: 3.509 ± 0.048	5.158LeuGly: 5.158 ± 0.057	2.15LeuHis: 2.15 ± 0.031	5.288LeuIle: 5.288 ± 0.054	5.869LeuLys: 5.869 ± 0.063	8.702LeuLeu: 8.702 ± 0.091	1.7LeuMet: 1.7 ± 0.029	4.974LeuAsn: 4.974 ± 0.052	4.91LeuPro: 4.91 ± 0.047	3.809LeuGln: 3.809 ± 0.049	4.962LeuArg: 4.962 ± 0.059	8.41LeuSer: 8.41 ± 0.072	5.187LeuThr: 5.187 ± 0.054	5.195LeuVal: 5.195 ± 0.057	0.913LeuTrp: 0.913 ± 0.023	2.57LeuTyr: 2.57 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	1.434MetAla: 1.434 ± 0.027	0.168MetCys: 0.168 ± 0.01	1.121MetAsp: 1.121 ± 0.026	1.147MetGlu: 1.147 ± 0.022	0.728MetPhe: 0.728 ± 0.018	1.078MetGly: 1.078 ± 0.023	0.407MetHis: 0.407 ± 0.014	1.116MetIle: 1.116 ± 0.024	1.269MetLys: 1.269 ± 0.025	1.807MetLeu: 1.807 ± 0.028	0.494MetMet: 0.494 ± 0.019	0.983MetAsn: 0.983 ± 0.021	1.014MetPro: 1.014 ± 0.024	0.876MetGln: 0.876 ± 0.021	1.134MetArg: 1.134 ± 0.023	2.087MetSer: 2.087 ± 0.032	1.257MetThr: 1.257 ± 0.025	1.018MetVal: 1.018 ± 0.023	0.17MetTrp: 0.17 ± 0.009	0.502MetTyr: 0.502 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.576AsnAla: 3.576 ± 0.04	0.452AsnCys: 0.452 ± 0.016	3.432AsnAsp: 3.432 ± 0.043	3.385AsnGlu: 3.385 ± 0.039	1.702AsnPhe: 1.702 ± 0.029	2.794AsnGly: 2.794 ± 0.041	1.074AsnHis: 1.074 ± 0.022	3.025AsnIle: 3.025 ± 0.036	3.422AsnLys: 3.422 ± 0.045	4.606AsnLeu: 4.606 ± 0.047	0.947AsnMet: 0.947 ± 0.02	3.051AsnAsn: 3.051 ± 0.049	2.376AsnPro: 2.376 ± 0.04	2.156AsnGln: 2.156 ± 0.031	2.197AsnArg: 2.197 ± 0.03	4.071AsnSer: 4.071 ± 0.049	2.894AsnThr: 2.894 ± 0.047	3.143AsnVal: 3.143 ± 0.036	0.628AsnTrp: 0.628 ± 0.015	1.638AsnTyr: 1.638 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.55ProAla: 3.55 ± 0.063	0.306ProCys: 0.306 ± 0.015	2.486ProAsp: 2.486 ± 0.037	3.21ProGlu: 3.21 ± 0.041	1.924ProPhe: 1.924 ± 0.033	2.404ProGly: 2.404 ± 0.035	1.09ProHis: 1.09 ± 0.023	2.858ProIle: 2.858 ± 0.038	2.796ProLys: 2.796 ± 0.041	4.168ProLeu: 4.168 ± 0.046	0.825ProMet: 0.825 ± 0.023	2.302ProAsn: 2.302 ± 0.036	3.99ProPro: 3.99 ± 0.087	2.38ProGln: 2.38 ± 0.038	2.244ProArg: 2.244 ± 0.032	5.342ProSer: 5.342 ± 0.065	3.515ProThr: 3.515 ± 0.048	2.743ProVal: 2.743 ± 0.041	0.456ProTrp: 0.456 ± 0.015	1.47ProTyr: 1.47 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.148GlnAla: 3.148 ± 0.048	0.325GlnCys: 0.325 ± 0.012	2.241GlnAsp: 2.241 ± 0.036	2.625GlnGlu: 2.625 ± 0.036	1.571GlnPhe: 1.571 ± 0.031	1.918GlnGly: 1.918 ± 0.033	1.075GlnHis: 1.075 ± 0.023	2.362GlnIle: 2.362 ± 0.036	2.451GlnLys: 2.451 ± 0.034	4.212GlnLeu: 4.212 ± 0.047	0.916GlnMet: 0.916 ± 0.024	1.95GlnAsn: 1.95 ± 0.031	2.539GlnPro: 2.539 ± 0.049	3.234GlnGln: 3.234 ± 0.092	2.423GlnArg: 2.423 ± 0.036	4.149GlnSer: 4.149 ± 0.048	2.41GlnThr: 2.41 ± 0.033	2.351GlnVal: 2.351 ± 0.035	0.407GlnTrp: 0.407 ± 0.012	1.126GlnTyr: 1.126 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	3.426ArgAla: 3.426 ± 0.043	0.53ArgCys: 0.53 ± 0.016	2.943ArgAsp: 2.943 ± 0.044	3.275ArgGlu: 3.275 ± 0.056	1.855ArgPhe: 1.855 ± 0.026	2.689ArgGly: 2.689 ± 0.048	1.176ArgHis: 1.176 ± 0.023	2.891ArgIle: 2.891 ± 0.038	3.741ArgLys: 3.741 ± 0.046	4.855ArgLeu: 4.855 ± 0.054	1.176ArgMet: 1.176 ± 0.024	2.449ArgAsn: 2.449 ± 0.032	2.344ArgPro: 2.344 ± 0.035	2.438ArgGln: 2.438 ± 0.04	3.766ArgArg: 3.766 ± 0.06	4.325ArgSer: 4.325 ± 0.048	2.693ArgThr: 2.693 ± 0.036	2.953ArgVal: 2.953 ± 0.033	0.59ArgTrp: 0.59 ± 0.016	1.548ArgTyr: 1.548 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.725SerAla: 5.725 ± 0.059	0.759SerCys: 0.759 ± 0.022	4.918SerAsp: 4.918 ± 0.057	4.623SerGlu: 4.623 ± 0.053	3.307SerPhe: 3.307 ± 0.041	4.496SerGly: 4.496 ± 0.049	1.985SerHis: 1.985 ± 0.03	5.352SerIle: 5.352 ± 0.06	5.373SerLys: 5.373 ± 0.058	8.041SerLeu: 8.041 ± 0.075	1.561SerMet: 1.561 ± 0.028	4.77SerAsn: 4.77 ± 0.054	4.437SerPro: 4.437 ± 0.077	3.913SerGln: 3.913 ± 0.052	4.298SerArg: 4.298 ± 0.054	9.037SerSer: 9.037 ± 0.118	5.984SerThr: 5.984 ± 0.062	4.627SerVal: 4.627 ± 0.051	0.877SerTrp: 0.877 ± 0.022	2.38SerTyr: 2.38 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	3.926ThrAla: 3.926 ± 0.041	0.524ThrCys: 0.524 ± 0.016	2.826ThrAsp: 2.826 ± 0.04	3.048ThrGlu: 3.048 ± 0.038	2.338ThrPhe: 2.338 ± 0.038	3.294ThrGly: 3.294 ± 0.043	1.278ThrHis: 1.278 ± 0.024	3.649ThrIle: 3.649 ± 0.048	3.349ThrLys: 3.349 ± 0.041	5.673ThrLeu: 5.673 ± 0.063	1.015ThrMet: 1.015 ± 0.023	2.863ThrAsn: 2.863 ± 0.043	3.868ThrPro: 3.868 ± 0.053	2.386ThrGln: 2.386 ± 0.038	2.772ThrArg: 2.772 ± 0.038	5.379ThrSer: 5.379 ± 0.058	3.821ThrThr: 3.821 ± 0.041	3.189ThrVal: 3.189 ± 0.044	0.554ThrTrp: 0.554 ± 0.018	1.596ThrTyr: 1.596 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	4.123ValAla: 4.123 ± 0.047	0.655ValCys: 0.655 ± 0.018	4.218ValAsp: 4.218 ± 0.044	4.033ValGlu: 4.033 ± 0.048	2.283ValPhe: 2.283 ± 0.036	3.474ValGly: 3.474 ± 0.053	1.323ValHis: 1.323 ± 0.026	3.503ValIle: 3.503 ± 0.042	3.761ValLys: 3.761 ± 0.039	5.238ValLeu: 5.238 ± 0.056	1.201ValMet: 1.201 ± 0.025	2.85ValAsn: 2.85 ± 0.038	2.647ValPro: 2.647 ± 0.04	2.35ValGln: 2.35 ± 0.038	2.733ValArg: 2.733 ± 0.039	4.327ValSer: 4.327 ± 0.047	2.963ValThr: 2.963 ± 0.046	3.809ValVal: 3.809 ± 0.056	0.663ValTrp: 0.663 ± 0.018	1.841ValTyr: 1.841 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	0.666TrpAla: 0.666 ± 0.018	0.149TrpCys: 0.149 ± 0.008	0.725TrpAsp: 0.725 ± 0.022	0.625TrpGlu: 0.625 ± 0.017	0.474TrpPhe: 0.474 ± 0.016	0.6TrpGly: 0.6 ± 0.017	0.256TrpHis: 0.256 ± 0.011	0.683TrpIle: 0.683 ± 0.02	0.762TrpLys: 0.762 ± 0.02	1.086TrpLeu: 1.086 ± 0.024	0.283TrpMet: 0.283 ± 0.013	0.594TrpAsn: 0.594 ± 0.018	0.393TrpPro: 0.393 ± 0.013	0.433TrpGln: 0.433 ± 0.015	0.625TrpArg: 0.625 ± 0.018	0.987TrpSer: 0.987 ± 0.019	0.652TrpThr: 0.652 ± 0.017	0.574TrpVal: 0.574 ± 0.016	0.178TrpTrp: 0.178 ± 0.009	0.356TrpTyr: 0.356 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.142TyrAla: 2.142 ± 0.035	0.351TyrCys: 0.351 ± 0.014	2.009TyrAsp: 2.009 ± 0.033	1.826TyrGlu: 1.826 ± 0.03	1.268TyrPhe: 1.268 ± 0.024	1.803TyrGly: 1.803 ± 0.034	0.733TyrHis: 0.733 ± 0.018	1.82TyrIle: 1.82 ± 0.03	1.821TyrLys: 1.821 ± 0.027	2.929TyrLeu: 2.929 ± 0.042	0.591TyrMet: 0.591 ± 0.017	1.73TyrAsn: 1.73 ± 0.033	1.303TyrPro: 1.303 ± 0.026	1.257TyrGln: 1.257 ± 0.026	1.467TyrArg: 1.467 ± 0.027	2.274TyrSer: 2.274 ± 0.036	1.802TyrThr: 1.802 ± 0.032	1.682TyrVal: 1.682 ± 0.029	0.356TyrTrp: 0.356 ± 0.014	1.006TyrTyr: 1.006 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4289 proteins (2169282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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