Amino acid dipepetide frequency for Streptococcus satellite phage Javan200

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.438AlaCys: 0.438 ± 0.343
5.261AlaAsp: 5.261 ± 1.603
5.261AlaGlu: 5.261 ± 1.78
1.315AlaPhe: 1.315 ± 0.804
5.261AlaGly: 5.261 ± 1.472
0.0AlaHis: 0.0 ± 0.0
5.699AlaIle: 5.699 ± 1.217
7.891AlaLys: 7.891 ± 2.36
3.946AlaLeu: 3.946 ± 1.129
2.63AlaMet: 2.63 ± 1.442
5.261AlaAsn: 5.261 ± 1.529
1.315AlaPro: 1.315 ± 0.852
1.754AlaGln: 1.754 ± 0.71
3.069AlaArg: 3.069 ± 1.177
3.069AlaSer: 3.069 ± 1.175
5.699AlaThr: 5.699 ± 1.93
2.192AlaVal: 2.192 ± 0.801
1.315AlaTrp: 1.315 ± 0.636
3.069AlaTyr: 3.069 ± 0.974
0.0AlaXaa: 0.0 ± 0.0
Cys
0.438CysAla: 0.438 ± 0.349
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.438CysGlu: 0.438 ± 0.455
0.438CysPhe: 0.438 ± 0.462
0.438CysGly: 0.438 ± 0.385
0.0CysHis: 0.0 ± 0.0
0.438CysIle: 0.438 ± 0.385
0.438CysLys: 0.438 ± 0.455
0.438CysLeu: 0.438 ± 0.462
0.0CysMet: 0.0 ± 0.0
0.438CysAsn: 0.438 ± 0.343
1.754CysPro: 1.754 ± 0.819
1.315CysGln: 1.315 ± 1.602
0.877CysArg: 0.877 ± 1.068
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.754AspAla: 1.754 ± 0.94
1.315AspCys: 1.315 ± 0.706
3.069AspAsp: 3.069 ± 1.074
2.63AspGlu: 2.63 ± 1.383
3.507AspPhe: 3.507 ± 1.016
2.63AspGly: 2.63 ± 1.315
0.0AspHis: 0.0 ± 0.0
4.822AspIle: 4.822 ± 1.342
7.453AspLys: 7.453 ± 1.319
6.576AspLeu: 6.576 ± 2.394
0.438AspMet: 0.438 ± 0.421
3.946AspAsn: 3.946 ± 1.622
1.754AspPro: 1.754 ± 0.953
0.877AspGln: 0.877 ± 0.587
1.754AspArg: 1.754 ± 0.999
1.315AspSer: 1.315 ± 0.601
2.63AspThr: 2.63 ± 0.882
2.192AspVal: 2.192 ± 0.542
0.877AspTrp: 0.877 ± 0.501
3.946AspTyr: 3.946 ± 0.792
0.0AspXaa: 0.0 ± 0.0
Glu
8.33GluAla: 8.33 ± 2.01
0.438GluCys: 0.438 ± 0.349
3.069GluAsp: 3.069 ± 1.143
7.453GluGlu: 7.453 ± 1.938
2.63GluPhe: 2.63 ± 1.101
3.507GluGly: 3.507 ± 1.261
0.438GluHis: 0.438 ± 0.385
8.768GluIle: 8.768 ± 2.226
5.261GluLys: 5.261 ± 0.912
11.399GluLeu: 11.399 ± 1.524
1.754GluMet: 1.754 ± 0.863
5.699GluAsn: 5.699 ± 1.154
1.754GluPro: 1.754 ± 0.765
3.069GluGln: 3.069 ± 0.863
6.576GluArg: 6.576 ± 1.894
3.946GluSer: 3.946 ± 1.961
2.192GluThr: 2.192 ± 0.781
4.384GluVal: 4.384 ± 1.062
0.877GluTrp: 0.877 ± 0.488
3.946GluTyr: 3.946 ± 2.09
0.0GluXaa: 0.0 ± 0.0
Phe
1.315PheAla: 1.315 ± 0.714
0.438PheCys: 0.438 ± 0.349
3.946PheAsp: 3.946 ± 1.468
3.507PheGlu: 3.507 ± 0.825
1.754PhePhe: 1.754 ± 0.853
2.63PheGly: 2.63 ± 0.774
1.315PheHis: 1.315 ± 0.547
3.069PheIle: 3.069 ± 0.778
1.315PheLys: 1.315 ± 0.541
4.384PheLeu: 4.384 ± 0.814
0.877PheMet: 0.877 ± 0.622
0.0PheAsn: 0.0 ± 0.0
1.754PhePro: 1.754 ± 0.942
0.877PheGln: 0.877 ± 0.669
0.877PheArg: 0.877 ± 0.67
2.63PheSer: 2.63 ± 1.094
2.192PheThr: 2.192 ± 0.84
0.877PheVal: 0.877 ± 0.488
0.877PheTrp: 0.877 ± 0.588
2.63PheTyr: 2.63 ± 1.204
0.0PheXaa: 0.0 ± 0.0
Gly
3.069GlyAla: 3.069 ± 1.059
0.0GlyCys: 0.0 ± 0.0
0.877GlyAsp: 0.877 ± 0.58
4.822GlyGlu: 4.822 ± 1.554
1.754GlyPhe: 1.754 ± 1.197
3.069GlyGly: 3.069 ± 1.269
0.438GlyHis: 0.438 ± 0.343
4.384GlyIle: 4.384 ± 0.995
3.946GlyLys: 3.946 ± 1.289
3.069GlyLeu: 3.069 ± 0.853
1.315GlyMet: 1.315 ± 0.722
2.63GlyAsn: 2.63 ± 0.794
0.0GlyPro: 0.0 ± 0.0
0.877GlyGln: 0.877 ± 0.549
1.754GlyArg: 1.754 ± 0.856
2.63GlySer: 2.63 ± 0.972
3.069GlyThr: 3.069 ± 0.89
5.261GlyVal: 5.261 ± 1.293
0.877GlyTrp: 0.877 ± 0.598
6.138GlyTyr: 6.138 ± 1.002
0.0GlyXaa: 0.0 ± 0.0
His
1.315HisAla: 1.315 ± 0.73
0.0HisCys: 0.0 ± 0.0
0.438HisAsp: 0.438 ± 0.466
0.438HisGlu: 0.438 ± 0.385
0.438HisPhe: 0.438 ± 0.343
1.754HisGly: 1.754 ± 1.035
0.0HisHis: 0.0 ± 0.0
0.438HisIle: 0.438 ± 0.343
0.877HisLys: 0.877 ± 0.637
1.315HisLeu: 1.315 ± 0.852
0.0HisMet: 0.0 ± 0.0
2.63HisAsn: 2.63 ± 0.851
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.877HisArg: 0.877 ± 0.557
0.438HisSer: 0.438 ± 0.343
0.877HisThr: 0.877 ± 0.477
0.438HisVal: 0.438 ± 0.478
0.0HisTrp: 0.0 ± 0.0
0.877HisTyr: 0.877 ± 0.631
0.0HisXaa: 0.0 ± 0.0
Ile
4.822IleAla: 4.822 ± 1.359
0.0IleCys: 0.0 ± 0.0
3.507IleAsp: 3.507 ± 1.276
6.576IleGlu: 6.576 ± 2.071
1.315IlePhe: 1.315 ± 0.71
1.315IleGly: 1.315 ± 0.627
0.877IleHis: 0.877 ± 0.631
2.192IleIle: 2.192 ± 0.929
8.33IleLys: 8.33 ± 1.969
6.138IleLeu: 6.138 ± 1.236
1.315IleMet: 1.315 ± 0.571
5.699IleAsn: 5.699 ± 1.08
2.192IlePro: 2.192 ± 1.175
2.192IleGln: 2.192 ± 1.024
1.754IleArg: 1.754 ± 0.756
2.63IleSer: 2.63 ± 1.174
4.384IleThr: 4.384 ± 0.818
2.63IleVal: 2.63 ± 1.067
0.438IleTrp: 0.438 ± 0.45
3.946IleTyr: 3.946 ± 1.096
0.0IleXaa: 0.0 ± 0.0
Lys
7.891LysAla: 7.891 ± 2.166
0.438LysCys: 0.438 ± 0.385
3.946LysAsp: 3.946 ± 1.465
10.083LysGlu: 10.083 ± 1.924
2.192LysPhe: 2.192 ± 0.84
5.261LysGly: 5.261 ± 2.444
1.315LysHis: 1.315 ± 0.74
4.822LysIle: 4.822 ± 1.772
8.768LysLys: 8.768 ± 1.9
9.645LysLeu: 9.645 ± 1.75
1.754LysMet: 1.754 ± 0.911
7.891LysAsn: 7.891 ± 2.025
3.069LysPro: 3.069 ± 1.015
5.699LysGln: 5.699 ± 0.978
8.33LysArg: 8.33 ± 2.371
7.453LysSer: 7.453 ± 2.028
6.576LysThr: 6.576 ± 0.798
3.069LysVal: 3.069 ± 1.111
0.877LysTrp: 0.877 ± 0.495
5.699LysTyr: 5.699 ± 1.044
0.0LysXaa: 0.0 ± 0.0
Leu
6.138LeuAla: 6.138 ± 1.075
0.877LeuCys: 0.877 ± 0.719
8.768LeuAsp: 8.768 ± 2.157
9.206LeuGlu: 9.206 ± 1.401
4.822LeuPhe: 4.822 ± 1.248
6.576LeuGly: 6.576 ± 1.863
1.315LeuHis: 1.315 ± 0.648
4.822LeuIle: 4.822 ± 0.995
12.275LeuLys: 12.275 ± 2.193
7.453LeuLeu: 7.453 ± 1.794
3.946LeuMet: 3.946 ± 1.033
3.946LeuAsn: 3.946 ± 1.012
1.754LeuPro: 1.754 ± 0.741
3.507LeuGln: 3.507 ± 1.345
3.069LeuArg: 3.069 ± 1.05
3.069LeuSer: 3.069 ± 1.019
7.891LeuThr: 7.891 ± 2.105
6.138LeuVal: 6.138 ± 2.063
0.877LeuTrp: 0.877 ± 0.58
2.192LeuTyr: 2.192 ± 0.766
0.0LeuXaa: 0.0 ± 0.0
Met
2.192MetAla: 2.192 ± 1.531
0.438MetCys: 0.438 ± 0.534
1.754MetAsp: 1.754 ± 0.907
1.754MetGlu: 1.754 ± 1.181
0.438MetPhe: 0.438 ± 0.534
0.438MetGly: 0.438 ± 0.466
0.438MetHis: 0.438 ± 0.421
0.877MetIle: 0.877 ± 0.553
1.754MetLys: 1.754 ± 0.852
3.946MetLeu: 3.946 ± 1.091
0.0MetMet: 0.0 ± 0.0
1.315MetAsn: 1.315 ± 0.554
0.438MetPro: 0.438 ± 0.478
0.438MetGln: 0.438 ± 0.343
0.877MetArg: 0.877 ± 0.719
0.438MetSer: 0.438 ± 0.385
3.507MetThr: 3.507 ± 1.136
2.192MetVal: 2.192 ± 1.087
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.946AsnAla: 3.946 ± 1.303
0.438AsnCys: 0.438 ± 0.462
1.754AsnAsp: 1.754 ± 0.979
3.946AsnGlu: 3.946 ± 1.414
1.754AsnPhe: 1.754 ± 0.882
3.946AsnGly: 3.946 ± 1.128
0.0AsnHis: 0.0 ± 0.0
1.315AsnIle: 1.315 ± 0.715
5.261AsnLys: 5.261 ± 1.257
5.261AsnLeu: 5.261 ± 1.301
1.315AsnMet: 1.315 ± 0.886
4.822AsnAsn: 4.822 ± 1.051
3.069AsnPro: 3.069 ± 1.108
2.192AsnGln: 2.192 ± 1.339
4.384AsnArg: 4.384 ± 0.973
3.069AsnSer: 3.069 ± 0.95
5.261AsnThr: 5.261 ± 2.068
3.507AsnVal: 3.507 ± 1.185
2.192AsnTrp: 2.192 ± 0.906
2.63AsnTyr: 2.63 ± 0.831
0.0AsnXaa: 0.0 ± 0.0
Pro
2.192ProAla: 2.192 ± 0.809
0.0ProCys: 0.0 ± 0.0
1.315ProAsp: 1.315 ± 0.809
2.63ProGlu: 2.63 ± 0.887
3.069ProPhe: 3.069 ± 0.841
0.0ProGly: 0.0 ± 0.0
0.877ProHis: 0.877 ± 0.703
1.315ProIle: 1.315 ± 0.617
5.261ProLys: 5.261 ± 1.364
1.315ProLeu: 1.315 ± 0.809
0.877ProMet: 0.877 ± 0.769
1.315ProAsn: 1.315 ± 0.555
0.877ProPro: 0.877 ± 0.499
0.438ProGln: 0.438 ± 0.385
1.754ProArg: 1.754 ± 0.651
0.877ProSer: 0.877 ± 0.843
1.754ProThr: 1.754 ± 0.956
2.192ProVal: 2.192 ± 0.998
0.0ProTrp: 0.0 ± 0.0
0.877ProTyr: 0.877 ± 0.67
0.0ProXaa: 0.0 ± 0.0
Gln
3.069GlnAla: 3.069 ± 1.205
0.438GlnCys: 0.438 ± 0.385
0.877GlnAsp: 0.877 ± 0.567
3.507GlnGlu: 3.507 ± 1.15
0.877GlnPhe: 0.877 ± 0.483
2.192GlnGly: 2.192 ± 1.379
0.877GlnHis: 0.877 ± 0.686
2.192GlnIle: 2.192 ± 0.957
4.384GlnLys: 4.384 ± 1.106
3.946GlnLeu: 3.946 ± 1.218
0.0GlnMet: 0.0 ± 0.0
3.069GlnAsn: 3.069 ± 1.422
0.877GlnPro: 0.877 ± 0.443
3.946GlnGln: 3.946 ± 1.554
0.877GlnArg: 0.877 ± 0.663
3.069GlnSer: 3.069 ± 1.186
1.754GlnThr: 1.754 ± 0.757
2.192GlnVal: 2.192 ± 0.815
0.0GlnTrp: 0.0 ± 0.0
1.754GlnTyr: 1.754 ± 0.672
0.0GlnXaa: 0.0 ± 0.0
Arg
3.946ArgAla: 3.946 ± 1.043
0.877ArgCys: 0.877 ± 1.068
2.192ArgAsp: 2.192 ± 1.233
2.63ArgGlu: 2.63 ± 0.818
1.315ArgPhe: 1.315 ± 0.78
3.507ArgGly: 3.507 ± 1.081
0.438ArgHis: 0.438 ± 0.343
3.946ArgIle: 3.946 ± 0.875
7.453ArgLys: 7.453 ± 1.829
6.138ArgLeu: 6.138 ± 2.012
0.877ArgMet: 0.877 ± 0.617
0.877ArgAsn: 0.877 ± 0.492
1.315ArgPro: 1.315 ± 0.9
3.507ArgGln: 3.507 ± 0.866
2.63ArgArg: 2.63 ± 0.996
1.754ArgSer: 1.754 ± 0.633
1.315ArgThr: 1.315 ± 0.743
2.63ArgVal: 2.63 ± 1.36
0.438ArgTrp: 0.438 ± 0.421
1.754ArgTyr: 1.754 ± 0.623
0.0ArgXaa: 0.0 ± 0.0
Ser
1.754SerAla: 1.754 ± 0.928
0.0SerCys: 0.0 ± 0.0
4.384SerAsp: 4.384 ± 1.213
5.261SerGlu: 5.261 ± 1.297
1.754SerPhe: 1.754 ± 0.705
0.877SerGly: 0.877 ± 0.569
1.754SerHis: 1.754 ± 1.061
3.507SerIle: 3.507 ± 1.611
5.261SerLys: 5.261 ± 1.357
4.384SerLeu: 4.384 ± 0.929
0.877SerMet: 0.877 ± 0.488
1.315SerAsn: 1.315 ± 0.86
0.877SerPro: 0.877 ± 0.593
2.63SerGln: 2.63 ± 0.994
1.754SerArg: 1.754 ± 0.941
0.438SerSer: 0.438 ± 0.455
3.069SerThr: 3.069 ± 0.725
1.315SerVal: 1.315 ± 0.561
0.0SerTrp: 0.0 ± 0.0
2.63SerTyr: 2.63 ± 0.86
0.0SerXaa: 0.0 ± 0.0
Thr
3.069ThrAla: 3.069 ± 0.881
0.0ThrCys: 0.0 ± 0.0
3.069ThrAsp: 3.069 ± 1.121
7.453ThrGlu: 7.453 ± 1.554
2.63ThrPhe: 2.63 ± 1.208
3.507ThrGly: 3.507 ± 1.353
0.877ThrHis: 0.877 ± 0.598
4.822ThrIle: 4.822 ± 1.117
8.768ThrLys: 8.768 ± 1.964
9.206ThrLeu: 9.206 ± 2.03
0.438ThrMet: 0.438 ± 0.385
2.192ThrAsn: 2.192 ± 0.752
3.069ThrPro: 3.069 ± 1.004
2.63ThrGln: 2.63 ± 0.674
1.315ThrArg: 1.315 ± 0.794
0.438ThrSer: 0.438 ± 0.421
3.069ThrThr: 3.069 ± 1.26
4.384ThrVal: 4.384 ± 0.963
0.0ThrTrp: 0.0 ± 0.0
3.507ThrTyr: 3.507 ± 0.617
0.0ThrXaa: 0.0 ± 0.0
Val
3.069ValAla: 3.069 ± 1.024
0.438ValCys: 0.438 ± 0.349
2.192ValAsp: 2.192 ± 1.061
3.946ValGlu: 3.946 ± 1.65
2.63ValPhe: 2.63 ± 0.933
1.315ValGly: 1.315 ± 0.625
1.754ValHis: 1.754 ± 0.949
2.192ValIle: 2.192 ± 0.938
6.138ValLys: 6.138 ± 2.061
3.507ValLeu: 3.507 ± 1.117
1.754ValMet: 1.754 ± 0.825
2.63ValAsn: 2.63 ± 1.311
1.754ValPro: 1.754 ± 0.671
0.877ValGln: 0.877 ± 0.769
2.192ValArg: 2.192 ± 1.15
2.63ValSer: 2.63 ± 0.753
5.261ValThr: 5.261 ± 1.525
1.754ValVal: 1.754 ± 0.676
0.438ValTrp: 0.438 ± 0.462
3.069ValTyr: 3.069 ± 0.772
0.0ValXaa: 0.0 ± 0.0
Trp
1.754TrpAla: 1.754 ± 0.705
0.0TrpCys: 0.0 ± 0.0
0.438TrpAsp: 0.438 ± 0.343
2.192TrpGlu: 2.192 ± 0.667
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.438TrpIle: 0.438 ± 0.462
0.0TrpLys: 0.0 ± 0.0
1.754TrpLeu: 1.754 ± 0.823
0.0TrpMet: 0.0 ± 0.0
1.315TrpAsn: 1.315 ± 0.693
0.0TrpPro: 0.0 ± 0.0
0.438TrpGln: 0.438 ± 0.455
0.877TrpArg: 0.877 ± 0.504
0.438TrpSer: 0.438 ± 0.343
0.438TrpThr: 0.438 ± 0.478
0.438TrpVal: 0.438 ± 0.45
0.877TrpTrp: 0.877 ± 0.483
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.384TyrAla: 4.384 ± 1.28
0.877TyrCys: 0.877 ± 0.637
2.63TyrAsp: 2.63 ± 1.209
1.754TyrGlu: 1.754 ± 0.753
2.63TyrPhe: 2.63 ± 1.331
1.754TyrGly: 1.754 ± 0.741
0.438TyrHis: 0.438 ± 0.466
2.192TyrIle: 2.192 ± 0.975
4.384TyrLys: 4.384 ± 1.219
4.822TyrLeu: 4.822 ± 1.316
2.63TyrMet: 2.63 ± 1.179
3.069TyrAsn: 3.069 ± 0.899
1.315TyrPro: 1.315 ± 0.773
2.63TyrGln: 2.63 ± 0.999
3.946TyrArg: 3.946 ± 1.407
3.507TyrSer: 3.507 ± 1.438
3.507TyrThr: 3.507 ± 1.305
1.754TyrVal: 1.754 ± 0.625
0.438TyrTrp: 0.438 ± 0.534
3.507TyrTyr: 3.507 ± 1.375
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 16 proteins (2282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski