Amino acid dipepetide frequency for Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.305AlaAla: 3.305 ± 0.77
1.377AlaCys: 1.377 ± 0.338
0.551AlaAsp: 0.551 ± 0.357
7.436AlaGlu: 7.436 ± 1.278
0.826AlaPhe: 0.826 ± 0.335
5.233AlaGly: 5.233 ± 1.077
1.102AlaHis: 1.102 ± 0.438
5.233AlaIle: 5.233 ± 1.167
4.406AlaLys: 4.406 ± 0.839
7.161AlaLeu: 7.161 ± 0.949
1.928AlaMet: 1.928 ± 0.556
1.652AlaAsn: 1.652 ± 0.9
1.928AlaPro: 1.928 ± 0.701
1.102AlaGln: 1.102 ± 0.433
3.58AlaArg: 3.58 ± 0.651
4.406AlaSer: 4.406 ± 1.077
4.957AlaThr: 4.957 ± 1.171
4.682AlaVal: 4.682 ± 1.022
1.652AlaTrp: 1.652 ± 0.514
1.102AlaTyr: 1.102 ± 0.533
0.0AlaXaa: 0.0 ± 0.0
Cys
0.551CysAla: 0.551 ± 0.433
0.551CysCys: 0.551 ± 0.706
0.551CysAsp: 0.551 ± 0.219
0.0CysGlu: 0.0 ± 0.0
2.203CysPhe: 2.203 ± 1.607
1.652CysGly: 1.652 ± 0.606
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.652CysLys: 1.652 ± 0.606
0.826CysLeu: 0.826 ± 0.534
0.551CysMet: 0.551 ± 0.219
1.652CysAsn: 1.652 ± 1.077
0.275CysPro: 0.275 ± 0.217
0.826CysGln: 0.826 ± 0.335
1.928CysArg: 1.928 ± 0.527
1.102CysSer: 1.102 ± 0.455
2.479CysThr: 2.479 ± 0.617
1.102CysVal: 1.102 ± 0.61
0.826CysTrp: 0.826 ± 0.335
1.102CysTyr: 1.102 ± 1.412
0.0CysXaa: 0.0 ± 0.0
Asp
1.652AspAla: 1.652 ± 0.441
2.754AspCys: 2.754 ± 0.56
1.377AspAsp: 1.377 ± 0.523
1.377AspGlu: 1.377 ± 0.809
1.928AspPhe: 1.928 ± 0.672
1.102AspGly: 1.102 ± 0.458
0.0AspHis: 0.0 ± 0.0
3.856AspIle: 3.856 ± 0.884
3.029AspLys: 3.029 ± 1.149
3.305AspLeu: 3.305 ± 1.584
0.551AspMet: 0.551 ± 0.387
1.652AspAsn: 1.652 ± 0.656
4.406AspPro: 4.406 ± 1.59
1.652AspGln: 1.652 ± 0.645
3.305AspArg: 3.305 ± 0.759
2.754AspSer: 2.754 ± 0.847
3.856AspThr: 3.856 ± 0.754
0.826AspVal: 0.826 ± 0.49
0.275AspTrp: 0.275 ± 0.441
0.826AspTyr: 0.826 ± 0.335
0.0AspXaa: 0.0 ± 0.0
Glu
6.059GluAla: 6.059 ± 1.0
0.0GluCys: 0.0 ± 0.0
3.029GluAsp: 3.029 ± 1.364
6.334GluGlu: 6.334 ± 1.603
1.102GluPhe: 1.102 ± 0.433
6.059GluGly: 6.059 ± 1.309
0.826GluHis: 0.826 ± 0.49
4.406GluIle: 4.406 ± 1.336
4.957GluLys: 4.957 ± 0.919
6.61GluLeu: 6.61 ± 1.066
1.652GluMet: 1.652 ± 0.6
2.203GluAsn: 2.203 ± 0.605
3.58GluPro: 3.58 ± 0.721
3.856GluGln: 3.856 ± 0.89
4.406GluArg: 4.406 ± 1.063
3.305GluSer: 3.305 ± 1.553
3.856GluThr: 3.856 ± 1.229
4.957GluVal: 4.957 ± 1.052
2.203GluTrp: 2.203 ± 0.744
0.826GluTyr: 0.826 ± 0.453
0.0GluXaa: 0.0 ± 0.0
Phe
0.826PheAla: 0.826 ± 0.335
0.275PheCys: 0.275 ± 0.217
0.826PheAsp: 0.826 ± 0.635
0.275PheGlu: 0.275 ± 0.396
1.102PhePhe: 1.102 ± 0.257
0.826PheGly: 0.826 ± 0.547
0.551PheHis: 0.551 ± 0.706
1.928PheIle: 1.928 ± 0.516
1.928PheLys: 1.928 ± 0.688
2.479PheLeu: 2.479 ± 0.63
0.0PheMet: 0.0 ± 0.0
2.754PheAsn: 2.754 ± 1.328
1.652PhePro: 1.652 ± 0.868
0.826PheGln: 0.826 ± 0.32
3.029PheArg: 3.029 ± 0.872
1.928PheSer: 1.928 ± 0.492
1.377PheThr: 1.377 ± 0.686
0.826PheVal: 0.826 ± 0.658
0.275PheTrp: 0.275 ± 0.163
1.377PheTyr: 1.377 ± 0.608
0.0PheXaa: 0.0 ± 0.0
Gly
5.508GlyAla: 5.508 ± 1.203
1.928GlyCys: 1.928 ± 0.519
2.479GlyAsp: 2.479 ± 0.886
4.131GlyGlu: 4.131 ± 0.361
1.377GlyPhe: 1.377 ± 0.642
6.61GlyGly: 6.61 ± 1.144
3.029GlyHis: 3.029 ± 1.635
6.059GlyIle: 6.059 ± 1.17
5.233GlyLys: 5.233 ± 1.233
6.059GlyLeu: 6.059 ± 1.517
0.826GlyMet: 0.826 ± 0.41
3.029GlyAsn: 3.029 ± 0.941
4.682GlyPro: 4.682 ± 1.044
5.233GlyGln: 5.233 ± 1.305
4.682GlyArg: 4.682 ± 0.982
4.406GlySer: 4.406 ± 0.949
3.58GlyThr: 3.58 ± 0.927
3.305GlyVal: 3.305 ± 0.532
1.928GlyTrp: 1.928 ± 0.89
1.928GlyTyr: 1.928 ± 0.62
0.0GlyXaa: 0.0 ± 0.0
His
0.551HisAla: 0.551 ± 0.433
0.826HisCys: 0.826 ± 0.704
0.0HisAsp: 0.0 ± 0.0
0.275HisGlu: 0.275 ± 0.163
1.377HisPhe: 1.377 ± 0.943
1.102HisGly: 1.102 ± 0.433
0.275HisHis: 0.275 ± 0.396
2.479HisIle: 2.479 ± 1.424
1.102HisLys: 1.102 ± 0.429
2.754HisLeu: 2.754 ± 0.588
0.551HisMet: 0.551 ± 0.79
1.377HisAsn: 1.377 ± 0.409
2.754HisPro: 2.754 ± 1.101
3.029HisGln: 3.029 ± 1.198
0.826HisArg: 0.826 ± 0.389
0.551HisSer: 0.551 ± 0.686
1.652HisThr: 1.652 ± 0.579
0.275HisVal: 0.275 ± 0.163
0.0HisTrp: 0.0 ± 0.0
0.275HisTyr: 0.275 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
4.682IleAla: 4.682 ± 0.726
1.102IleCys: 1.102 ± 0.438
0.826IleAsp: 0.826 ± 0.389
3.58IleGlu: 3.58 ± 0.779
0.551IlePhe: 0.551 ± 0.219
4.682IleGly: 4.682 ± 1.438
1.928IleHis: 1.928 ± 0.834
4.957IleIle: 4.957 ± 1.149
3.58IleLys: 3.58 ± 1.183
5.233IleLeu: 5.233 ± 0.615
0.826IleMet: 0.826 ± 0.232
2.754IleAsn: 2.754 ± 1.025
4.131IlePro: 4.131 ± 0.751
3.58IleGln: 3.58 ± 1.376
5.233IleArg: 5.233 ± 0.609
4.682IleSer: 4.682 ± 1.826
3.305IleThr: 3.305 ± 1.445
6.885IleVal: 6.885 ± 1.193
1.102IleTrp: 1.102 ± 0.257
1.928IleTyr: 1.928 ± 0.599
0.0IleXaa: 0.0 ± 0.0
Lys
6.059LysAla: 6.059 ± 0.836
1.652LysCys: 1.652 ± 0.482
4.131LysAsp: 4.131 ± 0.964
6.61LysGlu: 6.61 ± 0.776
1.102LysPhe: 1.102 ± 0.438
6.61LysGly: 6.61 ± 1.628
0.826LysHis: 0.826 ± 0.335
6.059LysIle: 6.059 ± 1.522
5.784LysLys: 5.784 ± 1.658
5.784LysLeu: 5.784 ± 1.125
0.551LysMet: 0.551 ± 0.327
2.479LysAsn: 2.479 ± 0.69
1.928LysPro: 1.928 ± 0.729
3.58LysGln: 3.58 ± 0.777
3.305LysArg: 3.305 ± 0.752
3.029LysSer: 3.029 ± 0.646
3.856LysThr: 3.856 ± 0.98
4.131LysVal: 4.131 ± 0.785
2.754LysTrp: 2.754 ± 0.852
2.203LysTyr: 2.203 ± 0.373
0.0LysXaa: 0.0 ± 0.0
Leu
5.233LeuAla: 5.233 ± 0.968
0.826LeuCys: 0.826 ± 0.404
5.233LeuAsp: 5.233 ± 0.663
7.436LeuGlu: 7.436 ± 1.163
2.479LeuPhe: 2.479 ± 1.187
6.885LeuGly: 6.885 ± 1.934
2.203LeuHis: 2.203 ± 0.673
3.856LeuIle: 3.856 ± 1.201
8.813LeuLys: 8.813 ± 1.225
7.436LeuLeu: 7.436 ± 1.842
0.551LeuMet: 0.551 ± 0.359
4.131LeuAsn: 4.131 ± 0.978
2.203LeuPro: 2.203 ± 0.724
4.957LeuGln: 4.957 ± 0.786
3.305LeuArg: 3.305 ± 0.762
3.58LeuSer: 3.58 ± 0.5
4.131LeuThr: 4.131 ± 1.087
5.508LeuVal: 5.508 ± 1.299
2.754LeuTrp: 2.754 ± 0.97
2.479LeuTyr: 2.479 ± 0.805
0.0LeuXaa: 0.0 ± 0.0
Met
1.102MetAla: 1.102 ± 0.526
0.0MetCys: 0.0 ± 0.0
0.551MetAsp: 0.551 ± 0.327
2.203MetGlu: 2.203 ± 0.927
0.551MetPhe: 0.551 ± 0.272
1.928MetGly: 1.928 ± 0.752
0.826MetHis: 0.826 ± 0.338
0.826MetIle: 0.826 ± 0.338
0.826MetLys: 0.826 ± 0.232
1.377MetLeu: 1.377 ± 0.587
1.102MetMet: 1.102 ± 0.543
0.551MetAsn: 0.551 ± 0.357
0.0MetPro: 0.0 ± 0.0
1.377MetGln: 1.377 ± 0.456
1.102MetArg: 1.102 ± 0.56
1.102MetSer: 1.102 ± 0.5
2.479MetThr: 2.479 ± 0.719
0.826MetVal: 0.826 ± 0.232
0.551MetTrp: 0.551 ± 0.433
1.377MetTyr: 1.377 ± 0.456
0.0MetXaa: 0.0 ± 0.0
Asn
2.203AsnAla: 2.203 ± 0.715
2.754AsnCys: 2.754 ± 0.631
1.928AsnAsp: 1.928 ± 0.702
3.305AsnGlu: 3.305 ± 0.854
2.479AsnPhe: 2.479 ± 0.678
1.652AsnGly: 1.652 ± 0.679
0.551AsnHis: 0.551 ± 0.706
2.203AsnIle: 2.203 ± 1.014
3.029AsnLys: 3.029 ± 0.818
3.58AsnLeu: 3.58 ± 1.024
1.652AsnMet: 1.652 ± 1.035
2.203AsnAsn: 2.203 ± 0.85
3.58AsnPro: 3.58 ± 0.5
0.826AsnGln: 0.826 ± 0.32
2.203AsnArg: 2.203 ± 0.522
1.652AsnSer: 1.652 ± 1.035
4.682AsnThr: 4.682 ± 0.702
1.652AsnVal: 1.652 ± 1.035
1.377AsnTrp: 1.377 ± 0.612
1.377AsnTyr: 1.377 ± 0.577
0.0AsnXaa: 0.0 ± 0.0
Pro
3.305ProAla: 3.305 ± 0.998
1.102ProCys: 1.102 ± 0.766
2.754ProAsp: 2.754 ± 0.949
3.305ProGlu: 3.305 ± 0.757
1.652ProPhe: 1.652 ± 0.62
6.334ProGly: 6.334 ± 1.305
0.275ProHis: 0.275 ± 0.163
3.856ProIle: 3.856 ± 0.816
3.58ProLys: 3.58 ± 1.425
4.131ProLeu: 4.131 ± 0.99
1.652ProMet: 1.652 ± 1.035
1.377ProAsn: 1.377 ± 0.879
3.305ProPro: 3.305 ± 1.327
3.029ProGln: 3.029 ± 0.798
3.58ProArg: 3.58 ± 0.914
3.305ProSer: 3.305 ± 1.24
2.479ProThr: 2.479 ± 0.931
4.682ProVal: 4.682 ± 1.004
1.102ProTrp: 1.102 ± 0.827
1.102ProTyr: 1.102 ± 0.515
0.0ProXaa: 0.0 ± 0.0
Gln
6.61GlnAla: 6.61 ± 1.28
0.275GlnCys: 0.275 ± 0.217
2.754GlnAsp: 2.754 ± 0.983
4.682GlnGlu: 4.682 ± 0.688
0.0GlnPhe: 0.0 ± 0.0
4.957GlnGly: 4.957 ± 0.802
1.377GlnHis: 1.377 ± 0.578
5.233GlnIle: 5.233 ± 0.979
4.406GlnLys: 4.406 ± 1.463
5.784GlnLeu: 5.784 ± 1.207
2.479GlnMet: 2.479 ± 0.78
3.856GlnAsn: 3.856 ± 1.045
1.928GlnPro: 1.928 ± 0.978
2.754GlnGln: 2.754 ± 0.878
3.029GlnArg: 3.029 ± 1.232
2.203GlnSer: 2.203 ± 0.782
1.102GlnThr: 1.102 ± 0.257
1.928GlnVal: 1.928 ± 0.8
1.652GlnTrp: 1.652 ± 0.393
1.928GlnTyr: 1.928 ± 0.653
0.0GlnXaa: 0.0 ± 0.0
Arg
5.233ArgAla: 5.233 ± 0.745
0.826ArgCys: 0.826 ± 0.906
2.479ArgAsp: 2.479 ± 0.678
5.784ArgGlu: 5.784 ± 1.058
1.652ArgPhe: 1.652 ± 0.727
3.305ArgGly: 3.305 ± 0.424
2.203ArgHis: 2.203 ± 1.514
3.58ArgIle: 3.58 ± 1.486
4.682ArgLys: 4.682 ± 0.738
3.58ArgLeu: 3.58 ± 0.586
1.102ArgMet: 1.102 ± 0.653
1.928ArgAsn: 1.928 ± 0.877
3.856ArgPro: 3.856 ± 1.236
5.508ArgGln: 5.508 ± 1.459
4.406ArgArg: 4.406 ± 1.973
1.652ArgSer: 1.652 ± 0.706
2.754ArgThr: 2.754 ± 0.715
2.754ArgVal: 2.754 ± 0.878
1.652ArgTrp: 1.652 ± 0.827
1.377ArgTyr: 1.377 ± 0.632
0.0ArgXaa: 0.0 ± 0.0
Ser
2.479SerAla: 2.479 ± 0.58
0.826SerCys: 0.826 ± 0.337
2.203SerAsp: 2.203 ± 0.594
4.682SerGlu: 4.682 ± 1.075
1.102SerPhe: 1.102 ± 0.358
3.305SerGly: 3.305 ± 1.116
1.377SerHis: 1.377 ± 0.727
1.652SerIle: 1.652 ± 0.54
2.203SerLys: 2.203 ± 1.198
5.784SerLeu: 5.784 ± 1.208
0.826SerMet: 0.826 ± 0.4
3.029SerAsn: 3.029 ± 0.705
3.856SerPro: 3.856 ± 0.928
4.682SerGln: 4.682 ± 1.679
2.203SerArg: 2.203 ± 0.889
2.754SerSer: 2.754 ± 1.565
2.754SerThr: 2.754 ± 0.895
1.928SerVal: 1.928 ± 0.319
1.102SerTrp: 1.102 ± 0.438
1.377SerTyr: 1.377 ± 0.879
0.0SerXaa: 0.0 ± 0.0
Thr
3.305ThrAla: 3.305 ± 0.91
0.275ThrCys: 0.275 ± 0.217
3.305ThrAsp: 3.305 ± 0.73
3.029ThrGlu: 3.029 ± 1.075
0.551ThrPhe: 0.551 ± 0.219
3.856ThrGly: 3.856 ± 0.9
1.102ThrHis: 1.102 ± 0.61
4.682ThrIle: 4.682 ± 1.058
3.305ThrLys: 3.305 ± 0.752
5.508ThrLeu: 5.508 ± 1.248
1.377ThrMet: 1.377 ± 0.577
2.754ThrAsn: 2.754 ± 0.786
4.682ThrPro: 4.682 ± 1.503
4.131ThrGln: 4.131 ± 0.63
3.029ThrArg: 3.029 ± 1.246
1.928ThrSer: 1.928 ± 0.691
4.682ThrThr: 4.682 ± 1.395
4.406ThrVal: 4.406 ± 1.201
1.652ThrTrp: 1.652 ± 0.452
1.377ThrTyr: 1.377 ± 0.669
0.0ThrXaa: 0.0 ± 0.0
Val
2.203ValAla: 2.203 ± 0.781
0.0ValCys: 0.0 ± 0.0
3.305ValAsp: 3.305 ± 0.952
2.754ValGlu: 2.754 ± 0.736
1.102ValPhe: 1.102 ± 0.438
6.334ValGly: 6.334 ± 1.078
2.479ValHis: 2.479 ± 0.429
3.029ValIle: 3.029 ± 0.578
5.508ValLys: 5.508 ± 1.321
4.406ValLeu: 4.406 ± 0.706
0.275ValMet: 0.275 ± 0.396
2.203ValAsn: 2.203 ± 0.916
4.406ValPro: 4.406 ± 0.804
3.856ValGln: 3.856 ± 0.712
3.305ValArg: 3.305 ± 0.828
3.305ValSer: 3.305 ± 0.714
2.203ValThr: 2.203 ± 0.875
2.479ValVal: 2.479 ± 0.896
2.203ValTrp: 2.203 ± 0.53
1.102ValTyr: 1.102 ± 0.433
0.0ValXaa: 0.0 ± 0.0
Trp
1.652TrpAla: 1.652 ± 0.393
1.377TrpCys: 1.377 ± 1.46
1.652TrpAsp: 1.652 ± 0.506
2.479TrpGlu: 2.479 ± 0.506
0.551TrpPhe: 0.551 ± 0.412
2.203TrpGly: 2.203 ± 0.947
0.275TrpHis: 0.275 ± 0.396
0.826TrpIle: 0.826 ± 0.335
2.203TrpLys: 2.203 ± 0.541
0.826TrpLeu: 0.826 ± 0.58
1.652TrpMet: 1.652 ± 0.482
1.377TrpAsn: 1.377 ± 0.917
1.102TrpPro: 1.102 ± 0.472
2.203TrpGln: 2.203 ± 0.772
1.652TrpArg: 1.652 ± 0.462
0.551TrpSer: 0.551 ± 0.449
1.928TrpThr: 1.928 ± 0.629
1.377TrpVal: 1.377 ± 0.37
0.551TrpTrp: 0.551 ± 0.327
0.551TrpTyr: 0.551 ± 0.219
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.102TyrAla: 1.102 ± 0.438
1.102TyrCys: 1.102 ± 0.766
0.551TyrAsp: 0.551 ± 0.327
0.551TyrGlu: 0.551 ± 0.219
1.377TyrPhe: 1.377 ± 0.526
1.377TyrGly: 1.377 ± 0.747
0.826TyrHis: 0.826 ± 0.605
0.826TyrIle: 0.826 ± 0.553
2.203TyrLys: 2.203 ± 0.775
1.377TyrLeu: 1.377 ± 0.409
0.275TyrMet: 0.275 ± 0.163
1.928TyrAsn: 1.928 ± 0.758
1.652TyrPro: 1.652 ± 0.656
2.203TyrGln: 2.203 ± 0.804
2.203TyrArg: 2.203 ± 0.714
1.928TyrSer: 1.928 ± 0.387
0.826TyrThr: 0.826 ± 0.41
1.928TyrVal: 1.928 ± 0.777
1.377TyrTrp: 1.377 ± 0.798
1.928TyrTyr: 1.928 ± 0.478
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (3632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski