Amino acid dipepetide frequency for Mucilaginibacter auburnensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.305AlaAla: 7.305 ± 0.091	0.741AlaCys: 0.741 ± 0.026	5.043AlaAsp: 5.043 ± 0.071	4.746AlaGlu: 4.746 ± 0.083	3.799AlaPhe: 3.799 ± 0.059	6.067AlaGly: 6.067 ± 0.085	1.297AlaHis: 1.297 ± 0.032	5.739AlaIle: 5.739 ± 0.078	4.97AlaLys: 4.97 ± 0.07	7.567AlaLeu: 7.567 ± 0.083	1.909AlaMet: 1.909 ± 0.037	4.164AlaAsn: 4.164 ± 0.069	2.587AlaPro: 2.587 ± 0.057	3.216AlaGln: 3.216 ± 0.049	2.686AlaArg: 2.686 ± 0.049	4.426AlaSer: 4.426 ± 0.06	4.533AlaThr: 4.533 ± 0.075	5.507AlaVal: 5.507 ± 0.071	0.791AlaTrp: 0.791 ± 0.029	3.057AlaTyr: 3.057 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.564CysAla: 0.564 ± 0.019	0.129CysCys: 0.129 ± 0.011	0.395CysAsp: 0.395 ± 0.02	0.385CysGlu: 0.385 ± 0.02	0.438CysPhe: 0.438 ± 0.02	0.609CysGly: 0.609 ± 0.026	0.167CysHis: 0.167 ± 0.012	0.572CysIle: 0.572 ± 0.025	0.468CysLys: 0.468 ± 0.022	0.749CysLeu: 0.749 ± 0.025	0.184CysMet: 0.184 ± 0.012	0.383CysAsn: 0.383 ± 0.019	0.301CysPro: 0.301 ± 0.019	0.202CysGln: 0.202 ± 0.012	0.318CysArg: 0.318 ± 0.016	0.528CysSer: 0.528 ± 0.023	0.429CysThr: 0.429 ± 0.019	0.486CysVal: 0.486 ± 0.019	0.085CysTrp: 0.085 ± 0.008	0.322CysTyr: 0.322 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.387AspAla: 4.387 ± 0.068	0.371AspCys: 0.371 ± 0.018	2.83AspAsp: 2.83 ± 0.059	3.591AspGlu: 3.591 ± 0.058	2.887AspPhe: 2.887 ± 0.053	3.813AspGly: 3.813 ± 0.065	0.918AspHis: 0.918 ± 0.024	3.924AspIle: 3.924 ± 0.056	4.018AspLys: 4.018 ± 0.068	4.781AspLeu: 4.781 ± 0.073	1.31AspMet: 1.31 ± 0.04	2.801AspAsn: 2.801 ± 0.053	2.019AspPro: 2.019 ± 0.042	1.638AspGln: 1.638 ± 0.034	2.155AspArg: 2.155 ± 0.05	2.815AspSer: 2.815 ± 0.053	2.684AspThr: 2.684 ± 0.049	3.954AspVal: 3.954 ± 0.058	0.686AspTrp: 0.686 ± 0.023	2.364AspTyr: 2.364 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.333GluAla: 4.333 ± 0.072	0.31GluCys: 0.31 ± 0.018	2.631GluAsp: 2.631 ± 0.055	3.528GluGlu: 3.528 ± 0.069	2.382GluPhe: 2.382 ± 0.043	3.3GluGly: 3.3 ± 0.056	1.175GluHis: 1.175 ± 0.036	3.986GluIle: 3.986 ± 0.068	4.29GluLys: 4.29 ± 0.07	5.744GluLeu: 5.744 ± 0.09	1.443GluMet: 1.443 ± 0.033	2.849GluAsn: 2.849 ± 0.051	1.745GluPro: 1.745 ± 0.042	2.644GluGln: 2.644 ± 0.052	2.691GluArg: 2.691 ± 0.056	2.551GluSer: 2.551 ± 0.047	2.759GluThr: 2.759 ± 0.055	3.908GluVal: 3.908 ± 0.051	0.629GluTrp: 0.629 ± 0.023	2.029GluTyr: 2.029 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.673PheAla: 3.673 ± 0.048	0.452PheCys: 0.452 ± 0.018	2.988PheAsp: 2.988 ± 0.05	2.663PheGlu: 2.663 ± 0.052	2.373PhePhe: 2.373 ± 0.059	3.425PheGly: 3.425 ± 0.054	0.708PheHis: 0.708 ± 0.026	3.543PheIle: 3.543 ± 0.064	3.375PheLys: 3.375 ± 0.051	4.046PheLeu: 4.046 ± 0.076	1.127PheMet: 1.127 ± 0.033	3.119PheAsn: 3.119 ± 0.057	1.637PhePro: 1.637 ± 0.035	1.231PheGln: 1.231 ± 0.033	1.744PheArg: 1.744 ± 0.039	3.437PheSer: 3.437 ± 0.057	3.212PheThr: 3.212 ± 0.06	2.974PheVal: 2.974 ± 0.06	0.586PheTrp: 0.586 ± 0.022	2.073PheTyr: 2.073 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.099GlyAla: 5.099 ± 0.07	0.6GlyCys: 0.6 ± 0.025	3.412GlyAsp: 3.412 ± 0.058	3.366GlyGlu: 3.366 ± 0.063	3.739GlyPhe: 3.739 ± 0.067	5.233GlyGly: 5.233 ± 0.097	1.181GlyHis: 1.181 ± 0.033	5.273GlyIle: 5.273 ± 0.078	5.153GlyLys: 5.153 ± 0.073	6.347GlyLeu: 6.347 ± 0.078	1.68GlyMet: 1.68 ± 0.034	3.683GlyAsn: 3.683 ± 0.067	1.748GlyPro: 1.748 ± 0.043	2.234GlyGln: 2.234 ± 0.041	2.69GlyArg: 2.69 ± 0.047	4.392GlySer: 4.392 ± 0.074	4.225GlyThr: 4.225 ± 0.08	4.791GlyVal: 4.791 ± 0.061	0.911GlyTrp: 0.911 ± 0.026	3.009GlyTyr: 3.009 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.185HisAla: 1.185 ± 0.034	0.181HisCys: 0.181 ± 0.011	0.9HisAsp: 0.9 ± 0.026	0.973HisGlu: 0.973 ± 0.031	1.054HisPhe: 1.054 ± 0.03	1.195HisGly: 1.195 ± 0.035	0.519HisHis: 0.519 ± 0.024	1.312HisIle: 1.312 ± 0.036	0.974HisLys: 0.974 ± 0.028	1.801HisLeu: 1.801 ± 0.046	0.388HisMet: 0.388 ± 0.018	0.917HisAsn: 0.917 ± 0.024	1.01HisPro: 1.01 ± 0.03	0.728HisGln: 0.728 ± 0.023	0.753HisArg: 0.753 ± 0.028	0.972HisSer: 0.972 ± 0.028	0.989HisThr: 0.989 ± 0.03	0.996HisVal: 0.996 ± 0.03	0.235HisTrp: 0.235 ± 0.014	0.803HisTyr: 0.803 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.314IleAla: 6.314 ± 0.075	0.68IleCys: 0.68 ± 0.024	4.325IleAsp: 4.325 ± 0.057	4.051IleGlu: 4.051 ± 0.076	2.97IlePhe: 2.97 ± 0.058	4.769IleGly: 4.769 ± 0.08	1.186IleHis: 1.186 ± 0.034	5.128IleIle: 5.128 ± 0.086	5.021IleLys: 5.021 ± 0.06	5.844IleLeu: 5.844 ± 0.079	1.395IleMet: 1.395 ± 0.037	4.383IleAsn: 4.383 ± 0.066	2.893IlePro: 2.893 ± 0.052	2.075IleGln: 2.075 ± 0.046	2.784IleArg: 2.784 ± 0.05	4.849IleSer: 4.849 ± 0.068	4.856IleThr: 4.856 ± 0.076	4.454IleVal: 4.454 ± 0.067	0.698IleTrp: 0.698 ± 0.026	2.568IleTyr: 2.568 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.602LysAla: 5.602 ± 0.081	0.327LysCys: 0.327 ± 0.016	3.705LysAsp: 3.705 ± 0.062	3.984LysGlu: 3.984 ± 0.074	2.645LysPhe: 2.645 ± 0.048	4.41LysGly: 4.41 ± 0.065	1.325LysHis: 1.325 ± 0.033	4.715LysIle: 4.715 ± 0.07	5.215LysLys: 5.215 ± 0.077	6.369LysLeu: 6.369 ± 0.079	1.827LysMet: 1.827 ± 0.04	4.024LysAsn: 4.024 ± 0.058	2.902LysPro: 2.902 ± 0.046	3.027LysGln: 3.027 ± 0.05	2.893LysArg: 2.893 ± 0.053	3.475LysSer: 3.475 ± 0.057	4.209LysThr: 4.209 ± 0.064	4.568LysVal: 4.568 ± 0.064	0.783LysTrp: 0.783 ± 0.024	2.814LysTyr: 2.814 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.323LeuAla: 7.323 ± 0.088	0.796LeuCys: 0.796 ± 0.027	4.61LeuAsp: 4.61 ± 0.067	4.48LeuGlu: 4.48 ± 0.074	4.57LeuPhe: 4.57 ± 0.067	5.736LeuGly: 5.736 ± 0.08	1.634LeuHis: 1.634 ± 0.039	6.568LeuIle: 6.568 ± 0.09	7.044LeuLys: 7.044 ± 0.083	9.574LeuLeu: 9.574 ± 0.116	2.263LeuMet: 2.263 ± 0.046	5.648LeuAsn: 5.648 ± 0.076	4.131LeuPro: 4.131 ± 0.065	3.664LeuGln: 3.664 ± 0.063	3.738LeuArg: 3.738 ± 0.057	6.539LeuSer: 6.539 ± 0.08	5.802LeuThr: 5.802 ± 0.068	5.625LeuVal: 5.625 ± 0.078	0.915LeuTrp: 0.915 ± 0.029	3.27LeuTyr: 3.27 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.107MetAla: 2.107 ± 0.043	0.144MetCys: 0.144 ± 0.011	1.201MetAsp: 1.201 ± 0.035	1.316MetGlu: 1.316 ± 0.033	0.879MetPhe: 0.879 ± 0.03	1.614MetGly: 1.614 ± 0.043	0.453MetHis: 0.453 ± 0.02	1.394MetIle: 1.394 ± 0.033	1.823MetLys: 1.823 ± 0.039	2.317MetLeu: 2.317 ± 0.051	0.59MetMet: 0.59 ± 0.024	1.197MetAsn: 1.197 ± 0.031	1.192MetPro: 1.192 ± 0.03	1.045MetGln: 1.045 ± 0.031	1.1MetArg: 1.1 ± 0.029	1.368MetSer: 1.368 ± 0.033	1.035MetThr: 1.035 ± 0.028	1.577MetVal: 1.577 ± 0.037	0.189MetTrp: 0.189 ± 0.013	0.681MetTyr: 0.681 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.376AsnAla: 4.376 ± 0.065	0.423AsnCys: 0.423 ± 0.021	2.835AsnAsp: 2.835 ± 0.052	2.936AsnGlu: 2.936 ± 0.048	2.672AsnPhe: 2.672 ± 0.059	4.159AsnGly: 4.159 ± 0.073	0.906AsnHis: 0.906 ± 0.029	4.198AsnIle: 4.198 ± 0.075	3.797AsnLys: 3.797 ± 0.062	4.886AsnLeu: 4.886 ± 0.074	1.258AsnMet: 1.258 ± 0.031	3.75AsnAsn: 3.75 ± 0.074	2.526AsnPro: 2.526 ± 0.05	1.972AsnGln: 1.972 ± 0.042	2.317AsnArg: 2.317 ± 0.051	3.278AsnSer: 3.278 ± 0.061	3.5AsnThr: 3.5 ± 0.064	3.588AsnVal: 3.588 ± 0.062	0.714AsnTrp: 0.714 ± 0.024	2.683AsnTyr: 2.683 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	3.401ProAla: 3.401 ± 0.061	0.222ProCys: 0.222 ± 0.014	2.672ProAsp: 2.672 ± 0.047	2.759ProGlu: 2.759 ± 0.054	1.962ProPhe: 1.962 ± 0.042	2.865ProGly: 2.865 ± 0.052	0.677ProHis: 0.677 ± 0.027	2.26ProIle: 2.26 ± 0.042	2.17ProLys: 2.17 ± 0.047	3.35ProLeu: 3.35 ± 0.053	0.754ProMet: 0.754 ± 0.023	1.964ProAsn: 1.964 ± 0.043	1.205ProPro: 1.205 ± 0.048	1.547ProGln: 1.547 ± 0.037	1.224ProArg: 1.224 ± 0.035	2.163ProSer: 2.163 ± 0.049	2.081ProThr: 2.081 ± 0.045	3.463ProVal: 3.463 ± 0.068	0.4ProTrp: 0.4 ± 0.019	1.523ProTyr: 1.523 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.763GlnAla: 2.763 ± 0.052	0.18GlnCys: 0.18 ± 0.012	1.501GlnAsp: 1.501 ± 0.032	1.808GlnGlu: 1.808 ± 0.047	1.691GlnPhe: 1.691 ± 0.036	2.049GlnGly: 2.049 ± 0.041	0.824GlnHis: 0.824 ± 0.029	2.552GlnIle: 2.552 ± 0.049	2.593GlnLys: 2.593 ± 0.051	4.13GlnLeu: 4.13 ± 0.067	0.905GlnMet: 0.905 ± 0.027	2.088GlnAsn: 2.088 ± 0.045	1.614GlnPro: 1.614 ± 0.042	2.343GlnGln: 2.343 ± 0.092	1.733GlnArg: 1.733 ± 0.041	2.089GlnSer: 2.089 ± 0.044	2.217GlnThr: 2.217 ± 0.036	2.365GlnVal: 2.365 ± 0.042	0.394GlnTrp: 0.394 ± 0.018	1.518GlnTyr: 1.518 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.65ArgAla: 2.65 ± 0.054	0.22ArgCys: 0.22 ± 0.012	2.104ArgAsp: 2.104 ± 0.046	2.351ArgGlu: 2.351 ± 0.046	2.187ArgPhe: 2.187 ± 0.04	2.356ArgGly: 2.356 ± 0.051	0.73ArgHis: 0.73 ± 0.026	3.044ArgIle: 3.044 ± 0.047	2.763ArgLys: 2.763 ± 0.052	3.82ArgLeu: 3.82 ± 0.06	1.148ArgMet: 1.148 ± 0.032	2.249ArgAsn: 2.249 ± 0.047	1.399ArgPro: 1.399 ± 0.041	1.618ArgGln: 1.618 ± 0.036	1.778ArgArg: 1.778 ± 0.044	2.359ArgSer: 2.359 ± 0.054	2.113ArgThr: 2.113 ± 0.04	2.703ArgVal: 2.703 ± 0.052	0.493ArgTrp: 0.493 ± 0.021	1.878ArgTyr: 1.878 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.011SerAla: 5.011 ± 0.059	0.479SerCys: 0.479 ± 0.02	2.956SerAsp: 2.956 ± 0.047	2.846SerGlu: 2.846 ± 0.053	3.252SerPhe: 3.252 ± 0.06	4.622SerGly: 4.622 ± 0.079	1.05SerHis: 1.05 ± 0.036	4.394SerIle: 4.394 ± 0.073	3.789SerLys: 3.789 ± 0.055	5.673SerLeu: 5.673 ± 0.077	1.236SerMet: 1.236 ± 0.033	3.22SerAsn: 3.22 ± 0.06	2.325SerPro: 2.325 ± 0.045	1.881SerGln: 1.881 ± 0.043	2.406SerArg: 2.406 ± 0.047	3.618SerSer: 3.618 ± 0.062	3.581SerThr: 3.581 ± 0.066	4.32SerVal: 4.32 ± 0.062	0.638SerTrp: 0.638 ± 0.023	2.541SerTyr: 2.541 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.999ThrAla: 4.999 ± 0.073	0.381ThrCys: 0.381 ± 0.019	3.513ThrAsp: 3.513 ± 0.059	3.086ThrGlu: 3.086 ± 0.054	2.818ThrPhe: 2.818 ± 0.051	5.077ThrGly: 5.077 ± 0.079	0.974ThrHis: 0.974 ± 0.03	4.33ThrIle: 4.33 ± 0.057	3.07ThrLys: 3.07 ± 0.058	5.509ThrLeu: 5.509 ± 0.067	1.063ThrMet: 1.063 ± 0.029	2.999ThrAsn: 2.999 ± 0.06	2.892ThrPro: 2.892 ± 0.058	2.028ThrGln: 2.028 ± 0.039	2.102ThrArg: 2.102 ± 0.04	3.489ThrSer: 3.489 ± 0.062	3.702ThrThr: 3.702 ± 0.081	4.25ThrVal: 4.25 ± 0.079	0.624ThrTrp: 0.624 ± 0.022	2.405ThrTyr: 2.405 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.384ValAla: 5.384 ± 0.071	0.629ValCys: 0.629 ± 0.021	3.616ValAsp: 3.616 ± 0.05	3.642ValGlu: 3.642 ± 0.056	3.269ValPhe: 3.269 ± 0.052	4.02ValGly: 4.02 ± 0.062	1.039ValHis: 1.039 ± 0.029	5.096ValIle: 5.096 ± 0.067	4.927ValLys: 4.927 ± 0.064	6.335ValLeu: 6.335 ± 0.091	1.622ValMet: 1.622 ± 0.038	4.032ValAsn: 4.032 ± 0.066	2.514ValPro: 2.514 ± 0.047	2.064ValGln: 2.064 ± 0.041	2.444ValArg: 2.444 ± 0.048	4.336ValSer: 4.336 ± 0.069	4.257ValThr: 4.257 ± 0.084	4.808ValVal: 4.808 ± 0.074	0.68ValTrp: 0.68 ± 0.027	2.703ValTyr: 2.703 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.759TrpAla: 0.759 ± 0.026	0.106TrpCys: 0.106 ± 0.01	0.595TrpAsp: 0.595 ± 0.024	0.561TrpGlu: 0.561 ± 0.022	0.612TrpPhe: 0.612 ± 0.026	0.793TrpGly: 0.793 ± 0.028	0.267TrpHis: 0.267 ± 0.016	0.695TrpIle: 0.695 ± 0.027	0.701TrpLys: 0.701 ± 0.021	1.181TrpLeu: 1.181 ± 0.036	0.359TrpMet: 0.359 ± 0.018	0.628TrpAsn: 0.628 ± 0.023	0.353TrpPro: 0.353 ± 0.017	0.557TrpGln: 0.557 ± 0.025	0.516TrpArg: 0.516 ± 0.024	0.56TrpSer: 0.56 ± 0.021	0.555TrpThr: 0.555 ± 0.025	0.713TrpVal: 0.713 ± 0.027	0.19TrpTrp: 0.19 ± 0.015	0.428TrpTyr: 0.428 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.922TyrAla: 2.922 ± 0.05	0.342TyrCys: 0.342 ± 0.018	2.113TyrAsp: 2.113 ± 0.039	1.853TyrGlu: 1.853 ± 0.039	2.187TyrPhe: 2.187 ± 0.042	2.652TyrGly: 2.652 ± 0.044	0.856TyrHis: 0.856 ± 0.022	2.52TyrIle: 2.52 ± 0.045	2.655TyrLys: 2.655 ± 0.044	3.906TyrLeu: 3.906 ± 0.056	0.761TyrMet: 0.761 ± 0.029	2.678TyrAsn: 2.678 ± 0.057	1.671TyrPro: 1.671 ± 0.041	1.642TyrGln: 1.642 ± 0.039	1.891TyrArg: 1.891 ± 0.04	2.59TyrSer: 2.59 ± 0.047	2.572TyrThr: 2.572 ± 0.053	2.365TyrVal: 2.365 ± 0.044	0.488TyrTrp: 0.488 ± 0.022	1.886TyrTyr: 1.886 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3606 proteins (1206224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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