Amino acid dipepetide frequency for Pedosphaera parvula (strain Ellin514)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.807AlaAla: 9.807 ± 0.081	0.991AlaCys: 0.991 ± 0.021	4.514AlaAsp: 4.514 ± 0.048	5.317AlaGlu: 5.317 ± 0.077	3.626AlaPhe: 3.626 ± 0.042	8.05AlaGly: 8.05 ± 0.092	1.767AlaHis: 1.767 ± 0.031	5.146AlaIle: 5.146 ± 0.052	4.382AlaLys: 4.382 ± 0.068	9.362AlaLeu: 9.362 ± 0.083	2.201AlaMet: 2.201 ± 0.033	3.913AlaAsn: 3.913 ± 0.062	4.197AlaPro: 4.197 ± 0.064	3.642AlaGln: 3.642 ± 0.046	5.105AlaArg: 5.105 ± 0.061	5.933AlaSer: 5.933 ± 0.071	5.774AlaThr: 5.774 ± 0.09	6.545AlaVal: 6.545 ± 0.063	1.408AlaTrp: 1.408 ± 0.029	2.366AlaTyr: 2.366 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.889CysAla: 0.889 ± 0.021	0.167CysCys: 0.167 ± 0.01	0.503CysAsp: 0.503 ± 0.016	0.549CysGlu: 0.549 ± 0.018	0.483CysPhe: 0.483 ± 0.016	0.904CysGly: 0.904 ± 0.022	0.308CysHis: 0.308 ± 0.013	0.538CysIle: 0.538 ± 0.016	0.363CysLys: 0.363 ± 0.013	1.141CysLeu: 1.141 ± 0.031	0.205CysMet: 0.205 ± 0.01	0.353CysAsn: 0.353 ± 0.013	0.556CysPro: 0.556 ± 0.017	0.365CysGln: 0.365 ± 0.012	0.603CysArg: 0.603 ± 0.018	0.682CysSer: 0.682 ± 0.02	0.539CysThr: 0.539 ± 0.02	0.734CysVal: 0.734 ± 0.02	0.165CysTrp: 0.165 ± 0.01	0.31CysTyr: 0.31 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.387AspAla: 4.387 ± 0.045	0.51AspCys: 0.51 ± 0.018	2.094AspAsp: 2.094 ± 0.034	2.707AspGlu: 2.707 ± 0.045	2.262AspPhe: 2.262 ± 0.034	4.458AspGly: 4.458 ± 0.072	1.085AspHis: 1.085 ± 0.026	2.388AspIle: 2.388 ± 0.036	2.102AspLys: 2.102 ± 0.041	4.901AspLeu: 4.901 ± 0.054	0.903AspMet: 0.903 ± 0.022	1.698AspAsn: 1.698 ± 0.035	2.622AspPro: 2.622 ± 0.037	1.737AspGln: 1.737 ± 0.026	2.54AspArg: 2.54 ± 0.041	2.745AspSer: 2.745 ± 0.037	2.422AspThr: 2.422 ± 0.039	3.19AspVal: 3.19 ± 0.043	0.993AspTrp: 0.993 ± 0.02	1.692AspTyr: 1.692 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.179GluAla: 5.179 ± 0.07	0.465GluCys: 0.465 ± 0.015	2.211GluAsp: 2.211 ± 0.043	3.25GluGlu: 3.25 ± 0.055	2.198GluPhe: 2.198 ± 0.034	3.452GluGly: 3.452 ± 0.049	1.202GluHis: 1.202 ± 0.025	3.333GluIle: 3.333 ± 0.046	3.438GluLys: 3.438 ± 0.054	5.812GluLeu: 5.812 ± 0.08	1.457GluMet: 1.457 ± 0.032	2.021GluAsn: 2.021 ± 0.033	2.328GluPro: 2.328 ± 0.036	2.393GluGln: 2.393 ± 0.042	3.356GluArg: 3.356 ± 0.054	2.997GluSer: 2.997 ± 0.045	3.003GluThr: 3.003 ± 0.04	3.861GluVal: 3.861 ± 0.057	0.8GluTrp: 0.8 ± 0.021	1.238GluTyr: 1.238 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.801PheAla: 3.801 ± 0.046	0.547PheCys: 0.547 ± 0.017	2.344PheAsp: 2.344 ± 0.031	2.118PheGlu: 2.118 ± 0.033	1.853PhePhe: 1.853 ± 0.036	3.481PheGly: 3.481 ± 0.047	0.89PheHis: 0.89 ± 0.02	2.09PheIle: 2.09 ± 0.034	1.787PheLys: 1.787 ± 0.028	3.904PheLeu: 3.904 ± 0.051	0.81PheMet: 0.81 ± 0.021	1.883PheAsn: 1.883 ± 0.033	2.045PhePro: 2.045 ± 0.032	1.553PheGln: 1.553 ± 0.028	2.176PheArg: 2.176 ± 0.034	3.044PheSer: 3.044 ± 0.041	2.794PheThr: 2.794 ± 0.045	2.908PheVal: 2.908 ± 0.036	0.713PheTrp: 0.713 ± 0.021	1.451PheTyr: 1.451 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.768GlyAla: 6.768 ± 0.081	0.896GlyCys: 0.896 ± 0.019	3.604GlyAsp: 3.604 ± 0.049	3.906GlyGlu: 3.906 ± 0.054	3.489GlyPhe: 3.489 ± 0.042	6.995GlyGly: 6.995 ± 0.136	1.654GlyHis: 1.654 ± 0.029	4.557GlyIle: 4.557 ± 0.043	4.248GlyLys: 4.248 ± 0.06	7.387GlyLeu: 7.387 ± 0.069	1.905GlyMet: 1.905 ± 0.033	3.666GlyAsn: 3.666 ± 0.069	2.863GlyPro: 2.863 ± 0.042	3.035GlyGln: 3.035 ± 0.045	4.1GlyArg: 4.1 ± 0.049	5.556GlySer: 5.556 ± 0.103	5.909GlyThr: 5.909 ± 0.134	5.463GlyVal: 5.463 ± 0.065	1.512GlyTrp: 1.512 ± 0.029	2.507GlyTyr: 2.507 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	1.784HisAla: 1.784 ± 0.033	0.289HisCys: 0.289 ± 0.009	1.108HisAsp: 1.108 ± 0.024	1.123HisGlu: 1.123 ± 0.026	1.072HisPhe: 1.072 ± 0.025	1.714HisGly: 1.714 ± 0.031	0.62HisHis: 0.62 ± 0.019	0.974HisIle: 0.974 ± 0.021	0.771HisLys: 0.771 ± 0.021	2.178HisLeu: 2.178 ± 0.041	0.408HisMet: 0.408 ± 0.014	0.708HisAsn: 0.708 ± 0.018	1.381HisPro: 1.381 ± 0.03	0.82HisGln: 0.82 ± 0.02	1.224HisArg: 1.224 ± 0.028	1.282HisSer: 1.282 ± 0.029	0.953HisThr: 0.953 ± 0.021	1.343HisVal: 1.343 ± 0.026	0.42HisTrp: 0.42 ± 0.016	0.716HisTyr: 0.716 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.298IleAla: 5.298 ± 0.056	0.684IleCys: 0.684 ± 0.021	2.652IleAsp: 2.652 ± 0.034	2.911IleGlu: 2.911 ± 0.042	2.204IlePhe: 2.204 ± 0.039	4.341IleGly: 4.341 ± 0.054	1.153IleHis: 1.153 ± 0.024	2.899IleIle: 2.899 ± 0.045	2.435IleLys: 2.435 ± 0.039	5.069IleLeu: 5.069 ± 0.059	0.964IleMet: 0.964 ± 0.023	2.216IleAsn: 2.216 ± 0.037	2.886IlePro: 2.886 ± 0.04	2.008IleGln: 2.008 ± 0.032	2.816IleArg: 2.816 ± 0.041	3.781IleSer: 3.781 ± 0.046	3.487IleThr: 3.487 ± 0.052	3.764IleVal: 3.764 ± 0.047	0.809IleTrp: 0.809 ± 0.023	1.645IleTyr: 1.645 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.394LysAla: 4.394 ± 0.053	0.393LysCys: 0.393 ± 0.015	2.359LysAsp: 2.359 ± 0.042	2.881LysGlu: 2.881 ± 0.051	1.779LysPhe: 1.779 ± 0.029	3.194LysGly: 3.194 ± 0.046	0.983LysHis: 0.983 ± 0.023	2.662LysIle: 2.662 ± 0.042	2.65LysLys: 2.65 ± 0.042	4.89LysLeu: 4.89 ± 0.062	1.33LysMet: 1.33 ± 0.027	1.844LysAsn: 1.844 ± 0.028	2.698LysPro: 2.698 ± 0.047	1.975LysGln: 1.975 ± 0.035	2.629LysArg: 2.629 ± 0.042	2.904LysSer: 2.904 ± 0.045	2.789LysThr: 2.789 ± 0.045	3.326LysVal: 3.326 ± 0.047	0.684LysTrp: 0.684 ± 0.019	1.209LysTyr: 1.209 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.059LeuAla: 10.059 ± 0.083	1.067LeuCys: 1.067 ± 0.023	4.647LeuAsp: 4.647 ± 0.053	5.355LeuGlu: 5.355 ± 0.076	3.925LeuPhe: 3.925 ± 0.053	7.392LeuGly: 7.392 ± 0.067	2.022LeuHis: 2.022 ± 0.035	5.111LeuIle: 5.111 ± 0.058	5.205LeuLys: 5.205 ± 0.064	9.893LeuLeu: 9.893 ± 0.109	1.993LeuMet: 1.993 ± 0.031	4.121LeuAsn: 4.121 ± 0.057	5.302LeuPro: 5.302 ± 0.058	3.778LeuGln: 3.778 ± 0.047	5.629LeuArg: 5.629 ± 0.072	6.584LeuSer: 6.584 ± 0.062	6.173LeuThr: 6.173 ± 0.075	6.893LeuVal: 6.893 ± 0.059	1.348LeuTrp: 1.348 ± 0.031	2.35LeuTyr: 2.35 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.238MetAla: 2.238 ± 0.037	0.181MetCys: 0.181 ± 0.009	1.107MetAsp: 1.107 ± 0.026	1.25MetGlu: 1.25 ± 0.025	0.717MetPhe: 0.717 ± 0.017	1.552MetGly: 1.552 ± 0.027	0.431MetHis: 0.431 ± 0.015	1.148MetIle: 1.148 ± 0.022	1.456MetLys: 1.456 ± 0.029	2.101MetLeu: 2.101 ± 0.034	0.499MetMet: 0.499 ± 0.016	1.099MetAsn: 1.099 ± 0.022	1.183MetPro: 1.183 ± 0.025	0.813MetGln: 0.813 ± 0.022	1.313MetArg: 1.313 ± 0.026	1.32MetSer: 1.32 ± 0.03	1.304MetThr: 1.304 ± 0.024	1.566MetVal: 1.566 ± 0.029	0.238MetTrp: 0.238 ± 0.013	0.379MetTyr: 0.379 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.97AsnAla: 3.97 ± 0.062	0.47AsnCys: 0.47 ± 0.024	1.851AsnAsp: 1.851 ± 0.036	1.894AsnGlu: 1.894 ± 0.033	1.885AsnPhe: 1.885 ± 0.04	4.296AsnGly: 4.296 ± 0.102	0.923AsnHis: 0.923 ± 0.023	2.161AsnIle: 2.161 ± 0.04	1.446AsnLys: 1.446 ± 0.023	4.301AsnLeu: 4.301 ± 0.057	0.748AsnMet: 0.748 ± 0.019	1.981AsnAsn: 1.981 ± 0.05	2.76AsnPro: 2.76 ± 0.04	1.858AsnGln: 1.858 ± 0.029	2.209AsnArg: 2.209 ± 0.032	3.118AsnSer: 3.118 ± 0.066	2.457AsnThr: 2.457 ± 0.053	2.876AsnVal: 2.876 ± 0.062	0.846AsnTrp: 0.846 ± 0.024	1.436AsnTyr: 1.436 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.309ProAla: 5.309 ± 0.063	0.364ProCys: 0.364 ± 0.014	2.859ProAsp: 2.859 ± 0.038	3.385ProGlu: 3.385 ± 0.049	2.009ProPhe: 2.009 ± 0.034	4.211ProGly: 4.211 ± 0.049	0.992ProHis: 0.992 ± 0.021	2.576ProIle: 2.576 ± 0.041	2.36ProLys: 2.36 ± 0.038	4.442ProLeu: 4.442 ± 0.049	1.153ProMet: 1.153 ± 0.024	2.124ProAsn: 2.124 ± 0.033	2.681ProPro: 2.681 ± 0.039	1.868ProGln: 1.868 ± 0.029	2.232ProArg: 2.232 ± 0.033	3.194ProSer: 3.194 ± 0.043	3.147ProThr: 3.147 ± 0.046	3.865ProVal: 3.865 ± 0.043	0.727ProTrp: 0.727 ± 0.019	1.293ProTyr: 1.293 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.656GlnAla: 3.656 ± 0.045	0.318GlnCys: 0.318 ± 0.012	1.456GlnAsp: 1.456 ± 0.028	1.897GlnGlu: 1.897 ± 0.037	1.693GlnPhe: 1.693 ± 0.028	2.534GlnGly: 2.534 ± 0.038	0.83GlnHis: 0.83 ± 0.019	2.335GlnIle: 2.335 ± 0.034	2.048GlnLys: 2.048 ± 0.041	3.965GlnLeu: 3.965 ± 0.043	1.034GlnMet: 1.034 ± 0.024	1.587GlnAsn: 1.587 ± 0.03	2.23GlnPro: 2.23 ± 0.034	1.776GlnGln: 1.776 ± 0.037	2.292GlnArg: 2.292 ± 0.043	2.476GlnSer: 2.476 ± 0.033	2.504GlnThr: 2.504 ± 0.04	2.682GlnVal: 2.682 ± 0.034	0.711GlnTrp: 0.711 ± 0.021	0.97GlnTyr: 0.97 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	4.454ArgAla: 4.454 ± 0.048	0.564ArgCys: 0.564 ± 0.016	2.622ArgAsp: 2.622 ± 0.039	3.576ArgGlu: 3.576 ± 0.059	2.59ArgPhe: 2.59 ± 0.037	3.419ArgGly: 3.419 ± 0.045	1.248ArgHis: 1.248 ± 0.029	3.277ArgIle: 3.277 ± 0.05	2.816ArgLys: 2.816 ± 0.046	5.735ArgLeu: 5.735 ± 0.069	1.385ArgMet: 1.385 ± 0.026	2.108ArgAsn: 2.108 ± 0.03	2.41ArgPro: 2.41 ± 0.04	2.342ArgGln: 2.342 ± 0.036	3.43ArgArg: 3.43 ± 0.043	3.198ArgSer: 3.198 ± 0.04	2.805ArgThr: 2.805 ± 0.039	3.689ArgVal: 3.689 ± 0.046	0.948ArgTrp: 0.948 ± 0.025	1.629ArgTyr: 1.629 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.042SerAla: 6.042 ± 0.072	0.603SerCys: 0.603 ± 0.017	3.033SerAsp: 3.033 ± 0.041	3.117SerGlu: 3.117 ± 0.04	2.939SerPhe: 2.939 ± 0.041	6.248SerGly: 6.248 ± 0.115	1.25SerHis: 1.25 ± 0.025	3.414SerIle: 3.414 ± 0.043	2.721SerLys: 2.721 ± 0.038	6.406SerLeu: 6.406 ± 0.061	1.371SerMet: 1.371 ± 0.027	2.78SerAsn: 2.78 ± 0.06	3.5SerPro: 3.5 ± 0.046	2.393SerGln: 2.393 ± 0.04	3.227SerArg: 3.227 ± 0.045	4.931SerSer: 4.931 ± 0.083	4.005SerThr: 4.005 ± 0.064	4.475SerVal: 4.475 ± 0.057	1.066SerTrp: 1.066 ± 0.023	1.899SerTyr: 1.899 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.607ThrAla: 5.607 ± 0.078	0.525ThrCys: 0.525 ± 0.017	2.77ThrAsp: 2.77 ± 0.038	2.715ThrGlu: 2.715 ± 0.041	2.581ThrPhe: 2.581 ± 0.045	5.323ThrGly: 5.323 ± 0.081	1.106ThrHis: 1.106 ± 0.024	3.421ThrIle: 3.421 ± 0.055	2.28ThrLys: 2.28 ± 0.032	6.08ThrLeu: 6.08 ± 0.074	1.134ThrMet: 1.134 ± 0.023	4.509ThrAsn: 4.509 ± 0.141	3.497ThrPro: 3.497 ± 0.047	1.915ThrGln: 1.915 ± 0.029	2.785ThrArg: 2.785 ± 0.037	3.935ThrSer: 3.935 ± 0.063	3.832ThrThr: 3.832 ± 0.081	4.604ThrVal: 4.604 ± 0.074	0.948ThrTrp: 0.948 ± 0.022	1.672ThrTyr: 1.672 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.855ValAla: 6.855 ± 0.065	0.777ValCys: 0.777 ± 0.019	3.474ValAsp: 3.474 ± 0.042	3.864ValGlu: 3.864 ± 0.052	2.832ValPhe: 2.832 ± 0.035	5.123ValGly: 5.123 ± 0.055	1.329ValHis: 1.329 ± 0.028	3.944ValIle: 3.944 ± 0.047	3.169ValLys: 3.169 ± 0.047	6.763ValLeu: 6.763 ± 0.066	1.55ValMet: 1.55 ± 0.031	2.888ValAsn: 2.888 ± 0.048	3.559ValPro: 3.559 ± 0.043	2.563ValGln: 2.563 ± 0.034	3.798ValArg: 3.798 ± 0.046	4.69ValSer: 4.69 ± 0.062	4.612ValThr: 4.612 ± 0.087	5.495ValVal: 5.495 ± 0.075	1.091ValTrp: 1.091 ± 0.025	1.868ValTyr: 1.868 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.186TrpAla: 1.186 ± 0.025	0.176TrpCys: 0.176 ± 0.008	0.702TrpAsp: 0.702 ± 0.02	0.765TrpGlu: 0.765 ± 0.02	0.699TrpPhe: 0.699 ± 0.022	1.089TrpGly: 1.089 ± 0.031	0.437TrpHis: 0.437 ± 0.014	0.892TrpIle: 0.892 ± 0.022	0.834TrpLys: 0.834 ± 0.02	1.783TrpLeu: 1.783 ± 0.033	0.389TrpMet: 0.389 ± 0.013	0.803TrpAsn: 0.803 ± 0.024	0.748TrpPro: 0.748 ± 0.021	0.834TrpGln: 0.834 ± 0.022	1.038TrpArg: 1.038 ± 0.027	1.088TrpSer: 1.088 ± 0.025	1.057TrpThr: 1.057 ± 0.03	1.015TrpVal: 1.015 ± 0.023	0.303TrpTrp: 0.303 ± 0.014	0.414TrpTyr: 0.414 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.363TyrAla: 2.363 ± 0.035	0.367TyrCys: 0.367 ± 0.014	1.524TyrAsp: 1.524 ± 0.037	1.416TyrGlu: 1.416 ± 0.024	1.356TyrPhe: 1.356 ± 0.028	2.247TyrGly: 2.247 ± 0.038	0.662TyrHis: 0.662 ± 0.018	1.157TyrIle: 1.157 ± 0.022	1.061TyrLys: 1.061 ± 0.024	2.734TyrLeu: 2.734 ± 0.042	0.455TyrMet: 0.455 ± 0.014	1.183TyrAsn: 1.183 ± 0.033	1.344TyrPro: 1.344 ± 0.028	1.33TyrGln: 1.33 ± 0.026	1.742TyrArg: 1.742 ± 0.028	1.963TyrSer: 1.963 ± 0.039	1.672TyrThr: 1.672 ± 0.035	1.95TyrVal: 1.95 ± 0.037	0.521TyrTrp: 0.521 ± 0.015	1.006TyrTyr: 1.006 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6492 proteins (2197852 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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