Amino acid dipepetide frequency for Wuhan pillworm virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.809AlaAla: 2.809 ± 1.298
0.255AlaCys: 0.255 ± 0.157
1.788AlaAsp: 1.788 ± 1.102
2.554AlaGlu: 2.554 ± 0.966
1.277AlaPhe: 1.277 ± 1.118
2.043AlaGly: 2.043 ± 0.664
1.021AlaHis: 1.021 ± 0.472
3.32AlaIle: 3.32 ± 0.58
2.043AlaLys: 2.043 ± 0.852
4.086AlaLeu: 4.086 ± 0.921
0.766AlaMet: 0.766 ± 0.472
0.766AlaAsn: 0.766 ± 0.532
1.788AlaPro: 1.788 ± 1.338
1.277AlaGln: 1.277 ± 0.386
3.575AlaArg: 3.575 ± 1.614
4.852AlaSer: 4.852 ± 1.189
2.809AlaThr: 2.809 ± 0.74
1.788AlaVal: 1.788 ± 0.526
0.766AlaTrp: 0.766 ± 0.375
2.043AlaTyr: 2.043 ± 0.934
0.0AlaXaa: 0.0 ± 0.0
Cys
1.021CysAla: 1.021 ± 0.501
0.255CysCys: 0.255 ± 0.157
0.511CysAsp: 0.511 ± 0.529
1.532CysGlu: 1.532 ± 0.849
0.766CysPhe: 0.766 ± 0.375
1.021CysGly: 1.021 ± 0.666
0.511CysHis: 0.511 ± 0.315
1.021CysIle: 1.021 ± 0.36
1.021CysLys: 1.021 ± 0.474
2.043CysLeu: 2.043 ± 1.649
0.255CysMet: 0.255 ± 0.157
0.766CysAsn: 0.766 ± 0.375
1.021CysPro: 1.021 ± 0.36
0.255CysGln: 0.255 ± 0.157
0.766CysArg: 0.766 ± 0.472
0.511CysSer: 0.511 ± 0.333
0.766CysThr: 0.766 ± 0.732
0.766CysVal: 0.766 ± 0.32
0.766CysTrp: 0.766 ± 0.458
1.021CysTyr: 1.021 ± 0.706
0.0CysXaa: 0.0 ± 0.0
Asp
1.277AspAla: 1.277 ± 0.518
1.021AspCys: 1.021 ± 0.379
5.363AspAsp: 5.363 ± 2.295
1.277AspGlu: 1.277 ± 0.61
3.83AspPhe: 3.83 ± 0.952
2.809AspGly: 2.809 ± 0.374
1.532AspHis: 1.532 ± 1.189
4.597AspIle: 4.597 ± 1.017
4.597AspLys: 4.597 ± 1.471
6.895AspLeu: 6.895 ± 1.11
1.021AspMet: 1.021 ± 0.426
2.809AspAsn: 2.809 ± 1.488
3.83AspPro: 3.83 ± 0.635
2.298AspGln: 2.298 ± 0.706
3.32AspArg: 3.32 ± 0.941
3.064AspSer: 3.064 ± 0.855
3.064AspThr: 3.064 ± 0.626
2.554AspVal: 2.554 ± 1.498
1.788AspTrp: 1.788 ± 0.993
2.043AspTyr: 2.043 ± 0.707
0.0AspXaa: 0.0 ± 0.0
Glu
2.298GluAla: 2.298 ± 0.765
0.511GluCys: 0.511 ± 0.333
4.852GluAsp: 4.852 ± 1.357
4.597GluGlu: 4.597 ± 1.302
3.064GluPhe: 3.064 ± 1.219
4.852GluGly: 4.852 ± 1.217
1.788GluHis: 1.788 ± 0.676
4.852GluIle: 4.852 ± 1.2
5.618GluLys: 5.618 ± 0.814
6.129GluLeu: 6.129 ± 1.365
1.021GluMet: 1.021 ± 0.79
2.809GluAsn: 2.809 ± 0.72
1.788GluPro: 1.788 ± 0.557
1.277GluGln: 1.277 ± 0.447
2.298GluArg: 2.298 ± 0.853
4.597GluSer: 4.597 ± 1.404
3.32GluThr: 3.32 ± 0.385
2.554GluVal: 2.554 ± 1.055
1.532GluTrp: 1.532 ± 0.849
3.064GluTyr: 3.064 ± 0.667
0.0GluXaa: 0.0 ± 0.0
Phe
2.554PheAla: 2.554 ± 0.676
0.511PheCys: 0.511 ± 0.329
3.32PheAsp: 3.32 ± 1.157
2.043PheGlu: 2.043 ± 1.024
3.83PhePhe: 3.83 ± 0.656
1.788PheGly: 1.788 ± 0.75
1.277PheHis: 1.277 ± 0.478
2.809PheIle: 2.809 ± 0.374
1.532PheLys: 1.532 ± 0.673
6.384PheLeu: 6.384 ± 0.936
1.277PheMet: 1.277 ± 0.733
2.809PheAsn: 2.809 ± 1.254
2.554PhePro: 2.554 ± 0.574
0.511PheGln: 0.511 ± 0.333
3.064PheArg: 3.064 ± 1.093
3.575PheSer: 3.575 ± 0.96
2.043PheThr: 2.043 ± 0.422
1.788PheVal: 1.788 ± 0.695
0.766PheTrp: 0.766 ± 0.472
1.277PheTyr: 1.277 ± 0.554
0.0PheXaa: 0.0 ± 0.0
Gly
1.532GlyAla: 1.532 ± 0.944
0.0GlyCys: 0.0 ± 0.0
3.32GlyAsp: 3.32 ± 0.732
3.83GlyGlu: 3.83 ± 1.059
2.554GlyPhe: 2.554 ± 0.61
5.107GlyGly: 5.107 ± 1.411
0.511GlyHis: 0.511 ± 0.315
4.341GlyIle: 4.341 ± 1.181
3.83GlyLys: 3.83 ± 0.91
9.704GlyLeu: 9.704 ± 1.22
1.532GlyMet: 1.532 ± 0.732
1.532GlyAsn: 1.532 ± 0.697
3.83GlyPro: 3.83 ± 2.164
2.809GlyGln: 2.809 ± 0.889
2.298GlyArg: 2.298 ± 0.635
4.341GlySer: 4.341 ± 0.578
3.064GlyThr: 3.064 ± 1.145
4.086GlyVal: 4.086 ± 2.342
2.554GlyTrp: 2.554 ± 0.978
1.788GlyTyr: 1.788 ± 0.947
0.0GlyXaa: 0.0 ± 0.0
His
0.766HisAla: 0.766 ± 0.346
0.511HisCys: 0.511 ± 0.333
2.043HisAsp: 2.043 ± 0.565
1.021HisGlu: 1.021 ± 0.657
1.277HisPhe: 1.277 ± 0.787
1.788HisGly: 1.788 ± 0.526
0.511HisHis: 0.511 ± 0.365
2.298HisIle: 2.298 ± 0.631
1.021HisLys: 1.021 ± 0.657
1.277HisLeu: 1.277 ± 0.596
0.766HisMet: 0.766 ± 0.877
0.766HisAsn: 0.766 ± 0.732
2.298HisPro: 2.298 ± 1.064
0.255HisGln: 0.255 ± 0.157
1.532HisArg: 1.532 ± 0.528
1.277HisSer: 1.277 ± 0.36
0.511HisThr: 0.511 ± 0.329
0.511HisVal: 0.511 ± 0.329
1.532HisTrp: 1.532 ± 0.849
0.511HisTyr: 0.511 ± 0.329
0.0HisXaa: 0.0 ± 0.0
Ile
2.809IleAla: 2.809 ± 0.616
1.021IleCys: 1.021 ± 0.36
4.086IleAsp: 4.086 ± 1.612
5.618IleGlu: 5.618 ± 1.413
3.32IlePhe: 3.32 ± 0.696
3.575IleGly: 3.575 ± 0.844
2.554IleHis: 2.554 ± 0.95
4.341IleIle: 4.341 ± 1.493
5.107IleLys: 5.107 ± 1.265
4.597IleLeu: 4.597 ± 1.418
0.766IleMet: 0.766 ± 0.408
2.809IleAsn: 2.809 ± 0.854
5.873IlePro: 5.873 ± 1.139
3.32IleGln: 3.32 ± 0.825
4.597IleArg: 4.597 ± 1.416
6.384IleSer: 6.384 ± 1.983
4.852IleThr: 4.852 ± 0.873
3.83IleVal: 3.83 ± 0.813
0.766IleTrp: 0.766 ± 0.424
2.043IleTyr: 2.043 ± 0.961
0.0IleXaa: 0.0 ± 0.0
Lys
2.298LysAla: 2.298 ± 0.777
0.766LysCys: 0.766 ± 0.732
3.575LysAsp: 3.575 ± 1.154
5.618LysGlu: 5.618 ± 0.959
3.83LysPhe: 3.83 ± 0.533
3.575LysGly: 3.575 ± 0.893
0.255LysHis: 0.255 ± 0.157
5.107LysIle: 5.107 ± 1.052
4.852LysLys: 4.852 ± 1.316
5.873LysLeu: 5.873 ± 0.876
1.788LysMet: 1.788 ± 0.392
2.809LysAsn: 2.809 ± 1.64
1.788LysPro: 1.788 ± 0.993
1.277LysGln: 1.277 ± 0.483
3.064LysArg: 3.064 ± 0.615
4.086LysSer: 4.086 ± 0.886
4.597LysThr: 4.597 ± 1.027
3.32LysVal: 3.32 ± 1.039
1.021LysTrp: 1.021 ± 0.379
2.809LysTyr: 2.809 ± 0.818
0.0LysXaa: 0.0 ± 0.0
Leu
4.852LeuAla: 4.852 ± 1.147
2.298LeuCys: 2.298 ± 0.912
5.363LeuAsp: 5.363 ± 1.726
6.384LeuGlu: 6.384 ± 1.788
4.086LeuPhe: 4.086 ± 1.188
7.15LeuGly: 7.15 ± 1.519
1.788LeuHis: 1.788 ± 1.319
8.427LeuIle: 8.427 ± 1.282
5.107LeuLys: 5.107 ± 1.108
9.193LeuLeu: 9.193 ± 2.111
2.298LeuMet: 2.298 ± 0.571
4.086LeuAsn: 4.086 ± 1.477
2.809LeuPro: 2.809 ± 1.276
2.554LeuGln: 2.554 ± 0.864
6.639LeuArg: 6.639 ± 2.144
6.384LeuSer: 6.384 ± 0.938
7.406LeuThr: 7.406 ± 0.918
5.873LeuVal: 5.873 ± 0.799
1.788LeuTrp: 1.788 ± 1.154
2.554LeuTyr: 2.554 ± 0.771
0.0LeuXaa: 0.0 ± 0.0
Met
1.277MetAla: 1.277 ± 0.787
0.511MetCys: 0.511 ± 0.329
1.021MetAsp: 1.021 ± 0.474
1.021MetGlu: 1.021 ± 0.379
1.277MetPhe: 1.277 ± 0.413
1.277MetGly: 1.277 ± 0.673
0.0MetHis: 0.0 ± 0.0
1.532MetIle: 1.532 ± 0.373
1.277MetLys: 1.277 ± 0.84
2.554MetLeu: 2.554 ± 1.101
0.766MetMet: 0.766 ± 0.556
0.511MetAsn: 0.511 ± 0.333
0.511MetPro: 0.511 ± 0.509
0.255MetGln: 0.255 ± 0.157
1.532MetArg: 1.532 ± 0.76
1.788MetSer: 1.788 ± 0.717
2.043MetThr: 2.043 ± 0.549
1.532MetVal: 1.532 ± 0.294
0.255MetTrp: 0.255 ± 0.381
0.766MetTyr: 0.766 ± 0.469
0.0MetXaa: 0.0 ± 0.0
Asn
1.532AsnAla: 1.532 ± 0.778
1.277AsnCys: 1.277 ± 0.456
2.554AsnAsp: 2.554 ± 1.056
2.043AsnGlu: 2.043 ± 1.124
1.532AsnPhe: 1.532 ± 0.812
1.021AsnGly: 1.021 ± 0.403
1.532AsnHis: 1.532 ± 0.616
2.043AsnIle: 2.043 ± 0.641
1.788AsnLys: 1.788 ± 0.84
3.83AsnLeu: 3.83 ± 0.658
0.766AsnMet: 0.766 ± 0.32
1.532AsnAsn: 1.532 ± 0.507
2.043AsnPro: 2.043 ± 0.723
1.021AsnGln: 1.021 ± 0.426
2.809AsnArg: 2.809 ± 1.244
4.086AsnSer: 4.086 ± 0.692
2.554AsnThr: 2.554 ± 0.942
2.043AsnVal: 2.043 ± 1.545
1.021AsnTrp: 1.021 ± 0.474
1.788AsnTyr: 1.788 ± 0.683
0.0AsnXaa: 0.0 ± 0.0
Pro
1.021ProAla: 1.021 ± 0.426
1.021ProCys: 1.021 ± 0.657
2.809ProAsp: 2.809 ± 1.027
2.554ProGlu: 2.554 ± 1.594
1.788ProPhe: 1.788 ± 0.61
2.554ProGly: 2.554 ± 1.171
0.766ProHis: 0.766 ± 0.414
3.32ProIle: 3.32 ± 0.636
2.809ProLys: 2.809 ± 0.803
4.852ProLeu: 4.852 ± 1.064
0.766ProMet: 0.766 ± 0.799
2.043ProAsn: 2.043 ± 0.59
2.043ProPro: 2.043 ± 1.152
2.043ProGln: 2.043 ± 1.032
3.064ProArg: 3.064 ± 0.904
5.107ProSer: 5.107 ± 1.532
3.32ProThr: 3.32 ± 0.827
3.83ProVal: 3.83 ± 0.66
0.766ProTrp: 0.766 ± 0.424
2.043ProTyr: 2.043 ± 0.324
0.0ProXaa: 0.0 ± 0.0
Gln
0.766GlnAla: 0.766 ± 0.346
0.766GlnCys: 0.766 ± 0.472
0.511GlnAsp: 0.511 ± 0.328
3.064GlnGlu: 3.064 ± 1.106
0.766GlnPhe: 0.766 ± 0.346
3.064GlnGly: 3.064 ± 1.042
1.277GlnHis: 1.277 ± 0.333
1.532GlnIle: 1.532 ± 0.373
1.532GlnLys: 1.532 ± 0.8
2.809GlnLeu: 2.809 ± 0.768
0.766GlnMet: 0.766 ± 0.375
0.511GlnAsn: 0.511 ± 0.569
1.532GlnPro: 1.532 ± 0.541
1.021GlnGln: 1.021 ± 0.364
1.021GlnArg: 1.021 ± 0.472
1.788GlnSer: 1.788 ± 0.637
2.554GlnThr: 2.554 ± 0.803
2.809GlnVal: 2.809 ± 0.623
1.277GlnTrp: 1.277 ± 0.541
1.277GlnTyr: 1.277 ± 0.796
0.0GlnXaa: 0.0 ± 0.0
Arg
3.83ArgAla: 3.83 ± 1.603
1.788ArgCys: 1.788 ± 1.171
3.32ArgAsp: 3.32 ± 0.944
3.32ArgGlu: 3.32 ± 1.268
2.809ArgPhe: 2.809 ± 0.86
3.32ArgGly: 3.32 ± 0.732
0.766ArgHis: 0.766 ± 0.472
5.107ArgIle: 5.107 ± 1.172
3.83ArgLys: 3.83 ± 0.666
3.83ArgLeu: 3.83 ± 1.033
1.277ArgMet: 1.277 ± 0.61
1.788ArgAsn: 1.788 ± 0.592
1.788ArgPro: 1.788 ± 0.876
1.788ArgGln: 1.788 ± 0.876
4.341ArgArg: 4.341 ± 2.311
5.363ArgSer: 5.363 ± 1.518
3.575ArgThr: 3.575 ± 1.227
3.064ArgVal: 3.064 ± 0.896
0.511ArgTrp: 0.511 ± 0.333
2.043ArgTyr: 2.043 ± 0.692
0.0ArgXaa: 0.0 ± 0.0
Ser
4.341SerAla: 4.341 ± 1.902
1.532SerCys: 1.532 ± 0.604
4.852SerAsp: 4.852 ± 1.08
4.852SerGlu: 4.852 ± 1.927
2.554SerPhe: 2.554 ± 0.757
4.852SerGly: 4.852 ± 0.897
1.021SerHis: 1.021 ± 0.63
5.107SerIle: 5.107 ± 1.123
4.341SerLys: 4.341 ± 1.039
8.427SerLeu: 8.427 ± 2.695
1.021SerMet: 1.021 ± 0.379
2.554SerAsn: 2.554 ± 1.222
4.086SerPro: 4.086 ± 0.896
2.554SerGln: 2.554 ± 0.67
5.618SerArg: 5.618 ± 0.889
4.341SerSer: 4.341 ± 0.914
5.107SerThr: 5.107 ± 1.4
5.873SerVal: 5.873 ± 1.308
1.788SerTrp: 1.788 ± 0.866
3.83SerTyr: 3.83 ± 0.533
0.0SerXaa: 0.0 ± 0.0
Thr
2.298ThrAla: 2.298 ± 1.07
1.277ThrCys: 1.277 ± 0.768
2.043ThrAsp: 2.043 ± 0.797
3.83ThrGlu: 3.83 ± 1.14
2.043ThrPhe: 2.043 ± 0.966
3.575ThrGly: 3.575 ± 0.844
2.043ThrHis: 2.043 ± 0.655
4.852ThrIle: 4.852 ± 0.926
6.129ThrLys: 6.129 ± 1.729
4.852ThrLeu: 4.852 ± 2.335
2.043ThrMet: 2.043 ± 0.27
1.788ThrAsn: 1.788 ± 0.526
3.575ThrPro: 3.575 ± 1.349
2.043ThrGln: 2.043 ± 0.735
2.809ThrArg: 2.809 ± 1.154
7.406ThrSer: 7.406 ± 1.044
6.129ThrThr: 6.129 ± 2.372
2.554ThrVal: 2.554 ± 0.707
1.788ThrTrp: 1.788 ± 0.683
2.809ThrTyr: 2.809 ± 0.887
0.0ThrXaa: 0.0 ± 0.0
Val
2.554ValAla: 2.554 ± 1.445
0.255ValCys: 0.255 ± 0.39
4.086ValAsp: 4.086 ± 1.017
3.064ValGlu: 3.064 ± 1.965
1.788ValPhe: 1.788 ± 0.526
4.597ValGly: 4.597 ± 1.291
2.043ValHis: 2.043 ± 0.917
4.852ValIle: 4.852 ± 0.607
3.064ValLys: 3.064 ± 1.296
4.852ValLeu: 4.852 ± 1.269
1.277ValMet: 1.277 ± 0.483
3.064ValAsn: 3.064 ± 0.99
2.554ValPro: 2.554 ± 1.003
2.043ValGln: 2.043 ± 1.029
2.809ValArg: 2.809 ± 1.128
3.83ValSer: 3.83 ± 0.698
3.32ValThr: 3.32 ± 0.415
5.618ValVal: 5.618 ± 2.178
0.766ValTrp: 0.766 ± 0.451
1.021ValTyr: 1.021 ± 0.63
0.0ValXaa: 0.0 ± 0.0
Trp
0.511TrpAla: 0.511 ± 0.315
0.0TrpCys: 0.0 ± 0.0
1.021TrpAsp: 1.021 ± 0.472
2.298TrpGlu: 2.298 ± 0.942
1.532TrpPhe: 1.532 ± 0.608
2.298TrpGly: 2.298 ± 0.746
0.511TrpHis: 0.511 ± 0.315
1.788TrpIle: 1.788 ± 0.76
1.277TrpLys: 1.277 ± 0.754
1.277TrpLeu: 1.277 ± 0.461
0.766TrpMet: 0.766 ± 0.8
1.021TrpAsn: 1.021 ± 0.474
1.021TrpPro: 1.021 ± 0.379
0.0TrpGln: 0.0 ± 0.0
0.255TrpArg: 0.255 ± 0.353
1.788TrpSer: 1.788 ± 0.38
2.298TrpThr: 2.298 ± 1.365
2.043TrpVal: 2.043 ± 1.371
0.0TrpTrp: 0.0 ± 0.0
0.511TrpTyr: 0.511 ± 0.569
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.277TyrAla: 1.277 ± 0.69
1.021TyrCys: 1.021 ± 0.379
2.554TyrAsp: 2.554 ± 1.339
2.298TyrGlu: 2.298 ± 0.565
1.788TyrPhe: 1.788 ± 0.814
2.298TyrGly: 2.298 ± 0.645
0.766TyrHis: 0.766 ± 0.346
1.277TyrIle: 1.277 ± 0.634
1.532TyrLys: 1.532 ± 0.75
3.575TyrLeu: 3.575 ± 1.346
0.511TyrMet: 0.511 ± 0.52
2.043TyrAsn: 2.043 ± 0.731
1.788TyrPro: 1.788 ± 0.557
2.043TyrGln: 2.043 ± 1.244
2.043TyrArg: 2.043 ± 0.78
4.086TyrSer: 4.086 ± 0.636
2.554TyrThr: 2.554 ± 0.574
1.021TyrVal: 1.021 ± 0.379
0.766TyrTrp: 0.766 ± 0.375
1.021TyrTyr: 1.021 ± 0.535
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski