Amino acid dipepetide frequency for Halorubrum hochstenium ATCC 700873

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.41AlaAla: 18.41 ± 0.23	0.731AlaCys: 0.731 ± 0.03	12.433AlaAsp: 12.433 ± 0.149	10.022AlaGlu: 10.022 ± 0.138	4.415AlaPhe: 4.415 ± 0.073	11.636AlaGly: 11.636 ± 0.137	1.769AlaHis: 1.769 ± 0.049	4.248AlaIle: 4.248 ± 0.08	1.647AlaLys: 1.647 ± 0.044	11.475AlaLeu: 11.475 ± 0.158	2.075AlaMet: 2.075 ± 0.047	2.349AlaAsn: 2.349 ± 0.053	4.489AlaPro: 4.489 ± 0.081	1.743AlaGln: 1.743 ± 0.044	6.823AlaArg: 6.823 ± 0.098	5.847AlaSer: 5.847 ± 0.092	7.45AlaThr: 7.45 ± 0.107	13.217AlaVal: 13.217 ± 0.154	1.213AlaTrp: 1.213 ± 0.043	2.862AlaTyr: 2.862 ± 0.059	0.002AlaXaa: 0.002 ± 0.002
Cys	0.621CysAla: 0.621 ± 0.028	0.066CysCys: 0.066 ± 0.008	0.516CysAsp: 0.516 ± 0.026	0.52CysGlu: 0.52 ± 0.028	0.184CysPhe: 0.184 ± 0.014	0.816CysGly: 0.816 ± 0.037	0.169CysHis: 0.169 ± 0.015	0.189CysIle: 0.189 ± 0.015	0.077CysLys: 0.077 ± 0.01	0.494CysLeu: 0.494 ± 0.028	0.089CysMet: 0.089 ± 0.011	0.153CysAsn: 0.153 ± 0.014	0.516CysPro: 0.516 ± 0.024	0.107CysGln: 0.107 ± 0.011	0.456CysArg: 0.456 ± 0.025	0.365CysSer: 0.365 ± 0.023	0.327CysThr: 0.327 ± 0.02	0.457CysVal: 0.457 ± 0.023	0.07CysTrp: 0.07 ± 0.009	0.162CysTyr: 0.162 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	13.868AspAla: 13.868 ± 0.191	0.566AspCys: 0.566 ± 0.027	9.116AspAsp: 9.116 ± 0.141	8.6AspGlu: 8.6 ± 0.126	1.88AspPhe: 1.88 ± 0.045	10.251AspGly: 10.251 ± 0.134	1.875AspHis: 1.875 ± 0.057	2.328AspIle: 2.328 ± 0.057	0.815AspLys: 0.815 ± 0.036	7.733AspLeu: 7.733 ± 0.092	1.189AspMet: 1.189 ± 0.031	1.063AspAsn: 1.063 ± 0.04	5.919AspPro: 5.919 ± 0.101	1.338AspGln: 1.338 ± 0.048	8.049AspArg: 8.049 ± 0.122	3.279AspSer: 3.279 ± 0.074	3.558AspThr: 3.558 ± 0.068	7.886AspVal: 7.886 ± 0.11	0.999AspTrp: 0.999 ± 0.036	1.652AspTyr: 1.652 ± 0.043	0.002AspXaa: 0.002 ± 0.002
Glu	9.979GluAla: 9.979 ± 0.161	0.456GluCys: 0.456 ± 0.025	5.046GluAsp: 5.046 ± 0.089	6.625GluGlu: 6.625 ± 0.132	2.983GluPhe: 2.983 ± 0.058	6.172GluGly: 6.172 ± 0.089	1.583GluHis: 1.583 ± 0.048	3.481GluIle: 3.481 ± 0.079	1.56GluLys: 1.56 ± 0.049	6.902GluLeu: 6.902 ± 0.095	1.718GluMet: 1.718 ± 0.04	1.908GluAsn: 1.908 ± 0.051	4.52GluPro: 4.52 ± 0.069	1.872GluGln: 1.872 ± 0.055	8.344GluArg: 8.344 ± 0.136	5.397GluSer: 5.397 ± 0.095	6.611GluThr: 6.611 ± 0.104	6.193GluVal: 6.193 ± 0.101	1.05GluTrp: 1.05 ± 0.035	2.512GluTyr: 2.512 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	4.139PheAla: 4.139 ± 0.075	0.242PheCys: 0.242 ± 0.014	3.407PheAsp: 3.407 ± 0.071	3.07PheGlu: 3.07 ± 0.07	0.951PhePhe: 0.951 ± 0.037	3.311PheGly: 3.311 ± 0.067	0.584PheHis: 0.584 ± 0.03	0.831PheIle: 0.831 ± 0.032	0.393PheLys: 0.393 ± 0.02	2.687PheLeu: 2.687 ± 0.067	0.463PheMet: 0.463 ± 0.023	0.633PheAsn: 0.633 ± 0.027	1.331PhePro: 1.331 ± 0.045	0.614PheGln: 0.614 ± 0.031	1.904PheArg: 1.904 ± 0.049	1.564PheSer: 1.564 ± 0.049	1.655PheThr: 1.655 ± 0.049	3.158PheVal: 3.158 ± 0.064	0.355PheTrp: 0.355 ± 0.018	0.768PheTyr: 0.768 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.319GlyAla: 9.319 ± 0.111	0.641GlyCys: 0.641 ± 0.027	8.998GlyAsp: 8.998 ± 0.129	8.012GlyGlu: 8.012 ± 0.091	3.322GlyPhe: 3.322 ± 0.063	9.466GlyGly: 9.466 ± 0.147	1.626GlyHis: 1.626 ± 0.054	3.818GlyIle: 3.818 ± 0.073	1.69GlyLys: 1.69 ± 0.047	7.508GlyLeu: 7.508 ± 0.112	1.551GlyMet: 1.551 ± 0.049	1.882GlyAsn: 1.882 ± 0.055	3.969GlyPro: 3.969 ± 0.081	1.665GlyGln: 1.665 ± 0.048	5.425GlyArg: 5.425 ± 0.097	5.627GlySer: 5.627 ± 0.092	5.745GlyThr: 5.745 ± 0.086	8.861GlyVal: 8.861 ± 0.1	1.059GlyTrp: 1.059 ± 0.038	2.624GlyTyr: 2.624 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.117HisAla: 2.117 ± 0.051	0.149HisCys: 0.149 ± 0.014	1.622HisAsp: 1.622 ± 0.052	1.5HisGlu: 1.5 ± 0.049	0.477HisPhe: 0.477 ± 0.024	1.838HisGly: 1.838 ± 0.047	0.439HisHis: 0.439 ± 0.024	0.429HisIle: 0.429 ± 0.023	0.252HisLys: 0.252 ± 0.017	1.502HisLeu: 1.502 ± 0.046	0.253HisMet: 0.253 ± 0.017	0.401HisAsn: 0.401 ± 0.024	1.101HisPro: 1.101 ± 0.034	0.34HisGln: 0.34 ± 0.022	1.215HisArg: 1.215 ± 0.036	0.704HisSer: 0.704 ± 0.029	0.893HisThr: 0.893 ± 0.032	1.792HisVal: 1.792 ± 0.052	0.21HisTrp: 0.21 ± 0.016	0.515HisTyr: 0.515 ± 0.023	0.001HisXaa: 0.001 ± 0.001
Ile	4.625IleAla: 4.625 ± 0.079	0.245IleCys: 0.245 ± 0.016	3.606IleAsp: 3.606 ± 0.07	3.78IleGlu: 3.78 ± 0.075	0.764IlePhe: 0.764 ± 0.042	3.503IleGly: 3.503 ± 0.082	0.674IleHis: 0.674 ± 0.031	0.919IleIle: 0.919 ± 0.041	0.566IleLys: 0.566 ± 0.022	2.373IleLeu: 2.373 ± 0.066	0.381IleMet: 0.381 ± 0.024	0.812IleAsn: 0.812 ± 0.037	1.772IlePro: 1.772 ± 0.049	0.792IleGln: 0.792 ± 0.036	2.271IleArg: 2.271 ± 0.05	1.612IleSer: 1.612 ± 0.052	1.863IleThr: 1.863 ± 0.05	3.082IleVal: 3.082 ± 0.067	0.226IleTrp: 0.226 ± 0.016	0.704IleTyr: 0.704 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.629LysAla: 1.629 ± 0.054	0.096LysCys: 0.096 ± 0.012	0.852LysAsp: 0.852 ± 0.035	1.153LysGlu: 1.153 ± 0.043	0.436LysPhe: 0.436 ± 0.022	1.229LysGly: 1.229 ± 0.041	0.371LysHis: 0.371 ± 0.02	0.578LysIle: 0.578 ± 0.026	0.421LysLys: 0.421 ± 0.028	1.394LysLeu: 1.394 ± 0.041	0.288LysMet: 0.288 ± 0.02	0.404LysAsn: 0.404 ± 0.023	0.824LysPro: 0.824 ± 0.029	0.57LysGln: 0.57 ± 0.029	1.57LysArg: 1.57 ± 0.047	0.977LysSer: 0.977 ± 0.033	1.043LysThr: 1.043 ± 0.036	1.05LysVal: 1.05 ± 0.039	0.212LysTrp: 0.212 ± 0.017	0.486LysTyr: 0.486 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	11.685LeuAla: 11.685 ± 0.146	0.506LeuCys: 0.506 ± 0.023	8.232LeuAsp: 8.232 ± 0.108	5.468LeuGlu: 5.468 ± 0.089	2.917LeuPhe: 2.917 ± 0.076	7.669LeuGly: 7.669 ± 0.108	1.27LeuHis: 1.27 ± 0.033	2.801LeuIle: 2.801 ± 0.066	1.356LeuLys: 1.356 ± 0.046	8.036LeuLeu: 8.036 ± 0.157	1.178LeuMet: 1.178 ± 0.039	1.621LeuAsn: 1.621 ± 0.043	4.131LeuPro: 4.131 ± 0.072	1.451LeuGln: 1.451 ± 0.046	6.124LeuArg: 6.124 ± 0.09	5.355LeuSer: 5.355 ± 0.089	4.682LeuThr: 4.682 ± 0.066	8.044LeuVal: 8.044 ± 0.113	0.804LeuTrp: 0.804 ± 0.032	1.981LeuTyr: 1.981 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.721MetAla: 1.721 ± 0.046	0.114MetCys: 0.114 ± 0.01	1.186MetAsp: 1.186 ± 0.038	1.027MetGlu: 1.027 ± 0.035	0.456MetPhe: 0.456 ± 0.027	1.248MetGly: 1.248 ± 0.044	0.213MetHis: 0.213 ± 0.015	0.578MetIle: 0.578 ± 0.023	0.394MetLys: 0.394 ± 0.022	1.245MetLeu: 1.245 ± 0.038	0.247MetMet: 0.247 ± 0.018	0.51MetAsn: 0.51 ± 0.025	0.733MetPro: 0.733 ± 0.03	0.311MetGln: 0.311 ± 0.021	1.111MetArg: 1.111 ± 0.036	1.46MetSer: 1.46 ± 0.037	1.394MetThr: 1.394 ± 0.043	1.148MetVal: 1.148 ± 0.034	0.143MetTrp: 0.143 ± 0.015	0.408MetTyr: 0.408 ± 0.024	0.001MetXaa: 0.001 ± 0.001
Asn	2.627AsnAla: 2.627 ± 0.063	0.178AsnCys: 0.178 ± 0.014	1.563AsnAsp: 1.563 ± 0.043	1.628AsnGlu: 1.628 ± 0.044	0.6AsnPhe: 0.6 ± 0.03	1.81AsnGly: 1.81 ± 0.048	0.387AsnHis: 0.387 ± 0.02	0.643AsnIle: 0.643 ± 0.028	0.331AsnLys: 0.331 ± 0.022	1.705AsnLeu: 1.705 ± 0.048	0.345AsnMet: 0.345 ± 0.019	0.446AsnAsn: 0.446 ± 0.027	1.396AsnPro: 1.396 ± 0.039	0.48AsnGln: 0.48 ± 0.028	1.432AsnArg: 1.432 ± 0.042	0.778AsnSer: 0.778 ± 0.03	1.06AsnThr: 1.06 ± 0.038	2.116AsnVal: 2.116 ± 0.048	0.252AsnTrp: 0.252 ± 0.02	0.531AsnTyr: 0.531 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.518ProAla: 5.518 ± 0.085	0.226ProCys: 0.226 ± 0.016	5.742ProAsp: 5.742 ± 0.097	4.836ProGlu: 4.836 ± 0.076	1.626ProPhe: 1.626 ± 0.042	4.371ProGly: 4.371 ± 0.079	0.865ProHis: 0.865 ± 0.036	1.733ProIle: 1.733 ± 0.044	0.718ProLys: 0.718 ± 0.033	3.644ProLeu: 3.644 ± 0.075	0.749ProMet: 0.749 ± 0.027	1.06ProAsn: 1.06 ± 0.033	2.316ProPro: 2.316 ± 0.056	0.76ProGln: 0.76 ± 0.034	2.501ProArg: 2.501 ± 0.056	2.663ProSer: 2.663 ± 0.059	3.186ProThr: 3.186 ± 0.064	4.6ProVal: 4.6 ± 0.079	0.468ProTrp: 0.468 ± 0.023	1.091ProTyr: 1.091 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.889GlnAla: 1.889 ± 0.043	0.117GlnCys: 0.117 ± 0.011	0.975GlnAsp: 0.975 ± 0.037	1.304GlnGlu: 1.304 ± 0.042	0.79GlnPhe: 0.79 ± 0.028	1.326GlnGly: 1.326 ± 0.035	0.385GlnHis: 0.385 ± 0.022	0.922GlnIle: 0.922 ± 0.035	0.458GlnLys: 0.458 ± 0.024	1.745GlnLeu: 1.745 ± 0.051	0.423GlnMet: 0.423 ± 0.021	0.538GlnAsn: 0.538 ± 0.026	0.839GlnPro: 0.839 ± 0.036	0.677GlnGln: 0.677 ± 0.034	1.616GlnArg: 1.616 ± 0.047	1.139GlnSer: 1.139 ± 0.039	1.15GlnThr: 1.15 ± 0.037	1.417GlnVal: 1.417 ± 0.046	0.27GlnTrp: 0.27 ± 0.02	0.611GlnTyr: 0.611 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.322ArgAla: 7.322 ± 0.118	0.453ArgCys: 0.453 ± 0.027	6.026ArgAsp: 6.026 ± 0.1	7.308ArgGlu: 7.308 ± 0.113	2.486ArgPhe: 2.486 ± 0.051	5.134ArgGly: 5.134 ± 0.089	1.204ArgHis: 1.204 ± 0.045	3.026ArgIle: 3.026 ± 0.059	1.224ArgLys: 1.224 ± 0.044	6.457ArgLeu: 6.457 ± 0.101	1.264ArgMet: 1.264 ± 0.037	1.623ArgAsn: 1.623 ± 0.046	2.843ArgPro: 2.843 ± 0.058	1.481ArgGln: 1.481 ± 0.044	5.368ArgArg: 5.368 ± 0.102	3.743ArgSer: 3.743 ± 0.068	3.919ArgThr: 3.919 ± 0.072	6.188ArgVal: 6.188 ± 0.095	0.798ArgTrp: 0.798 ± 0.03	2.007ArgTyr: 2.007 ± 0.052	0.001ArgXaa: 0.001 ± 0.001
Ser	5.835SerAla: 5.835 ± 0.088	0.275SerCys: 0.275 ± 0.021	4.802SerAsp: 4.802 ± 0.084	4.185SerGlu: 4.185 ± 0.077	1.755SerPhe: 1.755 ± 0.043	5.566SerGly: 5.566 ± 0.094	0.874SerHis: 0.874 ± 0.032	1.887SerIle: 1.887 ± 0.054	0.96SerLys: 0.96 ± 0.035	4.509SerLeu: 4.509 ± 0.076	0.893SerMet: 0.893 ± 0.031	1.081SerAsn: 1.081 ± 0.042	2.677SerPro: 2.677 ± 0.06	1.008SerGln: 1.008 ± 0.038	3.335SerArg: 3.335 ± 0.064	2.537SerSer: 2.537 ± 0.071	3.186SerThr: 3.186 ± 0.068	5.023SerVal: 5.023 ± 0.087	0.566SerTrp: 0.566 ± 0.026	1.259SerTyr: 1.259 ± 0.04	0.002SerXaa: 0.002 ± 0.001
Thr	7.128ThrAla: 7.128 ± 0.098	0.332ThrCys: 0.332 ± 0.017	5.624ThrAsp: 5.624 ± 0.09	4.501ThrGlu: 4.501 ± 0.073	1.974ThrPhe: 1.974 ± 0.051	5.785ThrGly: 5.785 ± 0.082	1.083ThrHis: 1.083 ± 0.038	2.057ThrIle: 2.057 ± 0.047	0.847ThrLys: 0.847 ± 0.031	5.322ThrLeu: 5.322 ± 0.08	0.811ThrMet: 0.811 ± 0.035	1.207ThrAsn: 1.207 ± 0.037	3.155ThrPro: 3.155 ± 0.063	1.059ThrGln: 1.059 ± 0.045	3.306ThrArg: 3.306 ± 0.063	2.395ThrSer: 2.395 ± 0.056	3.791ThrThr: 3.791 ± 0.072	6.973ThrVal: 6.973 ± 0.104	0.505ThrTrp: 0.505 ± 0.025	1.528ThrTyr: 1.528 ± 0.045	0.001ThrXaa: 0.001 ± 0.001
Val	12.546ValAla: 12.546 ± 0.157	0.667ValCys: 0.667 ± 0.03	9.109ValAsp: 9.109 ± 0.106	8.256ValGlu: 8.256 ± 0.116	2.891ValPhe: 2.891 ± 0.071	8.642ValGly: 8.642 ± 0.127	1.641ValHis: 1.641 ± 0.046	3.073ValIle: 3.073 ± 0.068	1.301ValLys: 1.301 ± 0.039	7.139ValLeu: 7.139 ± 0.116	1.232ValMet: 1.232 ± 0.046	1.797ValAsn: 1.797 ± 0.041	4.506ValPro: 4.506 ± 0.078	1.487ValGln: 1.487 ± 0.043	6.21ValArg: 6.21 ± 0.098	5.172ValSer: 5.172 ± 0.083	5.843ValThr: 5.843 ± 0.085	9.551ValVal: 9.551 ± 0.126	0.806ValTrp: 0.806 ± 0.033	2.02ValTyr: 2.02 ± 0.049	0.001ValXaa: 0.001 ± 0.001
Trp	0.967TrpAla: 0.967 ± 0.037	0.098TrpCys: 0.098 ± 0.011	0.706TrpAsp: 0.706 ± 0.028	0.769TrpGlu: 0.769 ± 0.034	0.401TrpPhe: 0.401 ± 0.024	0.782TrpGly: 0.782 ± 0.032	0.202TrpHis: 0.202 ± 0.016	0.468TrpIle: 0.468 ± 0.025	0.216TrpLys: 0.216 ± 0.014	1.135TrpLeu: 1.135 ± 0.034	0.184TrpMet: 0.184 ± 0.014	0.311TrpAsn: 0.311 ± 0.019	0.434TrpPro: 0.434 ± 0.024	0.28TrpGln: 0.28 ± 0.02	0.898TrpArg: 0.898 ± 0.035	0.547TrpSer: 0.547 ± 0.029	0.745TrpThr: 0.745 ± 0.031	0.841TrpVal: 0.841 ± 0.035	0.138TrpTrp: 0.138 ± 0.014	0.339TrpTyr: 0.339 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.909TyrAla: 2.909 ± 0.056	0.196TyrCys: 0.196 ± 0.014	2.404TyrAsp: 2.404 ± 0.051	2.349TyrGlu: 2.349 ± 0.063	0.752TyrPhe: 0.752 ± 0.027	2.253TyrGly: 2.253 ± 0.058	0.54TyrHis: 0.54 ± 0.027	0.562TyrIle: 0.562 ± 0.029	0.357TyrLys: 0.357 ± 0.02	2.305TyrLeu: 2.305 ± 0.058	0.315TyrMet: 0.315 ± 0.019	0.508TyrAsn: 0.508 ± 0.029	1.2TyrPro: 1.2 ± 0.036	0.555TyrGln: 0.555 ± 0.027	1.916TyrArg: 1.916 ± 0.051	1.055TyrSer: 1.055 ± 0.035	1.281TyrThr: 1.281 ± 0.041	2.291TyrVal: 2.291 ± 0.059	0.315TyrTrp: 0.315 ± 0.02	0.709TyrTyr: 0.709 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.004

Statistics based on 2931 proteins (858121 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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