Amino acid dipepetide frequency for Streptococcus phage Javan489

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.459AlaAla: 4.459 ± 1.418
0.243AlaCys: 0.243 ± 0.117
4.459AlaAsp: 4.459 ± 0.643
5.351AlaGlu: 5.351 ± 0.835
3.405AlaPhe: 3.405 ± 0.713
4.621AlaGly: 4.621 ± 1.117
0.568AlaHis: 0.568 ± 0.289
5.513AlaIle: 5.513 ± 1.108
6.81AlaLys: 6.81 ± 0.969
5.594AlaLeu: 5.594 ± 0.63
3.243AlaMet: 3.243 ± 0.565
4.621AlaAsn: 4.621 ± 0.581
0.811AlaPro: 0.811 ± 0.236
3.567AlaGln: 3.567 ± 0.617
2.108AlaArg: 2.108 ± 0.385
4.621AlaSer: 4.621 ± 0.819
4.459AlaThr: 4.459 ± 0.851
4.865AlaVal: 4.865 ± 1.227
0.892AlaTrp: 0.892 ± 0.292
2.27AlaTyr: 2.27 ± 0.451
0.0AlaXaa: 0.0 ± 0.0
Cys
0.324CysAla: 0.324 ± 0.157
0.081CysCys: 0.081 ± 0.082
0.405CysAsp: 0.405 ± 0.188
0.649CysGlu: 0.649 ± 0.208
0.162CysPhe: 0.162 ± 0.125
0.405CysGly: 0.405 ± 0.18
0.0CysHis: 0.0 ± 0.0
0.243CysIle: 0.243 ± 0.134
0.405CysLys: 0.405 ± 0.162
0.486CysLeu: 0.486 ± 0.18
0.0CysMet: 0.0 ± 0.0
0.243CysAsn: 0.243 ± 0.143
0.081CysPro: 0.081 ± 0.087
0.243CysGln: 0.243 ± 0.137
0.405CysArg: 0.405 ± 0.2
0.081CysSer: 0.081 ± 0.08
0.162CysThr: 0.162 ± 0.103
0.243CysVal: 0.243 ± 0.141
0.162CysTrp: 0.162 ± 0.108
0.243CysTyr: 0.243 ± 0.132
0.0CysXaa: 0.0 ± 0.0
Asp
2.919AspAla: 2.919 ± 0.486
0.405AspCys: 0.405 ± 0.196
3.081AspAsp: 3.081 ± 0.503
3.973AspGlu: 3.973 ± 0.687
3.081AspPhe: 3.081 ± 0.553
4.54AspGly: 4.54 ± 0.721
0.973AspHis: 0.973 ± 0.279
5.351AspIle: 5.351 ± 0.695
6.405AspLys: 6.405 ± 0.633
5.189AspLeu: 5.189 ± 0.713
1.54AspMet: 1.54 ± 0.319
3.162AspAsn: 3.162 ± 0.578
1.865AspPro: 1.865 ± 0.34
1.865AspGln: 1.865 ± 0.342
2.513AspArg: 2.513 ± 0.383
4.054AspSer: 4.054 ± 0.585
3.324AspThr: 3.324 ± 0.526
4.135AspVal: 4.135 ± 0.485
0.892AspTrp: 0.892 ± 0.321
3.324AspTyr: 3.324 ± 0.636
0.0AspXaa: 0.0 ± 0.0
Glu
5.432GluAla: 5.432 ± 0.607
0.162GluCys: 0.162 ± 0.113
3.0GluAsp: 3.0 ± 0.663
5.027GluGlu: 5.027 ± 1.014
2.757GluPhe: 2.757 ± 0.447
3.324GluGly: 3.324 ± 0.4
1.297GluHis: 1.297 ± 0.323
5.189GluIle: 5.189 ± 0.765
6.973GluLys: 6.973 ± 0.868
7.216GluLeu: 7.216 ± 0.927
2.27GluMet: 2.27 ± 0.405
3.486GluAsn: 3.486 ± 0.637
2.108GluPro: 2.108 ± 0.465
3.405GluGln: 3.405 ± 0.6
3.324GluArg: 3.324 ± 0.581
3.73GluSer: 3.73 ± 0.457
4.297GluThr: 4.297 ± 0.711
5.432GluVal: 5.432 ± 0.854
0.405GluTrp: 0.405 ± 0.198
3.405GluTyr: 3.405 ± 0.546
0.0GluXaa: 0.0 ± 0.0
Phe
2.838PheAla: 2.838 ± 0.646
0.243PheCys: 0.243 ± 0.14
3.081PheAsp: 3.081 ± 0.351
3.405PheGlu: 3.405 ± 0.494
1.378PhePhe: 1.378 ± 0.356
3.648PheGly: 3.648 ± 0.593
0.568PheHis: 0.568 ± 0.226
2.838PheIle: 2.838 ± 0.534
4.297PheLys: 4.297 ± 0.534
2.189PheLeu: 2.189 ± 0.369
0.811PheMet: 0.811 ± 0.253
2.594PheAsn: 2.594 ± 0.497
0.568PhePro: 0.568 ± 0.231
0.811PheGln: 0.811 ± 0.216
2.108PheArg: 2.108 ± 0.365
2.838PheSer: 2.838 ± 0.499
2.189PheThr: 2.189 ± 0.389
2.432PheVal: 2.432 ± 0.36
0.243PheTrp: 0.243 ± 0.124
1.216PheTyr: 1.216 ± 0.304
0.0PheXaa: 0.0 ± 0.0
Gly
4.378GlyAla: 4.378 ± 1.021
0.162GlyCys: 0.162 ± 0.105
3.973GlyAsp: 3.973 ± 0.786
3.405GlyGlu: 3.405 ± 0.426
2.919GlyPhe: 2.919 ± 0.512
3.892GlyGly: 3.892 ± 0.798
0.568GlyHis: 0.568 ± 0.223
3.892GlyIle: 3.892 ± 0.666
6.081GlyLys: 6.081 ± 0.65
5.675GlyLeu: 5.675 ± 1.13
1.784GlyMet: 1.784 ± 0.382
2.757GlyAsn: 2.757 ± 0.425
0.811GlyPro: 0.811 ± 0.307
2.27GlyGln: 2.27 ± 0.455
2.351GlyArg: 2.351 ± 0.412
3.405GlySer: 3.405 ± 0.605
4.946GlyThr: 4.946 ± 0.653
4.297GlyVal: 4.297 ± 0.55
0.73GlyTrp: 0.73 ± 0.247
3.0GlyTyr: 3.0 ± 0.564
0.0GlyXaa: 0.0 ± 0.0
His
0.649HisAla: 0.649 ± 0.214
0.0HisCys: 0.0 ± 0.0
0.568HisAsp: 0.568 ± 0.189
1.054HisGlu: 1.054 ± 0.311
0.73HisPhe: 0.73 ± 0.236
0.649HisGly: 0.649 ± 0.19
0.162HisHis: 0.162 ± 0.117
1.054HisIle: 1.054 ± 0.339
1.297HisLys: 1.297 ± 0.351
0.892HisLeu: 0.892 ± 0.29
0.162HisMet: 0.162 ± 0.101
0.811HisAsn: 0.811 ± 0.292
0.568HisPro: 0.568 ± 0.207
0.811HisGln: 0.811 ± 0.234
0.649HisArg: 0.649 ± 0.196
0.973HisSer: 0.973 ± 0.244
0.73HisThr: 0.73 ± 0.212
1.054HisVal: 1.054 ± 0.274
0.243HisTrp: 0.243 ± 0.13
0.486HisTyr: 0.486 ± 0.235
0.0HisXaa: 0.0 ± 0.0
Ile
5.108IleAla: 5.108 ± 0.629
0.243IleCys: 0.243 ± 0.149
6.405IleAsp: 6.405 ± 0.662
4.459IleGlu: 4.459 ± 0.618
2.432IlePhe: 2.432 ± 0.517
4.054IleGly: 4.054 ± 0.682
1.297IleHis: 1.297 ± 0.347
4.621IleIle: 4.621 ± 0.56
7.135IleLys: 7.135 ± 0.749
4.135IleLeu: 4.135 ± 0.539
1.054IleMet: 1.054 ± 0.236
5.432IleAsn: 5.432 ± 0.626
1.865IlePro: 1.865 ± 0.396
3.0IleGln: 3.0 ± 0.459
2.838IleArg: 2.838 ± 0.513
5.513IleSer: 5.513 ± 0.953
4.946IleThr: 4.946 ± 0.513
3.973IleVal: 3.973 ± 0.538
0.568IleTrp: 0.568 ± 0.212
2.432IleTyr: 2.432 ± 0.492
0.0IleXaa: 0.0 ± 0.0
Lys
6.892LysAla: 6.892 ± 0.847
0.0LysCys: 0.0 ± 0.0
4.865LysAsp: 4.865 ± 0.658
7.054LysGlu: 7.054 ± 0.84
3.324LysPhe: 3.324 ± 0.483
4.946LysGly: 4.946 ± 0.744
1.459LysHis: 1.459 ± 0.337
6.405LysIle: 6.405 ± 0.83
7.783LysLys: 7.783 ± 1.058
7.864LysLeu: 7.864 ± 0.873
2.757LysMet: 2.757 ± 0.407
5.189LysAsn: 5.189 ± 0.489
2.594LysPro: 2.594 ± 0.627
4.946LysGln: 4.946 ± 0.625
4.216LysArg: 4.216 ± 0.612
5.27LysSer: 5.27 ± 0.59
5.351LysThr: 5.351 ± 0.596
6.243LysVal: 6.243 ± 0.863
0.973LysTrp: 0.973 ± 0.264
3.405LysTyr: 3.405 ± 0.53
0.0LysXaa: 0.0 ± 0.0
Leu
6.567LeuAla: 6.567 ± 0.877
0.243LeuCys: 0.243 ± 0.142
7.297LeuAsp: 7.297 ± 0.704
8.27LeuGlu: 8.27 ± 0.885
3.0LeuPhe: 3.0 ± 0.438
5.27LeuGly: 5.27 ± 0.823
0.811LeuHis: 0.811 ± 0.274
4.946LeuIle: 4.946 ± 0.741
8.351LeuLys: 8.351 ± 0.919
6.243LeuLeu: 6.243 ± 0.735
1.946LeuMet: 1.946 ± 0.318
5.027LeuAsn: 5.027 ± 0.649
2.027LeuPro: 2.027 ± 0.35
3.081LeuGln: 3.081 ± 0.447
3.0LeuArg: 3.0 ± 0.538
6.0LeuSer: 6.0 ± 0.745
6.162LeuThr: 6.162 ± 0.565
4.297LeuVal: 4.297 ± 0.458
0.405LeuTrp: 0.405 ± 0.178
1.622LeuTyr: 1.622 ± 0.472
0.0LeuXaa: 0.0 ± 0.0
Met
3.405MetAla: 3.405 ± 0.632
0.0MetCys: 0.0 ± 0.0
1.378MetAsp: 1.378 ± 0.382
1.622MetGlu: 1.622 ± 0.378
1.054MetPhe: 1.054 ± 0.241
0.973MetGly: 0.973 ± 0.313
0.0MetHis: 0.0 ± 0.0
1.946MetIle: 1.946 ± 0.32
1.216MetLys: 1.216 ± 0.269
2.838MetLeu: 2.838 ± 0.442
0.324MetMet: 0.324 ± 0.152
1.297MetAsn: 1.297 ± 0.275
0.568MetPro: 0.568 ± 0.205
1.622MetGln: 1.622 ± 0.323
1.297MetArg: 1.297 ± 0.31
1.297MetSer: 1.297 ± 0.247
2.189MetThr: 2.189 ± 0.418
0.811MetVal: 0.811 ± 0.236
0.243MetTrp: 0.243 ± 0.128
0.568MetTyr: 0.568 ± 0.171
0.0MetXaa: 0.0 ± 0.0
Asn
4.459AsnAla: 4.459 ± 0.908
0.486AsnCys: 0.486 ± 0.175
2.108AsnAsp: 2.108 ± 0.409
3.811AsnGlu: 3.811 ± 0.663
2.027AsnPhe: 2.027 ± 0.33
4.297AsnGly: 4.297 ± 0.664
0.73AsnHis: 0.73 ± 0.246
4.297AsnIle: 4.297 ± 0.737
4.621AsnLys: 4.621 ± 0.586
6.324AsnLeu: 6.324 ± 0.497
0.973AsnMet: 0.973 ± 0.272
2.108AsnAsn: 2.108 ± 0.434
1.54AsnPro: 1.54 ± 0.365
2.919AsnGln: 2.919 ± 0.519
1.946AsnArg: 1.946 ± 0.543
3.405AsnSer: 3.405 ± 0.729
2.838AsnThr: 2.838 ± 0.519
2.594AsnVal: 2.594 ± 0.45
0.649AsnTrp: 0.649 ± 0.241
1.784AsnTyr: 1.784 ± 0.349
0.0AsnXaa: 0.0 ± 0.0
Pro
1.297ProAla: 1.297 ± 0.332
0.081ProCys: 0.081 ± 0.089
1.784ProAsp: 1.784 ± 0.348
1.784ProGlu: 1.784 ± 0.368
1.216ProPhe: 1.216 ± 0.289
0.811ProGly: 0.811 ± 0.214
0.324ProHis: 0.324 ± 0.147
1.784ProIle: 1.784 ± 0.308
2.351ProLys: 2.351 ± 0.43
1.703ProLeu: 1.703 ± 0.349
0.486ProMet: 0.486 ± 0.165
1.135ProAsn: 1.135 ± 0.286
0.892ProPro: 0.892 ± 0.32
1.459ProGln: 1.459 ± 0.301
0.811ProArg: 0.811 ± 0.245
1.459ProSer: 1.459 ± 0.334
1.865ProThr: 1.865 ± 0.381
2.027ProVal: 2.027 ± 0.402
0.243ProTrp: 0.243 ± 0.181
0.973ProTyr: 0.973 ± 0.398
0.0ProXaa: 0.0 ± 0.0
Gln
3.973GlnAla: 3.973 ± 0.95
0.649GlnCys: 0.649 ± 0.235
1.784GlnAsp: 1.784 ± 0.411
3.648GlnGlu: 3.648 ± 0.565
1.378GlnPhe: 1.378 ± 0.322
2.757GlnGly: 2.757 ± 0.454
0.486GlnHis: 0.486 ± 0.208
3.648GlnIle: 3.648 ± 0.426
4.297GlnLys: 4.297 ± 0.589
4.621GlnLeu: 4.621 ± 0.668
0.973GlnMet: 0.973 ± 0.28
2.432GlnAsn: 2.432 ± 0.445
1.054GlnPro: 1.054 ± 0.259
2.432GlnGln: 2.432 ± 0.531
1.459GlnArg: 1.459 ± 0.321
4.378GlnSer: 4.378 ± 0.76
2.513GlnThr: 2.513 ± 0.513
1.946GlnVal: 1.946 ± 0.394
0.405GlnTrp: 0.405 ± 0.273
0.892GlnTyr: 0.892 ± 0.252
0.0GlnXaa: 0.0 ± 0.0
Arg
2.432ArgAla: 2.432 ± 0.394
0.243ArgCys: 0.243 ± 0.143
2.027ArgAsp: 2.027 ± 0.441
3.0ArgGlu: 3.0 ± 0.549
1.135ArgPhe: 1.135 ± 0.307
2.27ArgGly: 2.27 ± 0.414
0.568ArgHis: 0.568 ± 0.248
3.243ArgIle: 3.243 ± 0.6
3.811ArgLys: 3.811 ± 0.553
4.216ArgLeu: 4.216 ± 0.45
0.973ArgMet: 0.973 ± 0.25
2.108ArgAsn: 2.108 ± 0.416
0.568ArgPro: 0.568 ± 0.171
2.027ArgGln: 2.027 ± 0.344
1.946ArgArg: 1.946 ± 0.427
2.594ArgSer: 2.594 ± 0.343
1.216ArgThr: 1.216 ± 0.327
2.513ArgVal: 2.513 ± 0.503
0.649ArgTrp: 0.649 ± 0.225
2.27ArgTyr: 2.27 ± 0.475
0.0ArgXaa: 0.0 ± 0.0
Ser
5.027SerAla: 5.027 ± 1.313
0.243SerCys: 0.243 ± 0.141
3.973SerAsp: 3.973 ± 0.585
3.811SerGlu: 3.811 ± 0.548
2.432SerPhe: 2.432 ± 0.42
4.216SerGly: 4.216 ± 0.691
1.297SerHis: 1.297 ± 0.308
5.351SerIle: 5.351 ± 0.61
6.081SerLys: 6.081 ± 0.759
4.702SerLeu: 4.702 ± 0.736
2.27SerMet: 2.27 ± 0.575
3.811SerAsn: 3.811 ± 0.664
1.459SerPro: 1.459 ± 0.308
3.486SerGln: 3.486 ± 0.748
3.0SerArg: 3.0 ± 0.375
4.54SerSer: 4.54 ± 1.022
3.892SerThr: 3.892 ± 0.722
4.459SerVal: 4.459 ± 0.533
0.649SerTrp: 0.649 ± 0.259
2.351SerTyr: 2.351 ± 0.466
0.0SerXaa: 0.0 ± 0.0
Thr
4.621ThrAla: 4.621 ± 0.836
0.405ThrCys: 0.405 ± 0.2
4.216ThrAsp: 4.216 ± 0.585
3.0ThrGlu: 3.0 ± 0.524
3.162ThrPhe: 3.162 ± 0.525
4.621ThrGly: 4.621 ± 0.955
0.973ThrHis: 0.973 ± 0.247
4.459ThrIle: 4.459 ± 0.5
4.297ThrLys: 4.297 ± 0.732
6.081ThrLeu: 6.081 ± 0.528
0.973ThrMet: 0.973 ± 0.274
2.757ThrAsn: 2.757 ± 0.593
1.946ThrPro: 1.946 ± 0.381
3.162ThrGln: 3.162 ± 0.408
1.946ThrArg: 1.946 ± 0.371
5.108ThrSer: 5.108 ± 0.562
5.027ThrThr: 5.027 ± 0.798
4.054ThrVal: 4.054 ± 0.546
0.486ThrTrp: 0.486 ± 0.191
1.54ThrTyr: 1.54 ± 0.358
0.0ThrXaa: 0.0 ± 0.0
Val
4.621ValAla: 4.621 ± 0.96
0.486ValCys: 0.486 ± 0.212
4.702ValAsp: 4.702 ± 0.544
5.919ValGlu: 5.919 ± 0.915
2.838ValPhe: 2.838 ± 0.377
3.73ValGly: 3.73 ± 0.794
0.892ValHis: 0.892 ± 0.216
3.567ValIle: 3.567 ± 0.453
4.865ValLys: 4.865 ± 0.807
4.459ValLeu: 4.459 ± 0.652
1.054ValMet: 1.054 ± 0.309
2.676ValAsn: 2.676 ± 0.385
1.865ValPro: 1.865 ± 0.326
2.27ValGln: 2.27 ± 0.384
2.27ValArg: 2.27 ± 0.369
4.54ValSer: 4.54 ± 0.706
4.459ValThr: 4.459 ± 0.633
4.054ValVal: 4.054 ± 0.531
0.486ValTrp: 0.486 ± 0.168
1.459ValTyr: 1.459 ± 0.394
0.0ValXaa: 0.0 ± 0.0
Trp
0.973TrpAla: 0.973 ± 0.307
0.081TrpCys: 0.081 ± 0.078
0.649TrpAsp: 0.649 ± 0.228
0.568TrpGlu: 0.568 ± 0.24
0.324TrpPhe: 0.324 ± 0.149
0.73TrpGly: 0.73 ± 0.231
0.081TrpHis: 0.081 ± 0.072
0.892TrpIle: 0.892 ± 0.291
1.135TrpLys: 1.135 ± 0.252
0.892TrpLeu: 0.892 ± 0.372
0.324TrpMet: 0.324 ± 0.178
0.243TrpAsn: 0.243 ± 0.118
0.162TrpPro: 0.162 ± 0.098
0.405TrpGln: 0.405 ± 0.162
0.649TrpArg: 0.649 ± 0.214
0.811TrpSer: 0.811 ± 0.221
0.0TrpThr: 0.0 ± 0.0
0.243TrpVal: 0.243 ± 0.141
0.243TrpTrp: 0.243 ± 0.142
0.405TrpTyr: 0.405 ± 0.164
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.108TyrAla: 2.108 ± 0.329
0.568TyrCys: 0.568 ± 0.227
2.838TyrAsp: 2.838 ± 0.525
2.432TyrGlu: 2.432 ± 0.513
1.54TyrPhe: 1.54 ± 0.399
1.54TyrGly: 1.54 ± 0.409
0.486TyrHis: 0.486 ± 0.221
2.27TyrIle: 2.27 ± 0.367
3.324TyrLys: 3.324 ± 0.475
3.243TyrLeu: 3.243 ± 0.612
0.649TyrMet: 0.649 ± 0.238
2.108TyrAsn: 2.108 ± 0.53
1.135TyrPro: 1.135 ± 0.352
1.946TyrGln: 1.946 ± 0.486
0.973TyrArg: 0.973 ± 0.263
2.432TyrSer: 2.432 ± 0.642
2.27TyrThr: 2.27 ± 0.411
1.54TyrVal: 1.54 ± 0.369
0.243TyrTrp: 0.243 ± 0.127
1.784TyrTyr: 1.784 ± 0.464
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (12335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski