Amino acid dipepetide frequency for Ketogulonicigenium vulgare (strain WSH-001)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.091AlaAla: 19.091 ± 0.204	0.879AlaCys: 0.879 ± 0.032	7.792AlaAsp: 7.792 ± 0.1	7.151AlaGlu: 7.151 ± 0.104	4.447AlaPhe: 4.447 ± 0.071	11.216AlaGly: 11.216 ± 0.134	2.376AlaHis: 2.376 ± 0.05	6.75AlaIle: 6.75 ± 0.087	3.19AlaLys: 3.19 ± 0.07	15.191AlaLeu: 15.191 ± 0.163	4.022AlaMet: 4.022 ± 0.072	2.938AlaAsn: 2.938 ± 0.067	6.385AlaPro: 6.385 ± 0.09	5.366AlaGln: 5.366 ± 0.09	9.275AlaArg: 9.275 ± 0.116	5.795AlaSer: 5.795 ± 0.086	6.422AlaThr: 6.422 ± 0.085	8.758AlaVal: 8.758 ± 0.107	1.577AlaTrp: 1.577 ± 0.045	2.584AlaTyr: 2.584 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.93CysAla: 0.93 ± 0.036	0.081CysCys: 0.081 ± 0.011	0.507CysAsp: 0.507 ± 0.027	0.29CysGlu: 0.29 ± 0.017	0.262CysPhe: 0.262 ± 0.016	0.796CysGly: 0.796 ± 0.032	0.222CysHis: 0.222 ± 0.017	0.402CysIle: 0.402 ± 0.023	0.14CysLys: 0.14 ± 0.011	0.673CysLeu: 0.673 ± 0.028	0.138CysMet: 0.138 ± 0.011	0.188CysAsn: 0.188 ± 0.013	0.368CysPro: 0.368 ± 0.018	0.229CysGln: 0.229 ± 0.016	0.441CysArg: 0.441 ± 0.021	0.303CysSer: 0.303 ± 0.019	0.393CysThr: 0.393 ± 0.019	0.465CysVal: 0.465 ± 0.024	0.092CysTrp: 0.092 ± 0.011	0.181CysTyr: 0.181 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.421AspAla: 7.421 ± 0.1	0.384AspCys: 0.384 ± 0.02	3.288AspAsp: 3.288 ± 0.083	3.236AspGlu: 3.236 ± 0.065	2.415AspPhe: 2.415 ± 0.061	5.181AspGly: 5.181 ± 0.085	1.374AspHis: 1.374 ± 0.039	3.295AspIle: 3.295 ± 0.061	1.396AspLys: 1.396 ± 0.05	6.755AspLeu: 6.755 ± 0.09	1.704AspMet: 1.704 ± 0.038	1.3AspAsn: 1.3 ± 0.039	3.645AspPro: 3.645 ± 0.063	2.29AspGln: 2.29 ± 0.048	4.021AspArg: 4.021 ± 0.084	2.293AspSer: 2.293 ± 0.047	2.766AspThr: 2.766 ± 0.053	4.172AspVal: 4.172 ± 0.077	1.05AspTrp: 1.05 ± 0.034	1.63AspTyr: 1.63 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.932GluAla: 6.932 ± 0.107	0.288GluCys: 0.288 ± 0.019	2.624GluAsp: 2.624 ± 0.053	2.487GluGlu: 2.487 ± 0.066	1.556GluPhe: 1.556 ± 0.042	4.337GluGly: 4.337 ± 0.077	0.905GluHis: 0.905 ± 0.032	3.23GluIle: 3.23 ± 0.063	1.587GluLys: 1.587 ± 0.048	4.326GluLeu: 4.326 ± 0.07	1.625GluMet: 1.625 ± 0.038	1.593GluAsn: 1.593 ± 0.041	2.0GluPro: 2.0 ± 0.051	1.743GluGln: 1.743 ± 0.049	3.466GluArg: 3.466 ± 0.075	2.113GluSer: 2.113 ± 0.05	3.038GluThr: 3.038 ± 0.062	4.09GluVal: 4.09 ± 0.071	0.624GluTrp: 0.624 ± 0.028	0.985GluTyr: 0.985 ± 0.032	0.001GluXaa: 0.001 ± 0.001
Phe	4.752PheAla: 4.752 ± 0.071	0.355PheCys: 0.355 ± 0.02	2.852PheAsp: 2.852 ± 0.055	1.846PheGlu: 1.846 ± 0.054	1.25PhePhe: 1.25 ± 0.042	3.841PheGly: 3.841 ± 0.072	0.731PheHis: 0.731 ± 0.03	1.845PheIle: 1.845 ± 0.05	0.752PheLys: 0.752 ± 0.03	3.224PheLeu: 3.224 ± 0.069	0.851PheMet: 0.851 ± 0.032	1.152PheAsn: 1.152 ± 0.038	1.594PhePro: 1.594 ± 0.042	1.167PheGln: 1.167 ± 0.041	2.078PheArg: 2.078 ± 0.049	2.194PheSer: 2.194 ± 0.048	2.268PheThr: 2.268 ± 0.049	2.627PheVal: 2.627 ± 0.047	0.555PheTrp: 0.555 ± 0.023	0.888PheTyr: 0.888 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.642GlyAla: 10.642 ± 0.13	0.687GlyCys: 0.687 ± 0.025	4.538GlyAsp: 4.538 ± 0.097	4.137GlyGlu: 4.137 ± 0.067	3.722GlyPhe: 3.722 ± 0.062	7.325GlyGly: 7.325 ± 0.102	1.885GlyHis: 1.885 ± 0.044	4.658GlyIle: 4.658 ± 0.068	2.769GlyLys: 2.769 ± 0.059	9.326GlyLeu: 9.326 ± 0.104	2.409GlyMet: 2.409 ± 0.055	2.182GlyAsn: 2.182 ± 0.056	3.55GlyPro: 3.55 ± 0.069	3.586GlyGln: 3.586 ± 0.068	5.764GlyArg: 5.764 ± 0.087	3.927GlySer: 3.927 ± 0.06	4.865GlyThr: 4.865 ± 0.065	6.253GlyVal: 6.253 ± 0.091	1.402GlyTrp: 1.402 ± 0.037	2.286GlyTyr: 2.286 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.385HisAla: 2.385 ± 0.056	0.198HisCys: 0.198 ± 0.016	1.447HisAsp: 1.447 ± 0.043	0.935HisGlu: 0.935 ± 0.031	0.895HisPhe: 0.895 ± 0.035	1.826HisGly: 1.826 ± 0.051	0.606HisHis: 0.606 ± 0.029	1.189HisIle: 1.189 ± 0.039	0.421HisLys: 0.421 ± 0.022	2.163HisLeu: 2.163 ± 0.047	0.564HisMet: 0.564 ± 0.026	0.48HisAsn: 0.48 ± 0.023	1.318HisPro: 1.318 ± 0.044	0.689HisGln: 0.689 ± 0.027	1.417HisArg: 1.417 ± 0.044	0.932HisSer: 0.932 ± 0.027	0.81HisThr: 0.81 ± 0.031	1.448HisVal: 1.448 ± 0.043	0.35HisTrp: 0.35 ± 0.02	0.579HisTyr: 0.579 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	8.47IleAla: 8.47 ± 0.106	0.575IleCys: 0.575 ± 0.024	3.618IleAsp: 3.618 ± 0.053	3.223IleGlu: 3.223 ± 0.069	1.911IlePhe: 1.911 ± 0.056	5.282IleGly: 5.282 ± 0.08	0.927IleHis: 0.927 ± 0.033	2.806IleIle: 2.806 ± 0.063	1.205IleLys: 1.205 ± 0.036	4.868IleLeu: 4.868 ± 0.081	1.324IleMet: 1.324 ± 0.039	1.488IleAsn: 1.488 ± 0.041	2.482IlePro: 2.482 ± 0.056	1.229IleGln: 1.229 ± 0.036	3.27IleArg: 3.27 ± 0.064	3.411IleSer: 3.411 ± 0.062	3.444IleThr: 3.444 ± 0.06	3.932IleVal: 3.932 ± 0.066	0.778IleTrp: 0.778 ± 0.028	1.295IleTyr: 1.295 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.122LysAla: 3.122 ± 0.074	0.123LysCys: 0.123 ± 0.012	1.378LysAsp: 1.378 ± 0.043	0.975LysGlu: 0.975 ± 0.038	0.77LysPhe: 0.77 ± 0.025	2.152LysGly: 2.152 ± 0.06	0.484LysHis: 0.484 ± 0.024	1.479LysIle: 1.479 ± 0.044	0.855LysLys: 0.855 ± 0.04	2.535LysLeu: 2.535 ± 0.052	0.782LysMet: 0.782 ± 0.038	0.624LysAsn: 0.624 ± 0.027	1.458LysPro: 1.458 ± 0.053	0.729LysGln: 0.729 ± 0.028	1.788LysArg: 1.788 ± 0.044	1.567LysSer: 1.567 ± 0.041	1.617LysThr: 1.617 ± 0.036	1.897LysVal: 1.897 ± 0.046	0.308LysTrp: 0.308 ± 0.02	0.5LysTyr: 0.5 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.367LeuAla: 13.367 ± 0.148	0.763LeuCys: 0.763 ± 0.033	6.121LeuAsp: 6.121 ± 0.083	4.503LeuGlu: 4.503 ± 0.08	3.457LeuPhe: 3.457 ± 0.063	8.436LeuGly: 8.436 ± 0.114	2.175LeuHis: 2.175 ± 0.048	5.676LeuIle: 5.676 ± 0.083	2.497LeuLys: 2.497 ± 0.058	9.726LeuLeu: 9.726 ± 0.139	2.847LeuMet: 2.847 ± 0.054	2.937LeuAsn: 2.937 ± 0.06	6.326LeuPro: 6.326 ± 0.105	3.594LeuGln: 3.594 ± 0.061	7.896LeuArg: 7.896 ± 0.108	6.663LeuSer: 6.663 ± 0.084	6.205LeuThr: 6.205 ± 0.093	6.993LeuVal: 6.993 ± 0.095	1.293LeuTrp: 1.293 ± 0.042	1.988LeuTyr: 1.988 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.594MetAla: 3.594 ± 0.067	0.136MetCys: 0.136 ± 0.013	1.376MetAsp: 1.376 ± 0.043	1.147MetGlu: 1.147 ± 0.04	0.812MetPhe: 0.812 ± 0.03	2.243MetGly: 2.243 ± 0.048	0.453MetHis: 0.453 ± 0.023	1.744MetIle: 1.744 ± 0.041	0.837MetLys: 0.837 ± 0.034	2.786MetLeu: 2.786 ± 0.063	0.842MetMet: 0.842 ± 0.029	0.866MetAsn: 0.866 ± 0.027	1.652MetPro: 1.652 ± 0.035	1.13MetGln: 1.13 ± 0.032	2.159MetArg: 2.159 ± 0.04	1.615MetSer: 1.615 ± 0.041	2.11MetThr: 2.11 ± 0.049	1.919MetVal: 1.919 ± 0.044	0.23MetTrp: 0.23 ± 0.016	0.332MetTyr: 0.332 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.458AsnAla: 3.458 ± 0.063	0.228AsnCys: 0.228 ± 0.016	1.432AsnAsp: 1.432 ± 0.042	1.036AsnGlu: 1.036 ± 0.036	0.978AsnPhe: 0.978 ± 0.032	2.423AsnGly: 2.423 ± 0.06	0.547AsnHis: 0.547 ± 0.024	1.547AsnIle: 1.547 ± 0.038	0.534AsnLys: 0.534 ± 0.024	2.675AsnLeu: 2.675 ± 0.058	0.719AsnMet: 0.719 ± 0.026	0.683AsnAsn: 0.683 ± 0.027	2.041AsnPro: 2.041 ± 0.049	0.803AsnGln: 0.803 ± 0.029	1.814AsnArg: 1.814 ± 0.04	1.2AsnSer: 1.2 ± 0.039	1.431AsnThr: 1.431 ± 0.037	1.867AsnVal: 1.867 ± 0.046	0.446AsnTrp: 0.446 ± 0.023	0.731AsnTyr: 0.731 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.15ProAla: 7.15 ± 0.084	0.28ProCys: 0.28 ± 0.018	3.833ProAsp: 3.833 ± 0.072	3.446ProGlu: 3.446 ± 0.071	1.976ProPhe: 1.976 ± 0.047	4.116ProGly: 4.116 ± 0.072	1.167ProHis: 1.167 ± 0.039	2.369ProIle: 2.369 ± 0.051	1.356ProLys: 1.356 ± 0.044	4.924ProLeu: 4.924 ± 0.071	1.349ProMet: 1.349 ± 0.039	1.343ProAsn: 1.343 ± 0.036	2.494ProPro: 2.494 ± 0.075	2.05ProGln: 2.05 ± 0.049	3.156ProArg: 3.156 ± 0.07	2.537ProSer: 2.537 ± 0.061	2.65ProThr: 2.65 ± 0.055	4.215ProVal: 4.215 ± 0.073	0.654ProTrp: 0.654 ± 0.026	1.247ProTyr: 1.247 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.281GlnAla: 4.281 ± 0.074	0.186GlnCys: 0.186 ± 0.014	1.858GlnAsp: 1.858 ± 0.044	1.368GlnGlu: 1.368 ± 0.038	1.131GlnPhe: 1.131 ± 0.039	2.821GlnGly: 2.821 ± 0.052	0.845GlnHis: 0.845 ± 0.032	2.647GlnIle: 2.647 ± 0.055	0.918GlnLys: 0.918 ± 0.029	3.416GlnLeu: 3.416 ± 0.063	1.302GlnMet: 1.302 ± 0.035	1.179GlnAsn: 1.179 ± 0.034	1.969GlnPro: 1.969 ± 0.048	1.474GlnGln: 1.474 ± 0.04	2.922GlnArg: 2.922 ± 0.064	2.073GlnSer: 2.073 ± 0.047	1.97GlnThr: 1.97 ± 0.046	2.706GlnVal: 2.706 ± 0.058	0.428GlnTrp: 0.428 ± 0.021	0.651GlnTyr: 0.651 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.157ArgAla: 9.157 ± 0.134	0.369ArgCys: 0.369 ± 0.023	4.359ArgAsp: 4.359 ± 0.07	3.501ArgGlu: 3.501 ± 0.071	2.664ArgPhe: 2.664 ± 0.052	4.988ArgGly: 4.988 ± 0.069	1.588ArgHis: 1.588 ± 0.046	4.116ArgIle: 4.116 ± 0.061	1.978ArgLys: 1.978 ± 0.052	7.535ArgLeu: 7.535 ± 0.106	1.922ArgMet: 1.922 ± 0.052	1.87ArgAsn: 1.87 ± 0.043	3.348ArgPro: 3.348 ± 0.07	2.537ArgGln: 2.537 ± 0.062	4.844ArgArg: 4.844 ± 0.089	2.995ArgSer: 2.995 ± 0.063	2.982ArgThr: 2.982 ± 0.059	4.755ArgVal: 4.755 ± 0.073	0.901ArgTrp: 0.901 ± 0.038	1.57ArgTyr: 1.57 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.382SerAla: 6.382 ± 0.087	0.348SerCys: 0.348 ± 0.021	3.07SerAsp: 3.07 ± 0.065	2.239SerGlu: 2.239 ± 0.051	2.29SerPhe: 2.29 ± 0.051	5.146SerGly: 5.146 ± 0.079	1.135SerHis: 1.135 ± 0.032	2.554SerIle: 2.554 ± 0.059	1.101SerLys: 1.101 ± 0.035	5.393SerLeu: 5.393 ± 0.079	1.216SerMet: 1.216 ± 0.033	1.39SerAsn: 1.39 ± 0.038	2.554SerPro: 2.554 ± 0.051	1.63SerGln: 1.63 ± 0.039	3.282SerArg: 3.282 ± 0.069	2.505SerSer: 2.505 ± 0.061	2.568SerThr: 2.568 ± 0.052	3.731SerVal: 3.731 ± 0.073	0.726SerTrp: 0.726 ± 0.029	1.4SerTyr: 1.4 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.939ThrAla: 6.939 ± 0.106	0.428ThrCys: 0.428 ± 0.023	3.057ThrAsp: 3.057 ± 0.055	2.467ThrGlu: 2.467 ± 0.052	2.126ThrPhe: 2.126 ± 0.049	5.309ThrGly: 5.309 ± 0.08	1.182ThrHis: 1.182 ± 0.033	2.951ThrIle: 2.951 ± 0.065	1.106ThrLys: 1.106 ± 0.037	6.287ThrLeu: 6.287 ± 0.084	1.276ThrMet: 1.276 ± 0.035	1.316ThrAsn: 1.316 ± 0.039	3.627ThrPro: 3.627 ± 0.069	1.686ThrGln: 1.686 ± 0.048	3.644ThrArg: 3.644 ± 0.063	2.835ThrSer: 2.835 ± 0.059	3.106ThrThr: 3.106 ± 0.06	4.169ThrVal: 4.169 ± 0.065	0.673ThrTrp: 0.673 ± 0.028	1.346ThrTyr: 1.346 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.068ValAla: 9.068 ± 0.104	0.475ValCys: 0.475 ± 0.021	4.13ValAsp: 4.13 ± 0.078	3.879ValGlu: 3.879 ± 0.076	2.724ValPhe: 2.724 ± 0.062	5.36ValGly: 5.36 ± 0.09	1.199ValHis: 1.199 ± 0.033	4.543ValIle: 4.543 ± 0.074	1.758ValLys: 1.758 ± 0.046	7.708ValLeu: 7.708 ± 0.11	2.243ValMet: 2.243 ± 0.053	2.032ValAsn: 2.032 ± 0.052	3.657ValPro: 3.657 ± 0.054	2.634ValGln: 2.634 ± 0.056	4.035ValArg: 4.035 ± 0.064	3.816ValSer: 3.816 ± 0.07	4.869ValThr: 4.869 ± 0.074	5.417ValVal: 5.417 ± 0.079	0.857ValTrp: 0.857 ± 0.03	1.423ValTyr: 1.423 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.374TrpAla: 1.374 ± 0.042	0.104TrpCys: 0.104 ± 0.011	0.713TrpAsp: 0.713 ± 0.026	0.553TrpGlu: 0.553 ± 0.023	0.505TrpPhe: 0.505 ± 0.024	1.003TrpGly: 1.003 ± 0.031	0.344TrpHis: 0.344 ± 0.019	0.668TrpIle: 0.668 ± 0.028	0.318TrpLys: 0.318 ± 0.019	1.688TrpLeu: 1.688 ± 0.046	0.399TrpMet: 0.399 ± 0.022	0.38TrpAsn: 0.38 ± 0.02	0.731TrpPro: 0.731 ± 0.031	0.767TrpGln: 0.767 ± 0.031	1.122TrpArg: 1.122 ± 0.033	0.75TrpSer: 0.75 ± 0.03	0.679TrpThr: 0.679 ± 0.029	0.942TrpVal: 0.942 ± 0.034	0.236TrpTrp: 0.236 ± 0.017	0.26TrpTyr: 0.26 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.69TyrAla: 2.69 ± 0.051	0.214TyrCys: 0.214 ± 0.015	1.624TyrAsp: 1.624 ± 0.046	1.131TyrGlu: 1.131 ± 0.036	0.931TyrPhe: 0.931 ± 0.029	2.112TyrGly: 2.112 ± 0.053	0.505TyrHis: 0.505 ± 0.024	1.066TyrIle: 1.066 ± 0.036	0.426TyrLys: 0.426 ± 0.024	2.269TyrLeu: 2.269 ± 0.05	0.448TyrMet: 0.448 ± 0.02	0.651TyrAsn: 0.651 ± 0.028	1.115TyrPro: 1.115 ± 0.036	0.81TyrGln: 0.81 ± 0.03	1.586TyrArg: 1.586 ± 0.043	1.132TyrSer: 1.132 ± 0.035	1.336TyrThr: 1.336 ± 0.036	1.471TyrVal: 1.471 ± 0.042	0.357TyrTrp: 0.357 ± 0.02	0.547TyrTyr: 0.547 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3049 proteins (950172 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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