Amino acid dipepetide frequency for Sphingomonas gilva

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.206AlaAla: 21.206 ± 0.239	1.042AlaCys: 1.042 ± 0.037	8.38AlaAsp: 8.38 ± 0.099	8.702AlaGlu: 8.702 ± 0.126	4.472AlaPhe: 4.472 ± 0.067	12.53AlaGly: 12.53 ± 0.176	2.436AlaHis: 2.436 ± 0.048	7.205AlaIle: 7.205 ± 0.096	3.925AlaLys: 3.925 ± 0.076	14.366AlaLeu: 14.366 ± 0.16	3.959AlaMet: 3.959 ± 0.062	3.29AlaAsn: 3.29 ± 0.064	6.863AlaPro: 6.863 ± 0.1	4.312AlaGln: 4.312 ± 0.069	11.208AlaArg: 11.208 ± 0.14	6.415AlaSer: 6.415 ± 0.095	6.749AlaThr: 6.749 ± 0.12	8.896AlaVal: 8.896 ± 0.113	1.872AlaTrp: 1.872 ± 0.043	2.626AlaTyr: 2.626 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.954CysAla: 0.954 ± 0.032	0.063CysCys: 0.063 ± 0.007	0.481CysAsp: 0.481 ± 0.023	0.367CysGlu: 0.367 ± 0.019	0.27CysPhe: 0.27 ± 0.015	0.792CysGly: 0.792 ± 0.029	0.183CysHis: 0.183 ± 0.013	0.299CysIle: 0.299 ± 0.016	0.129CysLys: 0.129 ± 0.011	0.581CysLeu: 0.581 ± 0.021	0.108CysMet: 0.108 ± 0.009	0.171CysAsn: 0.171 ± 0.014	0.427CysPro: 0.427 ± 0.019	0.162CysGln: 0.162 ± 0.011	0.517CysArg: 0.517 ± 0.024	0.355CysSer: 0.355 ± 0.021	0.35CysThr: 0.35 ± 0.017	0.493CysVal: 0.493 ± 0.02	0.093CysTrp: 0.093 ± 0.01	0.152CysTyr: 0.152 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.62AspAla: 8.62 ± 0.094	0.446AspCys: 0.446 ± 0.019	3.535AspAsp: 3.535 ± 0.071	3.443AspGlu: 3.443 ± 0.058	2.213AspPhe: 2.213 ± 0.051	5.951AspGly: 5.951 ± 0.095	1.266AspHis: 1.266 ± 0.036	2.957AspIle: 2.957 ± 0.06	1.482AspLys: 1.482 ± 0.042	5.719AspLeu: 5.719 ± 0.081	1.383AspMet: 1.383 ± 0.042	1.334AspAsn: 1.334 ± 0.036	4.17AspPro: 4.17 ± 0.075	1.727AspGln: 1.727 ± 0.041	5.425AspArg: 5.425 ± 0.07	2.292AspSer: 2.292 ± 0.055	2.719AspThr: 2.719 ± 0.055	4.001AspVal: 4.001 ± 0.077	1.119AspTrp: 1.119 ± 0.035	1.643AspTyr: 1.643 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.486GluAla: 8.486 ± 0.118	0.3GluCys: 0.3 ± 0.019	2.846GluAsp: 2.846 ± 0.061	3.075GluGlu: 3.075 ± 0.064	1.531GluPhe: 1.531 ± 0.04	5.038GluGly: 5.038 ± 0.08	1.099GluHis: 1.099 ± 0.04	3.03GluIle: 3.03 ± 0.06	1.655GluLys: 1.655 ± 0.042	4.928GluLeu: 4.928 ± 0.08	1.463GluMet: 1.463 ± 0.036	1.327GluAsn: 1.327 ± 0.038	2.774GluPro: 2.774 ± 0.055	1.873GluGln: 1.873 ± 0.051	5.317GluArg: 5.317 ± 0.082	2.269GluSer: 2.269 ± 0.046	3.228GluThr: 3.228 ± 0.06	3.651GluVal: 3.651 ± 0.056	0.828GluTrp: 0.828 ± 0.029	1.02GluTyr: 1.02 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	5.074PheAla: 5.074 ± 0.067	0.25PheCys: 0.25 ± 0.016	2.887PheAsp: 2.887 ± 0.049	2.038PheGlu: 2.038 ± 0.051	1.22PhePhe: 1.22 ± 0.039	3.657PheGly: 3.657 ± 0.072	0.673PheHis: 0.673 ± 0.025	1.372PheIle: 1.372 ± 0.038	0.79PheLys: 0.79 ± 0.027	2.915PheLeu: 2.915 ± 0.059	0.702PheMet: 0.702 ± 0.03	0.995PheAsn: 0.995 ± 0.04	1.473PhePro: 1.473 ± 0.039	0.87PheGln: 0.87 ± 0.032	2.306PheArg: 2.306 ± 0.053	1.781PheSer: 1.781 ± 0.047	1.951PheThr: 1.951 ± 0.042	2.662PheVal: 2.662 ± 0.05	0.516PheTrp: 0.516 ± 0.026	0.846PheTyr: 0.846 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.869GlyAla: 10.869 ± 0.146	0.797GlyCys: 0.797 ± 0.028	5.49GlyAsp: 5.49 ± 0.087	5.549GlyGlu: 5.549 ± 0.083	3.731GlyPhe: 3.731 ± 0.062	9.091GlyGly: 9.091 ± 0.149	1.858GlyHis: 1.858 ± 0.046	4.303GlyIle: 4.303 ± 0.069	3.054GlyLys: 3.054 ± 0.064	8.78GlyLeu: 8.78 ± 0.108	2.305GlyMet: 2.305 ± 0.048	2.212GlyAsn: 2.212 ± 0.066	3.838GlyPro: 3.838 ± 0.065	2.851GlyGln: 2.851 ± 0.054	7.282GlyArg: 7.282 ± 0.088	4.697GlySer: 4.697 ± 0.078	4.524GlyThr: 4.524 ± 0.088	6.795GlyVal: 6.795 ± 0.083	1.815GlyTrp: 1.815 ± 0.048	2.411GlyTyr: 2.411 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.484HisAla: 2.484 ± 0.054	0.176HisCys: 0.176 ± 0.015	1.198HisAsp: 1.198 ± 0.034	0.945HisGlu: 0.945 ± 0.032	0.756HisPhe: 0.756 ± 0.025	1.874HisGly: 1.874 ± 0.046	0.538HisHis: 0.538 ± 0.023	0.872HisIle: 0.872 ± 0.028	0.41HisLys: 0.41 ± 0.019	1.787HisLeu: 1.787 ± 0.044	0.412HisMet: 0.412 ± 0.021	0.412HisAsn: 0.412 ± 0.021	1.298HisPro: 1.298 ± 0.038	0.53HisGln: 0.53 ± 0.023	1.513HisArg: 1.513 ± 0.041	0.791HisSer: 0.791 ± 0.032	0.649HisThr: 0.649 ± 0.024	1.451HisVal: 1.451 ± 0.037	0.339HisTrp: 0.339 ± 0.021	0.526HisTyr: 0.526 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	8.463IleAla: 8.463 ± 0.103	0.346IleCys: 0.346 ± 0.018	4.189IleAsp: 4.189 ± 0.068	3.504IleGlu: 3.504 ± 0.064	1.452IlePhe: 1.452 ± 0.037	5.351IleGly: 5.351 ± 0.074	0.795IleHis: 0.795 ± 0.027	1.815IleIle: 1.815 ± 0.048	1.013IleLys: 1.013 ± 0.033	3.659IleLeu: 3.659 ± 0.058	0.814IleMet: 0.814 ± 0.03	1.212IleAsn: 1.212 ± 0.04	2.169IlePro: 2.169 ± 0.045	1.103IleGln: 1.103 ± 0.036	3.176IleArg: 3.176 ± 0.065	2.214IleSer: 2.214 ± 0.051	2.399IleThr: 2.399 ± 0.057	4.229IleVal: 4.229 ± 0.072	0.559IleTrp: 0.559 ± 0.027	0.967IleTyr: 0.967 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.806LysAla: 3.806 ± 0.074	0.128LysCys: 0.128 ± 0.012	1.354LysAsp: 1.354 ± 0.038	1.131LysGlu: 1.131 ± 0.04	0.693LysPhe: 0.693 ± 0.026	2.481LysGly: 2.481 ± 0.052	0.459LysHis: 0.459 ± 0.019	1.17LysIle: 1.17 ± 0.035	0.875LysLys: 0.875 ± 0.039	2.829LysLeu: 2.829 ± 0.058	0.636LysMet: 0.636 ± 0.025	0.616LysAsn: 0.616 ± 0.028	1.896LysPro: 1.896 ± 0.047	0.761LysGln: 0.761 ± 0.027	2.165LysArg: 2.165 ± 0.046	1.371LysSer: 1.371 ± 0.037	1.517LysThr: 1.517 ± 0.041	1.899LysVal: 1.899 ± 0.046	0.362LysTrp: 0.362 ± 0.019	0.514LysTyr: 0.514 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.645LeuAla: 14.645 ± 0.16	0.619LeuCys: 0.619 ± 0.025	6.245LeuAsp: 6.245 ± 0.085	4.619LeuGlu: 4.619 ± 0.071	3.516LeuPhe: 3.516 ± 0.059	8.425LeuGly: 8.425 ± 0.094	1.627LeuHis: 1.627 ± 0.042	4.878LeuIle: 4.878 ± 0.067	2.881LeuLys: 2.881 ± 0.054	8.718LeuLeu: 8.718 ± 0.128	1.975LeuMet: 1.975 ± 0.043	2.219LeuAsn: 2.219 ± 0.051	5.528LeuPro: 5.528 ± 0.074	2.254LeuGln: 2.254 ± 0.05	6.673LeuArg: 6.673 ± 0.088	5.447LeuSer: 5.447 ± 0.069	5.483LeuThr: 5.483 ± 0.084	7.055LeuVal: 7.055 ± 0.104	1.22LeuTrp: 1.22 ± 0.036	1.92LeuTyr: 1.92 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.351MetAla: 3.351 ± 0.057	0.131MetCys: 0.131 ± 0.01	1.08MetAsp: 1.08 ± 0.035	0.953MetGlu: 0.953 ± 0.036	0.676MetPhe: 0.676 ± 0.028	1.905MetGly: 1.905 ± 0.05	0.368MetHis: 0.368 ± 0.019	1.289MetIle: 1.289 ± 0.04	0.822MetLys: 0.822 ± 0.031	2.579MetLeu: 2.579 ± 0.052	0.567MetMet: 0.567 ± 0.024	0.605MetAsn: 0.605 ± 0.022	1.398MetPro: 1.398 ± 0.041	0.613MetGln: 0.613 ± 0.025	1.934MetArg: 1.934 ± 0.044	1.264MetSer: 1.264 ± 0.037	1.709MetThr: 1.709 ± 0.042	1.566MetVal: 1.566 ± 0.039	0.237MetTrp: 0.237 ± 0.016	0.268MetTyr: 0.268 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.254AsnAla: 3.254 ± 0.066	0.21AsnCys: 0.21 ± 0.014	1.304AsnAsp: 1.304 ± 0.046	1.086AsnGlu: 1.086 ± 0.033	0.881AsnPhe: 0.881 ± 0.037	2.318AsnGly: 2.318 ± 0.068	0.436AsnHis: 0.436 ± 0.022	1.251AsnIle: 1.251 ± 0.038	0.534AsnLys: 0.534 ± 0.023	2.345AsnLeu: 2.345 ± 0.05	0.491AsnMet: 0.491 ± 0.023	0.621AsnAsn: 0.621 ± 0.029	1.816AsnPro: 1.816 ± 0.048	0.716AsnGln: 0.716 ± 0.031	1.848AsnArg: 1.848 ± 0.045	1.092AsnSer: 1.092 ± 0.037	1.091AsnThr: 1.091 ± 0.038	1.797AsnVal: 1.797 ± 0.051	0.379AsnTrp: 0.379 ± 0.02	0.746AsnTyr: 0.746 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	7.639ProAla: 7.639 ± 0.096	0.311ProCys: 0.311 ± 0.018	3.957ProAsp: 3.957 ± 0.072	3.636ProGlu: 3.636 ± 0.069	1.964ProPhe: 1.964 ± 0.042	5.209ProGly: 5.209 ± 0.068	1.073ProHis: 1.073 ± 0.033	2.449ProIle: 2.449 ± 0.05	1.287ProLys: 1.287 ± 0.035	5.022ProLeu: 5.022 ± 0.077	1.156ProMet: 1.156 ± 0.035	1.292ProAsn: 1.292 ± 0.035	3.236ProPro: 3.236 ± 0.071	1.644ProGln: 1.644 ± 0.042	3.402ProArg: 3.402 ± 0.064	2.575ProSer: 2.575 ± 0.052	2.52ProThr: 2.52 ± 0.054	4.4ProVal: 4.4 ± 0.076	0.761ProTrp: 0.761 ± 0.031	1.101ProTyr: 1.101 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.249GlnAla: 4.249 ± 0.07	0.18GlnCys: 0.18 ± 0.015	1.309GlnAsp: 1.309 ± 0.036	1.14GlnGlu: 1.14 ± 0.039	1.044GlnPhe: 1.044 ± 0.033	2.444GlnGly: 2.444 ± 0.042	0.538GlnHis: 0.538 ± 0.023	1.487GlnIle: 1.487 ± 0.036	0.694GlnLys: 0.694 ± 0.027	2.862GlnLeu: 2.862 ± 0.054	0.761GlnMet: 0.761 ± 0.027	0.674GlnAsn: 0.674 ± 0.027	1.746GlnPro: 1.746 ± 0.038	1.096GlnGln: 1.096 ± 0.045	2.405GlnArg: 2.405 ± 0.069	1.518GlnSer: 1.518 ± 0.041	1.578GlnThr: 1.578 ± 0.041	2.088GlnVal: 2.088 ± 0.042	0.379GlnTrp: 0.379 ± 0.018	0.601GlnTyr: 0.601 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	10.147ArgAla: 10.147 ± 0.134	0.469ArgCys: 0.469 ± 0.022	4.461ArgAsp: 4.461 ± 0.061	4.337ArgGlu: 4.337 ± 0.081	3.265ArgPhe: 3.265 ± 0.063	5.703ArgGly: 5.703 ± 0.079	1.77ArgHis: 1.77 ± 0.044	4.399ArgIle: 4.399 ± 0.068	1.989ArgLys: 1.989 ± 0.052	8.442ArgLeu: 8.442 ± 0.112	2.11ArgMet: 2.11 ± 0.052	1.753ArgAsn: 1.753 ± 0.047	4.106ArgPro: 4.106 ± 0.07	2.417ArgGln: 2.417 ± 0.063	6.291ArgArg: 6.291 ± 0.093	3.547ArgSer: 3.547 ± 0.061	3.849ArgThr: 3.849 ± 0.063	5.19ArgVal: 5.19 ± 0.093	1.307ArgTrp: 1.307 ± 0.041	1.996ArgTyr: 1.996 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.263SerAla: 6.263 ± 0.091	0.353SerCys: 0.353 ± 0.021	2.912SerAsp: 2.912 ± 0.05	2.394SerGlu: 2.394 ± 0.05	1.975SerPhe: 1.975 ± 0.039	5.286SerGly: 5.286 ± 0.089	0.868SerHis: 0.868 ± 0.031	2.56SerIle: 2.56 ± 0.058	1.18SerLys: 1.18 ± 0.037	4.622SerLeu: 4.622 ± 0.064	1.026SerMet: 1.026 ± 0.034	1.25SerAsn: 1.25 ± 0.041	2.818SerPro: 2.818 ± 0.057	1.313SerGln: 1.313 ± 0.04	3.355SerArg: 3.355 ± 0.059	2.422SerSer: 2.422 ± 0.055	2.421SerThr: 2.421 ± 0.06	3.428SerVal: 3.428 ± 0.07	0.774SerTrp: 0.774 ± 0.026	1.28SerTyr: 1.28 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.543ThrAla: 6.543 ± 0.121	0.347ThrCys: 0.347 ± 0.017	2.93ThrAsp: 2.93 ± 0.059	2.343ThrGlu: 2.343 ± 0.048	1.722ThrPhe: 1.722 ± 0.041	5.454ThrGly: 5.454 ± 0.104	0.927ThrHis: 0.927 ± 0.03	2.977ThrIle: 2.977 ± 0.059	1.086ThrLys: 1.086 ± 0.033	5.719ThrLeu: 5.719 ± 0.073	1.131ThrMet: 1.131 ± 0.03	1.244ThrAsn: 1.244 ± 0.04	3.585ThrPro: 3.585 ± 0.059	1.355ThrGln: 1.355 ± 0.035	3.727ThrArg: 3.727 ± 0.073	2.501ThrSer: 2.501 ± 0.063	2.744ThrThr: 2.744 ± 0.081	4.066ThrVal: 4.066 ± 0.076	0.598ThrTrp: 0.598 ± 0.026	1.181ThrTyr: 1.181 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	10.055ValAla: 10.055 ± 0.135	0.475ValCys: 0.475 ± 0.017	4.422ValAsp: 4.422 ± 0.076	4.69ValGlu: 4.69 ± 0.071	2.175ValPhe: 2.175 ± 0.044	5.531ValGly: 5.531 ± 0.08	1.239ValHis: 1.239 ± 0.036	3.654ValIle: 3.654 ± 0.062	1.918ValLys: 1.918 ± 0.05	6.261ValLeu: 6.261 ± 0.083	1.573ValMet: 1.573 ± 0.038	1.882ValAsn: 1.882 ± 0.051	3.752ValPro: 3.752 ± 0.063	1.957ValGln: 1.957 ± 0.042	5.447ValArg: 5.447 ± 0.069	3.927ValSer: 3.927 ± 0.073	4.843ValThr: 4.843 ± 0.11	5.156ValVal: 5.156 ± 0.073	0.882ValTrp: 0.882 ± 0.029	1.361ValTyr: 1.361 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.56TrpAla: 1.56 ± 0.043	0.107TrpCys: 0.107 ± 0.01	0.772TrpAsp: 0.772 ± 0.026	0.635TrpGlu: 0.635 ± 0.019	0.564TrpPhe: 0.564 ± 0.022	1.045TrpGly: 1.045 ± 0.033	0.31TrpHis: 0.31 ± 0.017	0.687TrpIle: 0.687 ± 0.027	0.414TrpLys: 0.414 ± 0.02	1.763TrpLeu: 1.763 ± 0.053	0.364TrpMet: 0.364 ± 0.018	0.457TrpAsn: 0.457 ± 0.024	0.732TrpPro: 0.732 ± 0.027	0.567TrpGln: 0.567 ± 0.021	1.55TrpArg: 1.55 ± 0.04	0.869TrpSer: 0.869 ± 0.033	0.828TrpThr: 0.828 ± 0.029	0.836TrpVal: 0.836 ± 0.03	0.307TrpTrp: 0.307 ± 0.018	0.32TrpTyr: 0.32 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.787TyrAla: 2.787 ± 0.059	0.197TyrCys: 0.197 ± 0.014	1.695TyrAsp: 1.695 ± 0.059	1.152TyrGlu: 1.152 ± 0.032	0.857TyrPhe: 0.857 ± 0.03	2.165TyrGly: 2.165 ± 0.051	0.498TyrHis: 0.498 ± 0.023	0.777TyrIle: 0.777 ± 0.031	0.525TyrLys: 0.525 ± 0.022	2.05TyrLeu: 2.05 ± 0.046	0.379TyrMet: 0.379 ± 0.017	0.65TyrAsn: 0.65 ± 0.028	1.006TyrPro: 1.006 ± 0.032	0.673TyrGln: 0.673 ± 0.026	2.008TyrArg: 2.008 ± 0.042	1.153TyrSer: 1.153 ± 0.042	1.026TyrThr: 1.026 ± 0.038	1.541TyrVal: 1.541 ± 0.033	0.34TyrTrp: 0.34 ± 0.018	0.629TyrTyr: 0.629 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3257 proteins (1067601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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