Amino acid dipepetide frequency for Georgenia sp. Z446

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.565AlaAla: 23.565 ± 0.239
0.868AlaCys: 0.868 ± 0.031
8.61AlaAsp: 8.61 ± 0.105
8.658AlaGlu: 8.658 ± 0.105
3.345AlaPhe: 3.345 ± 0.059
14.49AlaGly: 14.49 ± 0.129
2.918AlaHis: 2.918 ± 0.051
4.136AlaIle: 4.136 ± 0.066
2.218AlaLys: 2.218 ± 0.052
14.633AlaLeu: 14.633 ± 0.139
2.808AlaMet: 2.808 ± 0.045
2.063AlaAsn: 2.063 ± 0.045
7.594AlaPro: 7.594 ± 0.101
3.954AlaGln: 3.954 ± 0.065
11.078AlaArg: 11.078 ± 0.112
6.073AlaSer: 6.073 ± 0.072
8.47AlaThr: 8.47 ± 0.094
13.892AlaVal: 13.892 ± 0.148
2.035AlaTrp: 2.035 ± 0.044
2.292AlaTyr: 2.292 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.765CysAla: 0.765 ± 0.028
0.069CysCys: 0.069 ± 0.009
0.347CysAsp: 0.347 ± 0.018
0.287CysGlu: 0.287 ± 0.015
0.162CysPhe: 0.162 ± 0.011
0.668CysGly: 0.668 ± 0.023
0.144CysHis: 0.144 ± 0.012
0.16CysIle: 0.16 ± 0.011
0.067CysLys: 0.067 ± 0.007
0.522CysLeu: 0.522 ± 0.02
0.086CysMet: 0.086 ± 0.008
0.098CysAsn: 0.098 ± 0.009
0.39CysPro: 0.39 ± 0.021
0.137CysGln: 0.137 ± 0.011
0.412CysArg: 0.412 ± 0.019
0.321CysSer: 0.321 ± 0.019
0.391CysThr: 0.391 ± 0.018
0.461CysVal: 0.461 ± 0.019
0.087CysTrp: 0.087 ± 0.009
0.116CysTyr: 0.116 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.58AspAla: 8.58 ± 0.09
0.245AspCys: 0.245 ± 0.016
4.051AspAsp: 4.051 ± 0.071
3.666AspGlu: 3.666 ± 0.061
1.388AspPhe: 1.388 ± 0.033
6.765AspGly: 6.765 ± 0.082
1.376AspHis: 1.376 ± 0.035
1.869AspIle: 1.869 ± 0.044
0.881AspLys: 0.881 ± 0.033
6.692AspLeu: 6.692 ± 0.073
0.793AspMet: 0.793 ± 0.025
0.876AspAsn: 0.876 ± 0.031
4.274AspPro: 4.274 ± 0.054
1.565AspGln: 1.565 ± 0.036
4.527AspArg: 4.527 ± 0.062
2.039AspSer: 2.039 ± 0.044
2.766AspThr: 2.766 ± 0.048
6.289AspVal: 6.289 ± 0.073
0.824AspTrp: 0.824 ± 0.025
1.069AspTyr: 1.069 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.171GluAla: 7.171 ± 0.092
0.229GluCys: 0.229 ± 0.014
3.038GluAsp: 3.038 ± 0.048
3.313GluGlu: 3.313 ± 0.057
1.26GluPhe: 1.26 ± 0.032
3.926GluGly: 3.926 ± 0.058
1.696GluHis: 1.696 ± 0.035
2.408GluIle: 2.408 ± 0.043
1.162GluLys: 1.162 ± 0.04
6.646GluLeu: 6.646 ± 0.082
1.052GluMet: 1.052 ± 0.03
1.033GluAsn: 1.033 ± 0.03
3.345GluPro: 3.345 ± 0.059
2.285GluGln: 2.285 ± 0.04
5.08GluArg: 5.08 ± 0.072
2.218GluSer: 2.218 ± 0.04
2.862GluThr: 2.862 ± 0.046
5.333GluVal: 5.333 ± 0.064
0.715GluTrp: 0.715 ± 0.025
0.996GluTyr: 0.996 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.563PheAla: 3.563 ± 0.054
0.167PheCys: 0.167 ± 0.013
1.901PheAsp: 1.901 ± 0.039
1.405PheGlu: 1.405 ± 0.036
0.889PhePhe: 0.889 ± 0.03
2.847PheGly: 2.847 ± 0.055
0.518PheHis: 0.518 ± 0.02
0.779PheIle: 0.779 ± 0.027
0.393PheLys: 0.393 ± 0.018
2.566PheLeu: 2.566 ± 0.049
0.402PheMet: 0.402 ± 0.018
0.558PheAsn: 0.558 ± 0.022
1.26PhePro: 1.26 ± 0.029
0.632PheGln: 0.632 ± 0.025
1.546PheArg: 1.546 ± 0.04
1.391PheSer: 1.391 ± 0.038
1.886PheThr: 1.886 ± 0.042
2.481PheVal: 2.481 ± 0.046
0.399PheTrp: 0.399 ± 0.019
0.567PheTyr: 0.567 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
12.629GlyAla: 12.629 ± 0.135
0.618GlyCys: 0.618 ± 0.024
5.031GlyAsp: 5.031 ± 0.067
5.226GlyGlu: 5.226 ± 0.069
2.719GlyPhe: 2.719 ± 0.047
8.37GlyGly: 8.37 ± 0.113
2.183GlyHis: 2.183 ± 0.042
3.528GlyIle: 3.528 ± 0.058
1.953GlyLys: 1.953 ± 0.044
9.401GlyLeu: 9.401 ± 0.108
2.139GlyMet: 2.139 ± 0.044
1.645GlyAsn: 1.645 ± 0.043
5.142GlyPro: 5.142 ± 0.07
2.778GlyGln: 2.778 ± 0.049
7.438GlyArg: 7.438 ± 0.094
4.927GlySer: 4.927 ± 0.063
6.313GlyThr: 6.313 ± 0.08
8.317GlyVal: 8.317 ± 0.093
1.747GlyTrp: 1.747 ± 0.038
2.123GlyTyr: 2.123 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.815HisAla: 2.815 ± 0.047
0.13HisCys: 0.13 ± 0.011
1.458HisAsp: 1.458 ± 0.035
1.225HisGlu: 1.225 ± 0.028
0.477HisPhe: 0.477 ± 0.017
2.311HisGly: 2.311 ± 0.042
0.661HisHis: 0.661 ± 0.027
0.604HisIle: 0.604 ± 0.021
0.279HisLys: 0.279 ± 0.013
2.547HisLeu: 2.547 ± 0.044
0.349HisMet: 0.349 ± 0.016
0.347HisAsn: 0.347 ± 0.015
1.596HisPro: 1.596 ± 0.041
0.61HisGln: 0.61 ± 0.021
1.931HisArg: 1.931 ± 0.038
0.841HisSer: 0.841 ± 0.027
1.147HisThr: 1.147 ± 0.03
2.008HisVal: 2.008 ± 0.043
0.274HisTrp: 0.274 ± 0.015
0.409HisTyr: 0.409 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.834IleAla: 4.834 ± 0.073
0.198IleCys: 0.198 ± 0.014
2.429IleAsp: 2.429 ± 0.052
2.009IleGlu: 2.009 ± 0.043
0.985IlePhe: 0.985 ± 0.034
3.478IleGly: 3.478 ± 0.054
0.568IleHis: 0.568 ± 0.021
1.157IleIle: 1.157 ± 0.039
0.606IleLys: 0.606 ± 0.025
2.738IleLeu: 2.738 ± 0.051
0.505IleMet: 0.505 ± 0.023
0.733IleAsn: 0.733 ± 0.029
1.687IlePro: 1.687 ± 0.04
0.741IleGln: 0.741 ± 0.026
2.027IleArg: 2.027 ± 0.043
1.775IleSer: 1.775 ± 0.037
2.258IleThr: 2.258 ± 0.048
3.317IleVal: 3.317 ± 0.052
0.378IleTrp: 0.378 ± 0.017
0.638IleTyr: 0.638 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.111LysAla: 2.111 ± 0.054
0.059LysCys: 0.059 ± 0.007
1.032LysAsp: 1.032 ± 0.031
0.912LysGlu: 0.912 ± 0.03
0.414LysPhe: 0.414 ± 0.017
1.301LysGly: 1.301 ± 0.041
0.365LysHis: 0.365 ± 0.016
0.762LysIle: 0.762 ± 0.027
0.53LysLys: 0.53 ± 0.025
1.457LysLeu: 1.457 ± 0.04
0.33LysMet: 0.33 ± 0.016
0.416LysAsn: 0.416 ± 0.02
0.921LysPro: 0.921 ± 0.03
0.504LysGln: 0.504 ± 0.021
1.102LysArg: 1.102 ± 0.033
0.871LysSer: 0.871 ± 0.029
1.015LysThr: 1.015 ± 0.032
1.711LysVal: 1.711 ± 0.043
0.183LysTrp: 0.183 ± 0.011
0.367LysTyr: 0.367 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
16.425LeuAla: 16.425 ± 0.155
0.56LeuCys: 0.56 ± 0.024
6.849LeuAsp: 6.849 ± 0.092
5.303LeuGlu: 5.303 ± 0.065
2.325LeuPhe: 2.325 ± 0.053
9.934LeuGly: 9.934 ± 0.106
2.046LeuHis: 2.046 ± 0.044
3.043LeuIle: 3.043 ± 0.062
1.407LeuLys: 1.407 ± 0.042
10.632LeuLeu: 10.632 ± 0.13
1.656LeuMet: 1.656 ± 0.044
1.519LeuAsn: 1.519 ± 0.034
5.942LeuPro: 5.942 ± 0.072
2.371LeuGln: 2.371 ± 0.05
8.089LeuArg: 8.089 ± 0.095
4.905LeuSer: 4.905 ± 0.071
7.085LeuThr: 7.085 ± 0.089
10.347LeuVal: 10.347 ± 0.121
1.192LeuTrp: 1.192 ± 0.03
1.541LeuTyr: 1.541 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.316MetAla: 2.316 ± 0.045
0.117MetCys: 0.117 ± 0.009
0.934MetAsp: 0.934 ± 0.025
0.693MetGlu: 0.693 ± 0.024
0.497MetPhe: 0.497 ± 0.018
1.441MetGly: 1.441 ± 0.031
0.338MetHis: 0.338 ± 0.017
0.653MetIle: 0.653 ± 0.023
0.345MetLys: 0.345 ± 0.017
1.872MetLeu: 1.872 ± 0.045
0.312MetMet: 0.312 ± 0.017
0.398MetAsn: 0.398 ± 0.02
1.172MetPro: 1.172 ± 0.033
0.444MetGln: 0.444 ± 0.019
1.505MetArg: 1.505 ± 0.039
1.453MetSer: 1.453 ± 0.03
1.694MetThr: 1.694 ± 0.034
1.619MetVal: 1.619 ± 0.034
0.228MetTrp: 0.228 ± 0.014
0.272MetTyr: 0.272 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.161AsnAla: 2.161 ± 0.045
0.104AsnCys: 0.104 ± 0.009
0.934AsnAsp: 0.934 ± 0.032
0.785AsnGlu: 0.785 ± 0.031
0.576AsnPhe: 0.576 ± 0.022
1.574AsnGly: 1.574 ± 0.04
0.403AsnHis: 0.403 ± 0.018
0.664AsnIle: 0.664 ± 0.026
0.31AsnLys: 0.31 ± 0.018
1.808AsnLeu: 1.808 ± 0.045
0.288AsnMet: 0.288 ± 0.016
0.401AsnAsn: 0.401 ± 0.018
1.353AsnPro: 1.353 ± 0.04
0.487AsnGln: 0.487 ± 0.02
1.101AsnArg: 1.101 ± 0.029
0.729AsnSer: 0.729 ± 0.024
0.972AsnThr: 0.972 ± 0.029
1.525AsnVal: 1.525 ± 0.039
0.221AsnTrp: 0.221 ± 0.015
0.383AsnTyr: 0.383 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
9.196ProAla: 9.196 ± 0.104
0.252ProCys: 0.252 ± 0.016
4.275ProAsp: 4.275 ± 0.058
3.83ProGlu: 3.83 ± 0.055
1.48ProPhe: 1.48 ± 0.033
6.459ProGly: 6.459 ± 0.084
1.253ProHis: 1.253 ± 0.032
1.492ProIle: 1.492 ± 0.036
0.782ProLys: 0.782 ± 0.028
4.987ProLeu: 4.987 ± 0.059
1.018ProMet: 1.018 ± 0.03
0.868ProAsn: 0.868 ± 0.027
3.146ProPro: 3.146 ± 0.061
1.465ProGln: 1.465 ± 0.037
3.89ProArg: 3.89 ± 0.065
2.892ProSer: 2.892 ± 0.047
3.757ProThr: 3.757 ± 0.054
5.553ProVal: 5.553 ± 0.083
0.899ProTrp: 0.899 ± 0.029
1.046ProTyr: 1.046 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.835GlnAla: 3.835 ± 0.063
0.152GlnCys: 0.152 ± 0.011
1.385GlnAsp: 1.385 ± 0.033
1.364GlnGlu: 1.364 ± 0.033
0.702GlnPhe: 0.702 ± 0.025
2.145GlnGly: 2.145 ± 0.041
0.653GlnHis: 0.653 ± 0.023
1.13GlnIle: 1.13 ± 0.032
0.42GlnLys: 0.42 ± 0.021
3.002GlnLeu: 3.002 ± 0.052
0.582GlnMet: 0.582 ± 0.022
0.487GlnAsn: 0.487 ± 0.022
1.574GlnPro: 1.574 ± 0.042
1.072GlnGln: 1.072 ± 0.029
2.319GlnArg: 2.319 ± 0.043
1.102GlnSer: 1.102 ± 0.033
1.361GlnThr: 1.361 ± 0.035
3.049GlnVal: 3.049 ± 0.047
0.422GlnTrp: 0.422 ± 0.02
0.562GlnTyr: 0.562 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
10.557ArgAla: 10.557 ± 0.111
0.452ArgCys: 0.452 ± 0.02
4.177ArgAsp: 4.177 ± 0.057
4.538ArgGlu: 4.538 ± 0.066
1.993ArgPhe: 1.993 ± 0.041
5.962ArgGly: 5.962 ± 0.081
1.952ArgHis: 1.952 ± 0.046
2.647ArgIle: 2.647 ± 0.038
1.252ArgLys: 1.252 ± 0.036
8.169ArgLeu: 8.169 ± 0.1
1.731ArgMet: 1.731 ± 0.036
1.145ArgAsn: 1.145 ± 0.035
4.668ArgPro: 4.668 ± 0.073
2.278ArgGln: 2.278 ± 0.044
7.956ArgArg: 7.956 ± 0.103
3.989ArgSer: 3.989 ± 0.067
5.126ArgThr: 5.126 ± 0.068
6.283ArgVal: 6.283 ± 0.083
1.437ArgTrp: 1.437 ± 0.038
1.654ArgTyr: 1.654 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.413SerAla: 6.413 ± 0.08
0.275SerCys: 0.275 ± 0.017
2.412SerAsp: 2.412 ± 0.046
2.241SerGlu: 2.241 ± 0.039
1.523SerPhe: 1.523 ± 0.033
5.192SerGly: 5.192 ± 0.069
0.92SerHis: 0.92 ± 0.026
1.615SerIle: 1.615 ± 0.036
0.764SerLys: 0.764 ± 0.028
4.692SerLeu: 4.692 ± 0.06
1.044SerMet: 1.044 ± 0.029
0.783SerAsn: 0.783 ± 0.024
2.955SerPro: 2.955 ± 0.053
1.234SerGln: 1.234 ± 0.032
3.575SerArg: 3.575 ± 0.059
2.635SerSer: 2.635 ± 0.056
3.232SerThr: 3.232 ± 0.053
4.176SerVal: 4.176 ± 0.066
0.872SerTrp: 0.872 ± 0.026
1.015SerTyr: 1.015 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.892ThrAla: 8.892 ± 0.088
0.364ThrCys: 0.364 ± 0.019
3.683ThrAsp: 3.683 ± 0.06
3.272ThrGlu: 3.272 ± 0.05
1.95ThrPhe: 1.95 ± 0.037
6.487ThrGly: 6.487 ± 0.085
1.236ThrHis: 1.236 ± 0.034
2.22ThrIle: 2.22 ± 0.05
1.045ThrLys: 1.045 ± 0.035
5.927ThrLeu: 5.927 ± 0.077
1.111ThrMet: 1.111 ± 0.028
1.065ThrAsn: 1.065 ± 0.032
3.992ThrPro: 3.992 ± 0.067
1.458ThrGln: 1.458 ± 0.036
4.024ThrArg: 4.024 ± 0.056
3.278ThrSer: 3.278 ± 0.06
4.43ThrThr: 4.43 ± 0.077
6.246ThrVal: 6.246 ± 0.082
1.041ThrTrp: 1.041 ± 0.028
1.291ThrTyr: 1.291 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
13.726ValAla: 13.726 ± 0.147
0.603ValCys: 0.603 ± 0.021
5.899ValAsp: 5.899 ± 0.071
5.336ValGlu: 5.336 ± 0.068
2.363ValPhe: 2.363 ± 0.039
7.966ValGly: 7.966 ± 0.083
2.05ValHis: 2.05 ± 0.038
3.22ValIle: 3.22 ± 0.057
1.411ValLys: 1.411 ± 0.038
11.062ValLeu: 11.062 ± 0.13
1.563ValMet: 1.563 ± 0.037
1.656ValAsn: 1.656 ± 0.038
5.742ValPro: 5.742 ± 0.07
2.252ValGln: 2.252 ± 0.044
7.477ValArg: 7.477 ± 0.077
4.372ValSer: 4.372 ± 0.053
6.247ValThr: 6.247 ± 0.075
11.015ValVal: 11.015 ± 0.12
1.126ValTrp: 1.126 ± 0.031
1.477ValTyr: 1.477 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.77TrpAla: 1.77 ± 0.044
0.102TrpCys: 0.102 ± 0.01
0.834TrpAsp: 0.834 ± 0.026
0.665TrpGlu: 0.665 ± 0.026
0.486TrpPhe: 0.486 ± 0.022
1.035TrpGly: 1.035 ± 0.028
0.368TrpHis: 0.368 ± 0.018
0.492TrpIle: 0.492 ± 0.021
0.237TrpLys: 0.237 ± 0.014
1.721TrpLeu: 1.721 ± 0.043
0.276TrpMet: 0.276 ± 0.015
0.326TrpAsn: 0.326 ± 0.016
0.774TrpPro: 0.774 ± 0.026
0.56TrpGln: 0.56 ± 0.021
1.347TrpArg: 1.347 ± 0.035
0.888TrpSer: 0.888 ± 0.029
0.935TrpThr: 0.935 ± 0.029
1.267TrpVal: 1.267 ± 0.033
0.381TrpTrp: 0.381 ± 0.018
0.295TrpTyr: 0.295 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.377TyrAla: 2.377 ± 0.038
0.127TyrCys: 0.127 ± 0.011
1.254TyrAsp: 1.254 ± 0.034
1.041TyrGlu: 1.041 ± 0.032
0.615TyrPhe: 0.615 ± 0.028
1.877TyrGly: 1.877 ± 0.044
0.369TyrHis: 0.369 ± 0.017
0.48TyrIle: 0.48 ± 0.024
0.3TyrLys: 0.3 ± 0.017
2.097TyrLeu: 2.097 ± 0.045
0.257TyrMet: 0.257 ± 0.014
0.361TyrAsn: 0.361 ± 0.018
1.013TyrPro: 1.013 ± 0.033
0.49TyrGln: 0.49 ± 0.021
1.546TyrArg: 1.546 ± 0.034
0.871TyrSer: 0.871 ± 0.024
1.063TyrThr: 1.063 ± 0.029
1.675TyrVal: 1.675 ± 0.039
0.302TyrTrp: 0.302 ± 0.015
0.395TyrTyr: 0.395 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3886 proteins (1259739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski