Amino acid dipepetide frequency for Methylacidimicrobium cyclopophantes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.911AlaAla: 12.911 ± 0.193	1.108AlaCys: 1.108 ± 0.039	4.588AlaAsp: 4.588 ± 0.092	7.509AlaGlu: 7.509 ± 0.132	4.147AlaPhe: 4.147 ± 0.081	8.665AlaGly: 8.665 ± 0.123	1.889AlaHis: 1.889 ± 0.057	5.172AlaIle: 5.172 ± 0.083	3.521AlaLys: 3.521 ± 0.074	12.382AlaLeu: 12.382 ± 0.17	1.978AlaMet: 1.978 ± 0.063	2.267AlaAsn: 2.267 ± 0.062	4.716AlaPro: 4.716 ± 0.079	3.409AlaGln: 3.409 ± 0.084	8.404AlaArg: 8.404 ± 0.125	6.264AlaSer: 6.264 ± 0.102	4.257AlaThr: 4.257 ± 0.09	7.252AlaVal: 7.252 ± 0.108	1.563AlaTrp: 1.563 ± 0.056	2.286AlaTyr: 2.286 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.044	0.171CysCys: 0.171 ± 0.019	0.459CysAsp: 0.459 ± 0.029	0.616CysGlu: 0.616 ± 0.036	0.468CysPhe: 0.468 ± 0.024	1.205CysGly: 1.205 ± 0.044	0.291CysHis: 0.291 ± 0.023	0.409CysIle: 0.409 ± 0.025	0.197CysLys: 0.197 ± 0.018	1.319CysLeu: 1.319 ± 0.045	0.119CysMet: 0.119 ± 0.015	0.221CysAsn: 0.221 ± 0.021	0.715CysPro: 0.715 ± 0.038	0.342CysGln: 0.342 ± 0.024	1.137CysArg: 1.137 ± 0.044	0.73CysSer: 0.73 ± 0.04	0.389CysThr: 0.389 ± 0.021	0.715CysVal: 0.715 ± 0.035	0.191CysTrp: 0.191 ± 0.017	0.255CysTyr: 0.255 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.83AspAla: 3.83 ± 0.082	0.479AspCys: 0.479 ± 0.028	1.458AspAsp: 1.458 ± 0.049	2.35AspGlu: 2.35 ± 0.064	1.976AspPhe: 1.976 ± 0.06	3.638AspGly: 3.638 ± 0.085	0.944AspHis: 0.944 ± 0.039	1.67AspIle: 1.67 ± 0.057	1.025AspLys: 1.025 ± 0.04	5.678AspLeu: 5.678 ± 0.107	0.514AspMet: 0.514 ± 0.032	0.709AspAsn: 0.709 ± 0.037	3.713AspPro: 3.713 ± 0.078	1.351AspGln: 1.351 ± 0.041	4.304AspArg: 4.304 ± 0.075	2.363AspSer: 2.363 ± 0.061	1.29AspThr: 1.29 ± 0.044	2.624AspVal: 2.624 ± 0.067	0.904AspTrp: 0.904 ± 0.042	1.302AspTyr: 1.302 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	8.494GluAla: 8.494 ± 0.128	0.572GluCys: 0.572 ± 0.029	2.526GluAsp: 2.526 ± 0.07	7.406GluGlu: 7.406 ± 0.142	2.15GluPhe: 2.15 ± 0.062	5.803GluGly: 5.803 ± 0.104	1.038GluHis: 1.038 ± 0.036	4.478GluIle: 4.478 ± 0.084	3.748GluLys: 3.748 ± 0.083	7.413GluLeu: 7.413 ± 0.113	1.461GluMet: 1.461 ± 0.049	1.677GluAsn: 1.677 ± 0.048	3.17GluPro: 3.17 ± 0.065	2.255GluGln: 2.255 ± 0.057	7.017GluArg: 7.017 ± 0.125	3.885GluSer: 3.885 ± 0.08	3.078GluThr: 3.078 ± 0.073	4.441GluVal: 4.441 ± 0.087	0.956GluTrp: 0.956 ± 0.036	1.179GluTyr: 1.179 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	4.217PheAla: 4.217 ± 0.078	0.688PheCys: 0.688 ± 0.032	1.952PheAsp: 1.952 ± 0.058	2.113PheGlu: 2.113 ± 0.06	2.29PhePhe: 2.29 ± 0.072	3.755PheGly: 3.755 ± 0.086	0.993PheHis: 0.993 ± 0.04	0.906PheIle: 0.906 ± 0.036	0.468PheLys: 0.468 ± 0.03	6.041PheLeu: 6.041 ± 0.125	0.381PheMet: 0.381 ± 0.025	0.72PheAsn: 0.72 ± 0.039	2.784PhePro: 2.784 ± 0.072	1.256PheGln: 1.256 ± 0.044	3.472PheArg: 3.472 ± 0.068	3.12PheSer: 3.12 ± 0.063	1.686PheThr: 1.686 ± 0.059	2.848PheVal: 2.848 ± 0.07	0.852PheTrp: 0.852 ± 0.04	1.142PheTyr: 1.142 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	7.677GlyAla: 7.677 ± 0.127	1.171GlyCys: 1.171 ± 0.042	3.286GlyAsp: 3.286 ± 0.082	5.972GlyGlu: 5.972 ± 0.106	3.774GlyPhe: 3.774 ± 0.084	7.136GlyGly: 7.136 ± 0.145	1.602GlyHis: 1.602 ± 0.061	4.917GlyIle: 4.917 ± 0.082	4.396GlyLys: 4.396 ± 0.086	8.759GlyLeu: 8.759 ± 0.127	2.02GlyMet: 2.02 ± 0.06	1.973GlyAsn: 1.973 ± 0.065	3.664GlyPro: 3.664 ± 0.073	2.267GlyGln: 2.267 ± 0.054	7.041GlyArg: 7.041 ± 0.105	5.824GlySer: 5.824 ± 0.099	3.853GlyThr: 3.853 ± 0.081	5.548GlyVal: 5.548 ± 0.097	1.699GlyTrp: 1.699 ± 0.06	2.231GlyTyr: 2.231 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.785HisAla: 1.785 ± 0.06	0.273HisCys: 0.273 ± 0.021	0.765HisAsp: 0.765 ± 0.041	0.927HisGlu: 0.927 ± 0.042	0.964HisPhe: 0.964 ± 0.04	1.877HisGly: 1.877 ± 0.071	0.558HisHis: 0.558 ± 0.033	0.729HisIle: 0.729 ± 0.036	0.489HisLys: 0.489 ± 0.029	2.369HisLeu: 2.369 ± 0.059	0.259HisMet: 0.259 ± 0.021	0.415HisAsn: 0.415 ± 0.026	1.744HisPro: 1.744 ± 0.06	0.579HisGln: 0.579 ± 0.029	1.868HisArg: 1.868 ± 0.062	1.104HisSer: 1.104 ± 0.043	0.63HisThr: 0.63 ± 0.03	1.197HisVal: 1.197 ± 0.042	0.448HisTrp: 0.448 ± 0.026	0.576HisTyr: 0.576 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.207IleAla: 5.207 ± 0.097	0.57IleCys: 0.57 ± 0.03	2.824IleAsp: 2.824 ± 0.079	3.335IleGlu: 3.335 ± 0.066	1.821IlePhe: 1.821 ± 0.056	4.304IleGly: 4.304 ± 0.099	1.105IleHis: 1.105 ± 0.044	1.118IleIle: 1.118 ± 0.05	0.826IleLys: 0.826 ± 0.04	5.831IleLeu: 5.831 ± 0.095	0.41IleMet: 0.41 ± 0.031	0.986IleAsn: 0.986 ± 0.046	3.19IlePro: 3.19 ± 0.071	1.461IleGln: 1.461 ± 0.046	4.153IleArg: 4.153 ± 0.089	2.577IleSer: 2.577 ± 0.058	1.81IleThr: 1.81 ± 0.06	3.728IleVal: 3.728 ± 0.088	0.555IleTrp: 0.555 ± 0.032	1.044IleTyr: 1.044 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.543LysAla: 3.543 ± 0.086	0.188LysCys: 0.188 ± 0.018	1.336LysAsp: 1.336 ± 0.048	3.19LysGlu: 3.19 ± 0.076	0.788LysPhe: 0.788 ± 0.035	2.845LysGly: 2.845 ± 0.072	0.46LysHis: 0.46 ± 0.027	2.042LysIle: 2.042 ± 0.06	1.728LysLys: 1.728 ± 0.061	3.37LysLeu: 3.37 ± 0.08	0.625LysMet: 0.625 ± 0.029	0.868LysAsn: 0.868 ± 0.039	1.869LysPro: 1.869 ± 0.054	0.947LysGln: 0.947 ± 0.04	2.905LysArg: 2.905 ± 0.067	1.799LysSer: 1.799 ± 0.053	1.776LysThr: 1.776 ± 0.051	2.089LysVal: 2.089 ± 0.061	0.375LysTrp: 0.375 ± 0.024	0.471LysTyr: 0.471 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.218LeuAla: 13.218 ± 0.15	1.493LeuCys: 1.493 ± 0.049	4.859LeuAsp: 4.859 ± 0.087	7.656LeuGlu: 7.656 ± 0.118	5.594LeuPhe: 5.594 ± 0.141	9.569LeuGly: 9.569 ± 0.145	2.459LeuHis: 2.459 ± 0.063	3.919LeuIle: 3.919 ± 0.08	2.351LeuLys: 2.351 ± 0.062	15.827LeuLeu: 15.827 ± 0.243	1.374LeuMet: 1.374 ± 0.051	1.907LeuAsn: 1.907 ± 0.061	7.717LeuPro: 7.717 ± 0.119	3.519LeuGln: 3.519 ± 0.074	10.737LeuArg: 10.737 ± 0.152	8.108LeuSer: 8.108 ± 0.11	4.562LeuThr: 4.562 ± 0.09	8.083LeuVal: 8.083 ± 0.113	1.923LeuTrp: 1.923 ± 0.071	2.412LeuTyr: 2.412 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.095MetAla: 2.095 ± 0.062	0.076MetCys: 0.076 ± 0.01	0.768MetAsp: 0.768 ± 0.035	1.322MetGlu: 1.322 ± 0.046	0.343MetPhe: 0.343 ± 0.021	1.657MetGly: 1.657 ± 0.054	0.338MetHis: 0.338 ± 0.025	0.889MetIle: 0.889 ± 0.04	0.767MetLys: 0.767 ± 0.033	1.546MetLeu: 1.546 ± 0.051	0.276MetMet: 0.276 ± 0.022	0.518MetAsn: 0.518 ± 0.03	0.977MetPro: 0.977 ± 0.041	0.5MetGln: 0.5 ± 0.031	1.409MetArg: 1.409 ± 0.044	1.044MetSer: 1.044 ± 0.045	1.005MetThr: 1.005 ± 0.042	1.267MetVal: 1.267 ± 0.054	0.133MetTrp: 0.133 ± 0.016	0.209MetTyr: 0.209 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.191AsnAla: 2.191 ± 0.064	0.238AsnCys: 0.238 ± 0.019	0.839AsnAsp: 0.839 ± 0.034	1.173AsnGlu: 1.173 ± 0.042	0.961AsnPhe: 0.961 ± 0.041	1.958AsnGly: 1.958 ± 0.062	0.412AsnHis: 0.412 ± 0.022	0.918AsnIle: 0.918 ± 0.039	0.444AsnLys: 0.444 ± 0.025	2.702AsnLeu: 2.702 ± 0.062	0.399AsnMet: 0.399 ± 0.026	0.499AsnAsn: 0.499 ± 0.037	2.028AsnPro: 2.028 ± 0.061	0.717AsnGln: 0.717 ± 0.035	2.048AsnArg: 2.048 ± 0.06	1.069AsnSer: 1.069 ± 0.042	0.807AsnThr: 0.807 ± 0.041	1.612AsnVal: 1.612 ± 0.06	0.377AsnTrp: 0.377 ± 0.028	0.613AsnTyr: 0.613 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.663ProAla: 5.663 ± 0.099	0.492ProCys: 0.492 ± 0.029	2.79ProAsp: 2.79 ± 0.068	5.187ProGlu: 5.187 ± 0.088	2.545ProPhe: 2.545 ± 0.063	4.96ProGly: 4.96 ± 0.097	1.116ProHis: 1.116 ± 0.047	2.793ProIle: 2.793 ± 0.077	2.054ProLys: 2.054 ± 0.057	6.289ProLeu: 6.289 ± 0.107	1.205ProMet: 1.205 ± 0.041	1.395ProAsn: 1.395 ± 0.05	3.74ProPro: 3.74 ± 0.11	1.718ProGln: 1.718 ± 0.055	3.815ProArg: 3.815 ± 0.086	4.13ProSer: 4.13 ± 0.083	2.598ProThr: 2.598 ± 0.065	3.917ProVal: 3.917 ± 0.079	1.051ProTrp: 1.051 ± 0.045	1.32ProTyr: 1.32 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.539GlnAla: 3.539 ± 0.089	0.224GlnCys: 0.224 ± 0.019	1.098GlnAsp: 1.098 ± 0.047	2.647GlnGlu: 2.647 ± 0.068	0.901GlnPhe: 0.901 ± 0.039	2.627GlnGly: 2.627 ± 0.067	0.447GlnHis: 0.447 ± 0.028	1.907GlnIle: 1.907 ± 0.051	1.574GlnLys: 1.574 ± 0.061	2.752GlnLeu: 2.752 ± 0.071	0.662GlnMet: 0.662 ± 0.037	0.808GlnAsn: 0.808 ± 0.036	1.624GlnPro: 1.624 ± 0.047	1.125GlnGln: 1.125 ± 0.056	2.507GlnArg: 2.507 ± 0.068	1.735GlnSer: 1.735 ± 0.048	1.458GlnThr: 1.458 ± 0.044	1.817GlnVal: 1.817 ± 0.059	0.604GlnTrp: 0.604 ± 0.027	0.672GlnTyr: 0.672 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.727ArgAla: 7.727 ± 0.118	0.924ArgCys: 0.924 ± 0.036	3.171ArgAsp: 3.171 ± 0.068	7.081ArgGlu: 7.081 ± 0.11	3.848ArgPhe: 3.848 ± 0.077	5.602ArgGly: 5.602 ± 0.094	1.621ArgHis: 1.621 ± 0.05	5.17ArgIle: 5.17 ± 0.097	3.859ArgLys: 3.859 ± 0.081	10.202ArgLeu: 10.202 ± 0.161	1.912ArgMet: 1.912 ± 0.054	2.133ArgAsn: 2.133 ± 0.062	4.251ArgPro: 4.251 ± 0.088	2.801ArgGln: 2.801 ± 0.061	7.855ArgArg: 7.855 ± 0.139	5.561ArgSer: 5.561 ± 0.106	3.429ArgThr: 3.429 ± 0.066	5.262ArgVal: 5.262 ± 0.083	1.674ArgTrp: 1.674 ± 0.056	2.214ArgTyr: 2.214 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.951SerAla: 5.951 ± 0.097	0.753SerCys: 0.753 ± 0.034	2.522SerAsp: 2.522 ± 0.067	3.806SerGlu: 3.806 ± 0.084	3.04SerPhe: 3.04 ± 0.075	5.919SerGly: 5.919 ± 0.109	1.237SerHis: 1.237 ± 0.04	2.645SerIle: 2.645 ± 0.062	1.537SerLys: 1.537 ± 0.046	7.596SerLeu: 7.596 ± 0.127	1.144SerMet: 1.144 ± 0.046	1.134SerAsn: 1.134 ± 0.04	4.254SerPro: 4.254 ± 0.094	1.81SerGln: 1.81 ± 0.049	5.114SerArg: 5.114 ± 0.097	4.3SerSer: 4.3 ± 0.085	2.526SerThr: 2.526 ± 0.072	4.188SerVal: 4.188 ± 0.079	1.229SerTrp: 1.229 ± 0.047	1.47SerTyr: 1.47 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.339ThrAla: 4.339 ± 0.095	0.36ThrCys: 0.36 ± 0.024	1.697ThrAsp: 1.697 ± 0.053	2.682ThrGlu: 2.682 ± 0.061	1.615ThrPhe: 1.615 ± 0.051	4.112ThrGly: 4.112 ± 0.084	0.863ThrHis: 0.863 ± 0.042	2.308ThrIle: 2.308 ± 0.062	1.253ThrLys: 1.253 ± 0.049	4.875ThrLeu: 4.875 ± 0.069	0.729ThrMet: 0.729 ± 0.031	1.017ThrAsn: 1.017 ± 0.047	2.786ThrPro: 2.786 ± 0.071	1.182ThrGln: 1.182 ± 0.047	2.732ThrArg: 2.732 ± 0.064	2.199ThrSer: 2.199 ± 0.059	2.093ThrThr: 2.093 ± 0.071	3.44ThrVal: 3.44 ± 0.082	0.46ThrTrp: 0.46 ± 0.026	0.964ThrTyr: 0.964 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	7.245ValAla: 7.245 ± 0.113	0.8ValCys: 0.8 ± 0.032	3.522ValAsp: 3.522 ± 0.076	5.112ValGlu: 5.112 ± 0.093	2.802ValPhe: 2.802 ± 0.076	5.812ValGly: 5.812 ± 0.099	1.357ValHis: 1.357 ± 0.045	3.011ValIle: 3.011 ± 0.08	1.718ValLys: 1.718 ± 0.048	7.56ValLeu: 7.56 ± 0.127	0.964ValMet: 0.964 ± 0.042	1.606ValAsn: 1.606 ± 0.06	3.729ValPro: 3.729 ± 0.086	2.002ValGln: 2.002 ± 0.059	5.832ValArg: 5.832 ± 0.108	4.182ValSer: 4.182 ± 0.078	2.844ValThr: 2.844 ± 0.084	5.372ValVal: 5.372 ± 0.105	0.953ValTrp: 0.953 ± 0.038	1.537ValTyr: 1.537 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.336TrpAla: 1.336 ± 0.043	0.177TrpCys: 0.177 ± 0.017	0.634TrpAsp: 0.634 ± 0.034	1.305TrpGlu: 1.305 ± 0.052	0.601TrpPhe: 0.601 ± 0.033	1.215TrpGly: 1.215 ± 0.053	0.306TrpHis: 0.306 ± 0.023	1.131TrpIle: 1.131 ± 0.04	0.849TrpLys: 0.849 ± 0.035	1.988TrpLeu: 1.988 ± 0.068	0.399TrpMet: 0.399 ± 0.023	0.576TrpAsn: 0.576 ± 0.036	0.753TrpPro: 0.753 ± 0.038	0.627TrpGln: 0.627 ± 0.029	1.432TrpArg: 1.432 ± 0.05	0.95TrpSer: 0.95 ± 0.04	0.767TrpThr: 0.767 ± 0.039	1.015TrpVal: 1.015 ± 0.041	0.281TrpTrp: 0.281 ± 0.025	0.351TrpTyr: 0.351 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.214TyrAla: 2.214 ± 0.062	0.294TyrCys: 0.294 ± 0.023	1.026TyrAsp: 1.026 ± 0.042	1.362TyrGlu: 1.362 ± 0.05	1.057TyrPhe: 1.057 ± 0.054	2.151TyrGly: 2.151 ± 0.06	0.52TyrHis: 0.52 ± 0.032	0.723TyrIle: 0.723 ± 0.037	0.41TyrLys: 0.41 ± 0.021	2.787TyrLeu: 2.787 ± 0.077	0.31TyrMet: 0.31 ± 0.026	0.57TyrAsn: 0.57 ± 0.038	1.355TyrPro: 1.355 ± 0.046	0.86TyrGln: 0.86 ± 0.041	2.516TyrArg: 2.516 ± 0.067	1.23TyrSer: 1.23 ± 0.045	0.848TyrThr: 0.848 ± 0.039	1.546TyrVal: 1.546 ± 0.05	0.468TyrTrp: 0.468 ± 0.026	0.66TyrTyr: 0.66 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2067 proteins (655861 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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