Amino acid dipepetide frequency for Plasmodium falciparum UGT5.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.947AlaAla: 0.947 ± 0.033
0.496AlaCys: 0.496 ± 0.016
1.053AlaAsp: 1.053 ± 0.018
1.184AlaGlu: 1.184 ± 0.022
0.932AlaPhe: 0.932 ± 0.015
0.746AlaGly: 0.746 ± 0.021
0.575AlaHis: 0.575 ± 0.013
1.606AlaIle: 1.606 ± 0.029
1.762AlaLys: 1.762 ± 0.027
1.929AlaLeu: 1.929 ± 0.026
0.365AlaMet: 0.365 ± 0.01
1.567AlaAsn: 1.567 ± 0.026
0.575AlaPro: 0.575 ± 0.018
0.708AlaGln: 0.708 ± 0.016
0.588AlaArg: 0.588 ± 0.014
1.483AlaSer: 1.483 ± 0.027
1.0AlaThr: 1.0 ± 0.025
0.861AlaVal: 0.861 ± 0.019
0.134AlaTrp: 0.134 ± 0.006
1.086AlaTyr: 1.086 ± 0.019
0.0AlaXaa: 0.0 ± 0.0
Cys
0.528CysAla: 0.528 ± 0.013
0.33CysCys: 0.33 ± 0.01
1.3CysAsp: 1.3 ± 0.025
1.14CysGlu: 1.14 ± 0.019
0.854CysPhe: 0.854 ± 0.016
0.716CysGly: 0.716 ± 0.017
0.328CysHis: 0.328 ± 0.01
1.77CysIle: 1.77 ± 0.026
1.644CysLys: 1.644 ± 0.029
1.551CysLeu: 1.551 ± 0.024
0.371CysMet: 0.371 ± 0.011
1.902CysAsn: 1.902 ± 0.027
0.47CysPro: 0.47 ± 0.017
0.356CysGln: 0.356 ± 0.01
0.504CysArg: 0.504 ± 0.015
1.448CysSer: 1.448 ± 0.024
0.956CysThr: 0.956 ± 0.018
0.903CysVal: 0.903 ± 0.015
0.071CysTrp: 0.071 ± 0.005
0.84CysTyr: 0.84 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
1.228AspAla: 1.228 ± 0.022
0.687AspCys: 0.687 ± 0.016
6.883AspAsp: 6.883 ± 0.108
5.804AspGlu: 5.804 ± 0.059
2.12AspPhe: 2.12 ± 0.028
1.734AspGly: 1.734 ± 0.032
1.467AspHis: 1.467 ± 0.024
7.387AspIle: 7.387 ± 0.056
6.743AspLys: 6.743 ± 0.061
3.753AspLeu: 3.753 ± 0.035
1.726AspMet: 1.726 ± 0.023
8.963AspAsn: 8.963 ± 0.087
0.994AspPro: 0.994 ± 0.019
1.444AspGln: 1.444 ± 0.024
1.216AspArg: 1.216 ± 0.032
3.131AspSer: 3.131 ± 0.039
2.694AspThr: 2.694 ± 0.036
2.85AspVal: 2.85 ± 0.035
0.224AspTrp: 0.224 ± 0.01
2.83AspTyr: 2.83 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
1.421GluAla: 1.421 ± 0.027
1.101GluCys: 1.101 ± 0.019
4.729GluAsp: 4.729 ± 0.056
8.052GluGlu: 8.052 ± 0.146
2.013GluPhe: 2.013 ± 0.023
2.018GluGly: 2.018 ± 0.036
1.857GluHis: 1.857 ± 0.029
5.311GluIle: 5.311 ± 0.061
10.732GluLys: 10.732 ± 0.088
4.518GluLeu: 4.518 ± 0.049
1.357GluMet: 1.357 ± 0.023
8.986GluAsn: 8.986 ± 0.072
0.975GluPro: 0.975 ± 0.023
2.663GluGln: 2.663 ± 0.032
2.127GluArg: 2.127 ± 0.035
3.29GluSer: 3.29 ± 0.043
2.396GluThr: 2.396 ± 0.03
2.046GluVal: 2.046 ± 0.053
0.488GluTrp: 0.488 ± 0.019
3.708GluTyr: 3.708 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
0.805PheAla: 0.805 ± 0.017
0.999PheCys: 0.999 ± 0.017
2.459PheAsp: 2.459 ± 0.029
2.335PheGlu: 2.335 ± 0.028
3.459PhePhe: 3.459 ± 0.052
1.155PheGly: 1.155 ± 0.027
1.151PheHis: 1.151 ± 0.02
4.363PheIle: 4.363 ± 0.047
3.704PheLys: 3.704 ± 0.038
5.136PheLeu: 5.136 ± 0.053
0.927PheMet: 0.927 ± 0.016
4.374PheAsn: 4.374 ± 0.044
1.006PhePro: 1.006 ± 0.018
1.129PheGln: 1.129 ± 0.019
0.986PheArg: 0.986 ± 0.017
3.267PheSer: 3.267 ± 0.038
1.597PheThr: 1.597 ± 0.024
1.978PheVal: 1.978 ± 0.023
0.208PheTrp: 0.208 ± 0.008
2.953PheTyr: 2.953 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
0.829GlyAla: 0.829 ± 0.021
0.533GlyCys: 0.533 ± 0.013
2.145GlyAsp: 2.145 ± 0.04
1.89GlyGlu: 1.89 ± 0.03
1.065GlyPhe: 1.065 ± 0.021
1.489GlyGly: 1.489 ± 0.036
0.621GlyHis: 0.621 ± 0.015
2.397GlyIle: 2.397 ± 0.033
3.091GlyLys: 3.091 ± 0.041
1.959GlyLeu: 1.959 ± 0.033
0.595GlyMet: 0.595 ± 0.013
3.092GlyAsn: 3.092 ± 0.039
0.556GlyPro: 0.556 ± 0.017
0.678GlyGln: 0.678 ± 0.014
0.886GlyArg: 0.886 ± 0.019
1.992GlySer: 1.992 ± 0.044
1.457GlyThr: 1.457 ± 0.028
1.299GlyVal: 1.299 ± 0.024
0.171GlyTrp: 0.171 ± 0.007
1.451GlyTyr: 1.451 ± 0.024
0.0GlyXaa: 0.0 ± 0.0
His
0.458HisAla: 0.458 ± 0.012
0.305HisCys: 0.305 ± 0.009
1.395HisAsp: 1.395 ± 0.024
1.326HisGlu: 1.326 ± 0.021
1.347HisPhe: 1.347 ± 0.023
0.604HisGly: 0.604 ± 0.016
0.758HisHis: 0.758 ± 0.022
2.98HisIle: 2.98 ± 0.036
2.335HisLys: 2.335 ± 0.031
1.923HisLeu: 1.923 ± 0.024
0.866HisMet: 0.866 ± 0.015
3.421HisAsn: 3.421 ± 0.045
0.547HisPro: 0.547 ± 0.011
0.526HisGln: 0.526 ± 0.013
0.532HisArg: 0.532 ± 0.012
1.42HisSer: 1.42 ± 0.019
1.177HisThr: 1.177 ± 0.022
1.176HisVal: 1.176 ± 0.028
0.089HisTrp: 0.089 ± 0.005
1.09HisTyr: 1.09 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
1.49IleAla: 1.49 ± 0.028
2.1IleCys: 2.1 ± 0.03
4.805IleAsp: 4.805 ± 0.045
5.152IleGlu: 5.152 ± 0.053
4.843IlePhe: 4.843 ± 0.052
2.185IleGly: 2.185 ± 0.035
2.673IleHis: 2.673 ± 0.03
8.607IleIle: 8.607 ± 0.079
10.774IleLys: 10.774 ± 0.087
8.464IleLeu: 8.464 ± 0.071
1.675IleMet: 1.675 ± 0.023
12.99IleAsn: 12.99 ± 0.106
2.367IlePro: 2.367 ± 0.036
2.991IleGln: 2.991 ± 0.037
2.28IleArg: 2.28 ± 0.025
6.211IleSer: 6.211 ± 0.041
3.488IleThr: 3.488 ± 0.037
2.842IleVal: 2.842 ± 0.037
0.502IleTrp: 0.502 ± 0.014
6.642IleTyr: 6.642 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
1.823LysAla: 1.823 ± 0.028
2.105LysCys: 2.105 ± 0.032
6.939LysAsp: 6.939 ± 0.062
10.153LysGlu: 10.153 ± 0.088
3.201LysPhe: 3.201 ± 0.027
3.423LysGly: 3.423 ± 0.037
2.385LysHis: 2.385 ± 0.024
9.626LysIle: 9.626 ± 0.072
20.016LysLys: 20.016 ± 0.19
7.47LysLeu: 7.47 ± 0.056
2.611LysMet: 2.611 ± 0.033
17.161LysAsn: 17.161 ± 0.11
1.497LysPro: 1.497 ± 0.027
3.151LysGln: 3.151 ± 0.034
4.257LysArg: 4.257 ± 0.039
6.207LysSer: 6.207 ± 0.054
4.252LysThr: 4.252 ± 0.043
3.359LysVal: 3.359 ± 0.033
0.638LysTrp: 0.638 ± 0.017
7.105LysTyr: 7.105 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
1.555LeuAla: 1.555 ± 0.025
1.822LeuCys: 1.822 ± 0.023
3.597LeuAsp: 3.597 ± 0.035
4.365LeuGlu: 4.365 ± 0.049
4.55LeuPhe: 4.55 ± 0.05
2.012LeuGly: 2.012 ± 0.034
1.88LeuHis: 1.88 ± 0.026
6.325LeuIle: 6.325 ± 0.06
9.199LeuLys: 9.199 ± 0.068
7.626LeuLeu: 7.626 ± 0.061
1.311LeuMet: 1.311 ± 0.021
8.917LeuAsn: 8.917 ± 0.07
1.815LeuPro: 1.815 ± 0.025
2.405LeuGln: 2.405 ± 0.029
2.356LeuArg: 2.356 ± 0.028
5.652LeuSer: 5.652 ± 0.043
2.913LeuThr: 2.913 ± 0.032
2.349LeuVal: 2.349 ± 0.032
0.477LeuTrp: 0.477 ± 0.011
5.096LeuTyr: 5.096 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
0.387MetAla: 0.387 ± 0.011
0.478MetCys: 0.478 ± 0.013
1.573MetAsp: 1.573 ± 0.022
1.513MetGlu: 1.513 ± 0.023
0.899MetPhe: 0.899 ± 0.016
0.579MetGly: 0.579 ± 0.013
0.437MetHis: 0.437 ± 0.012
1.566MetIle: 1.566 ± 0.022
2.904MetLys: 2.904 ± 0.035
1.695MetLeu: 1.695 ± 0.023
0.516MetMet: 0.516 ± 0.015
3.999MetAsn: 3.999 ± 0.066
0.393MetPro: 0.393 ± 0.012
0.532MetGln: 0.532 ± 0.012
0.539MetArg: 0.539 ± 0.011
1.41MetSer: 1.41 ± 0.023
0.686MetThr: 0.686 ± 0.016
0.689MetVal: 0.689 ± 0.014
0.126MetTrp: 0.126 ± 0.006
1.196MetTyr: 1.196 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
1.933AsnAla: 1.933 ± 0.027
1.61AsnCys: 1.61 ± 0.023
9.939AsnAsp: 9.939 ± 0.086
9.558AsnGlu: 9.558 ± 0.082
4.839AsnPhe: 4.839 ± 0.047
3.086AsnGly: 3.086 ± 0.046
2.863AsnHis: 2.863 ± 0.04
16.405AsnIle: 16.405 ± 0.125
15.521AsnLys: 15.521 ± 0.102
7.662AsnLeu: 7.662 ± 0.062
4.106AsnMet: 4.106 ± 0.066
32.735AsnAsn: 32.735 ± 0.443
1.706AsnPro: 1.706 ± 0.024
2.873AsnGln: 2.873 ± 0.04
2.488AsnArg: 2.488 ± 0.029
7.699AsnSer: 7.699 ± 0.083
5.525AsnThr: 5.525 ± 0.056
6.311AsnVal: 6.311 ± 0.055
0.333AsnTrp: 0.333 ± 0.011
7.171AsnTyr: 7.171 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
0.438ProAla: 0.438 ± 0.018
0.448ProCys: 0.448 ± 0.013
0.803ProAsp: 0.803 ± 0.018
1.061ProGlu: 1.061 ± 0.03
1.227ProPhe: 1.227 ± 0.021
0.551ProGly: 0.551 ± 0.014
0.549ProHis: 0.549 ± 0.013
1.675ProIle: 1.675 ± 0.026
1.673ProLys: 1.673 ± 0.026
1.857ProLeu: 1.857 ± 0.026
0.37ProMet: 0.37 ± 0.011
2.007ProAsn: 2.007 ± 0.029
0.807ProPro: 0.807 ± 0.031
0.691ProGln: 0.691 ± 0.018
0.543ProArg: 0.543 ± 0.015
1.61ProSer: 1.61 ± 0.026
1.017ProThr: 1.017 ± 0.022
0.774ProVal: 0.774 ± 0.017
0.139ProTrp: 0.139 ± 0.006
1.328ProTyr: 1.328 ± 0.02
0.0ProXaa: 0.0 ± 0.0
Gln
0.594GlnAla: 0.594 ± 0.013
0.422GlnCys: 0.422 ± 0.013
1.406GlnAsp: 1.406 ± 0.024
1.978GlnGlu: 1.978 ± 0.031
0.974GlnPhe: 0.974 ± 0.018
0.758GlnGly: 0.758 ± 0.014
0.746GlnHis: 0.746 ± 0.018
2.464GlnIle: 2.464 ± 0.031
3.607GlnLys: 3.607 ± 0.033
1.928GlnLeu: 1.928 ± 0.024
0.702GlnMet: 0.702 ± 0.016
4.287GlnAsn: 4.287 ± 0.053
0.546GlnPro: 0.546 ± 0.015
1.141GlnGln: 1.141 ± 0.035
0.842GlnArg: 0.842 ± 0.016
1.453GlnSer: 1.453 ± 0.025
1.296GlnThr: 1.296 ± 0.023
0.952GlnVal: 0.952 ± 0.019
0.17GlnTrp: 0.17 ± 0.007
1.392GlnTyr: 1.392 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
0.624ArgAla: 0.624 ± 0.015
0.455ArgCys: 0.455 ± 0.011
1.524ArgAsp: 1.524 ± 0.033
1.757ArgGlu: 1.757 ± 0.032
0.982ArgPhe: 0.982 ± 0.016
0.971ArgGly: 0.971 ± 0.022
0.573ArgHis: 0.573 ± 0.013
2.168ArgIle: 2.168 ± 0.023
3.958ArgLys: 3.958 ± 0.038
1.754ArgLeu: 1.754 ± 0.026
0.537ArgMet: 0.537 ± 0.011
3.417ArgAsn: 3.417 ± 0.038
0.46ArgPro: 0.46 ± 0.016
0.703ArgGln: 0.703 ± 0.014
1.437ArgArg: 1.437 ± 0.032
1.613ArgSer: 1.613 ± 0.027
1.141ArgThr: 1.141 ± 0.019
0.888ArgVal: 0.888 ± 0.019
0.206ArgTrp: 0.206 ± 0.009
1.357ArgTyr: 1.357 ± 0.019
0.0ArgXaa: 0.0 ± 0.0
Ser
1.375SerAla: 1.375 ± 0.023
1.274SerCys: 1.274 ± 0.018
3.97SerAsp: 3.97 ± 0.05
3.432SerGlu: 3.432 ± 0.041
3.559SerPhe: 3.559 ± 0.037
2.044SerGly: 2.044 ± 0.044
1.532SerHis: 1.532 ± 0.029
5.505SerIle: 5.505 ± 0.044
5.684SerLys: 5.684 ± 0.047
5.351SerLeu: 5.351 ± 0.045
1.192SerMet: 1.192 ± 0.018
8.183SerAsn: 8.183 ± 0.091
1.352SerPro: 1.352 ± 0.022
1.641SerGln: 1.641 ± 0.022
1.579SerArg: 1.579 ± 0.028
6.494SerSer: 6.494 ± 0.076
3.101SerThr: 3.101 ± 0.036
2.626SerVal: 2.626 ± 0.046
0.282SerTrp: 0.282 ± 0.009
3.867SerTyr: 3.867 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
0.933ThrAla: 0.933 ± 0.021
1.017ThrCys: 1.017 ± 0.019
2.036ThrAsp: 2.036 ± 0.028
2.07ThrGlu: 2.07 ± 0.049
2.233ThrPhe: 2.233 ± 0.029
1.112ThrGly: 1.112 ± 0.021
1.229ThrHis: 1.229 ± 0.022
3.131ThrIle: 3.131 ± 0.032
4.085ThrLys: 4.085 ± 0.035
3.407ThrLeu: 3.407 ± 0.035
0.675ThrMet: 0.675 ± 0.014
5.835ThrAsn: 5.835 ± 0.056
1.159ThrPro: 1.159 ± 0.024
1.365ThrGln: 1.365 ± 0.021
0.933ThrArg: 0.933 ± 0.017
3.228ThrSer: 3.228 ± 0.032
2.306ThrThr: 2.306 ± 0.042
1.314ThrVal: 1.314 ± 0.021
0.219ThrTrp: 0.219 ± 0.007
2.815ThrTyr: 2.815 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
0.953ValAla: 0.953 ± 0.023
0.843ValCys: 0.843 ± 0.017
2.642ValAsp: 2.642 ± 0.033
2.749ValGlu: 2.749 ± 0.054
1.595ValPhe: 1.595 ± 0.021
1.293ValGly: 1.293 ± 0.024
1.243ValHis: 1.243 ± 0.019
3.027ValIle: 3.027 ± 0.03
3.577ValLys: 3.577 ± 0.032
3.35ValLeu: 3.35 ± 0.035
0.689ValMet: 0.689 ± 0.013
4.051ValAsn: 4.051 ± 0.048
1.108ValPro: 1.108 ± 0.024
1.351ValGln: 1.351 ± 0.02
0.972ValArg: 0.972 ± 0.016
2.645ValSer: 2.645 ± 0.056
1.603ValThr: 1.603 ± 0.033
1.692ValVal: 1.692 ± 0.035
0.229ValTrp: 0.229 ± 0.009
1.977ValTyr: 1.977 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
0.157TrpAla: 0.157 ± 0.007
0.096TrpCys: 0.096 ± 0.005
0.289TrpAsp: 0.289 ± 0.009
0.316TrpGlu: 0.316 ± 0.012
0.261TrpPhe: 0.261 ± 0.01
0.217TrpGly: 0.217 ± 0.009
0.078TrpHis: 0.078 ± 0.004
0.472TrpIle: 0.472 ± 0.014
0.647TrpLys: 0.647 ± 0.017
0.427TrpLeu: 0.427 ± 0.013
0.108TrpMet: 0.108 ± 0.006
0.539TrpAsn: 0.539 ± 0.014
0.094TrpPro: 0.094 ± 0.005
0.095TrpGln: 0.095 ± 0.005
0.175TrpArg: 0.175 ± 0.008
0.311TrpSer: 0.311 ± 0.01
0.201TrpThr: 0.201 ± 0.008
0.232TrpVal: 0.232 ± 0.01
0.091TrpTrp: 0.091 ± 0.007
0.211TrpTyr: 0.211 ± 0.007
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.122TyrAla: 1.122 ± 0.019
0.862TyrCys: 0.862 ± 0.018
4.393TyrAsp: 4.393 ± 0.04
3.953TyrGlu: 3.953 ± 0.036
3.036TyrPhe: 3.036 ± 0.046
1.504TyrGly: 1.504 ± 0.022
1.328TyrHis: 1.328 ± 0.022
6.294TyrIle: 6.294 ± 0.071
5.721TyrLys: 5.721 ± 0.055
4.464TyrLeu: 4.464 ± 0.042
1.417TyrMet: 1.417 ± 0.024
7.938TyrAsn: 7.938 ± 0.078
1.14TyrPro: 1.14 ± 0.02
1.219TyrGln: 1.219 ± 0.017
1.282TyrArg: 1.282 ± 0.02
3.477TyrSer: 3.477 ± 0.038
2.297TyrThr: 2.297 ± 0.028
2.448TyrVal: 2.448 ± 0.027
0.22TyrTrp: 0.22 ± 0.008
3.513TyrTyr: 3.513 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5904 proteins (3939455 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski