Amino acid dipepetide frequency for Acinetobacter phage vB_ApiM_fHyAci03

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.865AlaAla: 4.865 ± 0.319
0.446AlaCys: 0.446 ± 0.087
3.585AlaAsp: 3.585 ± 0.273
4.768AlaGlu: 4.768 ± 0.333
2.539AlaPhe: 2.539 ± 0.258
4.361AlaGly: 4.361 ± 0.376
1.085AlaHis: 1.085 ± 0.16
5.814AlaIle: 5.814 ± 0.379
5.892AlaLys: 5.892 ± 0.324
6.182AlaLeu: 6.182 ± 0.318
1.938AlaMet: 1.938 ± 0.194
3.799AlaAsn: 3.799 ± 0.314
2.306AlaPro: 2.306 ± 0.223
3.295AlaGln: 3.295 ± 0.323
2.713AlaArg: 2.713 ± 0.235
3.876AlaSer: 3.876 ± 0.277
4.496AlaThr: 4.496 ± 0.464
4.206AlaVal: 4.206 ± 0.25
1.027AlaTrp: 1.027 ± 0.144
2.519AlaTyr: 2.519 ± 0.218
0.0AlaXaa: 0.0 ± 0.0
Cys
0.678CysAla: 0.678 ± 0.124
0.116CysCys: 0.116 ± 0.045
0.736CysAsp: 0.736 ± 0.122
0.911CysGlu: 0.911 ± 0.162
0.349CysPhe: 0.349 ± 0.094
0.678CysGly: 0.678 ± 0.108
0.31CysHis: 0.31 ± 0.079
0.775CysIle: 0.775 ± 0.144
0.698CysLys: 0.698 ± 0.119
0.736CysLeu: 0.736 ± 0.121
0.155CysMet: 0.155 ± 0.053
0.581CysAsn: 0.581 ± 0.114
0.446CysPro: 0.446 ± 0.112
0.368CysGln: 0.368 ± 0.077
0.678CysArg: 0.678 ± 0.096
0.853CysSer: 0.853 ± 0.149
0.717CysThr: 0.717 ± 0.132
0.678CysVal: 0.678 ± 0.106
0.136CysTrp: 0.136 ± 0.049
0.368CysTyr: 0.368 ± 0.087
0.0CysXaa: 0.0 ± 0.0
Asp
4.109AspAla: 4.109 ± 0.238
0.756AspCys: 0.756 ± 0.145
3.74AspAsp: 3.74 ± 0.288
5.078AspGlu: 5.078 ± 0.303
2.849AspPhe: 2.849 ± 0.232
4.341AspGly: 4.341 ± 0.343
0.969AspHis: 0.969 ± 0.121
4.167AspIle: 4.167 ± 0.296
4.632AspLys: 4.632 ± 0.307
4.768AspLeu: 4.768 ± 0.323
1.764AspMet: 1.764 ± 0.185
3.372AspAsn: 3.372 ± 0.27
2.558AspPro: 2.558 ± 0.237
1.531AspGln: 1.531 ± 0.173
2.151AspArg: 2.151 ± 0.199
4.031AspSer: 4.031 ± 0.26
3.159AspThr: 3.159 ± 0.293
3.702AspVal: 3.702 ± 0.27
1.066AspTrp: 1.066 ± 0.161
3.256AspTyr: 3.256 ± 0.266
0.0AspXaa: 0.0 ± 0.0
Glu
4.671GluAla: 4.671 ± 0.411
1.298GluCys: 1.298 ± 0.15
4.051GluAsp: 4.051 ± 0.302
4.496GluGlu: 4.496 ± 0.322
3.566GluPhe: 3.566 ± 0.294
3.14GluGly: 3.14 ± 0.27
1.415GluHis: 1.415 ± 0.204
5.33GluIle: 5.33 ± 0.355
3.954GluLys: 3.954 ± 0.265
7.5GluLeu: 7.5 ± 0.424
2.016GluMet: 2.016 ± 0.183
3.527GluAsn: 3.527 ± 0.295
1.55GluPro: 1.55 ± 0.183
2.675GluGln: 2.675 ± 0.259
3.217GluArg: 3.217 ± 0.28
3.469GluSer: 3.469 ± 0.3
4.438GluThr: 4.438 ± 0.257
4.496GluVal: 4.496 ± 0.331
0.736GluTrp: 0.736 ± 0.115
3.275GluTyr: 3.275 ± 0.234
0.0GluXaa: 0.0 ± 0.0
Phe
2.597PheAla: 2.597 ± 0.237
0.407PheCys: 0.407 ± 0.092
3.682PheAsp: 3.682 ± 0.237
3.469PheGlu: 3.469 ± 0.338
1.512PhePhe: 1.512 ± 0.224
2.926PheGly: 2.926 ± 0.247
0.698PheHis: 0.698 ± 0.116
3.527PheIle: 3.527 ± 0.293
3.663PheLys: 3.663 ± 0.285
2.481PheLeu: 2.481 ± 0.213
1.143PheMet: 1.143 ± 0.142
3.12PheAsn: 3.12 ± 0.251
1.337PhePro: 1.337 ± 0.162
1.008PheGln: 1.008 ± 0.131
1.492PheArg: 1.492 ± 0.162
2.83PheSer: 2.83 ± 0.217
2.364PheThr: 2.364 ± 0.246
2.849PheVal: 2.849 ± 0.234
0.504PheTrp: 0.504 ± 0.094
1.783PheTyr: 1.783 ± 0.211
0.0PheXaa: 0.0 ± 0.0
Gly
4.225GlyAla: 4.225 ± 0.279
0.426GlyCys: 0.426 ± 0.086
4.109GlyAsp: 4.109 ± 0.279
3.682GlyGlu: 3.682 ± 0.254
2.306GlyPhe: 2.306 ± 0.229
3.14GlyGly: 3.14 ± 0.325
0.93GlyHis: 0.93 ± 0.158
4.244GlyIle: 4.244 ± 0.266
4.128GlyLys: 4.128 ± 0.28
4.709GlyLeu: 4.709 ± 0.29
1.899GlyMet: 1.899 ± 0.221
3.256GlyAsn: 3.256 ± 0.298
1.531GlyPro: 1.531 ± 0.158
1.938GlyGln: 1.938 ± 0.192
2.19GlyArg: 2.19 ± 0.192
4.031GlySer: 4.031 ± 0.285
4.302GlyThr: 4.302 ± 0.449
4.167GlyVal: 4.167 ± 0.354
0.93GlyTrp: 0.93 ± 0.133
2.694GlyTyr: 2.694 ± 0.251
0.0GlyXaa: 0.0 ± 0.0
His
1.163HisAla: 1.163 ± 0.15
0.329HisCys: 0.329 ± 0.078
1.298HisAsp: 1.298 ± 0.159
1.337HisGlu: 1.337 ± 0.163
1.221HisPhe: 1.221 ± 0.156
1.318HisGly: 1.318 ± 0.174
0.562HisHis: 0.562 ± 0.134
1.512HisIle: 1.512 ± 0.187
1.337HisLys: 1.337 ± 0.155
1.415HisLeu: 1.415 ± 0.163
0.349HisMet: 0.349 ± 0.066
0.892HisAsn: 0.892 ± 0.129
0.775HisPro: 0.775 ± 0.118
0.659HisGln: 0.659 ± 0.119
0.911HisArg: 0.911 ± 0.144
1.066HisSer: 1.066 ± 0.153
1.085HisThr: 1.085 ± 0.153
1.24HisVal: 1.24 ± 0.18
0.271HisTrp: 0.271 ± 0.075
0.853HisTyr: 0.853 ± 0.14
0.0HisXaa: 0.0 ± 0.0
Ile
6.124IleAla: 6.124 ± 0.277
0.756IleCys: 0.756 ± 0.114
5.562IleAsp: 5.562 ± 0.292
5.368IleGlu: 5.368 ± 0.351
2.888IlePhe: 2.888 ± 0.238
3.837IleGly: 3.837 ± 0.285
1.376IleHis: 1.376 ± 0.189
4.302IleIle: 4.302 ± 0.312
5.989IleLys: 5.989 ± 0.405
4.729IleLeu: 4.729 ± 0.334
1.764IleMet: 1.764 ± 0.203
4.826IleAsn: 4.826 ± 0.329
2.675IlePro: 2.675 ± 0.216
2.752IleGln: 2.752 ± 0.228
3.624IleArg: 3.624 ± 0.269
4.709IleSer: 4.709 ± 0.336
4.477IleThr: 4.477 ± 0.33
4.341IleVal: 4.341 ± 0.251
0.814IleTrp: 0.814 ± 0.137
2.384IleTyr: 2.384 ± 0.189
0.0IleXaa: 0.0 ± 0.0
Lys
5.407LysAla: 5.407 ± 0.373
0.698LysCys: 0.698 ± 0.147
4.206LysAsp: 4.206 ± 0.307
4.496LysGlu: 4.496 ± 0.331
3.76LysPhe: 3.76 ± 0.306
4.07LysGly: 4.07 ± 0.3
1.996LysHis: 1.996 ± 0.218
5.039LysIle: 5.039 ± 0.325
3.43LysLys: 3.43 ± 0.27
6.221LysLeu: 6.221 ± 0.346
2.035LysMet: 2.035 ± 0.198
3.644LysAsn: 3.644 ± 0.265
2.81LysPro: 2.81 ± 0.221
2.171LysGln: 2.171 ± 0.233
3.14LysArg: 3.14 ± 0.255
4.496LysSer: 4.496 ± 0.326
4.264LysThr: 4.264 ± 0.34
5.291LysVal: 5.291 ± 0.291
0.833LysTrp: 0.833 ± 0.121
3.275LysTyr: 3.275 ± 0.235
0.0LysXaa: 0.0 ± 0.0
Leu
5.737LeuAla: 5.737 ± 0.358
0.892LeuCys: 0.892 ± 0.13
5.175LeuAsp: 5.175 ± 0.28
5.388LeuGlu: 5.388 ± 0.325
3.023LeuPhe: 3.023 ± 0.271
4.225LeuGly: 4.225 ± 0.268
1.415LeuHis: 1.415 ± 0.167
5.175LeuIle: 5.175 ± 0.298
6.648LeuLys: 6.648 ± 0.448
5.407LeuLeu: 5.407 ± 0.372
2.364LeuMet: 2.364 ± 0.227
4.671LeuAsn: 4.671 ± 0.297
3.256LeuPro: 3.256 ± 0.214
2.771LeuGln: 2.771 ± 0.218
3.45LeuArg: 3.45 ± 0.244
5.194LeuSer: 5.194 ± 0.356
4.903LeuThr: 4.903 ± 0.313
5.078LeuVal: 5.078 ± 0.324
0.659LeuTrp: 0.659 ± 0.114
3.275LeuTyr: 3.275 ± 0.195
0.0LeuXaa: 0.0 ± 0.0
Met
2.384MetAla: 2.384 ± 0.237
0.271MetCys: 0.271 ± 0.073
1.357MetAsp: 1.357 ± 0.18
1.609MetGlu: 1.609 ± 0.174
1.105MetPhe: 1.105 ± 0.149
1.105MetGly: 1.105 ± 0.15
0.407MetHis: 0.407 ± 0.09
1.609MetIle: 1.609 ± 0.169
2.519MetLys: 2.519 ± 0.209
2.112MetLeu: 2.112 ± 0.178
0.736MetMet: 0.736 ± 0.119
1.531MetAsn: 1.531 ± 0.138
0.95MetPro: 0.95 ± 0.147
1.066MetGln: 1.066 ± 0.155
1.066MetArg: 1.066 ± 0.144
2.016MetSer: 2.016 ± 0.164
1.454MetThr: 1.454 ± 0.161
1.434MetVal: 1.434 ± 0.172
0.329MetTrp: 0.329 ± 0.081
1.24MetTyr: 1.24 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
4.089AsnAla: 4.089 ± 0.253
0.543AsnCys: 0.543 ± 0.109
2.965AsnAsp: 2.965 ± 0.253
3.799AsnGlu: 3.799 ± 0.329
2.752AsnPhe: 2.752 ± 0.217
4.38AsnGly: 4.38 ± 0.392
1.124AsnHis: 1.124 ± 0.148
4.361AsnIle: 4.361 ± 0.333
3.682AsnLys: 3.682 ± 0.274
5.31AsnLeu: 5.31 ± 0.339
1.55AsnMet: 1.55 ± 0.169
3.159AsnAsn: 3.159 ± 0.258
2.423AsnPro: 2.423 ± 0.205
1.783AsnGln: 1.783 ± 0.188
2.5AsnArg: 2.5 ± 0.189
3.644AsnSer: 3.644 ± 0.281
3.702AsnThr: 3.702 ± 0.355
3.585AsnVal: 3.585 ± 0.259
0.601AsnTrp: 0.601 ± 0.097
2.112AsnTyr: 2.112 ± 0.18
0.0AsnXaa: 0.0 ± 0.0
Pro
2.326ProAla: 2.326 ± 0.237
0.368ProCys: 0.368 ± 0.093
2.229ProAsp: 2.229 ± 0.19
3.12ProGlu: 3.12 ± 0.265
1.415ProPhe: 1.415 ± 0.157
2.384ProGly: 2.384 ± 0.202
0.756ProHis: 0.756 ± 0.142
2.364ProIle: 2.364 ± 0.212
2.675ProLys: 2.675 ± 0.205
2.423ProLeu: 2.423 ± 0.227
0.523ProMet: 0.523 ± 0.104
2.539ProAsn: 2.539 ± 0.22
1.143ProPro: 1.143 ± 0.149
1.085ProGln: 1.085 ± 0.137
1.454ProArg: 1.454 ± 0.193
2.287ProSer: 2.287 ± 0.199
2.19ProThr: 2.19 ± 0.187
2.558ProVal: 2.558 ± 0.198
0.64ProTrp: 0.64 ± 0.115
1.589ProTyr: 1.589 ± 0.173
0.0ProXaa: 0.0 ± 0.0
Gln
2.326GlnAla: 2.326 ± 0.283
0.349GlnCys: 0.349 ± 0.082
1.492GlnAsp: 1.492 ± 0.157
2.326GlnGlu: 2.326 ± 0.201
1.705GlnPhe: 1.705 ± 0.193
1.764GlnGly: 1.764 ± 0.162
0.601GlnHis: 0.601 ± 0.109
3.082GlnIle: 3.082 ± 0.256
1.996GlnLys: 1.996 ± 0.205
3.45GlnLeu: 3.45 ± 0.272
1.182GlnMet: 1.182 ± 0.182
1.88GlnAsn: 1.88 ± 0.206
1.473GlnPro: 1.473 ± 0.176
1.221GlnGln: 1.221 ± 0.158
1.705GlnArg: 1.705 ± 0.177
1.957GlnSer: 1.957 ± 0.202
1.938GlnThr: 1.938 ± 0.193
1.977GlnVal: 1.977 ± 0.17
0.562GlnTrp: 0.562 ± 0.118
1.861GlnTyr: 1.861 ± 0.205
0.0GlnXaa: 0.0 ± 0.0
Arg
3.237ArgAla: 3.237 ± 0.272
0.426ArgCys: 0.426 ± 0.075
2.461ArgAsp: 2.461 ± 0.232
3.023ArgGlu: 3.023 ± 0.265
2.132ArgPhe: 2.132 ± 0.211
2.326ArgGly: 2.326 ± 0.244
0.872ArgHis: 0.872 ± 0.117
3.469ArgIle: 3.469 ± 0.295
3.159ArgLys: 3.159 ± 0.217
3.372ArgLeu: 3.372 ± 0.257
1.027ArgMet: 1.027 ± 0.143
2.287ArgAsn: 2.287 ± 0.204
1.415ArgPro: 1.415 ± 0.183
1.919ArgGln: 1.919 ± 0.197
2.209ArgArg: 2.209 ± 0.223
2.752ArgSer: 2.752 ± 0.255
2.112ArgThr: 2.112 ± 0.246
2.83ArgVal: 2.83 ± 0.246
0.659ArgTrp: 0.659 ± 0.125
1.415ArgTyr: 1.415 ± 0.166
0.0ArgXaa: 0.0 ± 0.0
Ser
3.895SerAla: 3.895 ± 0.293
0.446SerCys: 0.446 ± 0.098
3.799SerAsp: 3.799 ± 0.293
3.973SerGlu: 3.973 ± 0.265
2.675SerPhe: 2.675 ± 0.259
4.399SerGly: 4.399 ± 0.357
1.318SerHis: 1.318 ± 0.134
5.33SerIle: 5.33 ± 0.285
4.69SerLys: 4.69 ± 0.352
4.438SerLeu: 4.438 ± 0.285
1.454SerMet: 1.454 ± 0.154
3.799SerAsn: 3.799 ± 0.268
1.996SerPro: 1.996 ± 0.209
1.957SerGln: 1.957 ± 0.189
2.985SerArg: 2.985 ± 0.271
3.934SerSer: 3.934 ± 0.283
4.419SerThr: 4.419 ± 0.312
4.244SerVal: 4.244 ± 0.293
0.62SerTrp: 0.62 ± 0.144
2.558SerTyr: 2.558 ± 0.213
0.0SerXaa: 0.0 ± 0.0
Thr
4.225ThrAla: 4.225 ± 0.551
0.853ThrCys: 0.853 ± 0.125
3.605ThrAsp: 3.605 ± 0.36
3.469ThrGlu: 3.469 ± 0.225
2.81ThrPhe: 2.81 ± 0.265
3.915ThrGly: 3.915 ± 0.411
1.182ThrHis: 1.182 ± 0.145
4.477ThrIle: 4.477 ± 0.302
3.256ThrLys: 3.256 ± 0.268
4.806ThrLeu: 4.806 ± 0.353
1.24ThrMet: 1.24 ± 0.14
3.566ThrAsn: 3.566 ± 0.314
3.004ThrPro: 3.004 ± 0.218
2.636ThrGln: 2.636 ± 0.24
2.481ThrArg: 2.481 ± 0.199
4.07ThrSer: 4.07 ± 0.306
3.876ThrThr: 3.876 ± 0.427
4.264ThrVal: 4.264 ± 0.339
0.988ThrTrp: 0.988 ± 0.129
2.675ThrTyr: 2.675 ± 0.227
0.0ThrXaa: 0.0 ± 0.0
Val
4.283ValAla: 4.283 ± 0.255
0.872ValCys: 0.872 ± 0.137
4.031ValAsp: 4.031 ± 0.298
4.768ValGlu: 4.768 ± 0.304
2.5ValPhe: 2.5 ± 0.218
3.178ValGly: 3.178 ± 0.298
1.473ValHis: 1.473 ± 0.154
4.748ValIle: 4.748 ± 0.305
5.078ValLys: 5.078 ± 0.343
4.729ValLeu: 4.729 ± 0.28
1.686ValMet: 1.686 ± 0.169
4.147ValAsn: 4.147 ± 0.311
2.326ValPro: 2.326 ± 0.208
2.19ValGln: 2.19 ± 0.235
2.675ValArg: 2.675 ± 0.253
4.167ValSer: 4.167 ± 0.262
4.264ValThr: 4.264 ± 0.382
4.399ValVal: 4.399 ± 0.363
0.892ValTrp: 0.892 ± 0.139
2.752ValTyr: 2.752 ± 0.206
0.0ValXaa: 0.0 ± 0.0
Trp
0.698TrpAla: 0.698 ± 0.096
0.213TrpCys: 0.213 ± 0.072
0.95TrpAsp: 0.95 ± 0.151
0.872TrpGlu: 0.872 ± 0.15
0.523TrpPhe: 0.523 ± 0.104
0.485TrpGly: 0.485 ± 0.106
0.252TrpHis: 0.252 ± 0.064
0.814TrpIle: 0.814 ± 0.127
1.047TrpLys: 1.047 ± 0.146
0.892TrpLeu: 0.892 ± 0.122
0.523TrpMet: 0.523 ± 0.099
0.601TrpAsn: 0.601 ± 0.092
0.426TrpPro: 0.426 ± 0.076
0.678TrpGln: 0.678 ± 0.121
0.543TrpArg: 0.543 ± 0.109
0.736TrpSer: 0.736 ± 0.124
0.988TrpThr: 0.988 ± 0.133
0.95TrpVal: 0.95 ± 0.124
0.329TrpTrp: 0.329 ± 0.077
0.698TrpTyr: 0.698 ± 0.12
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.675TyrAla: 2.675 ± 0.197
0.504TyrCys: 0.504 ± 0.101
2.965TyrAsp: 2.965 ± 0.29
2.868TyrGlu: 2.868 ± 0.27
1.764TyrPhe: 1.764 ± 0.185
2.868TyrGly: 2.868 ± 0.206
0.853TyrHis: 0.853 ± 0.124
3.159TyrIle: 3.159 ± 0.212
2.83TyrLys: 2.83 ± 0.254
3.023TyrLeu: 3.023 ± 0.265
0.93TyrMet: 0.93 ± 0.142
2.868TyrAsn: 2.868 ± 0.253
1.667TyrPro: 1.667 ± 0.183
1.143TyrGln: 1.143 ± 0.145
1.919TyrArg: 1.919 ± 0.202
2.81TyrSer: 2.81 ± 0.245
2.248TyrThr: 2.248 ± 0.196
2.868TyrVal: 2.868 ± 0.272
0.62TyrTrp: 0.62 ± 0.106
1.725TyrTyr: 1.725 ± 0.228
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 247 proteins (51599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski