Amino acid dipepetide frequency for Erwinia phage vB_EhrS_59

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.181AlaAla: 12.181 ± 1.889
0.98AlaCys: 0.98 ± 0.294
6.02AlaAsp: 6.02 ± 0.617
5.88AlaGlu: 5.88 ± 0.804
3.36AlaPhe: 3.36 ± 0.397
7.28AlaGly: 7.28 ± 1.031
1.19AlaHis: 1.19 ± 0.353
4.97AlaIle: 4.97 ± 0.462
5.81AlaLys: 5.81 ± 0.759
8.89AlaLeu: 8.89 ± 0.995
3.36AlaMet: 3.36 ± 0.7
3.36AlaAsn: 3.36 ± 0.434
2.17AlaPro: 2.17 ± 0.423
4.55AlaGln: 4.55 ± 1.079
4.97AlaArg: 4.97 ± 0.599
6.3AlaSer: 6.3 ± 1.071
6.93AlaThr: 6.93 ± 0.9
5.32AlaVal: 5.32 ± 0.861
1.96AlaTrp: 1.96 ± 0.492
2.73AlaTyr: 2.73 ± 0.444
0.0AlaXaa: 0.0 ± 0.0
Cys
1.4CysAla: 1.4 ± 0.342
0.49CysCys: 0.49 ± 0.189
0.7CysAsp: 0.7 ± 0.225
0.77CysGlu: 0.77 ± 0.256
0.35CysPhe: 0.35 ± 0.147
1.4CysGly: 1.4 ± 0.358
0.35CysHis: 0.35 ± 0.163
0.7CysIle: 0.7 ± 0.235
0.84CysLys: 0.84 ± 0.269
0.84CysLeu: 0.84 ± 0.275
0.35CysMet: 0.35 ± 0.181
0.84CysAsn: 0.84 ± 0.248
1.12CysPro: 1.12 ± 0.313
0.42CysGln: 0.42 ± 0.146
1.26CysArg: 1.26 ± 0.328
0.84CysSer: 0.84 ± 0.232
0.49CysThr: 0.49 ± 0.205
0.28CysVal: 0.28 ± 0.138
0.28CysTrp: 0.28 ± 0.132
0.28CysTyr: 0.28 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
6.3AspAla: 6.3 ± 0.724
1.12AspCys: 1.12 ± 0.363
5.74AspAsp: 5.74 ± 0.662
3.99AspGlu: 3.99 ± 0.514
2.59AspPhe: 2.59 ± 0.434
4.9AspGly: 4.9 ± 0.574
0.63AspHis: 0.63 ± 0.211
3.22AspIle: 3.22 ± 0.441
3.43AspLys: 3.43 ± 0.595
4.9AspLeu: 4.9 ± 0.502
1.96AspMet: 1.96 ± 0.324
1.82AspAsn: 1.82 ± 0.414
2.24AspPro: 2.24 ± 0.449
1.89AspGln: 1.89 ± 0.376
3.08AspArg: 3.08 ± 0.436
4.2AspSer: 4.2 ± 0.484
3.15AspThr: 3.15 ± 0.528
3.01AspVal: 3.01 ± 0.481
0.91AspTrp: 0.91 ± 0.267
3.43AspTyr: 3.43 ± 0.489
0.0AspXaa: 0.0 ± 0.0
Glu
6.02GluAla: 6.02 ± 0.816
1.4GluCys: 1.4 ± 0.367
2.03GluAsp: 2.03 ± 0.371
4.2GluGlu: 4.2 ± 0.602
2.66GluPhe: 2.66 ± 0.382
3.78GluGly: 3.78 ± 0.645
1.33GluHis: 1.33 ± 0.405
3.92GluIle: 3.92 ± 0.577
3.99GluLys: 3.99 ± 0.697
5.11GluLeu: 5.11 ± 0.788
2.31GluMet: 2.31 ± 0.431
2.66GluAsn: 2.66 ± 0.375
2.03GluPro: 2.03 ± 0.45
3.64GluGln: 3.64 ± 0.647
3.92GluArg: 3.92 ± 0.637
4.06GluSer: 4.06 ± 0.486
2.38GluThr: 2.38 ± 0.415
4.13GluVal: 4.13 ± 0.457
1.12GluTrp: 1.12 ± 0.272
2.1GluTyr: 2.1 ± 0.348
0.0GluXaa: 0.0 ± 0.0
Phe
2.73PheAla: 2.73 ± 0.472
0.35PheCys: 0.35 ± 0.147
3.78PheAsp: 3.78 ± 0.491
2.03PheGlu: 2.03 ± 0.354
1.54PhePhe: 1.54 ± 0.403
2.52PheGly: 2.52 ± 0.425
0.91PheHis: 0.91 ± 0.227
2.38PheIle: 2.38 ± 0.389
1.47PheLys: 1.47 ± 0.315
1.82PheLeu: 1.82 ± 0.399
0.84PheMet: 0.84 ± 0.243
1.82PheAsn: 1.82 ± 0.382
0.84PhePro: 0.84 ± 0.287
0.7PheGln: 0.7 ± 0.238
2.45PheArg: 2.45 ± 0.483
2.45PheSer: 2.45 ± 0.401
3.29PheThr: 3.29 ± 0.609
2.24PheVal: 2.24 ± 0.321
0.7PheTrp: 0.7 ± 0.229
1.33PheTyr: 1.33 ± 0.318
0.0PheXaa: 0.0 ± 0.0
Gly
4.41GlyAla: 4.41 ± 0.705
1.19GlyCys: 1.19 ± 0.38
3.5GlyAsp: 3.5 ± 0.516
5.18GlyGlu: 5.18 ± 0.67
3.08GlyPhe: 3.08 ± 0.455
4.55GlyGly: 4.55 ± 0.606
1.47GlyHis: 1.47 ± 0.358
3.5GlyIle: 3.5 ± 0.439
5.95GlyLys: 5.95 ± 0.615
5.11GlyLeu: 5.11 ± 0.736
1.4GlyMet: 1.4 ± 0.319
2.8GlyAsn: 2.8 ± 0.505
1.19GlyPro: 1.19 ± 0.279
2.24GlyGln: 2.24 ± 0.481
3.99GlyArg: 3.99 ± 0.563
4.76GlySer: 4.76 ± 0.618
4.41GlyThr: 4.41 ± 0.536
5.32GlyVal: 5.32 ± 0.561
1.33GlyTrp: 1.33 ± 0.368
2.8GlyTyr: 2.8 ± 0.497
0.0GlyXaa: 0.0 ± 0.0
His
1.61HisAla: 1.61 ± 0.341
0.28HisCys: 0.28 ± 0.118
1.47HisAsp: 1.47 ± 0.262
0.63HisGlu: 0.63 ± 0.281
0.98HisPhe: 0.98 ± 0.247
1.4HisGly: 1.4 ± 0.497
0.49HisHis: 0.49 ± 0.177
0.84HisIle: 0.84 ± 0.276
0.84HisLys: 0.84 ± 0.319
1.61HisLeu: 1.61 ± 0.371
0.21HisMet: 0.21 ± 0.127
0.35HisAsn: 0.35 ± 0.134
0.77HisPro: 0.77 ± 0.214
0.63HisGln: 0.63 ± 0.224
1.4HisArg: 1.4 ± 0.344
0.77HisSer: 0.77 ± 0.245
1.19HisThr: 1.19 ± 0.392
0.98HisVal: 0.98 ± 0.273
0.49HisTrp: 0.49 ± 0.17
0.63HisTyr: 0.63 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
5.25IleAla: 5.25 ± 0.597
0.84IleCys: 0.84 ± 0.242
3.29IleAsp: 3.29 ± 0.503
3.92IleGlu: 3.92 ± 0.602
2.1IlePhe: 2.1 ± 0.415
5.11IleGly: 5.11 ± 0.615
0.84IleHis: 0.84 ± 0.237
2.8IleIle: 2.8 ± 0.449
3.15IleLys: 3.15 ± 0.462
3.36IleLeu: 3.36 ± 0.607
0.7IleMet: 0.7 ± 0.253
3.36IleAsn: 3.36 ± 0.755
2.52IlePro: 2.52 ± 0.35
2.73IleGln: 2.73 ± 0.367
2.24IleArg: 2.24 ± 0.305
3.78IleSer: 3.78 ± 0.581
3.78IleThr: 3.78 ± 0.516
2.66IleVal: 2.66 ± 0.393
1.12IleTrp: 1.12 ± 0.295
1.54IleTyr: 1.54 ± 0.346
0.0IleXaa: 0.0 ± 0.0
Lys
6.3LysAla: 6.3 ± 0.765
1.05LysCys: 1.05 ± 0.323
3.36LysAsp: 3.36 ± 0.564
3.22LysGlu: 3.22 ± 0.495
2.03LysPhe: 2.03 ± 0.34
3.36LysGly: 3.36 ± 0.498
1.05LysHis: 1.05 ± 0.252
2.73LysIle: 2.73 ± 0.541
2.94LysLys: 2.94 ± 0.47
4.83LysLeu: 4.83 ± 0.583
1.12LysMet: 1.12 ± 0.354
2.59LysAsn: 2.59 ± 0.511
3.85LysPro: 3.85 ± 0.661
2.52LysGln: 2.52 ± 0.408
3.78LysArg: 3.78 ± 0.515
4.2LysSer: 4.2 ± 0.5
2.8LysThr: 2.8 ± 0.449
4.27LysVal: 4.27 ± 0.594
0.77LysTrp: 0.77 ± 0.204
1.96LysTyr: 1.96 ± 0.405
0.0LysXaa: 0.0 ± 0.0
Leu
8.19LeuAla: 8.19 ± 0.932
1.12LeuCys: 1.12 ± 0.289
3.71LeuAsp: 3.71 ± 0.412
4.69LeuGlu: 4.69 ± 0.651
1.89LeuPhe: 1.89 ± 0.446
4.34LeuGly: 4.34 ± 0.438
1.4LeuHis: 1.4 ± 0.315
4.83LeuIle: 4.83 ± 0.574
4.27LeuLys: 4.27 ± 0.643
5.39LeuLeu: 5.39 ± 0.723
2.31LeuMet: 2.31 ± 0.469
4.41LeuAsn: 4.41 ± 0.514
2.94LeuPro: 2.94 ± 0.592
2.52LeuGln: 2.52 ± 0.438
4.9LeuArg: 4.9 ± 0.92
6.44LeuSer: 6.44 ± 0.847
5.81LeuThr: 5.81 ± 0.7
3.92LeuVal: 3.92 ± 0.462
0.84LeuTrp: 0.84 ± 0.225
2.1LeuTyr: 2.1 ± 0.368
0.0LeuXaa: 0.0 ± 0.0
Met
2.87MetAla: 2.87 ± 0.418
0.42MetCys: 0.42 ± 0.181
1.26MetAsp: 1.26 ± 0.268
1.54MetGlu: 1.54 ± 0.282
0.63MetPhe: 0.63 ± 0.217
1.47MetGly: 1.47 ± 0.356
0.35MetHis: 0.35 ± 0.163
1.33MetIle: 1.33 ± 0.265
2.1MetLys: 2.1 ± 0.422
1.26MetLeu: 1.26 ± 0.263
0.56MetMet: 0.56 ± 0.196
1.26MetAsn: 1.26 ± 0.249
1.19MetPro: 1.19 ± 0.233
1.05MetGln: 1.05 ± 0.259
1.54MetArg: 1.54 ± 0.379
2.59MetSer: 2.59 ± 0.359
2.24MetThr: 2.24 ± 0.486
1.75MetVal: 1.75 ± 0.393
0.49MetTrp: 0.49 ± 0.2
0.7MetTyr: 0.7 ± 0.187
0.0MetXaa: 0.0 ± 0.0
Asn
5.18AsnAla: 5.18 ± 0.711
0.42AsnCys: 0.42 ± 0.17
2.8AsnAsp: 2.8 ± 0.386
2.45AsnGlu: 2.45 ± 0.566
1.33AsnPhe: 1.33 ± 0.312
3.22AsnGly: 3.22 ± 0.481
0.98AsnHis: 0.98 ± 0.279
2.59AsnIle: 2.59 ± 0.346
2.17AsnLys: 2.17 ± 0.367
3.08AsnLeu: 3.08 ± 0.373
0.49AsnMet: 0.49 ± 0.192
2.03AsnAsn: 2.03 ± 0.348
1.75AsnPro: 1.75 ± 0.388
2.59AsnGln: 2.59 ± 0.464
2.66AsnArg: 2.66 ± 0.368
3.08AsnSer: 3.08 ± 0.591
2.73AsnThr: 2.73 ± 0.466
2.24AsnVal: 2.24 ± 0.456
0.49AsnTrp: 0.49 ± 0.17
0.91AsnTyr: 0.91 ± 0.207
0.0AsnXaa: 0.0 ± 0.0
Pro
3.15ProAla: 3.15 ± 0.543
0.42ProCys: 0.42 ± 0.17
2.94ProAsp: 2.94 ± 0.5
3.36ProGlu: 3.36 ± 0.609
1.12ProPhe: 1.12 ± 0.272
2.59ProGly: 2.59 ± 0.518
0.77ProHis: 0.77 ± 0.273
2.17ProIle: 2.17 ± 0.384
2.31ProLys: 2.31 ± 0.449
3.71ProLeu: 3.71 ± 0.637
1.12ProMet: 1.12 ± 0.292
1.61ProAsn: 1.61 ± 0.3
1.47ProPro: 1.47 ± 0.38
1.4ProGln: 1.4 ± 0.321
1.75ProArg: 1.75 ± 0.343
2.59ProSer: 2.59 ± 0.496
2.24ProThr: 2.24 ± 0.366
3.22ProVal: 3.22 ± 0.468
0.35ProTrp: 0.35 ± 0.154
0.42ProTyr: 0.42 ± 0.196
0.0ProXaa: 0.0 ± 0.0
Gln
4.62GlnAla: 4.62 ± 0.904
0.7GlnCys: 0.7 ± 0.231
1.19GlnAsp: 1.19 ± 0.261
2.59GlnGlu: 2.59 ± 0.291
1.33GlnPhe: 1.33 ± 0.303
2.24GlnGly: 2.24 ± 0.433
0.77GlnHis: 0.77 ± 0.217
2.1GlnIle: 2.1 ± 0.445
2.52GlnLys: 2.52 ± 0.544
3.92GlnLeu: 3.92 ± 0.617
1.26GlnMet: 1.26 ± 0.413
1.61GlnAsn: 1.61 ± 0.375
1.89GlnPro: 1.89 ± 0.372
3.01GlnGln: 3.01 ± 0.687
3.71GlnArg: 3.71 ± 0.518
3.15GlnSer: 3.15 ± 0.429
2.31GlnThr: 2.31 ± 0.427
2.73GlnVal: 2.73 ± 0.446
0.84GlnTrp: 0.84 ± 0.272
1.61GlnTyr: 1.61 ± 0.378
0.0GlnXaa: 0.0 ± 0.0
Arg
5.25ArgAla: 5.25 ± 0.554
0.7ArgCys: 0.7 ± 0.256
4.2ArgAsp: 4.2 ± 0.53
3.78ArgGlu: 3.78 ± 0.652
1.26ArgPhe: 1.26 ± 0.281
2.73ArgGly: 2.73 ± 0.461
1.33ArgHis: 1.33 ± 0.442
3.29ArgIle: 3.29 ± 0.5
5.18ArgLys: 5.18 ± 0.778
5.18ArgLeu: 5.18 ± 0.754
1.82ArgMet: 1.82 ± 0.344
2.45ArgAsn: 2.45 ± 0.373
2.17ArgPro: 2.17 ± 0.509
3.64ArgGln: 3.64 ± 0.522
4.06ArgArg: 4.06 ± 0.611
3.78ArgSer: 3.78 ± 0.577
3.08ArgThr: 3.08 ± 0.569
2.94ArgVal: 2.94 ± 0.357
1.05ArgTrp: 1.05 ± 0.342
2.24ArgTyr: 2.24 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
6.65SerAla: 6.65 ± 1.077
0.77SerCys: 0.77 ± 0.227
4.69SerAsp: 4.69 ± 0.631
4.41SerGlu: 4.41 ± 0.621
3.15SerPhe: 3.15 ± 0.579
6.16SerGly: 6.16 ± 0.733
0.98SerHis: 0.98 ± 0.304
3.43SerIle: 3.43 ± 0.544
3.08SerLys: 3.08 ± 0.475
5.11SerLeu: 5.11 ± 0.713
2.38SerMet: 2.38 ± 0.358
3.08SerAsn: 3.08 ± 0.469
2.66SerPro: 2.66 ± 0.41
3.71SerGln: 3.71 ± 0.531
3.43SerArg: 3.43 ± 0.517
3.01SerSer: 3.01 ± 0.557
4.06SerThr: 4.06 ± 0.535
4.69SerVal: 4.69 ± 0.569
1.12SerTrp: 1.12 ± 0.247
1.54SerTyr: 1.54 ± 0.431
0.0SerXaa: 0.0 ± 0.0
Thr
7.07ThrAla: 7.07 ± 0.957
0.56ThrCys: 0.56 ± 0.208
4.83ThrAsp: 4.83 ± 0.705
4.27ThrGlu: 4.27 ± 0.564
2.73ThrPhe: 2.73 ± 0.425
5.04ThrGly: 5.04 ± 0.692
0.7ThrHis: 0.7 ± 0.238
3.5ThrIle: 3.5 ± 0.637
2.87ThrLys: 2.87 ± 0.536
4.41ThrLeu: 4.41 ± 0.445
1.26ThrMet: 1.26 ± 0.339
2.66ThrAsn: 2.66 ± 0.513
2.8ThrPro: 2.8 ± 0.573
2.45ThrGln: 2.45 ± 0.492
3.08ThrArg: 3.08 ± 0.428
3.64ThrSer: 3.64 ± 0.647
4.2ThrThr: 4.2 ± 1.018
3.92ThrVal: 3.92 ± 0.559
1.47ThrTrp: 1.47 ± 0.369
1.68ThrTyr: 1.68 ± 0.387
0.0ThrXaa: 0.0 ± 0.0
Val
4.9ValAla: 4.9 ± 0.905
0.56ValCys: 0.56 ± 0.174
3.99ValAsp: 3.99 ± 0.525
3.71ValGlu: 3.71 ± 0.457
1.68ValPhe: 1.68 ± 0.298
3.78ValGly: 3.78 ± 0.492
1.12ValHis: 1.12 ± 0.277
4.34ValIle: 4.34 ± 0.556
3.64ValLys: 3.64 ± 0.379
3.43ValLeu: 3.43 ± 0.544
1.68ValMet: 1.68 ± 0.365
2.52ValAsn: 2.52 ± 0.463
3.22ValPro: 3.22 ± 0.526
2.31ValGln: 2.31 ± 0.331
3.43ValArg: 3.43 ± 0.507
4.9ValSer: 4.9 ± 0.535
5.11ValThr: 5.11 ± 0.64
2.52ValVal: 2.52 ± 0.378
0.91ValTrp: 0.91 ± 0.245
1.26ValTyr: 1.26 ± 0.23
0.0ValXaa: 0.0 ± 0.0
Trp
1.47TrpAla: 1.47 ± 0.368
0.21TrpCys: 0.21 ± 0.108
0.7TrpAsp: 0.7 ± 0.243
0.63TrpGlu: 0.63 ± 0.26
0.49TrpPhe: 0.49 ± 0.179
0.84TrpGly: 0.84 ± 0.238
0.49TrpHis: 0.49 ± 0.201
0.98TrpIle: 0.98 ± 0.245
1.12TrpLys: 1.12 ± 0.283
2.1TrpLeu: 2.1 ± 0.428
0.7TrpMet: 0.7 ± 0.211
0.56TrpAsn: 0.56 ± 0.243
0.42TrpPro: 0.42 ± 0.175
0.77TrpGln: 0.77 ± 0.263
1.33TrpArg: 1.33 ± 0.306
1.12TrpSer: 1.12 ± 0.38
1.47TrpThr: 1.47 ± 0.326
1.05TrpVal: 1.05 ± 0.254
0.35TrpTrp: 0.35 ± 0.146
0.35TrpTyr: 0.35 ± 0.145
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.73TyrAla: 2.73 ± 0.402
0.42TyrCys: 0.42 ± 0.159
2.31TyrAsp: 2.31 ± 0.375
1.54TyrGlu: 1.54 ± 0.321
1.89TyrPhe: 1.89 ± 0.375
1.47TyrGly: 1.47 ± 0.293
0.42TyrHis: 0.42 ± 0.165
1.47TyrIle: 1.47 ± 0.376
1.05TyrLys: 1.05 ± 0.293
1.96TyrLeu: 1.96 ± 0.368
0.7TyrMet: 0.7 ± 0.171
1.4TyrAsn: 1.4 ± 0.383
1.47TyrPro: 1.47 ± 0.387
1.33TyrGln: 1.33 ± 0.352
3.15TyrArg: 3.15 ± 0.471
2.45TyrSer: 2.45 ± 0.527
1.47TyrThr: 1.47 ± 0.356
1.82TyrVal: 1.82 ± 0.347
0.56TyrTrp: 0.56 ± 0.216
0.91TyrTyr: 0.91 ± 0.272
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (14286 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski