Amino acid dipepetide frequency for Legionella feeleii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.308AlaAla: 7.308 ± 0.118	1.175AlaCys: 1.175 ± 0.035	3.679AlaAsp: 3.679 ± 0.056	4.818AlaGlu: 4.818 ± 0.086	3.373AlaPhe: 3.373 ± 0.058	5.521AlaGly: 5.521 ± 0.099	1.808AlaHis: 1.808 ± 0.047	6.444AlaIle: 6.444 ± 0.095	5.122AlaLys: 5.122 ± 0.077	9.957AlaLeu: 9.957 ± 0.114	2.297AlaMet: 2.297 ± 0.053	3.679AlaAsn: 3.679 ± 0.062	2.577AlaPro: 2.577 ± 0.051	3.688AlaGln: 3.688 ± 0.075	3.8AlaArg: 3.8 ± 0.063	5.002AlaSer: 5.002 ± 0.074	4.387AlaThr: 4.387 ± 0.069	5.256AlaVal: 5.256 ± 0.072	0.852AlaTrp: 0.852 ± 0.028	2.676AlaTyr: 2.676 ± 0.052	0.003AlaXaa: 0.003 ± 0.002
Cys	0.847CysAla: 0.847 ± 0.032	0.216CysCys: 0.216 ± 0.018	0.554CysAsp: 0.554 ± 0.02	0.647CysGlu: 0.647 ± 0.026	0.724CysPhe: 0.724 ± 0.031	0.915CysGly: 0.915 ± 0.028	0.369CysHis: 0.369 ± 0.022	0.794CysIle: 0.794 ± 0.031	0.587CysLys: 0.587 ± 0.025	1.426CysLeu: 1.426 ± 0.041	0.267CysMet: 0.267 ± 0.018	0.461CysAsn: 0.461 ± 0.025	0.518CysPro: 0.518 ± 0.025	0.592CysGln: 0.592 ± 0.025	0.513CysArg: 0.513 ± 0.021	0.756CysSer: 0.756 ± 0.033	0.597CysThr: 0.597 ± 0.026	0.67CysVal: 0.67 ± 0.026	0.156CysTrp: 0.156 ± 0.014	0.472CysTyr: 0.472 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.604AspAla: 3.604 ± 0.062	0.625AspCys: 0.625 ± 0.026	2.341AspAsp: 2.341 ± 0.051	3.49AspGlu: 3.49 ± 0.069	2.505AspPhe: 2.505 ± 0.051	2.705AspGly: 2.705 ± 0.052	0.908AspHis: 0.908 ± 0.035	3.402AspIle: 3.402 ± 0.061	3.37AspLys: 3.37 ± 0.058	4.999AspLeu: 4.999 ± 0.073	1.075AspMet: 1.075 ± 0.037	2.292AspAsn: 2.292 ± 0.053	1.825AspPro: 1.825 ± 0.045	1.517AspGln: 1.517 ± 0.048	1.884AspArg: 1.884 ± 0.044	3.041AspSer: 3.041 ± 0.056	2.239AspThr: 2.239 ± 0.052	2.899AspVal: 2.899 ± 0.058	0.714AspTrp: 0.714 ± 0.026	2.165AspTyr: 2.165 ± 0.051	0.001AspXaa: 0.001 ± 0.001
Glu	4.775GluAla: 4.775 ± 0.084	0.526GluCys: 0.526 ± 0.026	2.39GluAsp: 2.39 ± 0.058	4.221GluGlu: 4.221 ± 0.092	2.274GluPhe: 2.274 ± 0.044	3.105GluGly: 3.105 ± 0.058	1.471GluHis: 1.471 ± 0.049	4.41GluIle: 4.41 ± 0.08	4.668GluLys: 4.668 ± 0.075	6.801GluLeu: 6.801 ± 0.091	1.491GluMet: 1.491 ± 0.045	2.778GluAsn: 2.778 ± 0.053	1.934GluPro: 1.934 ± 0.046	3.661GluGln: 3.661 ± 0.067	3.105GluArg: 3.105 ± 0.069	3.173GluSer: 3.173 ± 0.068	3.054GluThr: 3.054 ± 0.055	3.434GluVal: 3.434 ± 0.063	0.626GluTrp: 0.626 ± 0.029	1.559GluTyr: 1.559 ± 0.04	0.003GluXaa: 0.003 ± 0.002
Phe	3.741PheAla: 3.741 ± 0.068	0.658PheCys: 0.658 ± 0.027	2.354PheAsp: 2.354 ± 0.047	2.137PheGlu: 2.137 ± 0.052	2.544PhePhe: 2.544 ± 0.063	2.593PheGly: 2.593 ± 0.058	1.046PheHis: 1.046 ± 0.034	3.387PheIle: 3.387 ± 0.065	2.395PheLys: 2.395 ± 0.051	4.706PheLeu: 4.706 ± 0.069	0.998PheMet: 0.998 ± 0.028	2.306PheAsn: 2.306 ± 0.053	1.685PhePro: 1.685 ± 0.038	1.456PheGln: 1.456 ± 0.041	1.538PheArg: 1.538 ± 0.046	3.46PheSer: 3.46 ± 0.059	2.523PheThr: 2.523 ± 0.048	2.574PheVal: 2.574 ± 0.049	0.554PheTrp: 0.554 ± 0.027	1.669PheTyr: 1.669 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.481GlyAla: 4.481 ± 0.076	0.83GlyCys: 0.83 ± 0.031	2.818GlyAsp: 2.818 ± 0.055	3.483GlyGlu: 3.483 ± 0.061	3.257GlyPhe: 3.257 ± 0.064	4.107GlyGly: 4.107 ± 0.075	1.561GlyHis: 1.561 ± 0.042	4.701GlyIle: 4.701 ± 0.066	3.868GlyLys: 3.868 ± 0.066	6.865GlyLeu: 6.865 ± 0.093	1.68GlyMet: 1.68 ± 0.046	2.529GlyAsn: 2.529 ± 0.055	1.694GlyPro: 1.694 ± 0.042	2.554GlyGln: 2.554 ± 0.049	2.735GlyArg: 2.735 ± 0.064	3.727GlySer: 3.727 ± 0.075	2.945GlyThr: 2.945 ± 0.053	4.236GlyVal: 4.236 ± 0.078	0.895GlyTrp: 0.895 ± 0.034	2.42GlyTyr: 2.42 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.884HisAla: 1.884 ± 0.047	0.426HisCys: 0.426 ± 0.022	1.143HisAsp: 1.143 ± 0.033	1.327HisGlu: 1.327 ± 0.038	1.308HisPhe: 1.308 ± 0.037	1.619HisGly: 1.619 ± 0.047	0.911HisHis: 0.911 ± 0.043	1.422HisIle: 1.422 ± 0.039	1.11HisLys: 1.11 ± 0.036	2.785HisLeu: 2.785 ± 0.057	0.463HisMet: 0.463 ± 0.022	0.895HisAsn: 0.895 ± 0.027	1.281HisPro: 1.281 ± 0.034	1.245HisGln: 1.245 ± 0.034	1.166HisArg: 1.166 ± 0.032	1.509HisSer: 1.509 ± 0.045	1.066HisThr: 1.066 ± 0.032	1.251HisVal: 1.251 ± 0.035	0.404HisTrp: 0.404 ± 0.021	1.166HisTyr: 1.166 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	6.536IleAla: 6.536 ± 0.085	0.809IleCys: 0.809 ± 0.026	4.016IleAsp: 4.016 ± 0.058	4.485IleGlu: 4.485 ± 0.073	2.581IlePhe: 2.581 ± 0.061	4.331IleGly: 4.331 ± 0.085	1.72IleHis: 1.72 ± 0.041	4.713IleIle: 4.713 ± 0.08	4.266IleLys: 4.266 ± 0.062	6.627IleLeu: 6.627 ± 0.108	1.312IleMet: 1.312 ± 0.038	3.861IleAsn: 3.861 ± 0.073	3.312IlePro: 3.312 ± 0.063	2.628IleGln: 2.628 ± 0.054	3.072IleArg: 3.072 ± 0.052	4.63IleSer: 4.63 ± 0.068	3.957IleThr: 3.957 ± 0.058	4.099IleVal: 4.099 ± 0.066	0.603IleTrp: 0.603 ± 0.026	2.161IleTyr: 2.161 ± 0.047	0.003IleXaa: 0.003 ± 0.002
Lys	4.934LysAla: 4.934 ± 0.091	0.387LysCys: 0.387 ± 0.019	2.774LysAsp: 2.774 ± 0.062	4.26LysGlu: 4.26 ± 0.071	1.648LysPhe: 1.648 ± 0.041	3.145LysGly: 3.145 ± 0.06	1.31LysHis: 1.31 ± 0.044	4.29LysIle: 4.29 ± 0.072	4.622LysLys: 4.622 ± 0.083	5.844LysLeu: 5.844 ± 0.076	1.419LysMet: 1.419 ± 0.037	3.246LysAsn: 3.246 ± 0.068	2.769LysPro: 2.769 ± 0.047	3.374LysGln: 3.374 ± 0.059	3.141LysArg: 3.141 ± 0.068	3.436LysSer: 3.436 ± 0.058	3.68LysThr: 3.68 ± 0.062	3.126LysVal: 3.126 ± 0.053	0.488LysTrp: 0.488 ± 0.022	1.517LysTyr: 1.517 ± 0.039	0.006LysXaa: 0.006 ± 0.002
Leu	10.609LeuAla: 10.609 ± 0.132	1.42LeuCys: 1.42 ± 0.038	5.111LeuAsp: 5.111 ± 0.078	5.739LeuGlu: 5.739 ± 0.085	5.074LeuPhe: 5.074 ± 0.079	6.858LeuGly: 6.858 ± 0.088	2.541LeuHis: 2.541 ± 0.053	7.653LeuIle: 7.653 ± 0.101	6.248LeuLys: 6.248 ± 0.101	12.762LeuLeu: 12.762 ± 0.176	2.452LeuMet: 2.452 ± 0.055	4.912LeuAsn: 4.912 ± 0.077	5.342LeuPro: 5.342 ± 0.082	5.027LeuGln: 5.027 ± 0.073	4.883LeuArg: 4.883 ± 0.072	7.94LeuSer: 7.94 ± 0.096	6.445LeuThr: 6.445 ± 0.086	6.851LeuVal: 6.851 ± 0.091	1.1LeuTrp: 1.1 ± 0.033	3.23LeuTyr: 3.23 ± 0.061	0.004LeuXaa: 0.004 ± 0.002
Met	2.163MetAla: 2.163 ± 0.044	0.153MetCys: 0.153 ± 0.013	1.041MetAsp: 1.041 ± 0.031	1.148MetGlu: 1.148 ± 0.031	0.693MetPhe: 0.693 ± 0.032	1.427MetGly: 1.427 ± 0.036	0.598MetHis: 0.598 ± 0.021	1.46MetIle: 1.46 ± 0.037	1.469MetLys: 1.469 ± 0.039	2.463MetLeu: 2.463 ± 0.052	0.643MetMet: 0.643 ± 0.025	1.088MetAsn: 1.088 ± 0.032	1.23MetPro: 1.23 ± 0.037	1.233MetGln: 1.233 ± 0.037	1.165MetArg: 1.165 ± 0.035	1.543MetSer: 1.543 ± 0.039	1.48MetThr: 1.48 ± 0.04	1.437MetVal: 1.437 ± 0.039	0.177MetTrp: 0.177 ± 0.015	0.499MetTyr: 0.499 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.299AsnAla: 3.299 ± 0.063	0.565AsnCys: 0.565 ± 0.026	2.157AsnAsp: 2.157 ± 0.046	2.813AsnGlu: 2.813 ± 0.053	1.84AsnPhe: 1.84 ± 0.043	2.543AsnGly: 2.543 ± 0.06	1.306AsnHis: 1.306 ± 0.04	2.849AsnIle: 2.849 ± 0.059	2.931AsnLys: 2.931 ± 0.057	4.678AsnLeu: 4.678 ± 0.085	0.874AsnMet: 0.874 ± 0.028	2.393AsnAsn: 2.393 ± 0.058	2.626AsnPro: 2.626 ± 0.051	2.519AsnGln: 2.519 ± 0.058	2.101AsnArg: 2.101 ± 0.046	2.836AsnSer: 2.836 ± 0.062	2.479AsnThr: 2.479 ± 0.055	2.168AsnVal: 2.168 ± 0.046	0.58AsnTrp: 0.58 ± 0.022	1.996AsnTyr: 1.996 ± 0.042	0.001AsnXaa: 0.001 ± 0.001
Pro	3.435ProAla: 3.435 ± 0.063	0.439ProCys: 0.439 ± 0.02	2.225ProAsp: 2.225 ± 0.054	2.99ProGlu: 2.99 ± 0.059	1.964ProPhe: 1.964 ± 0.045	2.729ProGly: 2.729 ± 0.058	0.992ProHis: 0.992 ± 0.033	2.626ProIle: 2.626 ± 0.051	2.069ProLys: 2.069 ± 0.054	4.701ProLeu: 4.701 ± 0.078	0.896ProMet: 0.896 ± 0.028	1.695ProAsn: 1.695 ± 0.043	1.656ProPro: 1.656 ± 0.046	1.935ProGln: 1.935 ± 0.051	1.52ProArg: 1.52 ± 0.042	2.538ProSer: 2.538 ± 0.054	2.228ProThr: 2.228 ± 0.042	3.228ProVal: 3.228 ± 0.063	0.51ProTrp: 0.51 ± 0.022	1.45ProTyr: 1.45 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.55GlnAla: 4.55 ± 0.074	0.493GlnCys: 0.493 ± 0.025	1.923GlnAsp: 1.923 ± 0.04	2.895GlnGlu: 2.895 ± 0.061	2.07GlnPhe: 2.07 ± 0.042	2.797GlnGly: 2.797 ± 0.06	1.22GlnHis: 1.22 ± 0.037	2.954GlnIle: 2.954 ± 0.055	2.675GlnLys: 2.675 ± 0.053	5.607GlnLeu: 5.607 ± 0.085	1.003GlnMet: 1.003 ± 0.029	1.803GlnAsn: 1.803 ± 0.042	1.84GlnPro: 1.84 ± 0.047	3.283GlnGln: 3.283 ± 0.086	2.325GlnArg: 2.325 ± 0.044	2.665GlnSer: 2.665 ± 0.052	2.486GlnThr: 2.486 ± 0.053	2.796GlnVal: 2.796 ± 0.062	0.621GlnTrp: 0.621 ± 0.027	1.439GlnTyr: 1.439 ± 0.044	0.001GlnXaa: 0.001 ± 0.001
Arg	3.375ArgAla: 3.375 ± 0.056	0.541ArgCys: 0.541 ± 0.023	2.235ArgAsp: 2.235 ± 0.049	2.984ArgGlu: 2.984 ± 0.052	2.286ArgPhe: 2.286 ± 0.048	2.545ArgGly: 2.545 ± 0.051	1.199ArgHis: 1.199 ± 0.034	3.184ArgIle: 3.184 ± 0.056	2.43ArgLys: 2.43 ± 0.047	5.525ArgLeu: 5.525 ± 0.088	1.073ArgMet: 1.073 ± 0.035	1.908ArgAsn: 1.908 ± 0.039	1.527ArgPro: 1.527 ± 0.041	2.471ArgGln: 2.471 ± 0.046	2.207ArgArg: 2.207 ± 0.056	2.265ArgSer: 2.265 ± 0.048	2.043ArgThr: 2.043 ± 0.04	2.855ArgVal: 2.855 ± 0.058	0.589ArgTrp: 0.589 ± 0.028	1.862ArgTyr: 1.862 ± 0.041	0.001ArgXaa: 0.001 ± 0.001
Ser	4.703SerAla: 4.703 ± 0.078	0.798SerCys: 0.798 ± 0.029	2.917SerAsp: 2.917 ± 0.056	3.484SerGlu: 3.484 ± 0.061	3.043SerPhe: 3.043 ± 0.054	4.256SerGly: 4.256 ± 0.067	1.594SerHis: 1.594 ± 0.041	4.224SerIle: 4.224 ± 0.08	3.387SerLys: 3.387 ± 0.06	7.804SerLeu: 7.804 ± 0.103	1.607SerMet: 1.607 ± 0.04	2.704SerAsn: 2.704 ± 0.056	2.816SerPro: 2.816 ± 0.054	2.863SerGln: 2.863 ± 0.048	2.623SerArg: 2.623 ± 0.053	4.338SerSer: 4.338 ± 0.073	3.408SerThr: 3.408 ± 0.07	3.625SerVal: 3.625 ± 0.062	0.799SerTrp: 0.799 ± 0.027	2.207SerTyr: 2.207 ± 0.045	0.003SerXaa: 0.003 ± 0.002
Thr	4.631ThrAla: 4.631 ± 0.075	0.58ThrCys: 0.58 ± 0.023	2.503ThrAsp: 2.503 ± 0.053	2.792ThrGlu: 2.792 ± 0.054	2.026ThrPhe: 2.026 ± 0.044	3.711ThrGly: 3.711 ± 0.066	1.321ThrHis: 1.321 ± 0.032	3.975ThrIle: 3.975 ± 0.071	2.529ThrLys: 2.529 ± 0.054	6.364ThrLeu: 6.364 ± 0.092	1.161ThrMet: 1.161 ± 0.036	2.251ThrAsn: 2.251 ± 0.048	2.804ThrPro: 2.804 ± 0.068	2.364ThrGln: 2.364 ± 0.047	2.342ThrArg: 2.342 ± 0.057	3.342ThrSer: 3.342 ± 0.06	3.188ThrThr: 3.188 ± 0.059	3.53ThrVal: 3.53 ± 0.062	0.559ThrTrp: 0.559 ± 0.027	1.614ThrTyr: 1.614 ± 0.039	0.005ThrXaa: 0.005 ± 0.002
Val	5.284ValAla: 5.284 ± 0.083	0.726ValCys: 0.726 ± 0.029	3.289ValAsp: 3.289 ± 0.06	3.449ValGlu: 3.449 ± 0.069	2.789ValPhe: 2.789 ± 0.051	3.721ValGly: 3.721 ± 0.082	1.226ValHis: 1.226 ± 0.033	4.684ValIle: 4.684 ± 0.078	3.552ValLys: 3.552 ± 0.073	6.412ValLeu: 6.412 ± 0.086	1.547ValMet: 1.547 ± 0.042	2.993ValAsn: 2.993 ± 0.052	2.38ValPro: 2.38 ± 0.046	2.067ValGln: 2.067 ± 0.051	2.546ValArg: 2.546 ± 0.05	4.16ValSer: 4.16 ± 0.074	3.329ValThr: 3.329 ± 0.06	4.357ValVal: 4.357 ± 0.081	0.6ValTrp: 0.6 ± 0.025	1.799ValTyr: 1.799 ± 0.036	0.003ValXaa: 0.003 ± 0.002
Trp	0.729TrpAla: 0.729 ± 0.031	0.165TrpCys: 0.165 ± 0.013	0.54TrpAsp: 0.54 ± 0.023	0.538TrpGlu: 0.538 ± 0.023	0.58TrpPhe: 0.58 ± 0.025	0.693TrpGly: 0.693 ± 0.029	0.369TrpHis: 0.369 ± 0.018	0.702TrpIle: 0.702 ± 0.03	0.449TrpLys: 0.449 ± 0.02	1.685TrpLeu: 1.685 ± 0.046	0.256TrpMet: 0.256 ± 0.016	0.399TrpAsn: 0.399 ± 0.019	0.493TrpPro: 0.493 ± 0.022	0.873TrpGln: 0.873 ± 0.032	0.608TrpArg: 0.608 ± 0.027	0.679TrpSer: 0.679 ± 0.029	0.418TrpThr: 0.418 ± 0.021	0.762TrpVal: 0.762 ± 0.032	0.162TrpTrp: 0.162 ± 0.012	0.403TrpTyr: 0.403 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.532TyrAla: 2.532 ± 0.051	0.545TyrCys: 0.545 ± 0.024	1.592TyrAsp: 1.592 ± 0.039	1.757TyrGlu: 1.757 ± 0.04	1.744TyrPhe: 1.744 ± 0.046	2.064TyrGly: 2.064 ± 0.051	0.91TyrHis: 0.91 ± 0.031	1.847TyrIle: 1.847 ± 0.039	1.668TyrLys: 1.668 ± 0.04	4.184TyrLeu: 4.184 ± 0.07	0.598TyrMet: 0.598 ± 0.025	1.361TyrAsn: 1.361 ± 0.035	1.516TyrPro: 1.516 ± 0.044	2.093TyrGln: 2.093 ± 0.049	1.826TyrArg: 1.826 ± 0.043	2.161TyrSer: 2.161 ± 0.044	1.636TyrThr: 1.636 ± 0.033	1.758TyrVal: 1.758 ± 0.043	0.513TyrTrp: 0.513 ± 0.023	1.317TyrTyr: 1.317 ± 0.037	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.003XaaCys: 0.003 ± 0.002	0.002XaaAsp: 0.002 ± 0.002	0.001XaaGlu: 0.001 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.003XaaHis: 0.003 ± 0.002	0.002XaaIle: 0.002 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.005XaaLeu: 0.005 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.002	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.099XaaXaa: 0.099 ± 0.017

Statistics based on 3273 proteins (1025687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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