Amino acid dipepetide frequency for Xenopus laevis (African clawed frog)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.903AlaAla: 4.903 ± 0.024	1.23AlaCys: 1.23 ± 0.008	2.717AlaAsp: 2.717 ± 0.012	4.084AlaGlu: 4.084 ± 0.017	2.374AlaPhe: 2.374 ± 0.012	3.51AlaGly: 3.51 ± 0.02	1.369AlaHis: 1.369 ± 0.01	2.989AlaIle: 2.989 ± 0.014	3.375AlaLys: 3.375 ± 0.017	5.779AlaLeu: 5.779 ± 0.025	1.422AlaMet: 1.422 ± 0.01	2.263AlaAsn: 2.263 ± 0.013	2.999AlaPro: 2.999 ± 0.019	2.616AlaGln: 2.616 ± 0.014	2.591AlaArg: 2.591 ± 0.013	4.927AlaSer: 4.927 ± 0.02	3.271AlaThr: 3.271 ± 0.018	4.193AlaVal: 4.193 ± 0.017	0.61AlaTrp: 0.61 ± 0.007	1.493AlaTyr: 1.493 ± 0.009	0.0AlaXaa: 0.0 ± 0.0
Cys	1.249CysAla: 1.249 ± 0.01	0.73CysCys: 0.73 ± 0.008	1.161CysAsp: 1.161 ± 0.012	1.291CysGlu: 1.291 ± 0.013	0.987CysPhe: 0.987 ± 0.007	1.616CysGly: 1.616 ± 0.017	0.689CysHis: 0.689 ± 0.007	1.343CysIle: 1.343 ± 0.012	1.371CysLys: 1.371 ± 0.011	2.252CysLeu: 2.252 ± 0.013	0.534CysMet: 0.534 ± 0.005	1.124CysAsn: 1.124 ± 0.01	1.367CysPro: 1.367 ± 0.015	1.072CysGln: 1.072 ± 0.011	1.229CysArg: 1.229 ± 0.01	2.321CysSer: 2.321 ± 0.016	1.501CysThr: 1.501 ± 0.014	1.452CysVal: 1.452 ± 0.012	0.299CysTrp: 0.299 ± 0.004	0.725CysTyr: 0.725 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	2.55AspAla: 2.55 ± 0.013	1.138AspCys: 1.138 ± 0.012	2.751AspAsp: 2.751 ± 0.017	3.424AspGlu: 3.424 ± 0.018	2.172AspPhe: 2.172 ± 0.013	3.098AspGly: 3.098 ± 0.018	1.142AspHis: 1.142 ± 0.009	3.174AspIle: 3.174 ± 0.019	2.808AspLys: 2.808 ± 0.016	4.848AspLeu: 4.848 ± 0.019	1.223AspMet: 1.223 ± 0.009	2.151AspAsn: 2.151 ± 0.013	2.616AspPro: 2.616 ± 0.014	1.823AspGln: 1.823 ± 0.015	2.354AspArg: 2.354 ± 0.013	4.257AspSer: 4.257 ± 0.02	2.747AspThr: 2.747 ± 0.016	2.981AspVal: 2.981 ± 0.016	0.625AspTrp: 0.625 ± 0.006	1.591AspTyr: 1.591 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	4.058GluAla: 4.058 ± 0.018	1.445GluCys: 1.445 ± 0.018	4.161GluAsp: 4.161 ± 0.021	7.161GluGlu: 7.161 ± 0.04	2.066GluPhe: 2.066 ± 0.012	3.635GluGly: 3.635 ± 0.018	1.529GluHis: 1.529 ± 0.01	3.527GluIle: 3.527 ± 0.016	5.33GluLys: 5.33 ± 0.028	5.735GluLeu: 5.735 ± 0.028	1.738GluMet: 1.738 ± 0.011	3.426GluAsn: 3.426 ± 0.018	2.576GluPro: 2.576 ± 0.017	3.054GluGln: 3.054 ± 0.018	3.739GluArg: 3.739 ± 0.019	4.655GluSer: 4.655 ± 0.022	3.701GluThr: 3.701 ± 0.025	3.79GluVal: 3.79 ± 0.018	0.677GluTrp: 0.677 ± 0.007	1.711GluTyr: 1.711 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.002PheAla: 2.002 ± 0.012	1.129PheCys: 1.129 ± 0.009	1.713PheAsp: 1.713 ± 0.012	1.858PheGlu: 1.858 ± 0.012	1.786PhePhe: 1.786 ± 0.015	2.205PheGly: 2.205 ± 0.013	1.109PheHis: 1.109 ± 0.008	2.312PheIle: 2.312 ± 0.013	1.988PheLys: 1.988 ± 0.013	4.224PheLeu: 4.224 ± 0.024	0.905PheMet: 0.905 ± 0.007	1.634PheAsn: 1.634 ± 0.008	2.019PhePro: 2.019 ± 0.012	1.805PheGln: 1.805 ± 0.009	1.824PheArg: 1.824 ± 0.011	3.69PheSer: 3.69 ± 0.017	2.338PheThr: 2.338 ± 0.017	2.222PheVal: 2.222 ± 0.013	0.506PheTrp: 0.506 ± 0.006	1.37PheTyr: 1.37 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	3.347GlyAla: 3.347 ± 0.02	1.241GlyCys: 1.241 ± 0.011	2.919GlyAsp: 2.919 ± 0.017	3.715GlyGlu: 3.715 ± 0.024	2.45GlyPhe: 2.45 ± 0.014	3.946GlyGly: 3.946 ± 0.026	1.559GlyHis: 1.559 ± 0.01	3.104GlyIle: 3.104 ± 0.016	3.867GlyLys: 3.867 ± 0.018	4.869GlyLeu: 4.869 ± 0.022	1.347GlyMet: 1.347 ± 0.01	2.818GlyAsn: 2.818 ± 0.013	2.69GlyPro: 2.69 ± 0.035	2.463GlyGln: 2.463 ± 0.013	3.049GlyArg: 3.049 ± 0.017	5.24GlySer: 5.24 ± 0.024	3.533GlyThr: 3.533 ± 0.018	3.279GlyVal: 3.279 ± 0.016	0.7GlyTrp: 0.7 ± 0.007	1.888GlyTyr: 1.888 ± 0.013	0.0GlyXaa: 0.0 ± 0.0
His	1.222HisAla: 1.222 ± 0.009	0.761HisCys: 0.761 ± 0.008	0.938HisAsp: 0.938 ± 0.008	1.301HisGlu: 1.301 ± 0.009	1.179HisPhe: 1.179 ± 0.009	1.459HisGly: 1.459 ± 0.011	0.958HisHis: 0.958 ± 0.013	1.504HisIle: 1.504 ± 0.01	1.476HisLys: 1.476 ± 0.011	2.812HisLeu: 2.812 ± 0.014	0.665HisMet: 0.665 ± 0.007	1.134HisAsn: 1.134 ± 0.009	1.519HisPro: 1.519 ± 0.013	1.246HisGln: 1.246 ± 0.011	1.503HisArg: 1.503 ± 0.011	2.491HisSer: 2.491 ± 0.016	1.678HisThr: 1.678 ± 0.019	1.457HisVal: 1.457 ± 0.01	0.357HisTrp: 0.357 ± 0.005	0.933HisTyr: 0.933 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.842IleAla: 2.842 ± 0.016	1.444IleCys: 1.444 ± 0.011	2.331IleAsp: 2.331 ± 0.015	2.858IleGlu: 2.858 ± 0.015	2.267IlePhe: 2.267 ± 0.014	2.665IleGly: 2.665 ± 0.015	1.562IleHis: 1.562 ± 0.01	3.18IleIle: 3.18 ± 0.017	3.219IleLys: 3.219 ± 0.018	5.28IleLeu: 5.28 ± 0.024	1.238IleMet: 1.238 ± 0.01	2.438IleAsn: 2.438 ± 0.014	3.045IlePro: 3.045 ± 0.015	2.562IleGln: 2.562 ± 0.015	2.556IleArg: 2.556 ± 0.015	4.746IleSer: 4.746 ± 0.019	3.295IleThr: 3.295 ± 0.018	3.059IleVal: 3.059 ± 0.017	0.599IleTrp: 0.599 ± 0.006	1.817IleTyr: 1.817 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	3.669LysAla: 3.669 ± 0.016	1.39LysCys: 1.39 ± 0.011	3.43LysAsp: 3.43 ± 0.018	5.274LysGlu: 5.274 ± 0.025	1.794LysPhe: 1.794 ± 0.01	3.426LysGly: 3.426 ± 0.024	1.608LysHis: 1.608 ± 0.012	3.203LysIle: 3.203 ± 0.017	5.209LysLys: 5.209 ± 0.025	5.278LysLeu: 5.278 ± 0.024	1.621LysMet: 1.621 ± 0.011	2.885LysAsn: 2.885 ± 0.014	3.074LysPro: 3.074 ± 0.019	2.895LysGln: 2.895 ± 0.025	3.519LysArg: 3.519 ± 0.02	4.573LysSer: 4.573 ± 0.023	3.474LysThr: 3.474 ± 0.018	3.616LysVal: 3.616 ± 0.017	0.68LysTrp: 0.68 ± 0.006	1.8LysTyr: 1.8 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	5.472LeuAla: 5.472 ± 0.022	2.375LeuCys: 2.375 ± 0.016	4.47LeuAsp: 4.47 ± 0.019	6.214LeuGlu: 6.214 ± 0.028	3.583LeuPhe: 3.583 ± 0.022	4.869LeuGly: 4.869 ± 0.022	2.864LeuHis: 2.864 ± 0.015	4.502LeuIle: 4.502 ± 0.022	5.963LeuLys: 5.963 ± 0.024	9.945LeuLeu: 9.945 ± 0.043	2.081LeuMet: 2.081 ± 0.013	4.094LeuAsn: 4.094 ± 0.018	5.221LeuPro: 5.221 ± 0.026	5.387LeuGln: 5.387 ± 0.026	4.897LeuArg: 4.897 ± 0.022	8.262LeuSer: 8.262 ± 0.027	5.147LeuThr: 5.147 ± 0.022	5.142LeuVal: 5.142 ± 0.021	1.043LeuTrp: 1.043 ± 0.009	2.885LeuTyr: 2.885 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.792MetAla: 1.792 ± 0.011	0.531MetCys: 0.531 ± 0.006	1.374MetAsp: 1.374 ± 0.01	1.994MetGlu: 1.994 ± 0.012	0.888MetPhe: 0.888 ± 0.008	1.361MetGly: 1.361 ± 0.013	0.543MetHis: 0.543 ± 0.006	1.026MetIle: 1.026 ± 0.008	1.624MetLys: 1.624 ± 0.011	2.073MetLeu: 2.073 ± 0.012	0.634MetMet: 0.634 ± 0.007	1.08MetAsn: 1.08 ± 0.009	1.13MetPro: 1.13 ± 0.013	1.068MetGln: 1.068 ± 0.008	1.115MetArg: 1.115 ± 0.009	1.898MetSer: 1.898 ± 0.011	1.198MetThr: 1.198 ± 0.009	1.396MetVal: 1.396 ± 0.009	0.261MetTrp: 0.261 ± 0.005	0.746MetTyr: 0.746 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.35AsnAla: 2.35 ± 0.013	1.095AsnCys: 1.095 ± 0.01	1.95AsnAsp: 1.95 ± 0.013	2.687AsnGlu: 2.687 ± 0.016	1.643AsnPhe: 1.643 ± 0.011	2.928AsnGly: 2.928 ± 0.02	1.108AsnHis: 1.108 ± 0.009	2.841AsnIle: 2.841 ± 0.015	2.807AsnLys: 2.807 ± 0.014	4.106AsnLeu: 4.106 ± 0.019	1.184AsnMet: 1.184 ± 0.007	2.226AsnAsn: 2.226 ± 0.014	2.44AsnPro: 2.44 ± 0.014	1.916AsnGln: 1.916 ± 0.012	2.103AsnArg: 2.103 ± 0.011	3.854AsnSer: 3.854 ± 0.018	2.63AsnThr: 2.63 ± 0.016	2.711AsnVal: 2.711 ± 0.015	0.515AsnTrp: 0.515 ± 0.005	1.375AsnTyr: 1.375 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	3.417ProAla: 3.417 ± 0.02	1.171ProCys: 1.171 ± 0.011	2.59ProAsp: 2.59 ± 0.016	3.602ProGlu: 3.602 ± 0.018	2.017ProPhe: 2.017 ± 0.014	3.581ProGly: 3.581 ± 0.044	1.352ProHis: 1.352 ± 0.012	2.297ProIle: 2.297 ± 0.014	2.796ProLys: 2.796 ± 0.021	4.714ProLeu: 4.714 ± 0.023	1.09ProMet: 1.09 ± 0.009	2.162ProAsn: 2.162 ± 0.013	4.453ProPro: 4.453 ± 0.04	2.377ProGln: 2.377 ± 0.018	2.423ProArg: 2.423 ± 0.017	5.219ProSer: 5.219 ± 0.029	3.096ProThr: 3.096 ± 0.023	3.658ProVal: 3.658 ± 0.017	0.536ProTrp: 0.536 ± 0.006	1.527ProTyr: 1.527 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	2.698GlnAla: 2.698 ± 0.015	1.062GlnCys: 1.062 ± 0.01	2.25GlnAsp: 2.25 ± 0.019	3.515GlnGlu: 3.515 ± 0.02	1.456GlnPhe: 1.456 ± 0.009	2.504GlnGly: 2.504 ± 0.017	1.304GlnHis: 1.304 ± 0.01	2.365GlnIle: 2.365 ± 0.012	3.069GlnLys: 3.069 ± 0.02	4.306GlnLeu: 4.306 ± 0.022	1.19GlnMet: 1.19 ± 0.009	2.231GlnAsn: 2.231 ± 0.013	2.286GlnPro: 2.286 ± 0.018	2.948GlnGln: 2.948 ± 0.035	2.664GlnArg: 2.664 ± 0.015	3.502GlnSer: 3.502 ± 0.02	2.552GlnThr: 2.552 ± 0.016	2.572GlnVal: 2.572 ± 0.013	0.54GlnTrp: 0.54 ± 0.005	1.326GlnTyr: 1.326 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	2.76ArgAla: 2.76 ± 0.014	1.133ArgCys: 1.133 ± 0.012	2.552ArgAsp: 2.552 ± 0.013	3.497ArgGlu: 3.497 ± 0.019	1.853ArgPhe: 1.853 ± 0.011	2.914ArgGly: 2.914 ± 0.02	1.458ArgHis: 1.458 ± 0.01	2.649ArgIle: 2.649 ± 0.013	3.758ArgLys: 3.758 ± 0.019	4.522ArgLeu: 4.522 ± 0.018	1.21ArgMet: 1.21 ± 0.01	2.352ArgAsn: 2.352 ± 0.012	2.423ArgPro: 2.423 ± 0.016	2.353ArgGln: 2.353 ± 0.014	3.639ArgArg: 3.639 ± 0.026	4.12ArgSer: 4.12 ± 0.027	2.681ArgThr: 2.681 ± 0.013	2.765ArgVal: 2.765 ± 0.014	0.625ArgTrp: 0.625 ± 0.007	1.54ArgTyr: 1.54 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	5.087SerAla: 5.087 ± 0.022	2.192SerCys: 2.192 ± 0.016	4.354SerAsp: 4.354 ± 0.021	5.167SerGlu: 5.167 ± 0.023	3.432SerPhe: 3.432 ± 0.014	5.174SerGly: 5.174 ± 0.024	2.318SerHis: 2.318 ± 0.013	4.116SerIle: 4.116 ± 0.017	4.543SerLys: 4.543 ± 0.021	8.375SerLeu: 8.375 ± 0.033	1.867SerMet: 1.867 ± 0.012	3.609SerAsn: 3.609 ± 0.017	5.527SerPro: 5.527 ± 0.037	3.805SerGln: 3.805 ± 0.021	4.19SerArg: 4.19 ± 0.024	9.786SerSer: 9.786 ± 0.055	5.083SerThr: 5.083 ± 0.035	5.444SerVal: 5.444 ± 0.023	1.0SerTrp: 1.0 ± 0.009	2.437SerTyr: 2.437 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	3.626ThrAla: 3.626 ± 0.018	1.576ThrCys: 1.576 ± 0.018	2.953ThrAsp: 2.953 ± 0.015	3.976ThrGlu: 3.976 ± 0.028	2.366ThrPhe: 2.366 ± 0.013	3.622ThrGly: 3.622 ± 0.021	1.492ThrHis: 1.492 ± 0.02	3.01ThrIle: 3.01 ± 0.018	3.044ThrLys: 3.044 ± 0.019	5.411ThrLeu: 5.411 ± 0.021	1.268ThrMet: 1.268 ± 0.01	2.289ThrAsn: 2.289 ± 0.017	3.424ThrPro: 3.424 ± 0.022	2.354ThrGln: 2.354 ± 0.015	2.356ThrArg: 2.356 ± 0.012	5.179ThrSer: 5.179 ± 0.039	3.544ThrThr: 3.544 ± 0.055	4.112ThrVal: 4.112 ± 0.019	0.684ThrTrp: 0.684 ± 0.008	1.654ThrTyr: 1.654 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	3.625ValAla: 3.625 ± 0.018	1.595ValCys: 1.595 ± 0.013	2.792ValAsp: 2.792 ± 0.016	3.649ValGlu: 3.649 ± 0.016	2.494ValPhe: 2.494 ± 0.016	3.121ValGly: 3.121 ± 0.014	1.542ValHis: 1.542 ± 0.009	3.283ValIle: 3.283 ± 0.013	3.566ValLys: 3.566 ± 0.02	5.898ValLeu: 5.898 ± 0.025	1.394ValMet: 1.394 ± 0.01	2.544ValAsn: 2.544 ± 0.012	3.383ValPro: 3.383 ± 0.017	2.782ValGln: 2.782 ± 0.012	2.732ValArg: 2.732 ± 0.012	5.279ValSer: 5.279 ± 0.025	3.954ValThr: 3.954 ± 0.02	3.803ValVal: 3.803 ± 0.026	0.726ValTrp: 0.726 ± 0.006	1.866ValTyr: 1.866 ± 0.012	0.0ValXaa: 0.0 ± 0.0
Trp	0.633TrpAla: 0.633 ± 0.006	0.249TrpCys: 0.249 ± 0.004	0.623TrpAsp: 0.623 ± 0.007	0.734TrpGlu: 0.734 ± 0.007	0.445TrpPhe: 0.445 ± 0.006	0.63TrpGly: 0.63 ± 0.008	0.296TrpHis: 0.296 ± 0.005	0.704TrpIle: 0.704 ± 0.007	0.825TrpLys: 0.825 ± 0.006	1.128TrpLeu: 1.128 ± 0.01	0.35TrpMet: 0.35 ± 0.005	0.588TrpAsn: 0.588 ± 0.007	0.426TrpPro: 0.426 ± 0.005	0.511TrpGln: 0.511 ± 0.005	0.658TrpArg: 0.658 ± 0.007	0.859TrpSer: 0.859 ± 0.009	0.652TrpThr: 0.652 ± 0.007	0.688TrpVal: 0.688 ± 0.007	0.204TrpTrp: 0.204 ± 0.004	0.378TrpTyr: 0.378 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.412TyrAla: 1.412 ± 0.01	0.827TyrCys: 0.827 ± 0.008	1.446TyrAsp: 1.446 ± 0.01	1.711TyrGlu: 1.711 ± 0.011	1.387TyrPhe: 1.387 ± 0.01	1.764TyrGly: 1.764 ± 0.012	0.793TyrHis: 0.793 ± 0.009	1.871TyrIle: 1.871 ± 0.014	1.777TyrLys: 1.777 ± 0.014	2.858TyrLeu: 2.858 ± 0.017	0.768TyrMet: 0.768 ± 0.008	1.424TyrAsn: 1.424 ± 0.009	1.459TyrPro: 1.459 ± 0.014	1.304TyrGln: 1.304 ± 0.009	1.665TyrArg: 1.665 ± 0.012	2.649TyrSer: 2.649 ± 0.015	1.867TyrThr: 1.867 ± 0.014	1.689TyrVal: 1.689 ± 0.011	0.393TyrTrp: 0.393 ± 0.006	1.126TyrTyr: 1.126 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.032XaaXaa: 0.032 ± 0.012

Statistics based on 44580 proteins (19963946 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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