Amino acid dipepetide frequency for Luminiphilus syltensis NOR5-1B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.439AlaAla: 12.439 ± 0.154	1.094AlaCys: 1.094 ± 0.038	6.446AlaAsp: 6.446 ± 0.08	6.955AlaGlu: 6.955 ± 0.091	3.693AlaPhe: 3.693 ± 0.076	8.77AlaGly: 8.77 ± 0.099	1.925AlaHis: 1.925 ± 0.05	6.029AlaIle: 6.029 ± 0.083	3.181AlaLys: 3.181 ± 0.078	12.04AlaLeu: 12.04 ± 0.127	3.061AlaMet: 3.061 ± 0.057	2.929AlaAsn: 2.929 ± 0.061	4.452AlaPro: 4.452 ± 0.083	3.737AlaGln: 3.737 ± 0.07	6.377AlaArg: 6.377 ± 0.087	6.248AlaSer: 6.248 ± 0.091	5.517AlaThr: 5.517 ± 0.078	7.891AlaVal: 7.891 ± 0.108	1.245AlaTrp: 1.245 ± 0.039	2.474AlaTyr: 2.474 ± 0.046	0.002AlaXaa: 0.002 ± 0.002
Cys	1.07CysAla: 1.07 ± 0.041	0.169CysCys: 0.169 ± 0.014	0.641CysAsp: 0.641 ± 0.026	0.616CysGlu: 0.616 ± 0.026	0.412CysPhe: 0.412 ± 0.022	1.014CysGly: 1.014 ± 0.034	0.298CysHis: 0.298 ± 0.019	0.487CysIle: 0.487 ± 0.022	0.254CysLys: 0.254 ± 0.017	0.85CysLeu: 0.85 ± 0.031	0.191CysMet: 0.191 ± 0.015	0.303CysAsn: 0.303 ± 0.019	0.553CysPro: 0.553 ± 0.028	0.341CysGln: 0.341 ± 0.02	0.621CysArg: 0.621 ± 0.028	0.662CysSer: 0.662 ± 0.027	0.501CysThr: 0.501 ± 0.024	0.666CysVal: 0.666 ± 0.027	0.116CysTrp: 0.116 ± 0.012	0.294CysTyr: 0.294 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.643AspAla: 6.643 ± 0.089	0.623AspCys: 0.623 ± 0.027	3.941AspAsp: 3.941 ± 0.085	3.969AspGlu: 3.969 ± 0.072	2.684AspPhe: 2.684 ± 0.063	5.026AspGly: 5.026 ± 0.091	1.318AspHis: 1.318 ± 0.048	3.705AspIle: 3.705 ± 0.059	1.695AspLys: 1.695 ± 0.049	5.955AspLeu: 5.955 ± 0.08	1.405AspMet: 1.405 ± 0.038	2.004AspAsn: 2.004 ± 0.045	3.339AspPro: 3.339 ± 0.076	2.164AspGln: 2.164 ± 0.048	3.949AspArg: 3.949 ± 0.07	3.579AspSer: 3.579 ± 0.067	3.31AspThr: 3.31 ± 0.069	4.308AspVal: 4.308 ± 0.071	1.073AspTrp: 1.073 ± 0.034	2.149AspTyr: 2.149 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	6.894GluAla: 6.894 ± 0.107	0.503GluCys: 0.503 ± 0.027	3.284GluAsp: 3.284 ± 0.066	3.738GluGlu: 3.738 ± 0.081	2.191GluPhe: 2.191 ± 0.048	4.495GluGly: 4.495 ± 0.074	1.483GluHis: 1.483 ± 0.045	3.38GluIle: 3.38 ± 0.059	2.23GluLys: 2.23 ± 0.053	6.467GluLeu: 6.467 ± 0.087	1.481GluMet: 1.481 ± 0.039	1.863GluAsn: 1.863 ± 0.047	2.695GluPro: 2.695 ± 0.059	3.104GluGln: 3.104 ± 0.06	4.517GluArg: 4.517 ± 0.08	3.815GluSer: 3.815 ± 0.068	3.366GluThr: 3.366 ± 0.063	4.626GluVal: 4.626 ± 0.073	0.837GluTrp: 0.837 ± 0.027	1.453GluTyr: 1.453 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.733PheAla: 3.733 ± 0.077	0.485PheCys: 0.485 ± 0.02	3.04PheAsp: 3.04 ± 0.061	2.417PheGlu: 2.417 ± 0.056	1.563PhePhe: 1.563 ± 0.048	3.366PheGly: 3.366 ± 0.064	0.688PheHis: 0.688 ± 0.03	1.99PheIle: 1.99 ± 0.049	1.036PheLys: 1.036 ± 0.034	3.339PheLeu: 3.339 ± 0.071	0.882PheMet: 0.882 ± 0.035	1.42PheAsn: 1.42 ± 0.044	1.596PhePro: 1.596 ± 0.038	1.077PheGln: 1.077 ± 0.039	1.941PheArg: 1.941 ± 0.053	2.879PheSer: 2.879 ± 0.059	2.172PheThr: 2.172 ± 0.05	2.494PheVal: 2.494 ± 0.055	0.504PheTrp: 0.504 ± 0.024	1.169PheTyr: 1.169 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	7.788GlyAla: 7.788 ± 0.096	0.995GlyCys: 0.995 ± 0.037	5.102GlyAsp: 5.102 ± 0.087	5.025GlyGlu: 5.025 ± 0.084	3.707GlyPhe: 3.707 ± 0.065	6.808GlyGly: 6.808 ± 0.113	1.771GlyHis: 1.771 ± 0.042	4.684GlyIle: 4.684 ± 0.072	2.929GlyLys: 2.929 ± 0.067	7.973GlyLeu: 7.973 ± 0.112	2.177GlyMet: 2.177 ± 0.054	2.523GlyAsn: 2.523 ± 0.061	2.89GlyPro: 2.89 ± 0.065	2.679GlyGln: 2.679 ± 0.051	4.761GlyArg: 4.761 ± 0.073	5.043GlySer: 5.043 ± 0.08	4.205GlyThr: 4.205 ± 0.078	6.53GlyVal: 6.53 ± 0.083	1.284GlyTrp: 1.284 ± 0.038	2.442GlyTyr: 2.442 ± 0.049	0.003GlyXaa: 0.003 ± 0.002
His	1.807HisAla: 1.807 ± 0.046	0.333HisCys: 0.333 ± 0.017	1.092HisAsp: 1.092 ± 0.032	1.073HisGlu: 1.073 ± 0.038	0.904HisPhe: 0.904 ± 0.034	1.736HisGly: 1.736 ± 0.045	0.637HisHis: 0.637 ± 0.033	1.046HisIle: 1.046 ± 0.034	0.531HisLys: 0.531 ± 0.025	2.142HisLeu: 2.142 ± 0.051	0.444HisMet: 0.444 ± 0.025	0.605HisAsn: 0.605 ± 0.028	1.345HisPro: 1.345 ± 0.042	0.815HisGln: 0.815 ± 0.031	1.656HisArg: 1.656 ± 0.046	1.277HisSer: 1.277 ± 0.038	1.007HisThr: 1.007 ± 0.031	1.274HisVal: 1.274 ± 0.037	0.406HisTrp: 0.406 ± 0.021	0.72HisTyr: 0.72 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.527IleAla: 6.527 ± 0.094	0.494IleCys: 0.494 ± 0.021	4.548IleAsp: 4.548 ± 0.06	4.059IleGlu: 4.059 ± 0.075	1.651IlePhe: 1.651 ± 0.044	4.454IleGly: 4.454 ± 0.078	1.041IleHis: 1.041 ± 0.032	2.505IleIle: 2.505 ± 0.057	1.676IleLys: 1.676 ± 0.049	4.055IleLeu: 4.055 ± 0.062	0.96IleMet: 0.96 ± 0.031	2.053IleAsn: 2.053 ± 0.047	2.671IlePro: 2.671 ± 0.051	1.479IleGln: 1.479 ± 0.041	3.046IleArg: 3.046 ± 0.057	3.305IleSer: 3.305 ± 0.057	3.222IleThr: 3.222 ± 0.067	3.629IleVal: 3.629 ± 0.071	0.533IleTrp: 0.533 ± 0.027	1.291IleTyr: 1.291 ± 0.039	0.001IleXaa: 0.001 ± 0.001
Lys	3.426LysAla: 3.426 ± 0.077	0.203LysCys: 0.203 ± 0.014	1.495LysAsp: 1.495 ± 0.041	1.472LysGlu: 1.472 ± 0.043	0.839LysPhe: 0.839 ± 0.029	2.201LysGly: 2.201 ± 0.059	0.636LysHis: 0.636 ± 0.028	1.501LysIle: 1.501 ± 0.047	1.417LysLys: 1.417 ± 0.066	3.152LysLeu: 3.152 ± 0.063	0.666LysMet: 0.666 ± 0.032	1.009LysAsn: 1.009 ± 0.03	1.817LysPro: 1.817 ± 0.04	1.365LysGln: 1.365 ± 0.038	2.315LysArg: 2.315 ± 0.058	1.919LysSer: 1.919 ± 0.046	1.974LysThr: 1.974 ± 0.051	2.161LysVal: 2.161 ± 0.048	0.313LysTrp: 0.313 ± 0.018	0.699LysTyr: 0.699 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.392LeuAla: 11.392 ± 0.126	1.019LeuCys: 1.019 ± 0.035	6.526LeuAsp: 6.526 ± 0.092	6.428LeuGlu: 6.428 ± 0.096	3.687LeuPhe: 3.687 ± 0.064	8.129LeuGly: 8.129 ± 0.104	2.0LeuHis: 2.0 ± 0.052	5.161LeuIle: 5.161 ± 0.075	3.267LeuLys: 3.267 ± 0.059	10.667LeuLeu: 10.667 ± 0.155	2.386LeuMet: 2.386 ± 0.055	3.16LeuAsn: 3.16 ± 0.055	5.362LeuPro: 5.362 ± 0.086	3.557LeuGln: 3.557 ± 0.065	6.557LeuArg: 6.557 ± 0.11	6.992LeuSer: 6.992 ± 0.1	5.542LeuThr: 5.542 ± 0.074	7.244LeuVal: 7.244 ± 0.091	1.263LeuTrp: 1.263 ± 0.043	2.189LeuTyr: 2.189 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.887MetAla: 2.887 ± 0.055	0.175MetCys: 0.175 ± 0.015	1.209MetAsp: 1.209 ± 0.037	1.236MetGlu: 1.236 ± 0.039	0.644MetPhe: 0.644 ± 0.028	1.927MetGly: 1.927 ± 0.047	0.429MetHis: 0.429 ± 0.02	1.232MetIle: 1.232 ± 0.035	0.893MetLys: 0.893 ± 0.028	2.345MetLeu: 2.345 ± 0.053	0.622MetMet: 0.622 ± 0.027	0.826MetAsn: 0.826 ± 0.031	1.306MetPro: 1.306 ± 0.04	0.924MetGln: 0.924 ± 0.035	1.484MetArg: 1.484 ± 0.043	1.644MetSer: 1.644 ± 0.043	1.63MetThr: 1.63 ± 0.045	1.693MetVal: 1.693 ± 0.052	0.204MetTrp: 0.204 ± 0.015	0.413MetTyr: 0.413 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.344AsnAla: 3.344 ± 0.056	0.294AsnCys: 0.294 ± 0.019	1.789AsnAsp: 1.789 ± 0.044	1.721AsnGlu: 1.721 ± 0.039	1.177AsnPhe: 1.177 ± 0.045	2.516AsnGly: 2.516 ± 0.057	0.629AsnHis: 0.629 ± 0.027	1.615AsnIle: 1.615 ± 0.047	0.854AsnLys: 0.854 ± 0.028	2.957AsnLeu: 2.957 ± 0.059	0.609AsnMet: 0.609 ± 0.02	1.119AsnAsn: 1.119 ± 0.036	2.076AsnPro: 2.076 ± 0.043	1.039AsnGln: 1.039 ± 0.033	2.131AsnArg: 2.131 ± 0.048	1.735AsnSer: 1.735 ± 0.049	1.816AsnThr: 1.816 ± 0.05	2.127AsnVal: 2.127 ± 0.052	0.459AsnTrp: 0.459 ± 0.022	0.897AsnTyr: 0.897 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.754ProAla: 4.754 ± 0.084	0.368ProCys: 0.368 ± 0.019	3.551ProAsp: 3.551 ± 0.073	4.113ProGlu: 4.113 ± 0.058	1.684ProPhe: 1.684 ± 0.04	4.363ProGly: 4.363 ± 0.078	1.003ProHis: 1.003 ± 0.03	2.367ProIle: 2.367 ± 0.051	1.459ProLys: 1.459 ± 0.039	4.765ProLeu: 4.765 ± 0.071	1.201ProMet: 1.201 ± 0.031	1.375ProAsn: 1.375 ± 0.045	2.255ProPro: 2.255 ± 0.067	1.546ProGln: 1.546 ± 0.045	2.489ProArg: 2.489 ± 0.059	2.809ProSer: 2.809 ± 0.058	2.455ProThr: 2.455 ± 0.052	3.799ProVal: 3.799 ± 0.066	0.634ProTrp: 0.634 ± 0.03	1.195ProTyr: 1.195 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.627GlnAla: 3.627 ± 0.057	0.369GlnCys: 0.369 ± 0.022	1.589GlnAsp: 1.589 ± 0.047	1.779GlnGlu: 1.779 ± 0.048	1.406GlnPhe: 1.406 ± 0.036	2.516GlnGly: 2.516 ± 0.054	0.836GlnHis: 0.836 ± 0.03	1.862GlnIle: 1.862 ± 0.05	1.087GlnLys: 1.087 ± 0.036	4.246GlnLeu: 4.246 ± 0.07	0.866GlnMet: 0.866 ± 0.03	0.956GlnAsn: 0.956 ± 0.038	1.779GlnPro: 1.779 ± 0.039	1.86GlnGln: 1.86 ± 0.057	3.106GlnArg: 3.106 ± 0.058	2.317GlnSer: 2.317 ± 0.048	1.828GlnThr: 1.828 ± 0.042	2.563GlnVal: 2.563 ± 0.055	0.633GlnTrp: 0.633 ± 0.028	0.849GlnTyr: 0.849 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.887ArgAla: 5.887 ± 0.078	0.634ArgCys: 0.634 ± 0.026	3.964ArgAsp: 3.964 ± 0.077	4.258ArgGlu: 4.258 ± 0.075	2.815ArgPhe: 2.815 ± 0.058	4.591ArgGly: 4.591 ± 0.068	1.453ArgHis: 1.453 ± 0.041	3.455ArgIle: 3.455 ± 0.066	2.054ArgLys: 2.054 ± 0.055	6.928ArgLeu: 6.928 ± 0.107	1.527ArgMet: 1.527 ± 0.036	1.915ArgAsn: 1.915 ± 0.046	2.652ArgPro: 2.652 ± 0.056	2.601ArgGln: 2.601 ± 0.055	4.376ArgArg: 4.376 ± 0.093	3.758ArgSer: 3.758 ± 0.062	2.722ArgThr: 2.722 ± 0.052	4.622ArgVal: 4.622 ± 0.071	1.123ArgTrp: 1.123 ± 0.04	2.026ArgTyr: 2.026 ± 0.042	0.001ArgXaa: 0.001 ± 0.001
Ser	6.742SerAla: 6.742 ± 0.089	0.547SerCys: 0.547 ± 0.025	4.074SerAsp: 4.074 ± 0.069	3.946SerGlu: 3.946 ± 0.061	2.222SerPhe: 2.222 ± 0.055	5.868SerGly: 5.868 ± 0.087	1.233SerHis: 1.233 ± 0.039	3.333SerIle: 3.333 ± 0.064	1.797SerLys: 1.797 ± 0.047	6.451SerLeu: 6.451 ± 0.084	1.515SerMet: 1.515 ± 0.044	1.823SerAsn: 1.823 ± 0.041	2.896SerPro: 2.896 ± 0.058	2.063SerGln: 2.063 ± 0.055	3.697SerArg: 3.697 ± 0.062	3.758SerSer: 3.758 ± 0.062	3.192SerThr: 3.192 ± 0.059	4.659SerVal: 4.659 ± 0.08	0.823SerTrp: 0.823 ± 0.03	1.595SerTyr: 1.595 ± 0.044	0.002SerXaa: 0.002 ± 0.001
Thr	5.866ThrAla: 5.866 ± 0.094	0.515ThrCys: 0.515 ± 0.024	3.269ThrAsp: 3.269 ± 0.073	3.096ThrGlu: 3.096 ± 0.057	1.862ThrPhe: 1.862 ± 0.047	4.93ThrGly: 4.93 ± 0.089	1.086ThrHis: 1.086 ± 0.035	2.733ThrIle: 2.733 ± 0.057	1.121ThrLys: 1.121 ± 0.038	6.405ThrLeu: 6.405 ± 0.083	1.084ThrMet: 1.084 ± 0.031	1.425ThrAsn: 1.425 ± 0.039	3.241ThrPro: 3.241 ± 0.063	1.739ThrGln: 1.739 ± 0.047	3.152ThrArg: 3.152 ± 0.058	2.91ThrSer: 2.91 ± 0.055	3.055ThrThr: 3.055 ± 0.061	4.51ThrVal: 4.51 ± 0.085	0.691ThrTrp: 0.691 ± 0.03	1.312ThrTyr: 1.312 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	8.253ValAla: 8.253 ± 0.11	0.774ValCys: 0.774 ± 0.032	4.994ValAsp: 4.994 ± 0.083	4.388ValGlu: 4.388 ± 0.074	2.95ValPhe: 2.95 ± 0.055	5.496ValGly: 5.496 ± 0.076	1.356ValHis: 1.356 ± 0.044	4.349ValIle: 4.349 ± 0.071	2.043ValLys: 2.043 ± 0.049	7.264ValLeu: 7.264 ± 0.1	1.816ValMet: 1.816 ± 0.051	2.354ValAsn: 2.354 ± 0.053	3.295ValPro: 3.295 ± 0.065	2.05ValGln: 2.05 ± 0.048	4.048ValArg: 4.048 ± 0.063	4.956ValSer: 4.956 ± 0.082	4.474ValThr: 4.474 ± 0.082	6.203ValVal: 6.203 ± 0.101	0.802ValTrp: 0.802 ± 0.032	1.783ValTyr: 1.783 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.004TrpAla: 1.004 ± 0.036	0.159TrpCys: 0.159 ± 0.014	0.688TrpAsp: 0.688 ± 0.025	0.676TrpGlu: 0.676 ± 0.025	0.587TrpPhe: 0.587 ± 0.027	0.919TrpGly: 0.919 ± 0.032	0.372TrpHis: 0.372 ± 0.02	0.631TrpIle: 0.631 ± 0.027	0.416TrpLys: 0.416 ± 0.021	1.723TrpLeu: 1.723 ± 0.049	0.335TrpMet: 0.335 ± 0.018	0.457TrpAsn: 0.457 ± 0.025	0.599TrpPro: 0.599 ± 0.024	0.762TrpGln: 0.762 ± 0.031	1.063TrpArg: 1.063 ± 0.041	0.928TrpSer: 0.928 ± 0.034	0.629TrpThr: 0.629 ± 0.025	1.015TrpVal: 1.015 ± 0.032	0.211TrpTrp: 0.211 ± 0.017	0.362TrpTyr: 0.362 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.423TyrAla: 2.423 ± 0.052	0.306TyrCys: 0.306 ± 0.016	1.597TyrAsp: 1.597 ± 0.04	1.458TyrGlu: 1.458 ± 0.043	1.111TyrPhe: 1.111 ± 0.039	2.193TyrGly: 2.193 ± 0.044	0.655TyrHis: 0.655 ± 0.028	1.133TyrIle: 1.133 ± 0.037	0.641TyrLys: 0.641 ± 0.022	2.799TyrLeu: 2.799 ± 0.047	0.495TyrMet: 0.495 ± 0.022	0.784TyrAsn: 0.784 ± 0.032	1.369TyrPro: 1.369 ± 0.042	1.173TyrGln: 1.173 ± 0.033	2.075TyrArg: 2.075 ± 0.043	1.699TyrSer: 1.699 ± 0.042	1.385TyrThr: 1.385 ± 0.05	1.635TyrVal: 1.635 ± 0.044	0.384TyrTrp: 0.384 ± 0.021	0.807TyrTyr: 0.807 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.113XaaXaa: 0.113 ± 0.047

Statistics based on 2923 proteins (948102 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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