Amino acid dipepetide frequency for Streptomyces rubellomurinus (strain ATCC 31215)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.048AlaAla: 25.048 ± 0.218	1.125AlaCys: 1.125 ± 0.024	9.086AlaAsp: 9.086 ± 0.08	10.043AlaGlu: 10.043 ± 0.115	3.712AlaPhe: 3.712 ± 0.044	14.474AlaGly: 14.474 ± 0.109	2.924AlaHis: 2.924 ± 0.038	3.41AlaIle: 3.41 ± 0.044	2.806AlaLys: 2.806 ± 0.056	15.987AlaLeu: 15.987 ± 0.133	2.405AlaMet: 2.405 ± 0.036	2.05AlaAsn: 2.05 ± 0.035	7.887AlaPro: 7.887 ± 0.107	3.877AlaGln: 3.877 ± 0.05	10.542AlaArg: 10.542 ± 0.103	5.4AlaSer: 5.4 ± 0.059	7.189AlaThr: 7.189 ± 0.077	13.344AlaVal: 13.344 ± 0.111	1.954AlaTrp: 1.954 ± 0.037	2.561AlaTyr: 2.561 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.022	0.093CysCys: 0.093 ± 0.007	0.457CysAsp: 0.457 ± 0.015	0.406CysGlu: 0.406 ± 0.015	0.205CysPhe: 0.205 ± 0.009	0.993CysGly: 0.993 ± 0.028	0.19CysHis: 0.19 ± 0.01	0.157CysIle: 0.157 ± 0.009	0.114CysLys: 0.114 ± 0.008	0.747CysLeu: 0.747 ± 0.02	0.119CysMet: 0.119 ± 0.008	0.131CysAsn: 0.131 ± 0.008	0.518CysPro: 0.518 ± 0.02	0.176CysGln: 0.176 ± 0.009	0.629CysArg: 0.629 ± 0.019	0.464CysSer: 0.464 ± 0.016	0.496CysThr: 0.496 ± 0.015	0.578CysVal: 0.578 ± 0.017	0.136CysTrp: 0.136 ± 0.008	0.164CysTyr: 0.164 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.755AspAla: 7.755 ± 0.076	0.453AspCys: 0.453 ± 0.017	3.135AspAsp: 3.135 ± 0.043	3.697AspGlu: 3.697 ± 0.05	1.623AspPhe: 1.623 ± 0.03	6.544AspGly: 6.544 ± 0.061	1.506AspHis: 1.506 ± 0.028	1.469AspIle: 1.469 ± 0.032	1.031AspLys: 1.031 ± 0.025	6.719AspLeu: 6.719 ± 0.055	0.607AspMet: 0.607 ± 0.017	0.902AspAsn: 0.902 ± 0.024	4.697AspPro: 4.697 ± 0.048	1.665AspGln: 1.665 ± 0.03	5.034AspArg: 5.034 ± 0.065	2.232AspSer: 2.232 ± 0.037	3.05AspThr: 3.05 ± 0.041	4.378AspVal: 4.378 ± 0.057	1.097AspTrp: 1.097 ± 0.032	1.171AspTyr: 1.171 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.785GluAla: 7.785 ± 0.089	0.357GluCys: 0.357 ± 0.013	2.813GluAsp: 2.813 ± 0.042	3.348GluGlu: 3.348 ± 0.055	1.522GluPhe: 1.522 ± 0.032	4.043GluGly: 4.043 ± 0.046	1.673GluHis: 1.673 ± 0.032	2.02GluIle: 2.02 ± 0.037	1.187GluLys: 1.187 ± 0.029	7.698GluLeu: 7.698 ± 0.074	0.76GluMet: 0.76 ± 0.019	0.898GluAsn: 0.898 ± 0.021	3.475GluPro: 3.475 ± 0.043	2.478GluGln: 2.478 ± 0.045	5.679GluArg: 5.679 ± 0.065	2.226GluSer: 2.226 ± 0.038	2.458GluThr: 2.458 ± 0.035	4.612GluVal: 4.612 ± 0.054	0.693GluTrp: 0.693 ± 0.02	1.065GluTyr: 1.065 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.81PheAla: 3.81 ± 0.046	0.277PheCys: 0.277 ± 0.012	2.08PheAsp: 2.08 ± 0.035	1.442PheGlu: 1.442 ± 0.03	0.787PhePhe: 0.787 ± 0.024	2.993PheGly: 2.993 ± 0.042	0.637PheHis: 0.637 ± 0.018	0.62PheIle: 0.62 ± 0.018	0.455PheLys: 0.455 ± 0.018	2.541PheLeu: 2.541 ± 0.042	0.327PheMet: 0.327 ± 0.013	0.532PheAsn: 0.532 ± 0.017	1.415PhePro: 1.415 ± 0.027	0.709PheGln: 0.709 ± 0.02	1.768PheArg: 1.768 ± 0.032	1.345PheSer: 1.345 ± 0.023	1.924PheThr: 1.924 ± 0.034	2.13PheVal: 2.13 ± 0.036	0.409PheTrp: 0.409 ± 0.016	0.567PheTyr: 0.567 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.889GlyAla: 11.889 ± 0.102	0.858GlyCys: 0.858 ± 0.023	4.934GlyAsp: 4.934 ± 0.054	5.215GlyGlu: 5.215 ± 0.059	2.909GlyPhe: 2.909 ± 0.041	9.034GlyGly: 9.034 ± 0.086	2.401GlyHis: 2.401 ± 0.034	3.251GlyIle: 3.251 ± 0.042	2.157GlyLys: 2.157 ± 0.041	10.075GlyLeu: 10.075 ± 0.083	1.895GlyMet: 1.895 ± 0.031	1.688GlyAsn: 1.688 ± 0.034	5.663GlyPro: 5.663 ± 0.06	2.746GlyGln: 2.746 ± 0.036	8.051GlyArg: 8.051 ± 0.073	5.197GlySer: 5.197 ± 0.058	6.217GlyThr: 6.217 ± 0.069	7.536GlyVal: 7.536 ± 0.07	1.771GlyTrp: 1.771 ± 0.03	2.339GlyTyr: 2.339 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.779HisAla: 2.779 ± 0.045	0.24HisCys: 0.24 ± 0.01	1.25HisAsp: 1.25 ± 0.026	1.144HisGlu: 1.144 ± 0.025	0.642HisPhe: 0.642 ± 0.02	2.484HisGly: 2.484 ± 0.035	0.66HisHis: 0.66 ± 0.021	0.534HisIle: 0.534 ± 0.016	0.317HisLys: 0.317 ± 0.013	2.7HisLeu: 2.7 ± 0.035	0.281HisMet: 0.281 ± 0.013	0.371HisAsn: 0.371 ± 0.014	2.002HisPro: 2.002 ± 0.036	0.682HisGln: 0.682 ± 0.023	2.243HisArg: 2.243 ± 0.041	0.972HisSer: 0.972 ± 0.023	1.252HisThr: 1.252 ± 0.025	1.595HisVal: 1.595 ± 0.025	0.4HisTrp: 0.4 ± 0.013	0.484HisTyr: 0.484 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.609IleAla: 4.609 ± 0.052	0.291IleCys: 0.291 ± 0.013	2.091IleAsp: 2.091 ± 0.032	1.907IleGlu: 1.907 ± 0.034	0.589IlePhe: 0.589 ± 0.019	3.522IleGly: 3.522 ± 0.048	0.579IleHis: 0.579 ± 0.016	0.739IleIle: 0.739 ± 0.022	0.67IleLys: 0.67 ± 0.021	2.085IleLeu: 2.085 ± 0.037	0.385IleMet: 0.385 ± 0.013	0.65IleAsn: 0.65 ± 0.021	1.588IlePro: 1.588 ± 0.031	0.671IleGln: 0.671 ± 0.02	2.147IleArg: 2.147 ± 0.035	1.529IleSer: 1.529 ± 0.031	2.049IleThr: 2.049 ± 0.033	2.363IleVal: 2.363 ± 0.035	0.342IleTrp: 0.342 ± 0.015	0.424IleTyr: 0.424 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.785LysAla: 2.785 ± 0.044	0.089LysCys: 0.089 ± 0.007	1.178LysAsp: 1.178 ± 0.031	0.954LysGlu: 0.954 ± 0.03	0.424LysPhe: 0.424 ± 0.016	1.586LysGly: 1.586 ± 0.033	0.435LysHis: 0.435 ± 0.016	0.678LysIle: 0.678 ± 0.026	0.598LysLys: 0.598 ± 0.025	1.975LysLeu: 1.975 ± 0.035	0.36LysMet: 0.36 ± 0.016	0.433LysAsn: 0.433 ± 0.016	1.268LysPro: 1.268 ± 0.031	0.664LysGln: 0.664 ± 0.02	1.205LysArg: 1.205 ± 0.025	0.988LysSer: 0.988 ± 0.024	1.052LysThr: 1.052 ± 0.03	1.807LysVal: 1.807 ± 0.041	0.216LysTrp: 0.216 ± 0.01	0.419LysTyr: 0.419 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	17.831LeuAla: 17.831 ± 0.138	0.807LeuCys: 0.807 ± 0.02	7.181LeuAsp: 7.181 ± 0.069	4.751LeuGlu: 4.751 ± 0.059	2.564LeuPhe: 2.564 ± 0.045	9.904LeuGly: 9.904 ± 0.086	2.447LeuHis: 2.447 ± 0.035	3.026LeuIle: 3.026 ± 0.039	1.855LeuLys: 1.855 ± 0.038	12.203LeuLeu: 12.203 ± 0.12	1.494LeuMet: 1.494 ± 0.031	1.689LeuAsn: 1.689 ± 0.028	7.039LeuPro: 7.039 ± 0.07	2.194LeuGln: 2.194 ± 0.033	9.22LeuArg: 9.22 ± 0.079	4.977LeuSer: 4.977 ± 0.051	6.988LeuThr: 6.988 ± 0.06	9.1LeuVal: 9.1 ± 0.077	1.338LeuTrp: 1.338 ± 0.03	1.753LeuTyr: 1.753 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.168MetAla: 2.168 ± 0.037	0.117MetCys: 0.117 ± 0.008	0.839MetAsp: 0.839 ± 0.02	0.621MetGlu: 0.621 ± 0.019	0.411MetPhe: 0.411 ± 0.016	1.175MetGly: 1.175 ± 0.025	0.323MetHis: 0.323 ± 0.014	0.61MetIle: 0.61 ± 0.018	0.362MetLys: 0.362 ± 0.015	1.56MetLeu: 1.56 ± 0.033	0.258MetMet: 0.258 ± 0.012	0.383MetAsn: 0.383 ± 0.016	1.017MetPro: 1.017 ± 0.023	0.379MetGln: 0.379 ± 0.015	1.248MetArg: 1.248 ± 0.028	1.123MetSer: 1.123 ± 0.023	1.41MetThr: 1.41 ± 0.031	1.213MetVal: 1.213 ± 0.022	0.17MetTrp: 0.17 ± 0.009	0.279MetTyr: 0.279 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.193AsnAla: 2.193 ± 0.037	0.147AsnCys: 0.147 ± 0.008	0.893AsnAsp: 0.893 ± 0.023	0.773AsnGlu: 0.773 ± 0.018	0.473AsnPhe: 0.473 ± 0.015	1.996AsnGly: 1.996 ± 0.042	0.382AsnHis: 0.382 ± 0.014	0.583AsnIle: 0.583 ± 0.02	0.345AsnLys: 0.345 ± 0.014	1.724AsnLeu: 1.724 ± 0.036	0.27AsnMet: 0.27 ± 0.012	0.399AsnAsn: 0.399 ± 0.017	1.387AsnPro: 1.387 ± 0.03	0.542AsnGln: 0.542 ± 0.017	1.217AsnArg: 1.217 ± 0.026	0.89AsnSer: 0.89 ± 0.026	1.044AsnThr: 1.044 ± 0.027	1.276AsnVal: 1.276 ± 0.031	0.258AsnTrp: 0.258 ± 0.011	0.377AsnTyr: 0.377 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	10.23ProAla: 10.23 ± 0.104	0.348ProCys: 0.348 ± 0.014	4.476ProAsp: 4.476 ± 0.057	4.423ProGlu: 4.423 ± 0.052	1.542ProPhe: 1.542 ± 0.031	7.126ProGly: 7.126 ± 0.069	1.343ProHis: 1.343 ± 0.026	1.398ProIle: 1.398 ± 0.025	1.126ProLys: 1.126 ± 0.027	5.442ProLeu: 5.442 ± 0.054	0.912ProMet: 0.912 ± 0.024	1.001ProAsn: 1.001 ± 0.021	3.37ProPro: 3.37 ± 0.058	1.907ProGln: 1.907 ± 0.038	3.782ProArg: 3.782 ± 0.051	2.948ProSer: 2.948 ± 0.05	3.382ProThr: 3.382 ± 0.056	5.755ProVal: 5.755 ± 0.058	0.932ProTrp: 0.932 ± 0.023	1.335ProTyr: 1.335 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.104GlnAla: 4.104 ± 0.061	0.189GlnCys: 0.189 ± 0.009	1.428GlnAsp: 1.428 ± 0.027	1.383GlnGlu: 1.383 ± 0.027	0.681GlnPhe: 0.681 ± 0.018	2.327GlnGly: 2.327 ± 0.038	0.68GlnHis: 0.68 ± 0.022	0.965GlnIle: 0.965 ± 0.025	0.505GlnLys: 0.505 ± 0.017	3.363GlnLeu: 3.363 ± 0.041	0.409GlnMet: 0.409 ± 0.015	0.488GlnAsn: 0.488 ± 0.018	1.865GlnPro: 1.865 ± 0.042	1.364GlnGln: 1.364 ± 0.036	2.433GlnArg: 2.433 ± 0.041	1.222GlnSer: 1.222 ± 0.026	1.244GlnThr: 1.244 ± 0.022	2.492GlnVal: 2.492 ± 0.035	0.475GlnTrp: 0.475 ± 0.015	0.595GlnTyr: 0.595 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.733ArgAla: 10.733 ± 0.105	0.585ArgCys: 0.585 ± 0.02	4.007ArgAsp: 4.007 ± 0.05	4.704ArgGlu: 4.704 ± 0.058	2.28ArgPhe: 2.28 ± 0.039	5.616ArgGly: 5.616 ± 0.061	2.113ArgHis: 2.113 ± 0.032	3.268ArgIle: 3.268 ± 0.044	1.418ArgLys: 1.418 ± 0.029	9.336ArgLeu: 9.336 ± 0.088	1.642ArgMet: 1.642 ± 0.032	1.294ArgAsn: 1.294 ± 0.025	5.336ArgPro: 5.336 ± 0.074	2.272ArgGln: 2.272 ± 0.037	7.712ArgArg: 7.712 ± 0.073	3.832ArgSer: 3.832 ± 0.042	5.21ArgThr: 5.21 ± 0.06	5.538ArgVal: 5.538 ± 0.049	1.396ArgTrp: 1.396 ± 0.032	1.813ArgTyr: 1.813 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.402SerAla: 6.402 ± 0.059	0.448SerCys: 0.448 ± 0.017	2.292SerAsp: 2.292 ± 0.035	2.028SerGlu: 2.028 ± 0.034	1.422SerPhe: 1.422 ± 0.029	5.491SerGly: 5.491 ± 0.059	0.938SerHis: 0.938 ± 0.024	1.371SerIle: 1.371 ± 0.03	0.867SerLys: 0.867 ± 0.024	4.543SerLeu: 4.543 ± 0.053	1.002SerMet: 1.002 ± 0.022	0.876SerAsn: 0.876 ± 0.024	3.049SerPro: 3.049 ± 0.051	1.165SerGln: 1.165 ± 0.024	3.236SerArg: 3.236 ± 0.04	2.647SerSer: 2.647 ± 0.059	2.829SerThr: 2.829 ± 0.043	3.844SerVal: 3.844 ± 0.045	0.892SerTrp: 0.892 ± 0.023	1.147SerTyr: 1.147 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	9.372ThrAla: 9.372 ± 0.088	0.417ThrCys: 0.417 ± 0.016	3.434ThrAsp: 3.434 ± 0.042	3.055ThrGlu: 3.055 ± 0.041	1.479ThrPhe: 1.479 ± 0.029	6.825ThrGly: 6.825 ± 0.072	1.037ThrHis: 1.037 ± 0.025	1.578ThrIle: 1.578 ± 0.03	1.024ThrLys: 1.024 ± 0.025	5.517ThrLeu: 5.517 ± 0.046	0.84ThrMet: 0.84 ± 0.02	1.011ThrAsn: 1.011 ± 0.028	4.06ThrPro: 4.06 ± 0.053	1.192ThrGln: 1.192 ± 0.031	3.659ThrArg: 3.659 ± 0.045	2.736ThrSer: 2.736 ± 0.042	3.711ThrThr: 3.711 ± 0.049	6.146ThrVal: 6.146 ± 0.064	0.818ThrTrp: 0.818 ± 0.023	1.155ThrTyr: 1.155 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.934ValAla: 10.934 ± 0.089	0.69ValCys: 0.69 ± 0.018	5.141ValAsp: 5.141 ± 0.056	5.057ValGlu: 5.057 ± 0.062	2.454ValPhe: 2.454 ± 0.042	6.419ValGly: 6.419 ± 0.06	1.976ValHis: 1.976 ± 0.032	2.652ValIle: 2.652 ± 0.04	1.625ValLys: 1.625 ± 0.034	10.107ValLeu: 10.107 ± 0.085	1.242ValMet: 1.242 ± 0.029	1.616ValAsn: 1.616 ± 0.032	5.208ValPro: 5.208 ± 0.06	2.189ValGln: 2.189 ± 0.037	7.062ValArg: 7.062 ± 0.067	3.925ValSer: 3.925 ± 0.048	5.347ValThr: 5.347 ± 0.065	7.877ValVal: 7.877 ± 0.085	1.025ValTrp: 1.025 ± 0.025	1.476ValTyr: 1.476 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.723TrpAla: 1.723 ± 0.034	0.153TrpCys: 0.153 ± 0.009	0.778TrpAsp: 0.778 ± 0.019	0.758TrpGlu: 0.758 ± 0.021	0.459TrpPhe: 0.459 ± 0.017	1.06TrpGly: 1.06 ± 0.027	0.373TrpHis: 0.373 ± 0.014	0.51TrpIle: 0.51 ± 0.017	0.322TrpLys: 0.322 ± 0.013	1.767TrpLeu: 1.767 ± 0.035	0.253TrpMet: 0.253 ± 0.011	0.375TrpAsn: 0.375 ± 0.013	0.812TrpPro: 0.812 ± 0.02	0.642TrpGln: 0.642 ± 0.019	1.341TrpArg: 1.341 ± 0.026	0.937TrpSer: 0.937 ± 0.024	1.072TrpThr: 1.072 ± 0.027	0.985TrpVal: 0.985 ± 0.023	0.335TrpTrp: 0.335 ± 0.014	0.357TrpTyr: 0.357 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.589TyrAla: 2.589 ± 0.038	0.177TyrCys: 0.177 ± 0.009	1.273TyrAsp: 1.273 ± 0.025	1.081TyrGlu: 1.081 ± 0.025	0.59TyrPhe: 0.59 ± 0.017	2.217TyrGly: 2.217 ± 0.035	0.415TyrHis: 0.415 ± 0.014	0.392TyrIle: 0.392 ± 0.014	0.332TyrLys: 0.332 ± 0.015	2.271TyrLeu: 2.271 ± 0.031	0.203TyrMet: 0.203 ± 0.01	0.379TyrAsn: 0.379 ± 0.015	1.121TyrPro: 1.121 ± 0.027	0.694TyrGln: 0.694 ± 0.02	1.897TyrArg: 1.897 ± 0.032	0.899TyrSer: 0.899 ± 0.027	1.141TyrThr: 1.141 ± 0.026	1.456TyrVal: 1.456 ± 0.029	0.354TyrTrp: 0.354 ± 0.012	0.423TyrTyr: 0.423 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6267 proteins (1971839 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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